This is in one of the figures of the paper I'm reading. Love this man inspired by the triangular shape of an antibody

Good news my antibiotic resistant bacteria are indeed antibiotic resistant. This is fine I’m sure.

These bacteria were exposed to an antibiotic without the resistance gene.

These ones DID have the resistance gene.

Tada!

Lupine Publishers | Palauamine and Olympiadane Nano Molecules Incorporation into the Nano Polymeric Matrix (NPM) by Immersion of the Nano Polymeric Modified Electrode (NPME) as Molecular Enzymes and Drug Targets for Human Cancer Cells, Tissues and Tumors Treatment under Synchrotron and Synchrocyclotron Radiations

Editorial

In the current editorial, we study Palau’amine and Olympiadane Nano molecules (Figures 1 & 2) incorporation into the Nano Polymeric Matrix (NPM) by immersion of the Nano Polymeric Modified Electrode (NPME) as molecular enzymes and drug targets for human cancer cells, tissues and tumors treatment under synchrotron and synchrocyclotron radiations. In this regard, the development of Chemical Modified Electrodes (CEMs) is at present an area of great interest. CEMs can be divided broadly into two main categories; namely, surface modified and bulk modified electrodes. Methods of surface modification include adsorption, covalent bonding, attachment of polymer Nano films, etc. Polymer Nano film coated electrodes can be differentiated from other modification methods such as adsorption and covalent bonding in that they usually involve multilayer as opposed to monolayer frequently encountered for the latter methods. The thicker Nano films imply more active sites which lead to larger analytical signals. This advantage coupled with other, their versatility and wide applicability, makes polymer Nano film modified electrodes particularly suitable for analytical applications [1–27].

Electrochemical polymerization offers the advantage of reproducible deposition in terms of Nano film thickness and loading, making the immobilization procedure of a metal–based electro catalyst very simple and reliable for Palau’ amine and Olympiadane Nano molecules–encapsulating Carbon nanotubes incorporation into the Nano Polymeric Matrix (NPM) by immersion of the Nano Polymeric Modified Electrode (NPME) as molecular enzymes and drug targets for human cancer cells, tissues and tumors treatment under synchrotron and synchrocyclotron radiations. Also, it must be notice that the nature of working electrode substrate in electro preparation of polymeric Nano film is very important, because properties of polymeric Nano films depend on the working electrode anti–cancer Nano materials. The ease and fast preparation and of obtaining a new reproducible surface, the low residual current, porous surface and low cost of Multi–Walled Carbon Nanotubes (MWCNTs) paste are some advantages of Carbon Paste Electrode (CPE) over all other solid electrodes [28–92].

On the other hand, it has been shown that, macrocyclic complexes of Palau’amine and Olympiadane Nano molecules– encapsulating Carbon nanotubes are interest as modifying agents because in basic media Palau’amine and Olympiadane Nano molecules–encapsulating Carbon nanotubes redox centers show high catalytic activity towards the oxidation of small organic anti-cancer Nano compounds. The high–valence species of Palau’amine and Olympiadane Nano molecules–encapsulating Carbon nanotubes seem to act as strong oxidizing agents for low-electroactivity organic substrates. 1,2–Dioxetane (1,2– Dioxacyclobutane), 1,3–Dioxetane (1,3– Dioxacyclobutane), DMDM Hydantoin and Sulphobe as the anti–cancer organic intermediate products of methanol oxidation as well as formic acid, is important to investigate its electrochemical oxidation behavior in Palau’ amine and Olympiadane Nano molecules-encapsulating Carbon nanotubes incorporation into the Nano Polymeric Matrix (NPM) by immersion of the Nano Polymeric Modified Electrode (NPME) as molecular enzymes and drug targets for human cancer cells, tissues and tumors treatment under synchrotron and synchrocyclotron radiations [93–110].

