#profound anemia
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Woke up screaming from pain. I’m on my second period of the month and I’m passing clots so large I feel the cramps in my bones.
I can’t wait to have this tumor cut out of me.
#uterine fibroids#endometriosis#adenomyosis#pcos#profound anemia#osteoarthritis#god I just want the pain to stop
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Whenever I talk about the medical neglect and ableism I've encountered as a victim of the healthcare system, there's always some cockwaffle who feels entitled to come into my inbox and make the argument of "not all doctors" while talking about how "people like them" (because it's always someone in a field of medicine who does this) are doing their best and it's really hard because so many people fake being ill to get on welfare (Yikes), but like, yeah, obviously #not all doctors, because if all doctors were negligent, bullying scum bags, I'd be dead.
But here's the thing: while I truly believe that the majority of doctors are doing their best in a system stacked against them and their patients, their presence does not negate the mass harm caused by the bad ones. And there are far more bad ones than you realize.
Fuck, John Oliver literally did a segment on this last week:
youtube
Yes, the truly bad, malicious doctors are in the minority. Most are just horrifically burned out and fighting a losing battle against a system, killing both them and their patients through a lack of funding and resources and profound overwork.
But the malicious ones do exist, and they will go out of their way to harm patients who don't kowtow to them.
I almost lost my life because when I was in my early twenties, I told a doctor I didn't think she was listening to me, and I disagreed with her assessment of my mental health (she was not a mental health doctor, and I was there for heart palpitations and chronic pain). She retaliated by putting "non-compliant" in my file.
There was also a fun little "doesn't show respect" note too that lives rent-free in my head because I know I wasn't rude. I was polite. I just didn't agree with her, and my refusal to accept her off-handed comment that "you probably have bipolar or BPD" (again, I was there for heart palpitations and chronic pain) meant I was "refusing care."
I wasn't. I just refused to be slapped with a mood/personality disorder when I was there because I kept fucking fainting when I stood up.
(Spoiler alert: it was dysautonomia)
That "non-compliant" marker followed me around for years. It followed me across an ocean and effectively ensured that any doctor I saw was going to treat me like absolute dogshit because no one wants to help Difficult Patients. It wasn't until I was so undeniably ill, literally on the brink of death, that anyone helped me.
I'm alive because of a good doctor. And all the good ones that came after him because of him.
So, I know they exist. You don't have to tell me that.
But I really fucking need you to acknowledge the bad ones and that you're part of a system with a long, long history of abusing minorities and vulnerable people. I need you to acknowledge that because it's the only way we're going to survive this godforsaken nightmare and make things better.
So yeah, #notalldoctors, but if you feel the need to say that because someone talking about being literally left to die by the medical system hurts your feelings, I'm going to have to ask you to take a step back and ask yourself if you're going into medicine for the right reasons.
Namely: do you want to help people, even the "difficult" ones?
Even the ones who might disagree with you?
Even if they're on welfare?
Even if they'll never get "better" in a way that means "cured"?
Just a thought. But hey, what do I know. I'm just someone who experienced hemolytic anemia because doctors kept telling me I was anxious and needed to exercise more 🤷♀️.
#chronic health tag#medical abuse#medical neglect#medical#ableism#to all the good health care workers who follow me and leave supportive comments: I appreciate you so much#but you need to come get your fellow drs#and idk#give 'em a shake or something#Youtube
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Genetic engineering: CRISPR and beyond
In genetic engineering, we find ourselves amidst a scientific revolution with the advent of revolutionary technologies like CRISPR-Cas9. However, our journey into the intricate landscape of genetic manipulation is far from complete. This post delves into the nuanced world of genetic engineering, exploring cutting-edge technologies and their remarkable potential in shaping the future of medicine and biotechnology.
CRISPR-Cas9: Precision at the Molecular Level
CRISPR-Cas9, a revolutionary genome editing tool, stands for Clustered Regularly Interspaced Short Palindromic Repeats and CRISPR-associated protein 9. It utilizes a guide RNA (gRNA) to target specific DNA sequences, and the Cas9 protein acts as molecular scissors to cut the DNA at precisely defined locations. This break in the DNA prompts the cell's natural repair machinery to make changes, either through non-homologous end joining (NHEJ) or homology-directed repair (HDR). CRISPR-Cas9's precision allows for gene knockout, modification, or insertion with remarkable accuracy.
Beyond CRISPR: Emerging Technologies
While CRISPR-Cas9 has dominated the field of genetic engineering, numerous promising technologies have emerged on the horizon. These include CRISPR-Cas variants like CRISPR-Cas12 and CRISPR-Cas13, which offer unique advantages such as smaller size, increased specificity, and targeting of RNA. Additionally, base editing techniques, such as adenine base editors (ABEs) and cytosine base editors (CBEs), enable the direct conversion of one DNA base into another without causing double-strand breaks, expanding the range of genetic modifications possible.
Applications in Medicine
The implications of these advancements are profound, particularly in medicine. Genetic engineering can potentially treat various genetic disorders, from cystic fibrosis to sickle cell anemia, by correcting disease-causing mutations at their source. Precision medicine, tailored to an individual's genetic makeup, is becoming increasingly feasible, allowing for personalized therapies with minimal side effects.
Ethical Considerations and Regulation
As we venture further into the genetic frontier, we must acknowledge the ethical considerations surrounding genetic engineering. The ability to modify the human germline, with implications for future generations, raises ethical dilemmas that necessitate rigorous oversight and regulation. The international community is developing guidelines to ensure responsible use of these powerful tools.
Future Directions and Challenges
While genetic engineering offers immense promise, it is not without its challenges. Off-target effects, unintended consequences, and the potential for creating designer babies are among the issues that demand careful consideration. Researchers and ethicists must work in tandem to navigate this uncharted territory.
References
Doudna, J. A., & Charpentier, E. (2014). The new frontier of genome engineering with CRISPR-Cas9. Science, 346(6213), 1258096.
Anzalone, A. V., Randolph, P. B., Davis, J. R., Sousa, A. A., Koblan, L. W., Levy, J. M., … & Liu, D. R. (2019). Search-and-replace genome editing without double-strand breaks or donor DNA. Nature, 576(7785), 149-157.
