Having watched thru to the end of Hawaii Five O, I immediately ran to read all the fix-it’s and post-22 stories I could find. Still reading them.

And I’m thinking a lot about this H5O fandom (to which I came too late) and open vs closed canon fandoms.

Hmm. See, I get that fans go where the fannish energy is. But I hope fans who moved elsewhere get what a gift we got at the end of Five-O. Yes, Peter Lenkov is a putz in every way. But his bid to throw Steve and Catherine together on that plane was seriously awkward. And fans have written stories highlighting why that is. Clearly, Cole contacted Catherine re the cipher and told her about Steve’s plans. But, while Cole might not have known better, she sure should have. And her showing up makes her look so much more like Doris.

Now, if Steve had called Cath first, I might have believed the two might be okay together. But.. there was nothing there—no indication at all that Steve was pining for her while she was gone on her mission. And that handholding? Nothing compared to the hospital scene.

ETA: and the dialogue on the plane? Very, very odd. And awkward.

So… closed canon means there’s nothing Lenkov can do to eff things up further. The McDanno playground is ours, people!

Exercise vs Cancer

Exercise inhibits bone cancer metastasis as it mechanically-stimulates osteocytes [bone-forming cells] to secrete extracellular vesicles containing tumour suppressing microRNAs

Read the published research article here

Image from work by Jing Xie and colleagues

Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, Department of Cell Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China

Image originally published with a Creative Commons Attribution 4.0 International (CC BY 4.0)

Published in eLife, February 2024

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WHY is there an actual chicken mascot at the pollos hermanos in metastasis... I can't—

we as society don't talk about metastásis enough. it's a breaking bad adaptation that's like a shot-for-shot remake but colombian and on half the budget. Idk why it exists but i think every country should have a breaking bad remake actually

Metastasis (1971) by Toshio Matsumoto

love wins 💗

Gonna watch this before Breaking Bad just to make people angry.

what if this was the new superwholock

Malignant Evolution

Multi-pronged (whole-exome sequencing, RNA sequencing, and Imaging Mass Cytometry) approach characterises at the single-cell level the heterogeneity of upper tract urothelial carcinoma – cancers arising in the ureter and the kidney's 'pelvis' – from primary to metastatic

Read the published research article here

Image from work by Kentaro Ohara and colleagues

Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA

Image originally published with a Creative Commons Attribution 4.0 International (CC BY 4.0)

Published in Nature Communications, March 2024

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omg in metastasis Walt gets a 8008135 shirt instead of a kenny rogers shirt at the end of box cutter i'm screaming

2 HER2+ breast cancer cell lines, inject into mouse -> get brain mets at different times: early, late, and no outgrowth (latent/dormant cells only)

These isogenic cells are metabolically distinct - centered around glucose / glutamine utilization (isotopic tracing, these are the pathways that are looked at)

Metabolic differences are targetable - centered around lactate and glutamate secretion

Cell Metab Jan 2022, PMID: 34986341

Safe

* immobilized I thrive I have certainties I never thought of I feel put and safe as I lost much of me . .

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