In this editorial, we decided to combine the above mentioned advantageous features for the aim of Palau’ amine and Olympiadane Nano molecules–encapsulating Carbon nanotubes incorporation into the Nano Polymeric Matrix (NPM) by immersion of the Nano Polymeric Modified Electrode (NPME) as molecular enzymes and drug targets for human cancer cells, tissues and tumors treatment under synchrotron and synchrocyclotron radiations. Furthermore, in this editorial, we prepared poly Nano films by electropolymerization at the surface of Multi-Walled Carbon Nanotubes (MWCNTs) paste electrode. Then, Palau’amine and Olympiadane Nano molecules–encapsulating Carbon nanotubes were incorporated into the Nano Polymeric Matrix (NPM) by immersion of the Nano Polymeric Modified Electrode (NPME) in a solution. The modifier layer of Palau’amine and Olympiadane Nano molecules–encapsulating Carbon nanotubes at the electrode surface acts as a Nano catalyst for the treatment of human cancer cells, tissues and tumors under synchrotron and synchrocyclotron radiations. Suitability of this Palau’amine and Olympiadane Nano molecules–encapsulating Carbon nanotubes–modified polymeric Multi–Walled Carbon Nano tubes (MWCNTs) paste electrode toward the electrocatalytic treatment of human cancer cells, tissues and tumors under synchrotron and synchrocyclotron radiations in alkaline medium at ambient temperature was investigated [111– 153].

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Prevalence of Hypothyroidism in Ischemic Heart Disease

Abstract

Cardiovascular diseases affect younger population in developing countries like India and carry a higher mortality rate. Common risk factors responsible for myocardial infarction in India are dyslipidemia, smoking, hypertension, diabetes, abdominal obesity, physical inactivity, low fruits and vegetables intake, and psychosocial stress. Other risk factors account for lesser number of cases, one such risk factor being hypothyroidism. A retrospective study was done using hospital records who were admitted with the diagnosis of acute coronary syndrome during the period January 2021 to February 2022 Department of Cardiology , Bangabandhu Sheikh Mujib Medical University (BSMMU) Dhaka, Bangladesh. A total number of 326 patients were admitted with acute coronary syndrome, out of these patients 93 (28.53%) were screened with thyroid profile(male 30, female 63). Female patients were more likely to be screened with thyroid profile than male patients (p value <0.0001). 17.2% (16) of the patients had thyroid abnormality. Three female patients had subclinical hypothyroidism. Four male and nine female patients had ‘low T3 syndrome’. Of the 93 patients there were 7 deaths (7.5%). In the low T3 group the mortality was 38.5%. The mortality in the low T3 group was significantly higher and statistically significant (p value 0.0062), compared to euthyroid subjects. The study highlights the fact that low T3 syndrome in patients with acute coronary syndrome (NSTEMI and STEMI) acts has a poor prognosis factor. The study also highlights to the fact that, screening is less commonly utilized in patients with acute coronary syndrome.

Read more about this article:  https://lupinepublishers.com/biotechnology-microbiology/fulltext/prevalence-of-hypothyroidism-in-ischemic-heart-disease.ID.000148.php

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Being a biochemistry student is so funny because I’ll be staring off into space and look deep in thought but really I’m just thinking about CRISPR. The Roman Empire of every biochem student

my collection of handmade felt patches so far :)

I wanted to know how do you interpret Tanya's gender. After reading chapter 58 of the manga i got the impression that she is definitely trans coded, but maybe thats just me

Very good question.

To be honest, when I think too hard about Tanya’s gender (and sexuality, for that matter) it gives me brain worms. Fun brain worms, but brain worms nonetheless. I can’t explain it. Everything she’s got going on is complicated as shit there’s way too much to think about.

Like, she was a man, but now she's a girl. But at some points she says she still sees herself as a man internally so is this MtFtM? How does that work. And if she accepts she's a woman now, is that just MtF or do we add more letters. More importantly: Was Being X being Transphobic or being the Greatest Trans Ally of All Time with the free divinely issued sex change.

Ok ok, jokes aside. Confession: I actually do not keep up with the manga, so I had to go find the chapter and read it first. Having read it now though, I see what you mean.

The conversation she has with the Salaryman/herself in that chapter really does read as essentially saying “I’ve accepted who I am now.” It’s a far cry from a much earlier part of the manga I remember where she has a breakdown about being a man/people seeing her as a girl.

A friend of mine was actually showing me stuff from more recent chapters of the manga (don’t know which chapter tragically, but I know it’s not currently translated to English) and from what I gathered of it, Being X was showing Tanya a dream of being back in her past life and in response she basically demanded to go back to being Tanya immediately. It is definitely not just you, I 100% see the trans-coding you’re talking about.