Kime, E. (2021). CRISPR and the ethics of gene editing. Nature Reviews Genetics, 22(1), 3-4.
This post only scratches the surface of the profound transformations occurring in genetic engineering. The relentless pursuit of knowledge and ethical exploration will shape the future of this field as we continue to unlock the intricate secrets of our genetic code.
#science#biology#college#education#school#student#medicine#doctors#health#healthcare#genetics#genetic engineering#crispr#ethical genetics
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CW: blood and medical stuff
It is just over 7 years now since my diagnosis with an autoimmune* disease (~10 years since symptoms started) and I don't really have anything profound or useful to say, but A) don't let people tell you it's just stress without any further testing if you have unexplained internal bleeding and B) if you literally can't stay awake because you've been bleeding for a few months straight, don't listen to the PCP who tells you not to go to the hospital because your hands are too pink and rosy for you to actually be anemic and there's not much the hospital will be able to do for you anyway
Two-ish days after that appointment I was in the hospital and almost immediately getting a transfusion because I was so anemic. (I would end up getting a 2nd as well because continued bleeding + already low on blood = first one not enough.) Stayed there for almost a month until they got the bleeding under control.
This could have happened to anyone but it's hard not to think that being afab probably had something to do with the downplaying and dismissal of symptoms for 3ish years before being diagnosed. They did the classic "it's probably just stress" because I was a senior in college (and possibly because afab). I don't want to make this a never trust medical professionals kind of thing, because there are many good ones and some of them probably saved my life and/or prevented me from having major surgery (which turned out not to be necessary at the time b/c the med they tried started to work)... but also when things are obviously wrong and especially if they recur (like unexplained bleeding cropping up again and again over years) maybe don't take "it's just stress" as an explanation. Also fuck the doctor who thought he could diagnose anemia or lack thereof by hand color and who advised against further treatment ("just wait until your specialist appointment in a month!")
*there does seem to be some debate about whether my particular condition should be classified as autoimmune or not, but enough people do at this moment I'm just gonna go with it because it's treated like many autoimmune diseases are, with various immunosuppressants or immune system modulating medications
#time of year has made me contemplative#happy to say that despite being astronomically expensive my treatment seems to be working fairly well#big fuck you to the pharmaceutical company that makes my med tho#they gave various high up people massive raises and raised the price of my drug 🙃#anyway i also know that getting medical help isnt that easy and i fucking wish it were for everyone#im sorry that shit is fucked in the us and almost certainly other places as well in the same or different ways#but if you possibly can and if something is medically amiss i just want to encourage being an advocate for yourself#i know it fucking sucks and you shouldn't have to fucking fight just to get baseline competent treatment#but... yeah sometimes it just seems to have to be that way#medical stuff#blood#bodies can be the fucking worst with all the bullshit that can go wrong
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uh.. hello
today I wanted to talk about my most favorite game ever, it's a game that has been by my side for many years and has helped me at my worst times... so it's kind of my comfort zone.
I know it's not the usual, but.. I guess that's just me!
so, I'd like to talk about the first song of the game's soundtrack I ever heard.. even though it's actually the last track in the official playlist,,,, funny that, right?
THE TITLE SCREEN!
I can't really upload the video with the track.. i think, so, I'm going to just link the video. if the link doesn't work or the video is unavailable or something just please please just let me know..
youtube
Now, I know, I know... it looks creepy and scary, but it's going to be fine, okay? It won't hurt you, I promise. There aren't any weird sudden imagery or strident sounds.. it's just a quiet, eerie tune...
But! if the imagery is too unnerving I understand! you don't have to force yourself to experience these things if you don't want to. that doesn't make you weak or a coward! if anything, attempting to try new things is a very brave thing to do! and knowing when something isn't for you is a sign of wisdom and maturity. so whatever you do, be proud of yourself!
Now, I'm going to talk about dotflow's title screen for a bit.. would you entertain me?
"Very well, let us ramble on, then, my friend, old sport!"
A warm welcome.....
I am always amazed by how... empty and hollow the music sounds. And it's not just the simplicity of a loop or instruments used, but the sound, the melody and its endless repeating, somehow, when combined together, despite the fact that it's just sort of a remix of Yume Nikki's title theme, deliver a profound blow on consciousness... at least for me it feels that way.
I remember the first time I loaded the game, quite a while ago. It was during one of those times of my life, I was moved to that studio at the seaside town because they said the marine climate would alleviate my skin issue. I had just recovered from anemia and was feeling physically okay, but somehow my time there I felt so.... numb. I didn't know anyone in that fishing town, and the people were very cold and distant.. besides, this was during winter, so instead of a blue sky there were only foggy days and storms... which I kinda liked, actually,,, hehehe :,) I lived there by myself for around three weeks, and during those weeks this tune was just stuck in my head, I couldn't help but feel incredibly lonely, as if I was abandonned at the bottom of a lightless ocean...
Needless to say, the game itself was one hell of a nightmarish fever dream and I enjoyed every bit of it, despite the fear, despite the uneasiness I felt...
And I have to admit it, this game was scary. Not because of creepy and gory imagery (though there was plenty of that) and not because of sudden uncalled jumpscares (there were actually none of this kind) but because of the sheer persistent atmosphere of this... decrepit, defunct, rusted world, that is doomed to corrode and tumble down into oblivion more as the time passes. The decay, the silent unspoken hopelessness were present even in somewhat more colourful and cheerful areas, those little sanctuaries, (probably) representing past memories of Sabitsuki that didn't change the overall dreadful scheme of things one bit. I don't know, maybe the author tried to make their own "edgy dream diary game", because in certain parts it does feel that the game is being extreme for the sake of being extreme, but... I still love it. I keep coming back to it.
I still hear this tune in my head.
