SFADASD did bloodclan bring pillows and blankets with them?

NOPE, JUST BONE. His acromegaly gives him some pretty intense pain in his joints, so he's allowed to carry his lucky blankie and pillows whenever there's a slumber party away from home. uwu

The clan cats are pretty confused by it, but for some reason, nobody wants to risk making a fuss. :'D

This episode, “Lurch Learns to Dance,” is adorable. It also really showcases Ted Cassidy’s incredible comic timing as Lurch:

To think the character was supposed to be mute! Cassidy just ad-libbed his famous “You rang?” and luckily the show’s makers recognized his talent. His physical comedy in this episode is a thing of beauty.

Ted Cassidy died at only 46 - sadly, the complications from acromegaly were probably nothing like today - but if you look up his bio on Wikipedia you’ll be wowed by all he packed into his too-short life.

Acromegaly

-- rare but serious condition

-- caused by too much growth hormone (GH)

-- GH is released into the bloodstream by the pituitary gland at the base of the brain

-- in children, GH causes growth and development

-- in adults, GH effects energy, muscle strength, bone health, and sense of general well-being

-- too much GH in children results in gigantism

-- acromegaly typically occurs in middle-aged adults

-- acromegaly occurs in about 3 in every 1,000,000 people

The Monster Maker is a real small film that has a disastrous reputation. It’s by the numbers apart from working in the brief fascination with acromegaly from this period.

Mary Ann Bevan (1874 - 1933) was an English woman who toured the sideshow circuit as "the ugliest woman in the world" after her appearance drastically changed due to developing acromegaly. It leads to excess growth hormone which causes enlargement of the forehead, jaw, and nose.

“Since the changes are so slow, acromegaly is more tipically something that a random person at the mall might point at, rather than the person themselves or a family member noticing.”

I've been thinking a lot lately and I'm pretty sure I've reached the conclusion that a big part of my not-so-great relationship to my own personal transness comes down to the fact that (thanks to acromegaly) I was forced to confront my feelings about gender wayyy before I was ready.

Like consider the following: you're already dealing with what you are just now realizing is pronoun dysphoria, top dysphoria, all this shit and coming to terms with that and what it all means™ when your face starts insidiously masculinizing on its own without external hormones. (But it's just slow enough that no one believes you-- including doctors).

And of course this would change how others perceive you, but less talked about is how it changes how you perceive yourself, especially when you're already gender questioning. I am obviously in no way saying acromegaly made me trans™, I'm just saying dealing with the aftermath of this pushed a lot of feelings to the surface that I wasn't necessarily ready to deal with, especially in the midst of a much more urgent health crisis.

Like, I spent a good part of today researching plastic surgeons to get multiple cm of bone shaved off my browbone. (And no I do not really have money for this but at this point it's an imperative for me to maintain my fragile grip on sanity-- you know how it is). Which of course means being bombarded with terms like "MtF feminization surgery", "brow shaving to improve feminine aesthetics!" which tbh is an especially bizarre kind of dysphoria-inducing hell and I'm fucking exhausted. Like please god. do we really need the gendered terms? I just want to look normal!

Sometimes I feel like I am the only person in the world in this oddly specific situation. I have to be, right?

If you want to know what's wrong with me, this is it. If you see me joking about having "horns" or other shit, just look the other way because I'm fucking coping

Acromegaly

Overview

Acromegaly is a rare hormonal disorder that results from excessive production of growth hormone (GH) by the pituitary gland. This condition usually develops slowly over several years and is often not diagnosed until later stages. In most cases, acromegaly is caused by a benign tumor in the pituitary gland, called pituitary adenoma, that produces too much GH. Rarely, acromegaly can also be caused by tumors in other parts of the body that produce GH-releasing hormone (GHRH) or by non-tumor-related causes. The excess GH in acromegaly leads to an overgrowth of bones and tissues in the body, especially in the hands, feet, face, and internal organs. This results in a range of symptoms that can include: - Enlarged hands and feet - Coarse facial features - Increased sweating - Fatigue - Headaches - Joint pain - Carpal tunnel syndrome - Sleep apnea - Vision problems - Hypertension - Diabetes mellitus Acromegaly can also increase the risk of certain health problems, such as heart disease, stroke, and colon polyps. Treatment options for acromegaly include surgery to remove the pituitary tumor, medications to reduce GH production or block its effects, and radiation therapy. Treatment can improve symptoms, prevent complications, and reduce the risk of long-term health problems. Regular monitoring and follow-up care are important for managing this condition.

