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reasonsforhope · 9 months

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"One in five Americans will experience major depressive disorder in their lifetime, and many will not find relief from current therapies. But now researchers have identified an unexpected source of the problem: inflammation.

Inflammation in the body may be triggering or exacerbating depression in the brains of some patients. And clinical trial data suggests that targeting and treating the inflammation may be a way to provide more-precise care.

The findings have the potential to revolutionize medical care for depression, an often intractable illness that doesn't always respond to conventional drug treatments. While current drug treatments target certain neurotransmitters, the new research suggests that in some patients, depressive behaviors may be fueled by the inflammatory process.

It appears that inflammatory agents in the blood can break down the barrier between the body and the brain [and specifically the blood-brain barrier], causing neuroinflammation and altering key neural circuits, researchers say. In people at risk for depression, inflammation may be a trigger for the disorder.

Research suggests that only a subset of depressed patients - roughly 30 percent - have elevated inflammation, which is also associated with poor responses to antidepressants. This inflammatory subgroup may be a key to parsing out differences in underlying mechanisms for depression and personalizing treatment...

The inflamed body and the depressed brain

...A number of studies show that depressed patients tend to have increased inflammation compared with non-depressed subjects, including more inflammatory cytokines and C-reactive protein — which is produced by the liver in response to inflammation — circulating in the blood. Patients with autoimmune diseases have inordinately high rates of depression. And postmortem brain samples from people who died by suicide showed more activation of the brain’s immune cells, which release inflammatory agents.

Crucially, pro-inflammatory drugs can induce people to become depressed, which suggests a causative link. In one seminal study published in the New England Journal of Medicine, Miller and his colleagues conducted a double-blind study of 40 cancer patients undergoing treatment with interferon-alpha, an inflammatory cytokine.

Though none of the patients had depression to begin with, the inflammatory agent had a striking effect: Many became depressed, a finding that has been consistently replicated.

"The patients recognize pretty much immediately that, 'Hey, you gave me something, and now I feel this way. I don't know why I feel this way,'" Miller said.

Can treating inflammation treat depression?

If inflammation can induce or exacerbate depression and its symptoms, then reducing inflammation could provide relief.

Even if inflammation is a disease modifier rather than the cause of the problem, “you have to take care of it in order for you to be able to get your therapeutics working to restore your circuitry and what’s happening in the mind,” said Eleonore Beurel, a professor of psychiatry and behavioral sciences at the University of Miami Miller School of Medicine.

Anti-inflammatory drugs, used alone or in conjunction with a standard antidepressant, may help some depressed patients. A 2019 meta-analysis encompassing almost 10,000 patients from 36 randomized clinical trials found that different anti-inflammatory agents, including NSAIDs, cytokine inhibitors and statins, could improve depressive symptoms...

“We’ve come to the tipping point,” Miller said. “And we know enough at this point to begin to target the immune system and its downstream effects on the brain to treat depression. We are there.”

How to manage your own inflammation

Experts agreed that people should not take anti-inflammatories without talking with their health-care provider. Your doctor can order a C-reactive protein blood test to measure your level of inflammation.

“There are so many patients who do not respond to antidepressants,” said Ole Köhler-Forsberg, a physician and associate professor of psychiatry at Aarhus University who has given anti-inflammatory drugs to his patients in addition to antidepressants. “So there is the issue of how can we improve the individual outcomes.” Tailoring treatment for each individual on a holistic basis may add some benefit.

More clinical tests for inflammatory markers may be a way to differentiate the effectiveness of antidepressant treatment. If confirmed, it would “be the first actual biomarker in psychiatry,” Raison said. “I mean, we’ve been looking for biomarkers for 50 years and had zero luck. And it’s ironic that it’s not a brain chemical.”

In the meantime, “you get much more mileage out of the lifestyle changes than you would out of supplements or any other over-the-counter drugs at this point,” Miller said."

-via The Washington Post (via Yahoo News), February 24, 2023

#depression #cw sui mention #cw suicide mention #inflammation #autoimmune #cytokines #neuroscience #medical news #medical research #anti inflammatory #antidepressants #ssri #mental health #mental illness #good news #hope #way way more details at the source btw

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ghoulsencyclopedia · 7 months

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Bay Leaf

Associations:

Open Mindedness

Learning

Manifestation

Innovation

Learning

Self Awareness

Protection

Cleansing

Divination

Properties:

Anti Inflammatory

Antibacterial

Respiratory Aid

Digestive Aid

Stress Reducer

Heart Health

Correspondences:

Sun

Cancer

Solar Plexus, Third Eye

Yellow, Green

Feminine

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yiippii · 5 months

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I can’t believe I have to eat a certain diet to have clear skin. Not. Cool. At. All.

And right now we have so much sugar and candy at home and of course as I lack self control I’m acting like a pig, a glutton!!!! Ugh!!!

Anywho!

You know the drill already!

I LOVE YOU SO MUCHHHHHH!!!!!

Mommy loves you!!!! Mwahh!

