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#my white blood cell count is always high but it's been higher than normal for about 6 months and she keeps talking about it
adaine-party-wizard · 6 months
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got my bloodwork back (had to go in for a follow up, mono has done a number on my body)
good news: normal white blood cell count! body probably isn’t fighting infection
neutral news: my red blood cells are being weird in the same way they’ve always been weird. like they suggest iron deficient anemia but like… my iron levels were high. weird. i understand why the doctors thought i was dying as a kid.
bummer news: liver is still pissed. less pissed than it was! levels are max 2-3x higher than the max instead of like 8x so that’s progress. but a bummer because i’m leaving for montreal thursday and i wanna drink cute lil cocktails on dates with my boyfriend while we’re there but now that has to be a heavily considered decision
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How I'm attempting to fight off an undetermined infection as a chronically ill person with hypopituitarism and immune deficiency.
Firstly I have to double my steroid dose. I also have prescription zofran I've been taking.
Do the basics like drink lots (tons) of water and eat gentle foods (bananas, saltines, chicken ramen, jello (im eating zero sugar jello because i struggle with managing my sugars) yogurt etc). Electrolyte drinks.
I'm taking these supplements: Elderberry, echinacea (has antiviral, antibacterial, and antifungal properties), Goldenseal, coQ10, One a day triple Immune support, high strength multi strain probiotics. You can also try emergen-c ginger and tumeric drink packs and benefiber
I'm taking these otc medications to manage my symptoms: pepto, tylenol, aspirin, miralax.
Ginger candies by upspring help my nausea and horehound candies are great for nausea too!
If you are struggling to eat try meal replacement shakes like breakfast essentials or boost.
It sucks but don't take ur meds on an empty stomach!! Try to get something in you.
If your fever isn't super high (less than like 100.2) and isn't causing you discomfort then don't worry too much about bringing it down just keep an eye on it. Your body uses fever to fight off infection.
I've been on an off of a heating pad for muscle discomfort and switching between a heating pad and an ice pack for my headaches.
I've been laying in a dark room avoiding looking electronics for 3 days until now. I used audiobooks to cope with the boredom. If you have a headache and need light green light is the best for not triggering headaches.
I've also used some saline nasal spray and I've used an ear cleaning kit because I'm not sure what the origin on the infection was but my earwax buildup was pretty bad and my nose was dry anyway so it couldn't hurt. Make sure to use one of the kits like they use in the hospital and to use it as directed.
The er didn't help me but if you live in a place where the hospital is actually decent then I advise you see your doctor!! Always look at ur blood tests because they told me mine were normal but my white blood cell count is higher than it has ever been and my neutrophils and ensophils and monocytes were off. I'm waiting on an appointment with my primary care.
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isamabella · 2 years
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I’m driving myself crazy trying to understand possible reasons for my blood results. Not as in I’m thinking the absolute worst but I just want to understand and I’m being impatient even though my appointment is at the end of the week. I understand the high red cell count that’s just normal for me but the other wacky numbers have me intrigued
Basically iron dropped again (I suspect an infusion coming my way), but now my platelets are up, my white blood cells are up specifically neutrophils and lymphocytes. But I haven’t been sick in the usual ways I hear white blood cells go up. I mean I’ve had a lot of stomach issues lately but it’s calmed down a bit. My WBCs are higher now than when I was outright sick for about 3 weeks last year. I’m always some kind of stressed honestly but it’s lessened the last few months so idk
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voiceswithoutlips · 3 years
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Fallen - Chapter One
— pairing: OT7 x Reader (F) — genre: Fantasy AU, Vampire AU, Soulmate AU, Fluff, Eventual Smut, ANGST , Poly!BTS — word count: 2.8k — Rating: M — warnings: minor character death, slight gore — beta: Thank you so much @taegularities​ and @unoriginal-username15432​ for all you feedback <3
Click for Tag List
— chapter summary:  
The people you killed, they haunted your dreams. They would say to you, “What you do always comes back to you, there is no escape from this miserable life.” It was true, there was no escape. In your world there was only darkness, sorrow, fear, hate and death, always death.
— A/N: It is I, your idiotic author. Welcome to my blog <3
Ch. 2
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The sound of rain was like a roaring beast. It was almost midnight and the roads were lonely. You stood there in an alley facing a madman, uh, mad-vampire. His eyes were glowing red; he was wearing a dirty grey cloak on his rag like cloth. His brown hair had gotten messy when he’d run away from you but there he was, still as a dead body, waiting for you to attack. There were thick walls on both sides of the alley and behind him was a dead end. He was trapped.
“Lockham, why don’t you come back with me? That way I won’t have to kill you,” you suggested to the psycho killer vampire who stood a mere ten feet away from you. There was no way for him to run so maybe he would attack. You weighed your options - fight? That would’ve been nice; at least your body would’ve gotten some exercise.
He laughed. “You think you can win? Destiny is waiting for you Hunter,” he said in an impressive voice. Another one of those ‘destiny’ believers. Apparently the Goddess had a plan for us all, not that you had much faith in it. Gods don't care about who kills whom or who eats what, they’re more concerned about their own entertainment. You’d never put much faith in any higher power, God or not, nobody gave a shit.
“You’ve killed people Lockham, you’ve been a very naughty vampire and now it’s time for your punishment,”you said as a teacher would say to a naughty kid. He took a step back.
“Who are you to punish me?” he mocked, showing you his blood covered teeth. He was just having a meal when you found him and then you two had a nice chase. You were glad that he ran, you wanted to stretch out your legs anyway.
“Exactly, I’m no one,” you said and took a step forward; he took a step back simultaneously and vanished. What? Vanished? How? You walked forward to investigate and sighed. How careless of you. There was a hole, he fell into the sewer. He must have used cloaking so that it would look like he vanished. The only thing he forgot was to close the hole. You shook your head,  you hated wet places! You jumped down and landed lightly on your feet, without making a sound, perfect.
You were getting bored of chasing him, it was almost dawn and you needed your beauty sleep. You took a deep breath and pulled out your silver dagger. It was your favorite weapon. Silver was deadly to vampires. It was very pretty with a finely carved snake on the handle with emeralds where the eyes should be; a gift from someone you had known a long time ago.  You closed your eyes and let your mind wander through the tunnels. Just like your immunity to silver, your telepathy was stronger than centuries old vampires and you could perform magic. You were a half-witch after all.
You found him running through the tunnels. As soon as your mind touched him, he froze. You were inside his mind now. Reading someone’s mind was nothing like watching a movie or reading a book. It was like waking up from a dream, you don’t remember what you saw or heard but the thing that you remember is the feeling, the essence of the dream. Every being has a certain essence, unique to them. Like walls that you can’t see or touch, but you know they’re there. You could clearly see the tunnel before you, but it was like a distant memory, you were no longer there.
You were in a room, an old room with cobwebs and dust. It smelled of something rotten, like a thousand dead rats. There were worn out clothes hanging from the ceiling - correction, there was no ceiling, just clothes hanging midair and swaying with the wind, except there was no wind. At one corner sat two rusty iron chairs. The window with broken glass showed a full moon. 
There was an old cupboard on the wall with the yellow wallpaper. It was white as if someone had carved it from bone. There were noises coming from the cupboard, screeching, screaming, the cry of a baby, the soothing voice of a mother, someone’s last words. A shudder ran through your body. I will never ever do this again, you promised yourself. 
