#urological
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Common Urological Disorders, Conditions & Treatment
There are numerous Urological illnesses that men and women of various ages suffer from. Some are temporary, while others are long-term and difficult. Urologic disease can be treated early on; if you have any urological symptoms, there may be a problem. As a result, you must consult a Urologist for an accurate diagnosis and quick treatment.
Urological conditions influence the urinary tract system. Your urinary system includes the kidney, bladder, ureters, and urethra, which are responsible for removing waste items from the body by eliminating urine. The urinary tract must function regularly and in the proper order to remove waste from the body system.
Common symptoms that signal you should visit the top urologist in Dubai, New Concept Clinic.
#Urological#Urological Disorders#pregnancy#gynaecology#gynecologist#pregnant#pregnancy fantasy#pregnant women
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In the realm of urological health, finding the right specialist is paramount to ensuring optimal care and treatment outcomes. If you’re in Noida or its surrounding areas and seeking a urologist, navigating the myriad of options can be overwhelming. However, with careful consideration and informed decision-making, you can identify the ideal urologist to address your specific needs. In this guide, we’ll delve into essential factors to consider when choosing a urologist in Noida, with a special focus on the renowned Dr. Dushyant Nadar, a distinguished urologist, robotic surgeon, and renal transplant expert.
#Best Urologist In Noida#Urologist In Noida#best urologist doctor in noida#urological treatment#health#urological#Urologist Near Me
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Explore the world of urological care with Dr. Bivek Kumar's practice, dedicated to meeting all your urology needs comprehensively. Our skilled team offers personalized treatments for diverse issues, including kidney stones, UTIs, and prostate cancer, employing state-of-the-art technology and advanced imaging. With a commitment to compassion and respecting your privacy, we specialize in minimally invasive
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Jonathan I. Epstein - A Renowned Pathologist | SpeakerHub
Dedicated educator, Dr. Jonathan I. Epstein's commitment to education is evident in his role in training 89 genitourinary pathology fellows.
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#kingscollegelondon#gabrieleantonini#london#bestimplanter#urological#artificialerection#erectiledeficit#friends#penissurgery#phalloplasty#peyroniesdisease#ScuolaItalianaImplantologia#sexualimpotence#style
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Increasing Cases of Autoimmune Diseases Creating Global Demand for Catheters
The United Nations (UN) states that for the first time in history, people aged 65 years or more outnumbered children below 5 years of age in 2018, globally. As per the UN, approximately 16% of the world’s population will be aged over 65 years by 2050 and the number of persons aged 80 years or more will surge from 143 million in 2019 to 426 million in 2050. This age pool is creating a significant…
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Raul Fernandez-Crespo MD - Urology Specialist
Urology specialist Dr. Raul Fernandez-Crespo MD, practices at Tampa-area hospitals including James A. Haley Veterans’ Hospital, Advent Health, and Tampa General Hospital. Since 2019, he has been a member of the International Society for Sexual Medicine. He shares his expertise in the field of urology as an assistant professor at the University of South Florida Morsani College of Medicine. Dr. Fernandez-Crespo has performed extensive research on laparoscopic single-port renal surgery as an outpatient procedure in the pediatric population.
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Localised Cutaneous Amyloidosis of the Glans Penis: A Case Report and Review of the Literature by Victoria Hyett in International Journal of Clinical Images and Medical Reviews
Abstract
Amyloidosis represents a notable cause of morbidity within the developed world. Urological presentations of systemic or localised amyloidosis are rare, with penile amyloidosis being poorly reported. We performed a literature review investigating cases of penile cutaneous amyloidosis via the PubMed database during March 2020, in conjunction with clinical review of a local patient presenting with a penile lesion. Our patient is a 60-year-old uncircumcised, caucasian male presenting with a longstanding history of 2 irregular lesions affecting his glans penis and a further 2 lesions affecting the inner surface of his prepuce. He underwent excision biopsy of the largest lesion which represented cutaneous amyloid deposits. He underwent immunological testing for systemic disease which was negative.
In current literature, there are 13 cases of cutaneous amyloidosis affecting the glans penis, with 1 of those having evidence of extra genitourinary amyloid deposits. All the documented cases were treated with local excision and investigation for systemic disease. It is important to recognise alternative diagnoses in patients presenting with penile lesions. Despite cutaneous amyloidosis mimicking malignancy macroscopically, the morbidity and mortality is lower in comparison to penile cancer. Treatment remains surgical excision of the lesion and further investigations to exclude systemic disease.