Symptoms

The symptoms of acromegaly can vary widely from person to person and can develop slowly over several years. Some of the common signs and symptoms of acromegaly include: - Enlarged hands and feet: The bones in the hands and feet grow larger, and the fingers and toes become thicker and wider. - Coarse facial features: The bones in the face, especially the jaw and forehead, become more prominent, and the nose and lips may also increase in size. - Increased sweating: People with acromegaly often experience excessive sweating, particularly at night. - Fatigue: People with acromegaly may feel tired or lack energy, even after a good night's sleep. - Headaches: Chronic headaches are a common symptom of acromegaly, and they can be severe. - Joint pain: The growth of bones and tissues can cause joint pain and stiffness, particularly in the hips, knees, and shoulders. - Carpal tunnel syndrome: The growth of tissues in the wrist can compress the median nerve, causing carpal tunnel syndrome. - Sleep apnea: Enlargement of the soft tissues in the throat can cause sleep apnea, a condition in which breathing stops briefly during sleep. - Vision problems: The enlarged pituitary gland can press against the optic nerves, causing vision problems or even vision loss. - Hypertension: Excessive growth hormone can cause high blood pressure. - Diabetes mellitus: The excess growth hormone can also cause insulin resistance, leading to high blood sugar levels and an increased risk of diabetes mellitus. It's important to note that not all people with acromegaly experience all of these symptoms. Some people may have mild or no symptoms, while others may experience more severe symptoms. If you're experiencing any of these symptoms, it's important to see a doctor for an evaluation.

When to see a doctor

If you have any symptoms of acromegaly, it's important to see a doctor for an evaluation. Some of the common symptoms include enlarged hands and feet, coarse facial features, excessive sweating, fatigue, chronic headaches, joint pain, carpal tunnel syndrome, sleep apnea, vision problems, hypertension, and diabetes mellitus. In addition, if you have a family history of acromegaly or have a condition that increases your risk of developing this disorder, such as multiple endocrine neoplasia type 1 (MEN1) or Carney complex, you should talk to your doctor about screening for acromegaly. Early diagnosis and treatment of acromegaly can prevent or minimize the development of complications associated with this disorder, such as heart disease, stroke, and colon polyps. If you suspect that you or a loved one may have acromegaly, it's important to see a doctor as soon as possible. Your doctor can order blood tests to check for elevated levels of growth hormone and insulin-like growth factor-1 (IGF-1), which are markers of acromegaly. Imaging tests, such as magnetic resonance imaging (MRI), may also be ordered to visualize any pituitary tumors. Treatment options for acromegaly are available and can help manage the symptoms and reduce the risk of complications.

Causes

Acromegaly is caused by the overproduction of growth hormone (GH) by the pituitary gland, which is a small gland located at the base of the brain. The excess GH is usually caused by a benign tumor, called a pituitary adenoma, that grows on the pituitary gland and produces too much GH. In rare cases, acromegaly can also be caused by tumors in other parts of the body that produce GH-releasing hormone (GHRH), which stimulates the pituitary gland to produce GH. These tumors are usually found in the pancreas, lungs, or adrenal glands. Other less common causes of acromegaly include: - Familial acromegaly: In rare cases, acromegaly can be inherited in an autosomal dominant pattern, which means that a person only needs to inherit one copy of the abnormal gene from one parent to develop the disorder. - Non-tumor-related causes: In very rare cases, acromegaly can be caused by certain medical conditions, such as McCune-Albright syndrome, which is a rare genetic disorder that causes abnormal bone growth and hormonal imbalances. Acromegaly usually develops slowly over several years, and the symptoms may not be noticeable for a long time. Early diagnosis and treatment are important to prevent complications associated with this disorder. If you suspect that you may have acromegaly or have a family history of the disorder, it's important to talk to your doctor about screening and testing for this condition.

Risk factors

There are several risk factors associated with the development of acromegaly, including: - Age: Acromegaly can occur at any age, but it is more common in middle-aged adults. - Gender: Acromegaly affects both men and women equally. - Family history: People with a family history of acromegaly or multiple endocrine neoplasia type 1 (MEN1) or Carney complex have an increased risk of developing the disorder. - Medical history: People who have had radiation therapy to the head or neck or have a history of pituitary tumors are at an increased risk of developing acromegaly. - Genetics: Some genetic mutations have been associated with an increased risk of developing pituitary tumors, which can lead to acromegaly. - Insulin resistance: People with insulin resistance, which can occur in conditions such as obesity or type 2 diabetes, may be at an increased risk of developing acromegaly. It's important to note that having one or more of these risk factors does not necessarily mean that you will develop acromegaly. However, if you have one or more of these risk factors, it's important to be aware of the signs and symptoms of acromegaly and to talk to your doctor about screening and testing for the disorder. Early diagnosis and treatment are important to prevent complications associated with this disorder.