You heard a creak from behind and you swiftly turned back. There he was, sitting in a corner, the little boy. He held a tattered grey cloak in his hands. His body was folded at impossible angles. He was white as a sheet, there was no blood in his body. He was thin with brittle bones. Dull brown eyes in a sunken face held unimaginable terror. 
He looked up at you. “I’m tired, I want to sleep,” he whispered and quickly stole a glance at the cupboard.
“Then why don’t you sleep?” you whispered back, clearly not wanting to wake anything in there. Yeah, getting into someone’s mind was a nice thing, you could get full control over them... but there was a catch. If something went wrong in that mind or if you failed to escape in time, then you’d be trapped there forever, or die. You were pretty sure that you didn’t want to be trapped in this mind, not here.
“They don’t let me sleep, they keep me awake so that I could bring more and more food for them,” he replied, pointing a finger at the cupboard. Slowly, you understood what he was saying. ‘One without a soul feeds on other’s souls,’ the thought crossed your mind, not a good one.
“What if you don’t bring them food?” You already knew the answer but you asked anyway, maybe just to confirm it.
“I’ll go mad,” he whispered back with horrified eyes.
“Come to me, I’ll help you sleep.” The words left your lips, the real ones which were still attached to your face. Lockham turned back and slowly walked towards you. You could hear his heavy footsteps in the tunnel.  At last he took the last turn and there he stood right in front of you. His eyes were blank. It was like there was no soul in his body, no life. You had him entirely under your control. If you told him to do ballet, he would dance like a professional, but you weren't a sadist. Life had already tortured him enough. 
“Come forward,” you said softly, the sooner it ended the better. He walked forward and your silver dagger slashed through his throat, severing his spine, killing him in a second. Blood splashed and soaked his body. It was a merciful death, you had seen worse. There are worse things than death in this world. Death was just an easy escape.
You stood there for a moment, looking at him, wishing that the outcome would’ve been different. Were you feeling sorry for him? No, you were feeling sorry for yourself. You were a fifty year old vampire and in all your years as a hunter you’d killed hundreds of criminals, but you had never been able to save one. 
People knew and people talked. Some said that you were cursed; you were the representative of death, the spawn of darkness. As a result, the council only gave you high profile cases, criminals that were too far gone to be saved. It was always death. The people you killed, they haunted your dreams. They would say to you, “What you do always comes back to you, there is no escape from this miserable life.” It was true, there was no escape. In your world there was only darkness, sorrow, fear, hate and death, always death.
You pulled out your cell phone and called the police. They would take care of the body. You bent down to leave a tracker near it, so they would find it easily. Lockham’s eyes were wide open, and you closed them. “At least one of us is at peace,” you whispered. 
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“You’re home!!” little Lilly exclaimed happily as you walked through the door. Your  family was sitting in the dining room, having supper. You were the firstborn, the eldest of your father’s children. Your father was the Duke of Serafino, the City of Snake; one of the two warrior cities in the Vampire Kingdom. He was a nice man with brown eyes and hair, fair complexion, nicely built but a little short. 
Your stepmother was a beauty; she had blue eyes, fair complexion, sharp features and hair spun like gold. Her children took after her, all cream and gold. They all hated you, except for the little one, Lilly.
“Yay, I’m home,” you said sarcastically. It was hard not to be nice to the little girl who looked at you with wonder in her eyes; she was so full of life. To no one’s wonder you had blood on your clothes and your darling step mother eyed it with a look in her eyes that said filthy. For you, it was like an invitation. You were planning to have supper in your room just like any other day, but you sat down at the end of the table. Your father was seated at his normal seat which belonged to the head of the family. The chair right across from him was the place for his wife, but that was your mother’s place and now it belonged to you. 
Your mother had died in childbirth, you had her amber eyes and olive skin. Her name was Katina. People told you that she’d been a beauty; you had some of her pictures and sometimes you would feel her close beside you. It was a weird feeling, but not bad, not at all. You weren't a person who put her feelings on display, heck you hadn’t even cried in like twenty years! The only permanent feeling you had left was emptiness. You felt numb, like a shell, nothing inside, no love, no hope, not even sorrow after all these years. It felt like you were dead and it was true, your heart was dead.
“I would like some blood sausages Charles and don’t forget the wine,” you said cheerfully to the butler. He was a nice guy, always talked politely. You suspected that he was in love with the cook, Ms. Glen; it would be nice to have some love in this house which felt like living in a coffin.
“How was your day, Y/N?” Lilly asked, her cheerful eyes trained on you. You wondered for how long this child would be allowed to keep her innocence? When you’d been her age ...you shied away from that thought. Thoughts bring back memories and your memories were like old corpses, one would never want to dig them. Instead you took a bite of your sausage - man, they were delicious.
“It was almost nice, Bunny. I played who-can-catch-me with a friend and I won!!” Bunny was the nickname you had given her because she was never still. Everyone paused for a moment; it was really weird and funny at the same moment. You loved how all the eyes drifted to you and back to Lilly. She was beaming because you had won the game. You gave her a small smile.
“Oh that’s wonderful!! Where is your friend now?” Curious little kid, everyone paused again, including you this time.
“You see, we were playing on a bet. He lost the bet so he had to …go to another city.” You were very good at lying, but her beaming eyes and pure innocence made it hard. It was impossible to lie to that child.
“When would he come back?” she asked, and you sighed. Your plate was half empty and the looks everyone were giving you just killed the hunger inside. You stood up with the wine glass in my hand.
“Chew your food, Bunny,” you replied and left the room.
Your room was a mixture of blue and gold. The wallpapers were straight lines of different shades of blue. The furniture was of mahogany wood with fine carvings. The round rug was golden on the edge and blue in the middle, it looked like a pool of water. All the linen was blue and gold as well. Your bed was round and big with golden bedposts and curtains. You had a balcony of your own with a little fountain with a sculpture of a mother and her child. You had spent a lot of time taking care of the blue roses in your garden. 
The front wall was covered with your music collection. You found peace in music, it was the only time when you could just forget everything and float. You quickly changed and crawled under the sheets, picking up the remote from the side table and pressing the play button. It was Mozart’s duo. What an amazing symphony! It helped you drift back to your happy memories.
Unlike your half brothers and sisters, you were raised in Tiria. It was a small town on the edge of Serafino. You were raised by the Countess of Tiria, a very kind woman. She had grace, beauty, and wealth but no children. She showered you with love and pretty gifts. You had excellent teachers for your education. You learned everything from crochet to fencing. 
The manor there was old and beautiful. It had a beautiful garden and a whole forest around it. You would often go into the forest, just to explore it. Those were the happiest days of your life. Until your tenth birthday - the day the Countess died.
Just like the symphony, your thoughts turned darker. You’d been happy that day; the maids had told you that you were going to have a big birthday party. The Earl had been there for two weeks now. Your innocent mind had thought that he was there for your birthday. That morning you were out in the gardens, picking up some red roses for the Countess, it was something you did every day. You would just run into her room to put them on her side table, she loved that. You held the bunch of roses in your tiny hands, running through the house to her room. You were wearing a very pretty white dress with laces and pink ribbons. Your bare feet softly met the stone floor as you ran to her room and pushed the door, happily calling to her.