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Black Doctors and the Legacy of Racism in Medicine
Before we get to the AI - go buy "Legacy: A Black Physician Reckons with Racism in Medicine" by Uche Blackstock. She's a high school classmate of mine and on a recent AI panel I was on I told people that I thought should be required reading ( The other book I made required reading were "Weapond of Math Destruction " and " Unmasking bias" ) Why should book not explicitly about AI be required reading for those involved with AI? One of the major dangers in AI is that it uses data that contains bias from our current society to predict future outputs/outcomes. So if we don't understand the racism and bias that is in medicine right now, using AI anywhere in healthcare essentially calcifies these biases behind opaque mechanical systems.
Here's what Perplexity says about the book:
"Legacy: A Black Physician Reckons with Racism in Medicine" is a memoir by Dr. Uché Blackstock, an emergency medicine physician and CEO dedicated to dismantling racism in healthcare. The book delves into the historic health care inequities and systemic racism, detailing Dr. Blackstock's family legacy of black female physicians and her own experiences as a physician and patient. It offers a searing indictment of the U.S. healthcare system, serving as a generational family memoir and a call to action. The book sheds light on the profound and long-standing systemic inequities that lead to far worse health outcomes for Black Americans and endangers the well-being of communities. It also addresses the flawed system that hampers the progress of Black patients and physicians, making it a compelling and necessary read for healthcare professionals, policymakers, and the general public[1][2][3].
Citations:
[1] https://www.goodreads.com/en/book/show/66087028
[2] https://www.pbs.org/newshour/show/a-black-physicians-memoir-looks-at-the-legacy-of-medical-racism-in-america
[3] https://www.harvard.com/book/9780593491287_legacy/
[4] https://www.penguinrandomhouse.com/books/705871/legacy-by-uche-blackstock-md/
[5] https://www.amazon.com/Legacy-Physician-Reckons-Racism-Medicine/dp/0593491289
So for today I wanted to highilight some other achievements of black doctors:
Some notable black doctors in American history include:
Dr. James McCune Smith (1813–1865): He was the first black American to earn a medical degree and practice in the United States. He also opened what is thought to be the country's first African American-owned pharmacy[3].
Dr. Rebecca Lee Crumpler (1831–1895): She became the first black woman in the United States to receive an MD degree. After the Civil War, she moved to Richmond, Virginia, where she worked with other black doctors caring for formerly enslaved people in the Freedmen’s Bureau[2][3].
Dr. Daniel Hale Williams (1856–1931): He founded Chicago’s Provident Hospital, the country’s first black-owned, interracial hospital, and performed the first-ever successful heart surgery two years later[3].
Dr. Charles Richard Drew (1904–1950): Known as the "father of blood banking," he pioneered blood preservation techniques that led to thousands of lifesaving blood donations[3].
Dr. Louis Wade Sullivan (b. 1933): He became the founding dean of what became the Morehouse School of Medicine, the first predominantly black medical school[2].
Dr. Solomon Carter Fuller: He was the first black psychiatrist in the United States and became an authority on Alzheimer’s Disease research[3].
Dr. Marilyn Hughes Gaston: She published a study of sickle-cell anemia that led to a nationwide test for newborns and became the first African American and female director of a public health bureau[3].
These doctors overcame significant challenges, including racism and prejudice, and made pioneering contributions to the field of medicine in the United States[2][3].
Citations:
[1] https://www.everydayhealth.com/healthy-living/african-american-pioneers-who-changed-healthcare/
[2] https://www.aamc.org/news/celebrating-10-african-american-medical-pioneers
[3] https://www.auamed.org/blog/african-american-doctors/
[4] https://guides.mclibrary.duke.edu/blackhistorymonth/chronology
[5] https://interestingengineering.com/lists/black-doctors-medicine
From Gemini: Pioneering Healers: A Glimpse into the Lives and Achievements of African American Doctors
From overcoming systemic barriers to making groundbreaking contributions, African American doctors have woven a remarkable tapestry of resilience, dedication, and excellence within the annals of medicine. Their stories, etched in struggle and triumph, not only illuminate their individual journeys but also shed light on the broader fight for racial equality in the United States.
The earliest documented Black physician in America, James Durham, emerged during the tumultuous years of the Revolutionary War. Denied formal medical training due to his race, he honed his skills through apprenticeships and self-study, eventually serving Continental Army soldiers and establishing a successful practice in New Orleans. Dr. Durham's story exemplifies the resourcefulness and determination that characterized countless Black medical pioneers.
Throughout the 19th century, figures like David Augustus Chisolm, the first Black graduate of Harvard Medical School, and Rebecca Lee Crumpler, the first Black woman to earn an M.D. in America, defied prejudice and carved their own paths. They faced not only societal discrimination but also limited access to education and resources. Yet, their unwavering commitment to serving their communities propelled them forward, paving the way for future generations.
The 20th century witnessed a surge in Black medical advancements. Dr. Charles Drew, known for his groundbreaking work on blood plasma storage, revolutionized wartime medicine and saved countless lives. Dr. Dorothy Lavinia Brown, the first Black resident at New York Hospital, became a prominent surgeon and advocate for healthcare equity. Their achievements resonated far beyond the medical field, serving as powerful symbols of Black excellence and defying long-held stereotypes.
However, the journey towards equality has been fraught with challenges. Despite their qualifications and contributions, Black doctors have historically faced discrimination in hiring, promotions, and access to funding. The fight for equal opportunities continues, with disparities in healthcare access and representation still prevalent today.
Yet, the legacy of African American doctors remains an inspiration. Their unwavering dedication to healing, coupled with their courage in the face of adversity, serves as a testament to the enduring human spirit. Their stories remind us of the vital role they have played in shaping American medicine and underscore the continued need for equity and inclusion in the healthcare system.