Introduction
Amyloidosis is a notable cause of morbidity, and in some cases mortality within the developed world. Urological presentations of systemic or localised amyloidosis are rare, with primary penile amyloidosis being poorly reported in the literature. It can commonly mimic malignancy on imaging and macroscopically, thus representing an important differential diagnosis to be aware of when examining and investigating a penile lesion.
Case Presentation
A 60-year-old uncircumcised, Caucasian male was referred with multiple longstanding granular lesions of his penis. His past medical history included hypertension and insulin dependent type 2 diabetes. On initial assessment there were two irregular granular lesions on his glans penis and two further similar lesions on the inner prepuce. These were initially thought to be malignant and an excision biopsy of the largest one was performed.
The histopathological examination showed an abundance of relatively amorphous pink material in the superficial to mid dermis with positive Congo red staining and mild apple-green birefringence in keeping with cutaneous amyloidosis. Further analysis with immunohistochemical staining of the sample by the National Amyloidosis Centre confirmed this result and determined this to be of the AL Kappa subtype.
Following investigation under the care of the haematology department with serum free serum light chains, electrophoresis and Bence Jones’ protein, there was no evidence of systemic amyloidosis or multiple myeloma. A diagnosis of cutaneous AL amyloidosis of Kappa subtype affecting the glans penis and prepuce was made.
The patient underwent a circumcision for localised treatment of the remaining preputial lesions. The remaining glandular one was deemed high risk for meatal stenosis due to its proximity to the urethral meatus and therefore not excised.
The patient remains well under yearly review from the National Amyloidosis Centre.
Discussion
The term ‘Amyloid’ was first coined by Virchow in the 19th century to describe a macroscopic tissue abnormality characterised by a positive iodine staining reaction. Subsequent technological advancements in light microscopy furthered Virchow’s description to include distinct birefringence of the amyloid deposits when stained with Congo red dye [1].
The pathophysiology of amyloidosis stems from a failure of proteolysis of misfolded proteins resulting in oligomeric conglomerates referred to as amyloid fibrils. As amyloidosis is caused by misfolded proteins, there are multiple classifications of the disease specifically related to the original protein involved. All of the involved proteins may form extracellular deposits and lead to subsequent organ dysfunction [2]. The most common subtypes of amyloidosis include amyloid light chain (AL), the origin of which is an immunoglobulin arising from plasma cells, and amyloid associated (AA), arising from a non-immunoglobulin synthesised by the liver. Further classification can be made by the clinical presentation of the proteinaceous deposit; whether it be systemic or localised, and the clinical syndrome it produces.
The amyloid Light Chain (AL) subtype is characterized by clonal plasma cell dyscrasia, similarly to multiple myeloma [3]. This results in a failure to produce the classical alpha-helix configuration of either kappa or lambda light chains, instead producing a beta-pleated sheet which is inherently insoluble. Classically there is involvement of the kidneys, heart or nervous system however involvement of many organ systems has been documented.
Cutaneous amyloid deposits can be seen in both systemic and localized disease. Commonly up to 40% of systemic AL amyloidosis sufferers complain of epidermal disease, which reflects amyloid deposition within the capillaries of the skin involved. Cutaneous disease typically presents as petechiae or purpuric lesions, yellow macular or nodular lesions. There are also macular and lichen subtypes which can be associated with systemic connective tissue diseases.
Statistically, within the UK the age-adjusted prevalence of amyloidosis is between 5.1 and 12.8 per 1 million per year*. Approximately 10-20% of cases remain localised, with the remainder of cases being classified as systemic disease. Although the localised form is rarer, it carries a better prognosis [5]. Rarer still is localised penile amyloidosis, with only 14 documented cases, including ours, on literature review.
Merika et al. comments on the low prevalence of systemic disease in those presenting with cutaneous penile amyloid lesions as the primary presenting complaint. Their study also highlights the increased rate of primary nodular amyloidosis amongst those with penile cutaneous lesions [4]. Of the confirmed cases of cutaneous amyloidosis of the glans penis, only one reported a second site affected, namely the trachea. This was subsequently found to be a lone deposit, with no further evidence of widespread disease identified; however, this does not exclude the possibility of this representing systemic amyloidosis [16].