The Countess was there, lying on the floor in a pool of blood. There were bruises on her body and a sword, stabbed right through her heart. The handle of the sword was in the hands of the Earl. He twisted the blade with a cruel smile in his eyes. Then you screamed. The flowers falling from your hands, red roses into red blood - they were the same color. Your pretty white dress was now red. You backed away still screaming, leaving little red footprints on the floor. The maids came running to you and held you tight as you screamed and screamed. You don’t remember for how long you were screaming or what happened later.
You drifted off to sleep. 
It was a beautiful forest. The trees were so thick that sunlight barely touched the ground and everything was covered in moss. You were standing there in front of a giant wolf. It wasn’t a werewolf, it smelled like a  regular  one but just giant, like a direwolf. It was growling at you, baring his teeth. You had no weapons with you, you double checked. You looked around for an escape, you could kill him with your teeth but they weren’t as sharp as they’d used to be. You looked at your nails, they were fragile. Heck! You were human!!
“Y/N, wake up!!” the wolf suddenly spoke in a girly voice. It didn’t make sense, really.
“Are you a girl?” you asked the wolf who was ready to kill you. Talking to an animal, guess you had finally lost your sanity.
“Y/N!!” Someone was shaking you, trying to wake you up without much success. Then you realized you were sleeping under a bunch of blankets and pillows. It was three in the morning; you could tell by the smell of the air. You peeked at the person who had dared to disturbed you. It was Lily.
“What is it, Bunny?” you asked sleepily. It was good she had practice understanding you while you sleep talked, if it was anyone else, they would’ve thought you were talking gibberish.
“I had a bad dream,” she said with a puppy face. You knew what she wanted; she wanted to sleep with you. 
“Me too,” you replied and ran your tongue over your teeth, yup, still vampire. “Come here you,” you said, grabbing her and stuffing her under the pile of blankets and pillows. You loved a warm cozy place to sleep. You held her like a teddy bear and dozed off again. She was so soft in your arms and she held tight onto you. Protecting someone was a good feeling. You went back to sleep as if  you had never woken up.
NEXT
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trishmishtree · 4 years
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[Current as of March 13, 2020]
Dr. Shahed (screenshot above) is an emergency department physician in Ohio who shared this post on Facebook. It’s an account of COVID-19 from the perspective of an ICU doc working on the frontlines in Seattle. Some of my laypeople-friends were sharing it around (and I’ve seen it floating around on twitter and various internet forums], but I noticed that it’s really dense and contains a lot of medical abbreviations and jargon, like it was meant more for other physicians and isn’t really useful for the average reader. So I thought I’d provide a translation for my non-medblr followers who are looking to stay informed. (If you want further clarification, feel free to drop me an ask)
***
This is from a front-line ICU physician in a Seattle hospital
This is his personal account:
We have 21 patients and 11 deaths since 2/28.
We are seeing patients who are young (20s), fit, no comorbidities, critically ill. It does happen.
US has been past containment since January
Currently, all of ICU is for critically ill COVID patients, all of med-surg [medical-surgical] floors are for stable COVID patients and end-of-life care, half of PCU [progressive care unit], half of ER. New Pulmonary Clinic offshoot is open for patients with respiratory symptoms
CDC is no longer imposing home quarantine on providers who were wearing only droplet-isolation PPE when intubating, suctioning, bronching, and in one case doing bloody neurosurgery. Expect when it comes to your place you may initially have staff home-quarantined. Plan for this NOW. Consider wearing airborne-isolation PPE for aerosol-generating procedures in ANY patient in whom you suspect COVID, just to prevent the mass quarantines.
We ran out of N95s (thanks, Costco hoarders) and are bleaching and re-using PAPRs [powered air purifying respirators], which is not the manufacturer’s recommendation. Not surprised on N95s as we use mostly CAPRs [controlled air purifying respirators] anyway, but still.
Terminal cleans (including UV light) for ER COVID rooms are taking forever, Environmental Services is overwhelmed. This is bad, as patients are stuck coughing in the waiting room. Recommend planning now for Environmental Service upstaffing, or having a plan for sick patients to wait in their cars (that is not legal here, sadly).
CLINICAL INFO (based on our cases and info from CDC conference call today with other COVID providers in US):
The Chinese data on 80% mildly ill, 14% hospital-ill, 6-8% critically ill are generally on the mark. Data [in the US] very skewed by late and very limited testing, and the number of our elderly patients going to comfort care. 
Being young & healthy (zero medical problems) does not rule out becoming vented or dead 
Probably the time course to developing significant lower respiratory symptoms is about a week or longer (which also fits with timing of sick cases we started seeing here, after we all assumed it was endemic as of late Jan/early Feb). 
Based on our hospitalized cases (including the not-formally-diagnosed ones who are obviously COVID – it is quite clinically unique), about 1/3 of patients have mild lower respiratory symptoms and need 1-5L NC [1-5 liters of oxygen per minute, via nasal cannula]. 1/3 are sicker, need face mask or non-rebreather. 1/3 are intubated with ARDS [acute respiratory distress syndrome]. 
Thus far, everyone is seeing: 
normal WBC [white blood cell] count. Almost always lymphopenic, occasionally poly [neutrophil]-predominant but with normal total WBC count. Doesn’t change, even 10 days in. 
Bronchoalveolar lavage: lymphocytic despite blood being lymphopenic. (Try not to bronch these patients; this data is from pre-testing time when we had several idiopathic ARDS cases) 
Fevers, often high, may be intermittent; persistently febrile, often for >10 days. It isn’t the dexmed, it’s the SARS2. 
Low procalcitonin; may be useful to check initially for later trending if you are concerned later for VAP [ventilator-associated pneumonia], etc.
Elevated AST/ALT, sometimes alkaline phosphatase. Usually in 70-100 range. No fulminant hepatitis. Notably, in our small sample, higher transaminitis [elevated AST/ALT] (150-200) on admission correlates with clinical deterioration and progression to ARDS. LFTs [liver function tests] typically begin to bump in 2nd week of clinical course. 
Mild AKI [acute kidney injury] (creatinine <2). Uncertain if direct viral effect, but notably SARS2 RNA fragments have been identified in liver, kidneys, heart, and blood.</li>
Characteristic chest x-ray: always bilateral patchy or reticular infiltrates, sometimes peri-hilar despite normal ejection fraction and volume down at presentation. At time of presentation may be subtle, but always present, even in our patients on chronic high dose steroids. NO effusions.
CT is as expected, rarely mild mediastinal lymphadenopathy, occasional small effusions late in course, which might be related to volume status/cap leak.
Note - China is CT'ing everyone, even outpatients, as a primarily diagnostic modality. However, in US/Europe, CT is rare, since findings are nonspecific, would not change management, and the ENTIRE scanner and room have to be terminal-cleaned, which is just impossible in a busy hospital. Also, transport in PAPRs, etc. 
2 of our patients had CTs for idiopathic ARDS in the pre-test era; they looked like the CTs in the journal articles. Not more helpful than chest x-ray. 
When respiratory failure occurs, it is RAPID (likely 7-10 days out from symptom onset, but rapid progression from hospital admission). Common scenario for our patients is: admit on 1L/min oxygen via nasal cannula. Next 12 hrs escalate to NPPV [non-invasive positive pressure ventilation]. Next 12-24 hrs → vent/proned/Flolan. 
Interestingly, despite some needing Flolan, the hypoxia is not as refractory as with H1N1. Quite different, and quite unique. Odd enough that you’d notice and say hmmm. 