Reading List:
"Black Doctors in White America: Mobilization & Progress During World War II" by Charles W. Eagles
"Medical Apartheid: The Dark History of Medical Experimentation on Black Americans from Colonial Times to the Present" by Harriet A. Washington
"A Sickness in Our Land: Epidemics in the Atlantic World" by Virginia DeJohn Anderson
"Black Women Scientists in the United States" by Evelyn Fox Keller
"Charles R. Drew: The Man Who Saved the Blood" by Catherine Reef
"Dorothy Lavinia Brown: The Untold Story of the First Black Woman Surgeon" by Jessica M. Dorman
"Between Slavery and Freedom: Women of Color in the Civil War Era" by Stephanie Camp
"Medical Bondage: From Cotton to Crack" by Harriet A. Washington
"Black Skin, White Masks" by Frantz Fanon
"The Souls of Black Folk" by W.E.B. Du Bois
"Black Power: The Politics of Liberation in America" by Stokely Carmichael and Charles Hamilton
"Medical Nemesis: The Expropriation of Health" by Ivan Illich
"The Color of Violence: The Incarceration of the Innocent and the Making of an American Epidemic" by Evelyn Hoenig Jarvis
"Medical Racism: Race, Ethnicity, and Health Care in the United States" by Carlos V. Hill
"Do Black Patients Get the Same Care? Understanding Racial and Ethnic Disparities in Health Care" by Charles R. King
"Unbroken: A Story of Strength, Faith, and Survival in the Ever After" by Laura Hillenbrand
"Hidden Figures: The American Dream and the Untold Story of the Black Women Mathematicians Who Helped Win the Space Race" by Margot Lee Shetterly
"The Immortal Life of Henrietta Lacks" by Rebecca Skloot
"Educated" by Tara Westover
"Caste: The Origins of Our Discontents" by Isabel Wilkerson
This list, though not exhaustive, offers a diverse range of perspectives on the experiences and contributions of African American doctors within the broader context of American history and social justice. Through these voices, we gain a deeper understanding of their struggles, triumphs, and enduring legacy in the field of medicine.
It is important to note that the experiences of African American doctors are diverse and cannot be homogenized. This reading list attempts to offer a general overview of the topic, but further exploration into specific individuals and historical periods is encouraged.
#black history month#blackhistorymonth#equality#dalle3#africanamericanhistory#black doctors#Legacy#Weapons of Math destruction#Unmasking bias
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A Breakthrough in Advanced Functional Medicine Is the Potential of IV Methylene Blue
In the realm of advanced functional medicine, innovative treatments are continually emerging to address complex health issues. Among these, intravenous (IV) methylene blue has garnered increasing attention for its multifaceted therapeutic potential. This vibrant blue dye, long used in medical diagnostics and as an antidote for cyanide poisoning, is now being explored for its profound effects on various physiological processes, from energy metabolism to neuroprotection.
At the core of IV methylene blue's therapeutic prowess lies its ability to modulate cellular respiration and enhance mitochondrial function. Mitochondria, often dubbed the "powerhouses" of cells, play a crucial role in generating energy in the form of adenosine triphosphate (ATP). However, mitochondrial dysfunction is implicated in numerous health conditions, ranging from neurodegenerative disorders to metabolic syndromes. IV methylene blue intervenes in this process by facilitating electron transport in the mitochondrial respiratory chain, thereby bolstering ATP production and optimizing cellular energy metabolism.
Moreover, IV methylene blue exhibits potent antioxidant properties, which can counteract oxidative stress—a key contributor to aging and disease. By scavenging harmful free radicals and bolstering the body's antioxidant defenses, it helps mitigate cellular damage and protect against oxidative injury to vital organs, including the brain and heart.
Beyond its role in cellular energetics and antioxidant defense, IV methylene blue exerts remarkable neuroprotective effects. Studies suggest that it may enhance cognitive function, improve mood, and alleviate symptoms of neurodegenerative conditions such as Alzheimer's and Parkinson's diseases. Its ability to modulate neurotransmitter systems, including serotonin and dopamine, underscores its potential in mental health and neurological disorders.
Furthermore, IV methylene blue demonstrates promise in combating infections, particularly those caused by multidrug-resistant pathogens. Its broad-spectrum antimicrobial activity, coupled with its capacity to inhibit biofilm formation—a common defense mechanism of bacteria—positions it as a valuable adjunct in the fight against stubborn infections.
In clinical practice, IV methylene blue is administered under the supervision of healthcare professionals trained in its use. While generally well-tolerated, precautions are warranted, especially in individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency, as it can precipitate hemolytic anemia in susceptible individuals.
In conclusion, IV methylene blue represents a paradigm shift in advanced functional medicine, offering a holistic approach to health optimization and disease management. Its multifaceted therapeutic benefits, spanning mitochondrial enhancement, antioxidant support, neuroprotection, and antimicrobial activity, underscore its potential as a versatile tool in the pursuit of wellness. As research continues to unravel its mechanisms and clinical applications, IV methylene blue holds promise as a cornerstone therapy in the evolving landscape of personalized medicine.
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Women's Anemia: Causes, Symptoms, Diagnosis, and Management
Anaemia, a widespread health condition characterized by iron deficiency, poses significant challenges to women’s health globally. The impact of anaemia is profound, with approximately 1.62 billion people affected worldwide, according to the World Health Organization (WHO). Astonishingly, around 41.8% of pregnant women worldwide suffer from anaemia, highlighting the urgency of addressing this issue. Maternal anaemia is particularly concerning due to its association with increased risks of preterm birth, low birth weight, and maternal mortality.
Understanding the multifaceted nature of anaemia is crucial. Here, we delve into the causes, symptoms, diagnosis, and management strategies pertaining specifically to women’s health.
Causes of Anaemia in Women:
Iron Deficiency: Iron deficiency is the primary culprit behind anaemia in women, exacerbated by factors such as menstrual blood loss, pregnancy, and childbirth. Inadequate intake of iron-rich foods and poor iron absorption further contribute to this deficiency.
Chronic Disease: Chronic conditions like inflammatory bowel disease, chronic kidney disease, and autoimmune disorders can lead to anaemia by disrupting red blood cell production and haemoglobin formation.
Vitamin Deficiencies: Vitamins play a crucial role in red blood cell formation, with deficiencies in folate, vitamin B12, and vitamin C increasing the risk of anaemia.
Genetic Factors: Genetic disorders such as sickle cell anaemia and thalassemia affect haemoglobin structure and production, elevating the risk of anaemia in women.
Menstrual Disorders: Heavy menstrual bleeding, or menorrhagia, contributes significantly to anaemia in women of all ages, further complicating iron levels.