Complications

Acromegaly can lead to a number of complications if left untreated or poorly managed, including: - Cardiovascular disease: Excess growth hormone can cause the heart to work harder, leading to an increased risk of hypertension, heart disease, and stroke. - Diabetes: Acromegaly can lead to insulin resistance, which can increase the risk of developing type 2 diabetes. - Sleep apnea: Enlarged soft tissues in the mouth and throat can obstruct breathing during sleep, leading to sleep apnea and poor quality sleep. - Joint problems: Excess growth hormone can cause bones and cartilage to grow abnormally, leading to joint pain and arthritis. - Carpal tunnel syndrome: Enlarged bones and tissues in the hands can compress the median nerve, causing numbness, tingling, and weakness in the hands and wrists. - Vision problems: Enlarged pituitary tumors can compress the optic nerve, leading to vision problems and even blindness. - Colorectal polyps and cancer: People with acromegaly are at an increased risk of developing polyps in the colon, which can lead to colorectal cancer if left untreated. - Increased risk of infections: People with acromegaly are at an increased risk of developing infections due to the effects of excess growth hormone on the immune system. - Psychosocial problems: People with acromegaly may experience depression, anxiety, and social isolation due to the physical and emotional effects of the disorder. It's important for people with acromegaly to receive early and appropriate treatment to prevent or manage these complications. Treatment options for acromegaly may include surgery, radiation therapy, and medication, depending on the underlying cause and severity of the disorder. Read the full article

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Since Talk uploaded their art of this design, I'm obligated to post it! My design for Bone. He suffers from acromegaly, a disorder in which the pituitary gland produces excess growth hormone. He is also a soft gay himbo. uwu

Causes of Acromegaly

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This guy is hands down the biggest character in the cast, but he’s a gentle giant. He would crush you to death with a hug.

You can read more about him here!

Watching the anterior pituitary endocrine lecture in the onlinemeded videos.

Prolactinoma presents as amenorrhea and galactorrhea in women. We tend to notice the effects of a prolactinoma before it gets big enough to cause visual disturbance. Men may notice decreased libido, but often don't notice it until it grows big enough to cause visual disturbance (bitemporal hemianopia).

Prolactinoma w/u: assess medications (d/c meds that cause elevated prolactin such as DA antagonists). Then check TSH (hypothyroidism can cause elevated prolactin). Then check prolactin level. Then get MRI brain to locate the tumor.

Prolactinoma tx: dopamine agonist (cabergoline or bromocriptine)

DA inhibits PRL secretion

Growth hormone secreting tumors cause acromegaly in adults and gigantism in kids. GH tumor increases cancer risk because it makes cells grow. People get large visceral organs due to excess GH, which can cause diastolic HF if heart grows and can't fill adequately.

GH tells liver to release IGF-1 and glucose. So pts with acromegaly have diabetes.

GH/acromegaly w/u: get IGF-1 level (GH causes liver to release IGF-1, so if IGF-1 is elevated, it's because of excess GH). If IGF-1 elevated, do glucose stimulation test next. Normally when you have an intake of glucose, insulin will increase and insulin causes the other hormones to decrease. So if you give the patient glucose and GH doesn't go down, it confirms excess GH secretion. Then confirm the diagnosis with MRI.

Acromegaly tx: surgery to remove the GH-secreting tumor. Octreotide can be given for residual tissue secreting excess GH.

Hypopituitarism is acute or chronic.

Acute panhypopituitarism is due to infection, infarction, or iatrogenic causes. Iatrogenic hypopituitarism could be due to removing too much tissue to correct hyperpituitarism. No cortisol-> can't regulate blood pressure-> hypotension, tachycardia.

No TSH-> no T4-> lethargy, coma

Tx: steroids, levothyroxine

Sheehan syndrome is due to prolonged delivery in pregnant women; loss of blood means decreased blood to the pituitary-> hypopituitarism.

Apoplexy = large tumor; pt becomes obtunded/nuchal rigidity, HA

Chronic hypopituitarism can be due to autoimmune disease, deposition disease, or tumor. Brain will preserve what is most needed: ACTH, TSH. FSH, LH, and GH aren't vital for survival, so those levels will be low. Pt will thus have decreased libido, fatigue, dysmenorrhea.

Dx: insulin or vasopressin stimulation test. If you give insulin, BG falls; normally, epinephrine, cortisol, and GH should then increase to correct low BG. If those hormones don't increase, it's a positive insulin stimulation test. If positive insulin stimulation test, get MRI.

Tx: replace missing hormones & fix underlying disease

Empty sella syndrome - the anterior and posterior pituitary are not in the sella turcica, but are still present. You only find out about it if you do a brain MRI for something else--it's an incidental finding.

not a bingo ask (unless you want it to be lol) but do you think the giant in the cave in Ambarino is real, or just another weirdo who thinks he's magic? (a la the devil in the cave and the wolf man)

based on the interactions with him and how he kinda implies that he used to live in civilisation and was forced out into the wilderness, I think he's probably just a man with gigantism who was outcast from his village/town for being viewed as a "freak" and possibly viewed as a drain on resources too since he mentions that "nobody wants giant kids because they eat too much." but then again there is a literal giant skeleton in the game that's too big to be from a person with gigantism so who knows 💀 maybe he is a real giant in the mythical sense

the grey one is trixie and the black one is jack!!! my beasts :D

!!!!!!!!! Beasts!!!!!!!!!!! And I love how Trixie keeps laying claim to random objects,,,,,, the plastic bag,,,,, the pencil case,,,,, Theirs Now

perhaps someday I will share pictures of My beasts,,,,, I usually just take pictures of them when they’re doing silly things so I’ll have to find some actual good pictures of them