Thus far many are dying of cardiac arrest rather than inability to ventilate/oxygenate. 
Given the inevitable rapid progression to ETT [endotracheal tube, aka intubation] once respiratory decompensation begins, we and other hospitals, including Wuhan, are doing early intubation. Face mask is fine, but if patients are needing HFNC [high-flow nasal cannula] or NPPV [non-invasive positive pressure ventilation], just tube them. They definitely will need a tube anyway, and no point risking the aerosols.
No MOSF [multi-organ system failure]. There’s the mild AST/ALT elevation, maybe a small creatinine bump, but no florid failure. Exception is cardiomyopathy.
Multiple patients here have had normal EF [ejection fraction] on formal Echo or POCUS [point-of-care ultrasound] at time of admission (or in a couple of cases, EF 40ish, chronically). Also normal troponins from emergency department. Then they get the horrible respiratory failure, sans sepsis or shock. Then they turn the corner, come off Flolan, supined, vent weaning, looking good, never any pressor requirement. Then over 12 hrs, newly cold, clamped, multiple-pressor shock that looks cardiogenic, EF 10% or less. Then either VT [ventricular tachycardia, aka V-tach] → VF [ventricular fibrillation, aka V-fib] → dead, or PEA [pulseless electrical activity] → asystole in less than a day. Needless to say, this is awful for families who had started to have hope. 
We have actually had more asystole than VT. Other facilities report more VT/VF, but same time course, a few days or a week after admission, around the time they’re turning the corner. This occurs on med-surg patients too. One today, who is elderly and chronically ill but with baseline EF preserved, became newly hypotensive overnight, EF <10. Already no escalation, has since passed. So presumably there is a viral cardiomyopathy aspect, which presents later in the course of disease.
Of note, no wall motion abnormalities on Echo, right ventricular function preserved, troponins don’t bump. Could be unrelated, but I’ve never seen anything like it before, especially in a patient who had been hemodynamically stable without sepsis.
TREATMENT:
Remdesivir might work, some hospitals have seen improvement with it quite rapidly, marked improvement in 1-3 days. ARDS trajectory is impressive with it, patients improve much more rapidly than expected in usual ARDS.
Recommended course is 10 days, but due to scarcity, all hospitals have stopped it when the patient is clinically out of the woods. None have continued >5 days. It might cause LFT bump, but interestingly seem to bump (200s-ish) for a day or 2 after starting, then rapidly back to normal, suggests this is not a primary toxic hepatitis.
Unfortunately, the Gilead compassionate use and trial programs require AST/ALT <5x normal, which is pretty much almost no actual COVID patients. Also CrCl [creatinine clearance] >30, which is fine. CDC is working with Gilead to get LFT requirements changed now that we know this is a mild viral hepatitis.
Currently the Gilead trial is wrapping up, NIH trial still enrolling, some new trial soon to begin, can’t remember where.
Steroids are up in the air. In China, usual clinical practice for all ARDS is high dose methylprednisolone. Thus, ALL of their patients have had high dose methylprednisolone. Some question whether this practice increases mortality.
It is likely that it increases secondary VAP/HAP [ventilator-associated pneumonia/hospital-acquired pneumonia]. China has had a high rate of drug-resistant GNR [Gram-negative rod] HAP/VAP and fungal pneumonia in these patients, with resulting increases in mortality. We have seen none, even in the earlier patients who were vented for >10 days before being bronch’ed (prior to test availability. Again, it is not a great idea to bronch these patients now).
Unclear whether VAP-prevention strategies are also different [in China vs US], but wouldn’t think so?
Hong Kong is currently running an uncontrolled trial of HC 100IV Q8 [hydrocortisone 100 mg IV every 8 hours].
General consensus here (in US among doctors who have cared for COVID patients) is that steroids will do more harm than good, unless needed for other indications.
Many of our patients have COPD on ICS [inhaled corticosteroids]. Current consensus at Evergreen, after some observation & some clinical judgment, is to stop ICS if able, based on known data with other viral pneumonias and increased susceptibility to HAP. Thus far patients are tolerating that, no major issues with ventilating them that can’t be managed with vent changes. We also have quite a few on AE-COPD [acute exacerbation of COPD]/asthma doses of methylprednisolone, so will be interesting to see how they do.
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rxbodybuilding · 5 years
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Posted by Masswithclass on Musclesci Bloodwork Knowledge Blood tests You just had some blood work done, and the friggin' doctor or his nurses are guarding the results as if they're state secrets. However, after much cajoling and explaining that you'd like to at least be an informed partner in your own goshdarn health care, they begrudgingly give you a copy of your lab tests. Trouble is, as much as you've been posturing about how you've had more than a smattering of medical education, you still can't figure out what half the tests are for and whether or not those abnormal values are anything to worry about. Well, in the following article, I'm going to go over each of the most common tests. I'll include why it's performed, what it tells you, and what the typical ranges are for normal humans. That way, you'll have something more to go on in assessing your health other than your family doctor saying, "Well, these few values are a little worrisome, but you'll probably be okay." One note, though, before I get started. The values I'll be listing are merely averages and the ranges may vary slightly from laboratory to laboratory. Also, if there's only one range given, it applies to both men and women. Lipid Panel — Used to determine possible risk for coronary and vascular disease. In other words, heart disease. HDL/LDL and Total Cholesterol These lipoproteins should look rather familiar to most of you. HDL is simply the "good" lipoprotein that acts as a scavenger molecule and prevents a buildup of material. LDL is the "bad" lipoprotein which collects in arterial walls and causes blockage or a reduction in blood flow. The total cholesterol to HDL ratio is also important. I went in to detail about this particular subject — as well as how to improve your lipid profile — in my article "Bad Blood". Nevertheless, a quick remonder: your HDL should be 35 or higher; LDL below 130; and total to HDL ratio should be below 3.5. Oh and don't forget VLDL (very low density lipoprotein) which can be extremely worrisome. You should have less than 30 mg/dl in order to not be considered at risk for heart disease. On a side note, I'm sure some of you are wishing that you had abnormally low plasma cholesterol levels (as if it's something to brag about), but the fact is that having extremely low cholesterol levels is actually indicative of severe liver disease. Triglycerides Triglycerides are simply a form of fat that exists in the bloodstream. They're transported by two other culprits, VLDL and LDL. A high level of triglycerides is also a risk factor for heart disease as well. Triglycerides levels can be increased if food or alcohol is consumed 12 to 24 hours prior to the blood draw and this is the reason why you're asked to fast for 12-14 hours from food and abstain from alcohol for 24 hours. Here are the normal ranges for healthy humans. 