As for my personal interpretation of her gender, I touched very briefly on it once before, but I honestly think she wouldn’t want to label herself as anything. At first, this is out of hesitance and not wanting to acknowledge that anything might be ““wrong”” or ““different”” about her. Later on it turns into character growth, more along the lines of, “I don’t need the label to define me, I just am what I am/like what I like. I don’t care about it any more than that.” Yes this is 100% projection on my part. No, I won’t apologize for it lmao.

Of course, that's entirely my own headcanon. I definitely am not saying it’s the only way to interpret her, it’s just my personal thoughts. Especially since my opinion is subject to change on a dime depending on what I’m reading/working on myself. The Tanya gender is, in fact, transient, shifting like water.

Like. A transfem Tanya fic that focuses on her adapting to life in her new world and coming to discover she doesn’t actually hate her new body? I’d totally read that. I’ve seen a few fics that include that as a part of the narrative and those scenes of acceptance were among my favorite parts.

I get the feeling this is the route that the manga is going as well. It’s a bit of a shame that we don't have those aforementioned scenes in the light novel (or at least, I don't remember them), but I don’t think that Carlo Zen really intended that to be the focus/narrative in the first place. And honestly, I also think that’s a good thing because it allows for so much more room for interpretation and headcanon around Tanya’s character.

Anyway, the other direction is also compelling to me. A transmasc Tanya fic where, after feeling uncomfortable and hating how feminine he looks for years and years, he finally goes ‘Fuck this, I’m gonna go back to being a man’? I would read the fuck out of that too.

Could also be paired with him finally choosing to defect, where they think about it like, ‘Well there’s nothing to hold me back now, right? I don’t have to maintain appearances anymore. Also, since I’m defecting this would be a great way to hide myself. They’d all be looking for the wrong person. Two birds with one stone, how efficient.’ …Now we’re getting to fic ideas I won’t ever get to so it’s time to move on I think.

Semi-related to the Trans Tanya Concept, this actually brings me to a bit of a lore/headcanon/idea/question I want to present to the public for opinions. In Norden, during the inciting battle of the war, Tanya uses magic to “dope up” so she could enhance her strength and reaction time and kill pain. I took this to mean she used a formula to synthesize the narcotics/adrenaline hormone/whatever else directly into herself, right?

Can you see where I’m going with this? As long as you know which hormones to make, how they’re made up, and what quantities you need… Well, don’t you think magic HRT is completely possible? Of course, as I'm not sure it makes sense for Salaryman to have known the detailed specifics about it from the modern world, it would require a lot of in-universe research/science advancement for someone to actually do that, but theoretically...

The magic system in this universe has so much potential to be explored, I’m fascinated by what you can theoretically do with it. Although, this is long and off-topic already I think this should be the end, lol.

I think I talked too much? I’m sorry, you were probably not expecting such an answer. I told you, Tanya gives me brain worms (mental illness).

I guess the TL;DR is this: that kid definitely ain’t cishet.

Call it orgasmic chemistry, because I'm loving it 😳😳😤🥵

Fun Facts about Fireflies and Fluorescence under the cut :)

FUN ANIMAL FACT: Fireflies glow due to a chemical reaction between the molecule Luciferin and the enzyme Luciferase (and quite a few other molecules including ATP and oxygen). While fireflies use their bioluminescence for mating reasons, the reaction can be used in a test named the -ATP fluorescence assay- to detect bacteria in various bodily samples and monitor levels of photosynthesis in crop fields (although it was originally developed to potentially detect living cells on Mars)

two rabbits enjoying a romantic cuddle in the "private room". Since so many space rabbit cultures and dwellings are based on the family and social interactions, it's important to have at least one private room for one or two individuals at most to escape to when things get loud and chaotic.

they're enjoying a nice snack as well! its a nasty mixture of hot melted fats and other such innards with melting stirring sticks made of blended plant matter and sweet sap.

Also, i think a lot of their language sounds like silly nonsense word and squeaks so hence the "gwah". Gwahwahwa waaaaa hoooooo like that i think

What's your favorite poison and why?

Finally an interesting question. There are many answers to this, depending on the used definition of poison and for what it would be intended for. Whether I find a poison interesting enough is mostly determined by how fascinating it’s biochemical mechanisms are, but also if it’s nondetectable and rare, how clever it would be in a murder. 