Goodnight!!🩷💤🌙

#anti inflammatory #inflammatory #non inflammatory diet #acne #bad skin #dieting #coquette #coquette aesthetic #girlblogging #girly blog #girly girl #let’s be friends #looking for friends #be my frieeennnddd #be my friend #wanna be friends?

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originalistideas · 16 days

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🚨🔥🔥🚨 Are you sick of your pain? Do you suffer from Neuropathy or circulation problems? Do you have Foot fungus? There’s hope. This is my natural blend that is a powerful pain reliever, anti inflammatory, antiviral, and antibacterial. The powers of Oregano, Clove, Cayenne pepper, Castor Oil, olive oil and DMSO make this oil master of pain and circulation.

This is me doing my part to help you. I’ve created an all natural pain reliever. I’ve tested it on every friend and family member I had with every kind of pain.

When you realize taking pain meds all the time are slowly killing you, You might consider finding a more natural way to stop the pain… well I have!

If you’re interested in actual pain relief that works literally in seconds shoot me an email. This 2ounce bottle is $25.00 + any shipping and handling due to the ingredients that make it so effective. It’s a carrier oil that penetrates deep. It kills muscle, and joint pain in seconds. It promotes circulation so it helps with neuropathy in your legs. In days it can bring back sensation.

#castor oil #pain relief #cayenne pepper #neuropathy #circulation #antiviral #antibacterial #anti inflammatory #antifungalcream #all natural

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legumepowered · 1 month

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hey btw if u have insane chronic pain, take a look at what yr eating. * I recently figured out that eating a lot of white flour for a couple days in a row makes me SUPER inflamed and basically makes my entire body sore/tender for a week. When my pain was at the highest, I was eating fast food/fried fish sandwiches + a ton of sugar in soda EVERY day bc i worked in fast food.

So definitely look at what you eat on a regular basis and look up commonly inflammatory foods. ESP if u have autism (or adhd too I'm sure). Cross River Therapy has an article from 2023 about the link between autism and inflammation, it's a really interesting read.

also if you have autism, yr gut is probably fucked up too n eating better would help.

* it's not always possible to change what yr eating whether you have ARFID or yr living situation or financial situation. however it's always good to have the info.

#mine #inflammation #anti inflammatory #autism #comorbid conditions #autism comorbidities

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sidewalkchemistry · 11 months

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How to Reverse Autoimmune Disease, or Almost Any Chronic Disease with Supermarket Foods (Dr. Brooke Goldner)

While in high school, this doctor had a diagnosis of lupus with even stage 4 kidney failure (which normally takes people's lives within a few months). She put it into remission with conventional treatments, but it came out with more life-threatening ramifications (mini strokes) while she was in the stress of medical school. Through lifestyle shifts, she found out how to live beyond her expectancy, joyfully, and even give birth to healthy children.

Her own experience mixed with in-depth research helped her to ensure the protocol could be reproducible and safe. So, she started to work on these methods with her patients. Healthy emotional habits + hypernourishment (what I personally refer to as food centric herbalism) is central to her practice. It's not miracle work. It's based on limiting the obstructions on the body's abilities to naturally restore itself (just like the healing of a minor wound). It's scientific and effective.

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pcos-and-endo-awareness · 1 year

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#endometriosis #pcos #chronic inflammation #remedies #anti inflammatory #nutrition #I’ve seen an improvement in my inflammation by focusing on these foods

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kbeautynotes · 11 months

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The Ultimate Guide to Niacinamide: Benefits, Uses, and More

In the vast world of skincare, new ingredients are constantly emerging, but only a few stand the test of time. Niacinamide (vitamin B3 or nicotinamide) is one such ingredient that has garnered immense popularity for its remarkable skincare benefits.

Learn everything you need to know about Niacinamide: Benefits, Uses, and More, in this blog post: https://kbeautynotes.com/the-ultimate-guide-to-niacinamide-benefits/

Do you like Niacinamide in skincare?

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healthtruth101 · 1 year

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The Best PREDNISONE Alternative

#youtube #alternative health #alternative medicine #vitamin d #anti inflammatory #auto immune disease #sarcoidosis #dr berg

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saddie-to-baddie · 1 year

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Week 1 Game Plan.

This week I'm focusing on better planning my lunches for work and cutting out a few major offenders in my diet.

My current home situation doesn't really provide me with much control over what's for dinner. I know I can always make my own on the side but I want to get there gradually and not overwhelm myself. So instead I'm babystepping into this, and I may not end up getting fully AIP compliant but I'm going to try my best to give myself the biggest chance of healing.

Here's the goals:

1. WATER 💧 : Drink at least 2 bottles of water each day this week. I'm not counting sparkling water in this but it is allowed for now while I'm cutting out soda.

2. Pack a lunch every day for work, and compliant snacks. Only 4 days this week. Today is Monday so I'll be making myself a ton of Chicken Salad. Snacks I haven't decided on but I very well may just pack extra chicken and snack on that.

3. Avoid the list below as much as possible. If I mess up I am not allowed to use "I'll start again tomorrow" as an excuse to go wild for the rest of the day.