Of the cases identified, most were diagnosed on a serological and histological basis, more in depth modalities such as serum amyloid protein component (SAP) scintigraphy and genetic testing were not performed routinely. SAP scintigraphy is highly sensitive for AL and AA amyloidosis (90% for both subtypes), with a specificity of 93%. The use of SAP scintigraphy may give a more definitive answer regarding the presence of systemic disease however the modiality itself is often not available in local centres [17,18].
Treatment of the lesions remains case dependent and requires a multi-disciplinary approach [19]. The underlying amyloid subtype also greatly influences management. In systemic AL amyloidosis, treatment aims to suppress plasma cell production of amyloid which predominantly involves using dexamethasone and mephalan, an oral chemotherapeutic agent, alongside supportive care for the underlying organs involved. Similarly, AA amyloidosis requires management of the underlying disease process often involving immunomodulation [19]. Localised cutaneous amyloidosis is typically managed by surgical excision, or laser ablation, systemic chemotherapeutic agents are usually not employed due to their side effect profile [16]. The majority of cases reported were treated with local excision as in our case.
Conclusion
These cases highlight the importance of consideration of alternative diagnoses in patients presenting with cutaneous penile lesions. Fortunately, despite penile cutaneous amyloidosis mimicking malignancy, the morbidity and mortality are low due to the low incidence of systemic amyloidosis in patients who present with a penile lesion. Treatment remains local excision of the lesion, histological and immunochemical confirmation of the amyloid subtype and further investigations to exclude systemic disease. Consideration could be made for the introduction of SAP scintigraphy in these cases, however the benefit of this remains unclear with such a small demographic to review.
For more details: https://ijcimr.org/editorial-board/
#Amyloidosis#Urological#poorly#immunological#genitourinary#macroscopically#amorphous pink#Victoria Hyett#ijcimr
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Urologic diseases are a wide variety of conditions, all related to the urine out of the body Here’s some of the most things of urologic diseases. Urologic diseases can range from mild conditions, such as urinary tract infection, to very severe health issues, such as kidney failure. Depending upon this condition. Due to this unclear nature of urological diseases, one should always aim for having a good urological health. You can achieve it by just visiting a professional urologist, like Dr. Saket Narnoli, he is best urologist doctor in Dhanbad, Jharkhand.
#common urological disease#urologic disease#Urologic disease overview#urological#urological diseases#urology related diseases
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easily on the list of top 10 things they didn't need to know
#trobed#troy barnes#abed nadir#troy and abed#community#community nbc#community tv#jeff winger#annie edison#s3#screencaps#basic lupine urology
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This was found in a Restore in Charlotte NC. I did not buy it.
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A decent biography of the worst military leader since Major Depression.
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Me personally feels that Saiki’s powers are related a lot to his nervous system, so the limiters could have been attached anywhere on the central nervous system—obviously the brain, but along the spinal cord or maybe even the brain stem. Of course, the brain stem would be a lot more dangerous—even more so than the literal brain itself) because at least the limiters only seem long enough to breach the cerebral cortex—but I think that they would give him a lot more control over his powers that are still kind-of-really disabling.
Of course, I sincerely doubt that Kusuo would be willing to allow Kusuke to cut into his brain that deep, even if I think that he would be physically fine from that invasive of a surgery. And that’s why Akechi should become a neurosurgeon and—
#realistically we alllll know akechi would be interested in urology first#this is all very silly I don’t actually think wiring stuff to Kusuo’s brainstorm would be the way to go#nor do I think Kusuo would even want to do that#however I do think the spinal cord would be a good option for more fine-tuned control for him#and I do also really think that Saiki’s powers depend heavily on his nervous system :3#saiki k#fluffy cooks a headcanon
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Prof. Gabriele Antonini tiene una lezione sulle protesi peniene al Guy's Hospital di Londra MD PhD Gabriele Antonini {A World-Class Men’s Health Clinic - Penile Implant Surgery} 🔹 (+39) 06 6482.1375 ♂️[email protected] 🌐 antoniniurology.com 🌐 isurgerytube.com 🌐 https://antoniniurology.com/31-5-23-guys-hospital/
#guyshospital#gabrieleantonini#london#bestimplanter#urological#artificialerection#erectiledeficit#friends#penissurgery#phalloplasty#peyroniesdisease#scuolaitalianaimplantologia#sexualimpotence#style#men
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“Unlike a drama queen called the testicle, the ovary is very grateful and loves to come back to life after you uncoil it.”
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Urologeilla on paljon pippelitietoa
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