16-19 yr. old male 40-163 mg/dl Adult Male 40-160 mg/dl 16-19 yr. old female 40-128 mg/dl Adult Female 35-135 mg/dl Homocysteine Unfortunately, this test isn't always ordered by the doctor. It should be. Homocysteine is formed in the metabolism of the dietary amino acid methionine. The problem is that it's a strong risk factor for atherosclerosis. In other words, high levels may cause you to have a heart attack. A good number of lifters should be concerned with this value as homocysteine levels rise with anabolic steroid usage. Luckily, taking folic acid (about 400-800 mcg.) as well as taking a good amount of all B vitamins in general will go a long way in terms of preventing a rise in levels of homocysteine. Normal ranges: Males and Females age 0-30 4.6-8.1 umol/L Males age 30-59 6.3-11.2 umol/L Females age 30-59 4.5-7.9 umol/L >59 years of age 5.8-11.9 umol/L The Hemo Profile These are various tests that examine a number of components of your blood and look for any abnormalities that could be indicative of serious diseases that may result in you being an extra in the HBO show, "Six Feet Under." WBC Total (White Blood Cell) Also referred to as leukocytes, a fluctuation in the number of these types of cells can be an indicator of things like infections and disease states dealing with immunity, cancer, stress, etc. Normal ranges: 4,500-11,000/mm3 Neutrophils This is one type of white blood cell that's in circulation for only a very short time. Essentially their job is phagocytosis, which is the process of killing and digesting bacteria that cause infection. Both severe trauma and bacterial infections, as well as inflammatory or metabolic disorders and even stress, can cause an increase in the number of these cells. Having a low number of neutrophils can be indicative of a viral infection, a bacterial infection, or a rotten diet. Normal ranges: 2,500-8,000 cells per mm3 RBC (Red Blood Cell) These blood cells also called erythrocytes and their primary function is to carry oxygen (via the hemoglobin contained in each RBC) to varioustissues as well as giving our blood that cool "red" color. Unlike WBC, RBC survive in peripheral blood circulation for approximately 120 days. A decrease in the number of these cells can result in anemia which could stem from dietary insufficiencies. An increase in number can occur when androgens are used. This is because androgens increase EPO (erythropoietin) production which in turn increases RBC count and thus elevates blood volume. This is essentially why some androgens are better than others at increasing "vascularity." Anyhow, the danger in this could be an increase in blood pressure or a stroke. Androgen-using lifters who have high values should consider making modifications to their stack and/or immediately donating some blood. Normal ranges: Adult Male 4,700,000-6,100,000 cells/uL Adult Female 4,200,000-5,400,000 cells/uL Hemoglobin Hemoglobin is what serves as a carrier for both oxygen and carbon dioxide transportation. Molecules of this are found within each red blood cell. An increase in hemoglobin can be an indicator of congenital heart disease, congestive heart failure, sever burns, or dehydration. Being at high altitudes, or the use of androgens, can cause an increase as well. A decrease in number can be a sign of anemia, lymphoma, kidney disease, sever hemorrhage, cancer, sickle cell anemia, etc. Normal ranges: Males and females 6-18 years 10-15.5 g/dl Adult Males 14-18 g/dl Adult Females 12-16 g/dl Hematocrit The hematocrit is used to measure the percentage of the total blood volume that's made up of red blood cells. An increase in percentage may be indicative of congenital heart disease, dehydration, diarrhea, burns, etc. A decrease in levels may be indicative of anemia, hyperthyroidism, cirrhosis, hemorrhage, leukemia, rheumatoid arthritis, pregnancy, malnutrition, a sucking knife wound to the chest, etc. Normal ranges: Male and Females age 6-18 years 32-44% Adult Men 42-52% Adult Women 37-47% MCV (Mean Corpuscular Volume) This is one of three red blood cell indices used to check for abnormalities. The MCV is the size or volume of the average red blood cell. A decrease in MCV would then indicate that the RBC's are abnormally large(or macrocytic), and this may be an indicator of iron deficiency anemia or thalassemia. When an increase is noted, that would indicate abnormally small RBC (microcytic), and this may be indicative of a vitamin B12 or folic acid deficiency as well as liver disease. Normal ranges: Adult Male 80-100 fL Adult Female 79-98 fL 12-18 year olds 78-100 fL MCH (Mean Corpuscular Hemoglobin) The MCH is the weight of hemoglobin present in the average red blood cell. This is yet another way to assess whether some sort of anemia or deficiency is present. Normal ranges: 12-18 year old 35-45 pg Adult Male 26-34 pg Adult Female 26-34 pg MCHC (Mean Corpuscular Hemoglobin Concentration) The MCHC is the measurement of the amount of hemoglobin present in the average red blood cell as compared to its size. A decrease in number is an indicator of iron deficiency, thalassemia, lead poisoning, etc. An increase is sometimes seen after androgen use. Normal ranges: 12-18 year old 31-37 g/dl Adult Male 31-37 g/dl Adult Female 30-36 g/dl RDW (Red Cell Distribution Width) The RDW is an indicator of the variation in red blood cell size. It's used in order to help classify certain types of anemia, and to see if some of the red blood cells need their suits tailored. An increase in RDW can be indicative of iron deficiency anemia, vitamin B12 or folate deficiency anemia, and diseases like sickle cell anemia. Normal ranges: Adult Mal 11.7-14.2% Adult Female 11.7-14.2% Platelets Platelets or thrombocytes are essential for your body's ability to form blood clots and thus stop bleeding. They're measured in order to assess the likelihood of certain disorders or diseases. An increase can be indicative of a malignant disorder, rheumatoid arthritis, iron deficiency anemia, etc. A decrease can be indicative of much more, including things like infection, various types of anemia, leukemia, etc. On a side note for these ranges, anything above 1 million/mm3 would be considered a critical value and should warrant concern and/or giving second thoughts as to whether you should purchase a lifetime subscription to Muscle Media. Normal ranges: Child 150,000-400,000/mm3 (Most commonly displayed in SI units of 150-400 x 10(9th)/L Adult 150,000-400,000/mm3 (Most commonly displayed in SI units of 150-400 x 10(9th)/L ABS (Differential Count) The differential count measures the percentage of each type of leukocyte or white blood cell present in the same specimen. Using this, they can determine whether there's a bacterial or parasitic infection, as well as immune reactions, etc. Pt. 2 Neutrophils As explained previously, severe trauma and bacterial infections, as well as inflammatory disorders, metabolic disorders, and even stress can cause an increase in the number of these cells. Also, on the other side of the spectrum, a low number of these cells can indicate a viral infection, a bacterial infection, or a deficient diet. Percentile Range: 55-70% Basophils These cells, and in particular, eosinophils, are present in the event of an allergic reaction as well as when a parasite is present. These types of cells don't increase in response to viral or bacterial infections so if an increased count is noted, it can be deduced that either an allergic response has occurred or a parasite has taken up residence in your shorts. Percentile Range: Basophils 0.5-1% Eosinophils 1-4% Lymphocytes and Monocytes Lymphocytes can be divided in to two different types of cells: T cells and B cells. T cells are involved in immune reactions and B cells are involved in antibody production. The main job of lymphocytes in general is to fight off — Bruce Lee style — bacterial and viral infections. Monocytes are similar to neutrophils but are produced more rapidly and stay in the system for a longer period of time. Percentile Range: Lymphocytes 20-40% Monocytes 2-8% Selected Clinical Values Sodium This cation (an ion with a postive charge) is mainly found in extracellular spaces and is responsible for maintaining a balance of water in the body. When sodium in the blood rises, the kidneys will conserve water and when the sodium concentration is low, the kidneys conserve sodium and excrete water. Increased levels can result from excessive dietary intake, Cushing's syndrome, excessive sweating, burns, forgetting to drink for a week, etc. Decreased levels can result from a deficient