4. Take all of my work breaks and take a walk during them.

Here's what I'm avoiding (for now):

1. Dairy 🐄

2. Coffee ☕️

3. Bread 🍞

4. Spicy Stuff 😭 This is going to be the hardest, but it's proven to be a big contributor to my aches and pains.

5. Soda/Energy Drinks 🥤

6. Alcohol. 🍷 This is probably going to be the easiest to start off, but hard to maintain.

7. Candy 🍬 I've become a major candy snacker at work recently and I really need to plan ahead for something to replace these impulse grabs.

It feels like sooo much listed out, but I’m actually feeling pretty confident about it.

#saddie to baddie #spoonie #self improvement #aip diet #autoimmune protocol #autoimmine disease #multiple sclerosis #anti inflammatory #paleo #gut health #i need extra spoons #self care #game plan #pain pain go away #meal planning

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levinletlive · 2 years

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My Recipe Book: Pineapple-Mint Cranberry Juice Cocktail

I'm still sick, and the entire house is a wreck because of it. A stuffy nose is annoying, but there is little more frustrating than an itchy, sore throat. Heat and itching don't really blend, so for that symptom I needed something cool and soothing and this is what I came up with. It's a very simple drink to make, it tastes great, and it's fairly effective at providing some relief.

Servings: 1

Serving size: 10-12 oz.

Season: Autumn/Winter

Category: Drinks

Method: Simple

Prep time: 2 minutes

Cook time: N/A

Ingredients

8 oz. Cranberry juice or cranberry juice cocktail

1/2 cup Pineapple, chopped

6 fresh Mint leaves, muddled

Tools

A mortar and pestle, or spoon and bowl if you don't have one

A standard drinking glass or cup

Instructions

First, go ahead and muddle that mint. Really, you're just crushing it up to release the menthol, which is the chemical that provides that cooling sensation we're all familiar with. Add the leaves to the bottom of the glass.

Chop up your pineapple if you bought it fresh. Smaller pieces are better. I chopped, then sliced. It's better fresh. Put the pineapple in the glass atop the mint.

Add some ice now, if you want it.

Add your cranberry juice or juice cocktail to the glass until full. Use a spoon or straw to mix the ingredients. The mint and some parts of the pineapple will float to the top.

That's it, that's all you have to do.

Some notes:

Menthol is the chemical in mint products responsible for that "cooling" sensation, often used medically to numb or suppress pain.

Pineapple contain an enzyme called bromelain, which is produced as a defense mechanism against predators. It's the stuff that makes your tongue feel weird after eating too much. Anyway, it's also supposed to be food for reducing sinusitis (nasal swelling) and swelling of the mouth and gums.

Cranberries have been studied pretty extensively and are known to protect against intestinal inflammation and urinary tract infections, which can be a risk if you aren't drinking enough water to flush your bladder or tract. They're also full of antioxidants.

And that's that. My throat is still a bit itchy, but better than before.

Photo Gallery:

#cooking #drinks #cocktails #fruit juice #cranberry #pineapple #mint #menthol #bromelain #anti inflammatory #antibacterial #antioxidants #my recipe book #my recipes #common cold #science based #sourced #natural remedies

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chroniclesofchronicillness · 9 months

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Here’s an oxymoron - my anti inflammatories are causing me inflammation! SMH

#chronic illness #chronically ill #chroniclesofchronicillness #chronic pain #invisible illness #invisible disability #spoonie #mental health #pots #svt #inflammation #anti inflammatory

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ghoulsencyclopedia · 7 months

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Basil

Associations:

Connection

Love

Luck

Wealth

Growth

Passion

Protection

Properties:

Anti Inflammatory

Antibacterial

Mood Booster

Stress Reducer

Correspondences:

Heart

Green, White, Purple

#basil #herb #passion #love #luck #wealth #protection #growth #connection #anti inflammatory #antibacterial #stress reducer #mood booster #heart #white #green #purple

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ranjit7853 · 10 months

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Honey: A Super Food

Honey is a natural sweetener that is made by honey bees. It is a good source of carbohydrates, vitamins, and minerals.The nutritional content of honey varies depending on the type of honey and the flowers that the bees have visited. Honey is a solution of its components in the water. So it’s composition and taste will depend on the area and kind of flowers from which the bees will suck the…

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#Anti inflammatory #Anti microbial #Antioxidant #bees #Buckwheat Honey #carbohydrates #Clover Honey #Fructose #Glucose #Health benefits #Honey #Manuka honey #Minerals #Sugar #Tupelo gum trees #Tupelo honey #vitamins

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theantiinflammationstation · 2 years

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Poke bowl, feat. tempeh, carrot, cucumber, cabbage, baby corn, brown rice, and microgreensThis colourful salad was extremely filling and tasty!

#AntiInflammatory #anti-inflammatory #anti inflammatory #arthrits #poke #poke bowl #salad #salad recipe #healthy lunch #carrot #tempeh #cabbage #microgreens #low fodmap #vegan #vegetarian

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pcos-and-endo-awareness · 1 year

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#pcos #endometriosis #polycystic ovarian syndrome #invisible illness #pcos tips #nutrition #anti inflammatory

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