Some more common poisons can have very fascinating biochemical properties like cyanide, which inhibits enzymes neccessary for aerobic respiration and suffocating a person on a cellular level. But they are more commonly used in murders, making them more easily traceable, less creative and thus less interesting then. Just obvious. I prefer rarer poisons, less obvious. The more cunning and sophisticated, the better. Toxins which you can barely detect, unless you know what you are looking for, but most people are idiots and won’t think about it. Perfect murder. Unless you consult me of course.

And especially natural poisons are the most toxic, like Botulinum toxin which was used in some of my cases. Especially neurotoxins like this work in fascinating ways, Tetrodotoxin from pufferfish, shutting down nerve cell communication, slowly paralysing and shutting the body down by respiratory failure. This poison is especially cruel because the victim can still be conscious and lucid, even if they are completely paralyzed, unable to talk or move, to do nothing except to suffer and wait for death approaching. 

Another very potent and very rare poison is Polonium-210, killing by acute irradiation, no antidote and it takes days to show effects, giving the murderer enough time to get an alibi or leave the country. Of course the trail of radiation can lead to the killer if not handled correctly. Very fascinating poison, but difficult to acquire, which is why it’s only knowinlgy used by secret services, but there might be more cases where it was never detected. As you can see it’s difficult to pick favourites with such diverse acting mechanisms of poisons and their interesting ways to kill.  

However, if you meant favourite poison in a more recreational way, then my clear answer is cocaine. Which also has cardiotoxic effects so it can be used as a poison resulting in overdoses, but it’s subjective personal effects are much better than to use it to kill someone, I assure. A more poisonous drug would be fentanyl, very strong opioid resulting in respiratory depression, 120 times stronger than morphine, difficult to dosage. Though I prefer morphine for personal use. But even nicotine can be considered a poison if overdosed. But it’s all just subjective defintions, to quote Paracelsus  “What is there that is not poison? All things are poison and nothing is without poison.”

Yeehaw cooked up some antibiotic resistant bacteria in the lab today, surely there will be no negative consequences.

Microbial Remediation of Dichloro-Diphenyl- Trichloroethane (DDT)

Abstract

The insecticide had been intensively applied for agricultural pest control since 1940. It was disqualified because it persists in the environment, accumulates in fatty tissues, and can cause bad health effects on wildlife and human being. The organochlorine (DDT) has been programmed under the Stockholm Convention to protect human health and the environment from Persistent Organic Pollutants (POPs). Biodegradation is carried out by microorganisms (bacteria and fungi) that naturally live in the environment. Bacteria and fungi have very diverse metabolisms, and they use a wide variety of food and energy sources and perform many important functions by decomposition. Complete biodegradation of DDT involves the oxidation of parent compound to form carbon dioxide and water and provides both carbon and energy for the growth and reproduction of microbes. Each degradation step is catalyzed by specific enzyme produced by a degrading cell or enzyme found external to the cell. Degradation of insecticide by enzyme will stop at any step if an appropriate enzyme is not present. Effects of DDT on human health and the environment depend on the dose of DDT and the timespan and frequency of exposure. It effects also depend on the health of a person and certain environmental factors. DDE and DDT can pass to the fetus in pregnant women. Both chemicals are found in breast milk, resulting in exposure to nursing infants. Microbes can be screened out from soil and wastewater as an effective tool for biodegradation of toxic organic chemicals. Phanerochaete and related fungi that have the ability to attack wood possess a powerful extracellular enzyme that, acts on a broad array of organic compounds.

Read more about this article: https://lupinepublishers.com/biotechnology-microbiology/fulltext/microbial-remediation-of-dichloro-diphenyl-trichloroethane.ID.000134.php

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I got the brand of neurospicy where whenever I see a small space, my immediate thought is "huh i wonder if you could fit a person in there," which led to a wonderful interaction in my chemistry lab today.

My TA: *looks inside flammable chemical cabinet* "oh wow theres nothing in here"

Another student: "it honestly looks much cleaner than the rest of the lab"

Me: *looking into my TA's soul* "i wonder what would happen if someone got put in there"

My TA: *looking horrified*

Me: "No WAIT not like THAT"

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would Pon Farr in transmasc Vulcans include the blood fever, or just immense hormones without the violence? How would it work?