diet, Addison's disease, diarrhea, vomiting, chronic renal insufficiency, excessive water intake, congestive heart failure, etc. Anabolic steroids will lead to an increased level of sodium as well. Normal range: Adults 136-145 mEq/L Potassium On the other side of the spectrum, you have the most important intracellular cation. Increased levels can be an indicator of excessive dietary intake, acute renal failure, aldosterone-inhibiting diuretics, a crushing injury to tissues, infection, acidosis, dehydration, etc. Decreased levels can be indicative of a deficient dietary intake, burns, diarrhea or vomiting, diuretics, Cushing's syndrome, licorice consumption, insulin use, cystic fibrosis, trauma, surgery, etc. Normal range: Adults 3.5-5 mEq/L Chloride This is the major extracellular anion (an ion carrying a negative charge). Its purpose it is to maintain electrical neutrality with sodium. It also serves as a buffer in order to maintain the pH balance of the blood. Chloride typically accompanies sodium and thus the causes for change are essentially the same. Normal range: Adult 98-106 mEq/L Carbon Dioxide The CO2 content is used to evaluate the pH of the blood as well as aid in evaluation of electrolyte levels. Increased levels can be indicative of severe diarrhea, starvation, vomiting, emphysema, metabolic alkalosis, etc. Increased levels could also mean that you're a plant. Decreased levels can be indicative of kidney failure, metabolic acidosis, shock, and starvation. Normal range: Adults 23-30 mEq/L Glucose The amount of glucose in the blood after a prolonged period of fasting (12-14 hours) is used to determine whether a person is in a hypoglycemic (low blood glucose) or hyperglycemic (high blood glucose) state. Both can be indicators of serious conditions. Increased levels can be indicative of diabetes mellitus, acute stress, Cushing's syndrome, chronic renal failure, corticosteroid therapy, acromegaly, etc. Decreased levels could be indicative of hypothyroidism, insulinoma, liver disease, insulin overdose, and starvation. Normal range: Adult Male 65-120 mg/dl Adult Female 65-120 mg/dl BUN (Blood Urea Nitrogen) This test measures the amount of urea nitrogen that's present in the blood. When protein is metabolized, the end product is urea which is formed in the liver and excreted from the bloodstream via the kidneys. This is why BUN is a good indicator of both liver and kidney function. Increased levels can stem from shock, burns, dehydration, congestive hear failure, myocardial infarction, excessive protein ingestion, excessive protein catabolism, starvation, sepsis, renal disease, renal failure, etc. Causes of a decrease in levels can be liver failure, overhydration, negative nitrogen balance via malnutrition, pregnancy, etc. Normal range: Adults 10-20 mg/dl Creatinine Creatinine is a byproduct of creatine phosphate, the chemical used in contraction of skeletal muscle. So, the more muscle mass you have, the higher the creatine levels and therefore the higher the levels of creatinine. Also, when you ingest large amounts of beef or other meats that have high levels of creatine in them, you can increase creatinine levels as well. Since creatinine levels are used to measure the functioning of the kidneys, this easily explains why creatine has been accused of causing kidney damage, since it naturally results in an increase in creatinine levels. However, we need to remember that these tests are only indicators of functioning and thus outside drugs and supplements can influence them and give false results, as creatine may do. This is why creatine, while increasing creatinine levels, does not cause renal damage or impair function. Generally speaking, though, increased levels are indicative of urinary tract obstruction, acute tubular necrosis, reduced renal blood flow (stemming from shock, dehydration, congestive heart failure, atherosclerosis), as well as acromegaly. Decreased levels can be indicative of debilitation, and decreased muscle mass via disease or some other cause. Normal range: Adult Male 0.6-1.2 mg/dl Adult Female 0.5-1.1 mg/dl BUN/Creatinine Ratio A high ratio may be found in states of shock, volume depletion, hypotension, dehydration, gastrointestinal bleeding, and in some cases, a catabolic state. A low ratio can be indicative of a low protein diet, malnutrition, pregnancy, severe liver disease, ketosis, etc. Keep in mind, though, that the term BUN, when used in the same sentence as hamburger or hotdog, usually means something else entirely. An important thing to note again is that with a high protein diet, you'll likely have a higher ratio and this is nothing to worry about. Normal range: Adult 6-25 Calcium Calcium is measured in order to assess the function of the parathyroid and calcium metabolism. Increased levels can stem from hyperparathyroidism, metastatic tumor to the bone, prolonged immobilization, lymphoma, hyperthyroidism, acromegaly, etc. It's also important to note that anabolic steroids can also increase calcium levels. Decreased levels can stem from renal failure, rickets, vitamin D deficiency, malabsorption, pancreatitis, and alkalosis. Normal range: Adult 9-10.5 mg/dl Liver Function Total Protein This measures the total level of albumin and globulin in the body. Albumin is synthesized by the liver and as such is used as an indicator of liver function. It functions to transport hormones, enzymes, drugs and other constituents of the blood. Globulins are the building blocks of your body's antibodies. Measuring the levels of these two proteins is also an indicator of nutritional status. Increased albumin levels can result from dehydration, while decreased albumin levels can result from malnutrition, pregnancy, liver disease, overhydration, inflammatory diseases, etc. Increased globulin levels can result from inflammatory diseases, hypercholesterolemia (high cholesterol), iron deficiency anemia, as well as infections. Decreased globulin levels can result from hyperthyroidism, liver dysfunction, malnutrition, and immune deficiencies or disorders. As another important side note, anabolic steroids, growth hormone, and insulin can all increase protein levels. Normal range: Adult Total Protein: 6.4-8.3 g/dl Albumin: 3.5-5 g/dl Globulin: 2.3-3.4 g/dl Albumin/Globulin Ratio: Adult 0.8-2.0 Bilirubin Bilirubin is one of the many constituents of bile, which is formed in the liver. An increase in levels of bilirubin can be indicative of liver stress or damage/inflammation. Drugs that may increase bilirubin include oral anabolic steroids (17-AA), antibiotics, diuretics, morphine, codeine, contraceptives, etc. Drugs that may decrease levels are barbiturates and caffeine. Non-drug induced increased levels can be indicative of gallstones, extensive liver metastasis, and cholestasis from certain drugs, hepatitis, sepsis, sickle cell anemia, cirrhosis, etc. Normal range: Total Bilirubin for Adult 0.3-1.0 mg/dl Alkaline Phosphatase This enzyme is found in very high concentrations in the liver and for this reason is used as an indicator of liver stress or damage. Increased levels can stem from cirrhosis, liver tumor, pregnancy, healing fracture, normal bones of growing children, and rheumatoid arthritis. Decreased levels can stem from hypothyroidism, malnutrition, pernicious anemia, scurvy (vitamin C deficiency) and excess vitamin B ingestion. As a side note, antibiotics can cause an increase in the enzyme levels. Normal range: 16-21 years 30-200 U/L Adult 30-120 U/L Pt. 3 AST (Aspartate Aminotransferase, previously known as SGOT) This is yet another enzyme that's used to determine if there's damage or stress to the liver. It may also be used to see if heart disease is a possibility as well, but this isn't as accurate. When the liver is damaged or inflamed, AST levels can rise to a very high level (20 times the normal value). This happens because AST is released when the cells of that particular organ (liver) are lysed. The AST then enters blood circulation and an elevation can be seen. Increased levels can be indicative of heart disease, liver disease, skeletal muscle disease or injuries, as well as heat stroke. Decreased