Pregnancy: Pregnant women with low iron reserves or experiencing significant blood loss during childbirth face heightened risks of anaemia, as the body requires additional iron to support fetal and placental development.
Symptoms and Diagnosis:
Anaemia manifests through various symptoms, including weakness, fatigue, and shortness of breath, stemming from insufficient oxygen delivery to body tissues due to low haemoglobin levels. Diagnosis typically involves blood tests to measure haemoglobin levels and assess factors such as iron stores, red blood cell count, and vitamin levels.
Management Strategies:
Effective management of anaemia in women encompasses dietary modifications, supplementation, and treatment of underlying conditions. Strategies may include:
Iron Supplementation: Oral iron supplements are commonly prescribed to replenish iron stores and alleviate symptoms.
Dietary Changes: Encouraging consumption of iron-rich foods such as leafy greens, red meat, and fortified cereals can help boost iron levels.
Vitamin Supplementation: In cases of vitamin deficiencies, supplementation with folate, vitamin B12, or vitamin C may be necessary.
Medical Treatment: Addressing underlying chronic conditions and menstrual disorders is essential for long-term management of anaemia.
Prenatal Care: Monitoring iron levels during pregnancy and providing prenatal supplements can help prevent and manage anaemia in expectant mothers.
In conclusion, anaemia in women is a multifaceted health concern with significant implications for maternal and fetal well-being. By understanding its causes, symptoms, and management strategies, healthcare professionals can better address the complex challenges posed by this prevalent condition.
Read More:
https://toneop.com/blog/anaemia-in-women
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#Anaemia#Anemia#blooddisorder#HowcanwepreventAnaemia?#Howdoyouconqueranemia?#irondeficiency#redbloodcells#symptomsofanemia#typesofanemia
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CRISPR-Cas9, a revolutionary technology that emerged in the early 21st century, has transformed the landscape of genetic engineering, offering unprecedented precision, efficiency, and flexibility in editing the genomes of living organisms. The acronym CRISPR stands for Clustered Regularly Interspaced Short Palindromic Repeats, with Cas9 referring to the CRISPR-associated protein 9, a key enzyme that acts like molecular scissors to cut DNA at specific sites. This essay explores the discovery, mechanisms, applications, ethical considerations, and future prospects of CRISPR-Cas9 technology.
### Discovery and Mechanism
The foundations of CRISPR technology were laid through the observation of an adaptive immune system in bacteria and archaea, which use CRISPR sequences to protect themselves against viral invaders. Scientists Jennifer Doudna and Emmanuelle Charpentier, among others, were pivotal in understanding how these sequences, along with Cas proteins, could be harnessed for genome editing. They discovered that the Cas9 enzyme could be guided by a synthetic RNA molecule to a specific DNA sequence, where it would make a precise cut. This cut could then be used to delete, insert, or modify DNA sequences, allowing for targeted genetic manipulation.
### Applications
CRISPR-Cas9 has broad and transformative applications across various fields. In medicine, it holds the promise for treating genetic disorders by correcting mutations at their source. Diseases like cystic fibrosis, sickle cell anemia, and Huntington's disease are potential targets for CRISPR-based therapies. In agriculture, CRISPR is being used to engineer crops with desirable traits such as drought resistance, improved nutritional content, and resistance to pests and diseases, promising a future of more sustainable and productive farming practices.
Furthermore, CRISPR technology is a powerful tool in basic scientific research, enabling researchers to explore gene function and regulation with an ease and precision that was previously unattainable. This can accelerate our understanding of complex biological processes and disease mechanisms, leading to new discoveries and innovations.
### Ethical Considerations
The power of CRISPR-Cas9 technology also brings with it significant ethical and societal implications. One of the most controversial aspects is the potential for germline editing, where genetic modifications can be passed on to future generations. This raises profound questions about the morality of altering human evolution and the risks of unintended consequences. There are also concerns about access and equity, as the benefits of CRISPR technology could exacerbate existing inequalities if they are not equitably distributed. Regulatory frameworks and international consensus are crucial to ensuring that CRISPR is used responsibly.
### Future Prospects
Looking ahead, CRISPR technology is expected to continue evolving, becoming more efficient, precise, and versatile. Newer versions of CRISPR, such as base editing and prime editing, offer the potential for even more precise genetic alterations without introducing double-strand breaks. As these technologies mature, we may see their integration into clinical practice, offering cures for genetic diseases that were once thought incurable.
In agriculture, CRISPR could play a critical role in addressing the challenges of food security and environmental sustainability. By developing crops that require fewer resources and are more resilient to climate change, CRISPR could help feed a growing global population while reducing the agricultural sector's environmental footprint.
### Conclusion
CRISPR-Cas9 technology represents a paradigm shift in the field of genetic engineering, offering a powerful tool for understanding and manipulating the code of life. While its potential to improve human health, agriculture, and scientific research is immense, it also necessitates careful consideration of ethical, societal, and environmental implications. As we stand on the cusp of this genetic revolution, it is imperative that we navigate its challenges with wisdom, ensuring that CRISPR's enormous potential is harnessed for the greater good of humanity and the planet.
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Healthcare Cold Chain Logistics Market Size, Share, Trends, Growth Opportunities and Competitive Outlook
"Healthcare Cold Chain Logistics Market business report provides a profound overview of product specification, technology, product type and production analysis considering major factors such as revenue, cost, and gross margin. The data and information collected to generate this top-notch market report has been derived from the trusted sources such as company websites, white papers, journals, and mergers etc. Healthcare Cold Chain Logistics Market report includes basic, secondary and advanced information related to the global status, recent trends, market size, sales volume, market share, growth, future trends analysis and segment.
With the complete understanding of business environment that is best suitable for the requirements of the client, Healthcare Cold Chain Logistics Market business report has been generated. Businesses can also achieve insights into profit growth and sustainability programs with this market report. Market drivers and market restraints explained in this report gives idea about the rise or fall in the consumer demand for the particular product depending on several factors. This market document contains all the company profiles of the major players and brands. Each of the topics is properly elaborated with the in-depth research and analysis for generating an absolute Healthcare Cold Chain Logistics Market survey report.
Access Full 350 Pages PDF Report @
Table of Content:
Part 01: Executive Summary
Part 02: Scope of the Report
Part 03: Global Healthcare Cold Chain Logistics Market Landscape
Part 04: Global Healthcare Cold Chain Logistics Market Sizing
Part 05: Global Healthcare Cold Chain Logistics Market Segmentation by Product
Part 06: Five Forces Analysis
Part 07: Customer Landscape
Part 08: Geographic Landscape
Part 09: Decision Framework
Part 10: Drivers and Challenges
Part 11: Market Trends
Part 12: Vendor Landscape
Part 13: Vendor Analysis
Healthcare Cold Chain Logistics Key Benefits over Global Competitors:
The report provides a qualitative and quantitative analysis of the Healthcare Cold Chain Logistics Market trends, forecasts, and market size to determine new opportunities.
Porter’s Five Forces analysis highlights the potency of buyers and suppliers to enable stakeholders to make strategic business decisions and determine the level of competition in the industry.
Top impacting factors & major investment pockets are highlighted in the research.
The major countries in each region are analyzed and their revenue contribution is mentioned.
The market player positioning segment provides an understanding of the current position of the market players active in the Personal Care Ingredients
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Fertility Clinic Winnipeg: Evaluating Prenatal Risk Factors
The gestational period, characterized by expectancy and joy, simultaneously necessitates an augmented focus on maternal and fetal health. Profound understanding and identification of prenatal risk factors are paramount for safeguarding a salubrious pregnancy. This discourse examines pivotal risk factors inherent in pregnancy noted at fertility clinic Winnipeg, offering insights for expectant mothers and medical practitioners.
Maternal Age-Related Considerations
Maternal age significantly influences gestational outcomes. Adolescents under 20 and women above 35 encounter augmented complications risks. Adolescent pregnancies may be complicated by the physiological immaturity of the mother, while advanced maternal age increases the probability of fetal genetic anomalies, gestational diabetes, and hypertensive disorders.
Lifestyle Determinants
Pregnancy outcomes are profoundly impacted by lifestyle choices. Tobacco use, alcohol intake, and illicit drug consumption are linked to fetal low birth weight, preterm birth, and developmental impediments. Additionally, suboptimal nutrition and obesity predispose to gestational diabetes, hypertensive complications, and an escalated cesarean section incidence.
Preexisting Medical Conditions
A comprehensive evaluation of the woman's medical history is crucial in assessing prenatal risks. Chronic ailments such as diabetes, hypertension, and thyroid dysfunctions can adversely affect pregnancy. A history of miscarriages, antecedent preterm births, or complications in prior pregnancies may signal heightened risks in subsequent gestations and might require close monitoring at fertility clinic Winnipeg.
Genetic Susceptibilities
Genetic predispositions can modulate specific pregnancy-associated risks. Familial histories of genetic disorders, such as cystic fibrosis or sickle cell anemia, heighten the likelihood of fetal inheritance of these conditions. Prenatal genetic screening and counseling are instrumental in identifying and managing these risks.
Environmental Influences
Pregnancy is susceptible to certain environmental exposures. Contact with toxic elements like lead or specific chemicals can induce congenital anomalies or developmental challenges. Pregnant individuals should also exhibit vigilance regarding exposure to infectious diseases, as pathogens like rubella or Zika virus can provoke severe fetal complications.
Psychological Well-being
The significance of mental health in pregnancy risk assessment is frequently underrecognized. Psychological stress, anxiety, and depression not only impact maternal health but can lead to fetal low birth weight and premature delivery. It is imperative for pregnant women experiencing mental health issues to seek appropriate support and intervention.
Healthcare Accessibility
The availability and quality of prenatal healthcare profoundly influence pregnancy outcomes. Regular antenatal consultations facilitate fetal development monitoring and early complication detection and management. Inadequate access to proficient healthcare can result in overlooked or poorly managed conditions, posing serious risks to both mother and child.
Conclusion
The identification and management of prenatal risk factors at a fertility clinic Winnipeg are crucial for maternal and fetal well-being. Comprehension of age-related risks, lifestyle determinants, preexisting medical conditions, genetic susceptibilities, environmental influences, psychological well-being, and healthcare accessibility enables expectant mothers and healthcare providers to undertake proactive measures for a healthier pregnancy. Consistent prenatal evaluations, lifestyle modifications, and transparent communication with healthcare professionals are integral to navigating these risks efficaciously. Awareness and proactive management of these elements can foster improved outcomes and a more affirmative pregnancy experience.
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Iron Infusion
Iron Infusions Iron deficiency can have profound effects on one's health, and an Iron Infusion provides a targeted solution. Administered intravenously, this medical procedure is designed to replenish iron levels efficiently, addressing conditions such as anemia. The Iron Infusion is a vital medical intervention that can restore energy levels, improve oxygen transport in the body, and contribute to overall health and well-being.
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Cervical Cancer Surgery in India
Cervical cancer originates in the cervix, which is the lowest part of the uterus that connects to the vagina. The fourth most common disease among women is cervical cancer. 2018 saw almost 570,000 women receive a diagnosis. The majority of cases of cervical cancer are associated with high-risk human papillomavirus (HPV) infection, which is responsible for 99% of cases. It's one of the most effectively treated cancers when detected and managed at an early stage. Two primary forms are recognized: adenocarcinomas (10–20%) and squamous cell carcinomas (80–90%). Cervical cancer is most commonly identified in people between the ages of 35 and 45, and in low- and middle-income countries. HIV-positive women are six times more likely to get the virus, placing them at a much greater risk.
Surgical Advancements: Revolutionary advancements in cervical cancer surgery have been made in India to maintain fertility and improve treatment results. These days, it's increasingly common to use procedures like radical trachelectomy and cone biopsy, which remove malignant tissue without damaging the uterus.
Developments in Radiation Therapy: The developments in radiation treatment for cervical cancer demonstrate India's dedication to remaining at the forefront of medical science. Brachytherapy and External Beam Radiation Therapy (EBRT) are now considered standard treatments because of their ability to precisely target malignant cells.