levels can be indicative of acute kidney disease, beriberi, diabetic ketoacidosis, pregnancy, and renal dialysis. Normal range: Adult 0-35 U/L (Females may have slightly lower levels) ALT (Alanine Aminotransferase, previously known as SGPT) This is yet another enzyme that is found in high levels within the liver. Injury or disease of the liver will result in an increase in levels of ALT. I should note however, that because lesser quantities are found in skeletal muscle, there could be a weight-training induced increase . Weight training causes damage to muscle tissue and thus could slightly elevate these levels, giving a false indicator for liver disease. Still, for the most part, it's a rather accurate diagnostic tool. Increased levels can be indicative of hepatitis, hepatic necrosis, cirrhosis, cholestasis, hepatic tumor, hepatotoxic drugs, and jaundice, as well as severe burns, trauma to striated muscle (via weight training), myocardial infarction, mononucleosis, and shock. Normal range: Adult 4-36 U/L Endocrine Function Testosterone(Free and Total) This is of course the hormone that you should all be extremely familiar with as it's the name of this here magazine! Anyhow, just as some background info, about 95% of the circulating Testosterone in a man's body is formed by the Leydig cells, which are found in the testicles. Women also have a small amount of Testosterone in their body as well. (Some more than others, which accounts for the bearded ladies you see at the circus, or hanging around with Chris Shugart.) This is from a very small amount of Testosterone secreted by the ovaries and the adrenal gland (in which the majority is made from the adrenal conversion of androstenedione to Testosterone via 17-beta HSD). Nomal range, total Testosterone: Male Age 14 <1200 ng/dl Age 15-16 100-1200 ng/dl Age 17-18 300-1200 ng/dl Age 19-40 300-950 ng/dl Over 40 240-950 ng/dl Female Age 17-18 20-120 ng/dl Over 18 20-80 ng/dl Normal range, free Testosterone: Male 50-210 pg/ml LH (Luteinizing Hormone) LH is a glycoprotein that's secreted by the anterior pituitary gland and is responsible for signaling the leydig cells to produce Testosterone. Measuring LH can be very useful in terms of determining whether a hypogonadic state (low Testosterone) is caused by the testicles not being responsive despite high or normal LH levels (primary), or whether it's the pituitary gland not secreting enough LH (secondary). Of course, the hypothalamus — which secretes LH-RH (luteinizing hormone releasing hormone) — could also be the culprit, as well as perhaps both the hypothalamus and the pituitary. If it's a case of the testicles not being responsive to LH, then things like clomiphene and HCG really won't help. If the problem is secondary, then there's a better chance for improvement with drug therapy. Increased levels can be indicative of hypogonadism, precocious puberty, and pituitary adenoma. Decreased levels can be indicative of pituitary failure, hypothalamic failure, stress, and malnutrition. Normal ranges: Adult Male 1.24-7.8 IU/L Adult Female Follicular phase: 1.68-15 IU/L Ovulatory phase: 21.9-56.6 IU/L Luteal phase: 0.61-16.3 IU/L Postmenopausal: 14.2-52.3 IU/L Estradiol With this being the most potent of the estrogens, I'm sure you're all aware that it can be responsible for things like water retention, hypertrophy of adipose tissue, gynecomastia, and perhaps even prostate hypertrophy and tumors. As a male it's very important to get your levels of this hormone checked for the above reasons. Also, it's the primary estrogen that's responsible for the negative feedback loop which suppresses endogenous Testosterone production. So, if your levels of estradiol are rather high, you can bet your ass that you'll be hypogonadal as well. Increased estradiol levels can be indicative of a testicular tumor, adrenal tumor, hepatic cirrhosis, necrosis of the liver, hyperthyroidism, etc. Normal ranges: Adult Male 10-50 pg/ml Adult Female Follicular phase: 20-350 pg/ml Midcycle peak: 150-750 pg/ml Luteal phase: 30-450 pg/ml Postmenopausal: 20 pg/ml or less Thyroid (t3, T4 Total and Free, TSH) T3 (Triiodothyronine) T3 is the more metabolically active hormone out of T4 and T3. When levels are below normal it's generally safe to assume that the individual is suffering from hypothyroidism. Drugs that may increase T3 levels include estrogen and oral contraceptives. Drugs that may decrease T3 levels include anabolic steroids/androgens as well as propanolol (a beta adrenergic blocker) and high dosages of salicylates. Increased levels can be indicative of Graves disease, acute thyroiditis, pregnancy, hepatitis, etc. Decreased levels can be indicative of hypothyroidism, protein malnutrition, kidney failure, Cushing's syndrome, cirrhosis, and liver diseases. Normal ranges: 16-20 years old 80-210 ng/dl 20-50 years 75-220 ng/dl or 1.2-3.4 nmol/L Over 50 40-180 ng/dl or 0.6-2.8 nmol/L T4 (Thyroxine) T4 is just another indicator of whether or not someone is in a hypo or hyperthyroid state. It too is rather reliable but free thyroxine levels should be assessed as well. Drugs that increase of decrease T3 will, in most cases, do the same with T4. Increased levels are indicative of the same things as T3 and a decrease can be indicative of protein depleted states, iodine insufficiency, kidney failure, Cushing's syndrome, and cirrhosis. Normal ranges: Adult Male 4-12 ug/dl or 51-154 nmol/L Adult Female 5-12 ug/dl or 64-154 nmol/L Free T4 or Thyroxine Since only 1-5% of the total amount of T4 is actually free and useable, this test is a far better indicator of the thyroid status of the patient. An increase indicates a hyperthyroid state and a decrease indicates a hypothyroid state. Drugs that increase free T4 are heparin, aspirin, danazol, and propanolol. Drugs that decrease it are furosemide, methadone, and rifampicin. Increased and decreased levels are indicative of the same possible diseases and states that are seen with T4 and T3. Normal ranges: 0.8-2.8 ng/dl or 10-36 pmol/L TSH (Thyroid Stimulating Hormone) Measuring the level of TSH can be very helpful in terms of determining if the problem resides with the thyroid itself or the pituitary gland. If TSH levels are high, then it's merely the thyroid gland not responding for some reason but if TSH levels are low, it's the hypothalamus or pituitary gland that has something wrong with it. The problem could be a tumor, some type of trauma, or an infarction. Drugs that can increase levels of TSH include lithium, potassium iodide and TSH itself. Drugs that may decrease TSH are aspirin, heparin, dopamine, T3, etc. Increased TSH is indicative of thyroiditis, hypothyroidism, and congenital cretinism. Decreased levels are indicative of hypothyroidism (pituitary dysfunction), hyperthyroidism, and pituitary hypofunction. Normal ranges: Adult 2-10 uU/ml or 2-10 mU/L Knowing how to interpret these tests can be a very valuable tool in terms of health and your body building and athletic progress. Use your new knowledge wisely.
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musclegymfactory · 4 years
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walking for weight loss [ Updated ]
Hello again! to walking for weight loss [ Updated ]
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In this article, we will talk a little about several ways to lose weight and maintain it, as we will talk a little about some of the tricks that you can follow to facilitate weight loss for you by walking. By entering here, you are definitely looking for weight loss without trouble, perhaps because you do not like exercise or even because you do not have time and this is something very normal because not all people can exercise every day and not all people have the same mood to exercise so there is nothing wrong in finding new ways It is easy to achieve the goal and at the same time help you succeed in the challenge of losing weight. Perhaps you are one of the few people that know that we always say that weight loss is the result of a decrease in your calories, but if you suffer from eating problems as well, then read on. This article is for you.