Customized Chemotherapy for Effective Outcomes: For the treatment of advanced cervical cancer, a combination of radiation therapy and low-dose chemotherapy is successful. India's medical experts carefully customize chemotherapy treatments based on the individual requirements of every patient. The addition of targeted therapy, which targets certain chemicals found in cancer cells, also improves cervical cancer treatment effectiveness.
Immunotherapy: In India, immunotherapy has become a potentially useful therapeutic option for cervical cancer. Immunotherapy provides a focused and individualized treatment by using the body's immune system to identify and eliminate cancer cells.
One of the most important factors in treating cervical cancer successfully is early diagnosis. India has remarkable survival rates because of its dedication to encouraging routine checkups and breakthroughs in treatment approaches. Early detection of cervical cancer can result in a five-year relative survival rate of over 90%, highlighting the profound impact of early and focused therapies. Cervical cancer treatment cost in India is between $3500 to $12000. When combined with top-notch facilities, the affordability of medical procedures makes India a desirable travel destination for patients looking for life-changing treatments. Prominent doctors in the treatment of cervical cancer may be found in India's best hospitals, such as Artemis Hospital, Indraprastha Apollo Hospitals, and Medanta - The Medicity. Leading interdisciplinary teams, surgeons like Praveen Kumar Garg, Ankur Bahl, and Sandeep Batra make sure that patients receive the best possible treatment.
Al Afiya Medi Tour is a leading medical tourism company in India. We are offer medical tourism services in India foreign patients. Some of the main countries are Bangladesh, South Africa, Uganda, Zambia, Namibia, Iraq, Kenya, Ethiopia, Nigeria, and so on. We provide free assistance for TURP surgery cost, lung cancer treatment, breast cancer surgery cost, stomach cancer treatment, ovarian cancer treatment cost, liver transplant cost, best hospital for heart valve replacement, liver cancer treatment cost, bone marrow transplant cost,prostate cancer treatment cost, arthroscopic surgery, best liver transplant hospital, brain tumor surgery cost in India, kidney transplant, liver cancer treatment, aplastic anemia treatment cost, best bone marrow hospital, acute lymphoblastic leukemia treatment cost etc. If you are searching for free medical and healthcare consulting to find the best hospitals and top doctors and surgeons in India for any treatment then contact us- Alafiyameditour.com. Source: https://alafiyameditour1.blogspot.com/2024/01/cervical-cancer-surgery-in-india.html
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Empowering Health: Navigating the Benefits and Considerations of Leuprolide Acetate
In the intricate tapestry of medical advancements, Leuprolide Acetate emerges as a transformative medication, addressing a spectrum of health challenges. This gonadotropin-releasing hormone (GnRH) agonist is available in various formulations, including Eligard, Lupron Depot, and Fensolvi. Renowned for its versatility, Leuprolide Acetate is a cornerstone in the treatment of advanced prostate cancer, central precocious puberty (CPP), and endometriosis. In this extensive exploration, we delve deep into the nuances of Leuprolide Acetate, unraveling its mechanism of action, diverse applications, administration protocols, potential side effects, and its pivotal role in shaping contemporary healthcare strategies.
Understanding the Purpose: A Multifaceted Approach
Leuprolide Acetate's therapeutic journey begins with a profound understanding of its purpose. Primarily prescribed for advanced prostate cancer, the medication orchestrates a significant reduction in specific hormones within the body. Beyond prostate cancer, it plays a crucial role in mitigating the effects of central precocious puberty (CPP) in children and addresses the complexities of endometriosis. Additionally, Leuprolide Acetate is instrumental in managing anemia caused by uterine fibroids, showcasing its versatility in diverse medical scenarios.
Mechanism of Action: The Molecular Dance
At the heart of Leuprolide Acetate's effectiveness lies its intricate molecular dance. By interacting with progesterone receptors on target cells, the medication initiates downstream changes to target genes. These receptors are distributed across various tissues, including the reproductive tract, breast, pituitary, hypothalamus, skeletal tissue, and the central nervous system. Binding to these receptors sets in motion a cascade of effects, influencing hormonal levels and physiological processes.
Contraceptive Efficacy and Hormonal Regulation
One of the distinctive features of Leuprolide Acetate is its multifaceted approach to contraception. The medication alters cervical mucus, enhancing its cell content and viscosity, creating a formidable barrier that impedes sperm transport and migration. Simultaneously, it induces changes in the endometrium, rendering it inhospitable for implantation. Through a negative feedback loop, Leuprolide Acetate suppresses the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH), effectively preventing follicular development, ovulation, and corpus luteum development.
Administration Protocols: Precision in Treatment
Leuprolide Acetate's effectiveness is closely linked to precise administration protocols. Administered through intramuscular or subcutaneous injections, the choice of formulation and frequency depends on the specific medical condition and individual response. Treatment durations vary, ranging from monthly injections to intervals of 3, 4, or 6 months. Adherence to the prescribed treatment plan is paramount to ensure optimal efficacy.
Special Precautions and Considerations
Before embarking on Leuprolide Acetate treatment, individuals and healthcare providers must navigate a landscape of precautions and considerations. Allergies to the medication or related compounds, such as goserelin, histrelin, and nafarelin, must be disclosed. Additionally, current medications, medical history, and any unusual vaginal bleeding should be communicated. Special attention is given to factors like osteoporosis risk, history of alcohol or tobacco use, and conditions such as depression, seizures, and diabetes.
Pregnancy and Birth Control: Safeguarding Well-being
Leuprolide Acetate introduces specific considerations for pregnancy and birth control. Contraindicated in pregnant or breastfeeding women, a mandatory pregnancy test precedes treatment initiation. Reliable nonhormonal birth control methods are recommended during treatment, even in the absence of regular menstrual periods. A vigilant approach to pregnancy awareness and communication is vital to prevent potential harm to the fetus.
Potential Side Effects of Leuprolide Injection
Leuprolide Injection is a potent medication with a broad spectrum of applications, from treating advanced prostate cancer to managing conditions like central precocious puberty (CPP) and endometriosis. While it offers significant therapeutic benefits, like any medication, Leuprolide Injection may be associated with certain side effects. It's crucial for individuals and healthcare providers to be aware of these potential side effects to facilitate proactive management and ensure optimal treatment outcomes.
Common Side Effects:
Tiredness:
Fatigue is a common side effect reported by individuals undergoing Leuprolide Injection treatment. It's essential to communicate the severity of fatigue to healthcare providers for appropriate management.
Hot Flashes:
A sudden wave of mild or intense body heat, often accompanied by sweating or clamminess, is a common occurrence with Leuprolide Injection. While this side effect is generally temporary, it can be bothersome for some individuals.
Breast Changes:
Both men and women may experience breast tenderness, pain, or changes in size as a result of Leuprolide Injection treatment. Monitoring these changes and discussing them with healthcare providers is crucial.
Vaginal Changes in Women:
Female individuals undergoing Leuprolide Injection treatment may experience changes in vaginal discharge, dryness, or itching. It's important to communicate any discomfort or unusual changes to healthcare providers for appropriate guidance.
Menstrual Changes:
Women using Leuprolide Injection, especially in the context of endometriosis treatment, may experience changes in menstruation, including spotting or alterations in the menstrual cycle. Open communication with healthcare providers helps manage these changes effectively.
Decrease in Testicle Size:
Men undergoing Leuprolide Injection treatment may notice a decrease in the size of testicles. While this is an expected effect, individuals should report any concerns or unusual changes to their healthcare providers.
Changes in Sexual Ability or Desire:
Leuprolide Injection treatment may impact sexual function, leading to changes in sexual ability or desire. Open communication with healthcare providers is essential to address any concerns in this regard.
Swelling:
Some individuals may experience swelling of the hands, feet, ankles, or lower legs as a side effect of Leuprolide Injection. Monitoring the extent of swelling and reporting it to healthcare providers is crucial.
Pain or Tingling at the Injection Site:
Pain, burning, or tingling at the site where the injection was given is a possible side effect. Individuals should report these symptoms to healthcare providers for assessment and guidance.
Change in Weight:
Some individuals may experience changes in weight during Leuprolide Injection treatment. Monitoring weight changes and discussing them with healthcare providers helps manage overall well-being.
Conclusion
In the expansive landscape of hormonal therapies, Leuprolide Acetate stands as a beacon of hope, offering transformative solutions to diverse health challenges. This comprehensive exploration aimed to unravel the medication's mechanism of action, diverse applications, administration protocols, precautions, and potential side effects. Empowered with knowledge, individuals and healthcare providers can navigate the complexities of medical treatments, fostering informed decisions and a sense of control in the face of health challenges. Leuprolide Acetate emerges not merely as a medication but as a pivotal force in shaping contemporary healthcare strategies and improving the quality of life for individuals across various medical scenarios.
Source: https://adorefem1.blogspot.com/2024/01/empowering-health-navigating-benefits.html
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Exploring the Brave New World of Gene Editing and Ethical Frontiers
Gene Editing has emerged as a groundbreaking technology with the potential to revolutionize various fields, from healthcare to agriculture. However, as we delve deeper into this brave new world of gene editing, ethical concerns, and frontiers come to the forefront. Let's explore the advancements in gene editing and the ethical considerations surrounding them.
Recent Advancements in Gene Editing
At the forefront of gene editing advancements stands the revolutionary CRISPR-Cas9 system—a groundbreaking technology often likened to molecular scissors. Derived from bacterial defense systems, this remarkable tool has the ability to precisely alter DNA, enabling scientists to make targeted modifications to the genetic code. With its ability to add, remove, or alter specific gene sequences, CRISPR-Cas9 has opened up unprecedented possibilities in the world of genetic manipulation.
Key Developments
Precision and Efficiency: The accuracy of CRISPR has improved significantly, reducing off-target effects (unintended changes to DNA). Researchers are continually refining CRISPR to increase its precision.
New Variants and Systems: Beyond CRISPR-Cas9, new variants like CRISPR-Cas12 and CRISPR-Cas13 offer different functionalities. For instance, CRISPR-Cas13 targets RNA instead of DNA, opening up new avenues for research and therapy.
Therapeutic Applications: Gene editing is making strides in treating genetic disorders. Clinical trials are underway for conditions like sickle cell anemia, beta-thalassemia, and certain forms of blindness.
Agricultural Improvements: In agriculture, CRISPR is being used to enhance crop resilience, nutritional value, and yield. It offers a faster and more precise alternative to traditional breeding methods.
Ethical Considerations
As gene editing technologies evolve, they raise important ethical questions:
Safety and Unintended Consequences: While CRISPR is precise, it's not infallible. Off-target effects can potentially lead to unforeseen health issues. The long-term impacts of gene editing are still largely unknown.
Equity and Access: There's a concern that gene editing technologies could widen health disparities. Treatments might be expensive, making them accessible only to the wealthy.
Germline Editing: Editing genes in human embryos (germline editing) can affect future generations. This raises complex ethical questions about consent and the potential for unintended impacts on the human gene pool.
Designer Babies: The prospect of using CRISPR for non-therapeutic enhancements, like selecting physical traits, raises concerns about eugenics and the commodification of human life.
Regulation and Oversight: The rapid pace of technological advancement outstrips existing regulatory frameworks. There's a global debate about how to regulate gene editing, particularly in humans.
The Future of Gene Editing
The potential of gene editing is indeed vast, with promising breakthroughs in medicine and various other fields. However, the trajectory of its future is not solely dependent on scientific advancements; it is also intricately tied to how society grapples with the ethical challenges it presents. In order to ensure the responsible and equitable use of gene editing, it is imperative to foster ongoing and inclusive dialogues involving scientists, ethicists, policymakers, and the public.
Closing Note
Gene editing represents a remarkable scientific advancement that holds immense promise for our future. However, its potential also necessitates a profound examination of its implications. As we navigate the frontiers of gene editing, finding the delicate balance between harnessing its power and upholding ethical responsibility emerges as one of the pivotal tasks of our generation.
Original Source: https://weoneit.com/read-blog/10681
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