Table Of Contents
• How the body reduces weight?
Starting a specific diet means a decrease in the number of daily calories, which leads to a disturbance in the functioning of the organs inside the body, especially in the first week, mainly because the body has not gotten used to that few calories. And for the body to start losing weight, you must provide the appropriate conditions for that, and your body never loves to eat from stored fats, but rather increases your feeling of hunger to be forced to eat and if it refuses, and here the body begins to eat from stored fats by secreting growth hormone at a rate Big and because the stomach is empty, the hormone insulin is also low. To understand it simple: Low insulin in the blood and high growth hormone is the main condition for your body to start burning fat rocketly. Insulin is a hormone mainly related to the percentage of sugar in the blood, meaning that whenever the food you eat contains a lot of sugar, the more insulin secreted, and the higher the blood in the blood, the more food is converted into fats. The growth hormone is the opposite of insulin, which is a hormone produced by the body if there is not enough food to eat and its main role is to break down fat cells and burn them as energy. These two hormones work in reverse, so you should always respect this condition in case you are interested in accelerating weight loss. Read also: apple cider vinegar for weight loss Weight Loss Tips And Compatible Diet Best diet to lose weight fast
• How will the body maintain the new weight?
By following a specific diet, you will directly reduce the number of calories by about 500 calories daily and for a period that can be long or short, it depends mainly on your body type, because of the three types of bodies  Perhaps you now find yourself in a confusing situation because of the time the diet will take, and this is a normal thing, so it is advised to buy a scale and take measurements every day, and if the weight changes for more than 3 days, you must lose another 100 calories to a total of 600 calories, and so on until that You reach your ideal weight. To find out your ideal weight, convert your weight to a kilogram and compare it with your height. If, for example, you weigh 110 kilograms and your height does not exceed 1.7 meters, this means that you have a long and hard way ahead because you are about to start decreasing approximately 40 kilograms so that your height and weight are commensurate with 170 cm with 70 Kg. To maintain the weight that you have achieved, you are required to follow a final diet called a weight-stabilizing diet. The role of this diet is to take the same number of calories that your body needs every day regularly, for no less than 28 days at the very least. Read also: acupuncture for weight loss The best exercise to lose weight Is walking enough to lose weight?
Why 28 days?
 If you have read the article I wrote about my experiment with the keto diet, then you will know that the time required to stir up a new habit for the brain is 28 days. Once the new habit is established, the brain will immediately eliminate the old eating habits and keep the new ones only, thereby preserving the weight it has reached.
• Walking for weight loss
Imagine this scenario in front of you, as you are now on a diet and suppose you eat 1500 calories instead of 2000 calories and your body begins to lose weight day after day, but one day this gradual decline will stop, so what are you doing then? Only then you can start walking continuously for not less than 30 minutes and without stopping during this stage your body will start to break down more fat cells by offering to keep up the effort and such as to supply you with the necessary energy, it is preferable to walk in the morning on an empty stomach, but if you cannot, then there is no problem It is also preferred to wear a smartwatch to calculate the calories burned while walking. Why do you count calories while walking? We said that you take 1500 calories, but your weight is transmitted and you cannot get off afterward so you have been walking continuously for at least 30 minutes. The next day, you checked your weight and noticed that it came down. This means that walking has stimulated your body to lose more weight. Now if you cannot walk every day, you will take the calories that you calculated while walking and reduce them from your threatening calories. Suppose you have burned 100 calories while walking for one hour, we will also decrease 100 calories from the 1500 calories that you take and thus begin to take 1400 calories and so on until you reach the goal simply. Read also: Lose weight without training keys and tips 5 RULES TO LOSE WEIGHT + 3 FREE COURSES 15 EXERCISES AND TIPS TO LOSE FAT BY TRAINING LEGS
• Foods that help you lose appetite?
Green tea Always fill your stomach with water Almonds and nuts Low-fat yogurt Ginger Apples
• The best diet for beginners?
* Intermittent fasting is the best way to start, as this system is excellent if you want to have a perfect body * This system is mainly based on fasting for 16 hours and eating for 8 hours. This is the easiest way to start. I went to sleep. It is calculated within the time of fasting. Also, during fasting, insulin levels are very very low while levels of growth hormone are very high and as we mentioned earlier, this is It is the ideal equation for weight loss. * It is preferable to divide meals during eating into 4 or 5 small meals so that insulin levels do not rise dramatically, as it is not preferable to use white sugar because it is the direct cause of obesity, but rather it is preferable to use natural sugar, and we mention stevia which is considered a pure product of nature. * It is advised to eat a lot of fiber during this diet, by offering to perfectly clean the body When you reach the ideal weight, it is advised to follow a normal diet so that your body can get used to eating calories throughout the day, not for a specific and sufficient period. Read Next: WEIGHT LOSS DIET AWAKE THE BEAST WITHIN YOU 6 STEPS TO LOSE WEIGHT  LOSE WEIGHT EASY TIPS mbtTOC(); weight loss from Blogger https://ift.tt/2N1KVgA via IFTTT
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wrecklessimagine · 7 years
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Depression...Part 3
(Part 1  Part 2)
And sure enough, the doctor was right.
As you sat there and looked at the scans of your head, the massive spot on the screen made you sick to your stomach.
“We will need her in surgery as soon as possible,” the doctor begins.
But you were zoning in and out of the conversation.
You weren’t depressed?
You weren’t...moody?
You couldn’t remember a time where you didn’t have these traits.
Had it always been there?
Were you gonna die?
“Y/N?” Spencer says as he takes your hand within his.
Your eyes slowly flickered over to the doctor as you looked at him.
“You’re going to be just fine,” the doctor says.
“How do you know?” you whisper as tears well in your eyes.
“Because your white blood cell count in your body isn’t elevated nearly as high as is necessary for a tumor this size to be malignant,” the doctor says.
“He’s 90% sure that the tumor is benign,” Spencer smiles.
But you didn’t feel anything.
Nothing at all.
Again.
“Miss Y/L/N,” the doctor begins, “I know that you aren’t feeling anything right now, so let me just tell you what is going to happen.  I am going to leave the room and schedule an OR.  When I come back, we will get you ready for surgery, and when you come to in six or so hours, we will go from there.”
Six hours?
“Y/N?” Spencer asks as he tugs on your arm lightly, “What are you thinking?”
You didn’t know.
There just...wasn’t anything.
“I don’t know,” you say monotonously.
Spencer furrowed his brow in worry.
“Don’t worry,” the doctor says as he begins to step out of the room, “I’ll be right back.”
And you sat and stared out the window as you tried to remember the burning sensation of the salt water in your throat.
It was so painful.
And you remembered how good it felt to feel.
Six hours.
Spencer had been pacing for six hours before the doctor came out.
“We managed to get all of it, and we are sending it off to the lab for an emergency evaluation.  I don’t want anyone going to sleep tonight without knowing what our next move is.”
Spencer liked this doctor more and more.
He sat beside your bed as he held your hand.  He watched your chest rise and fall with a peaceful bliss that he hadn’t recalled in quite some time.  Usually you tossed and turned, flipped and sighed.
It had been months since he had seen you this peaceful.
He remembered what the doctor had told him.  The doctor had said that, judging by the calcification around parts of the tumor, that it had been growing for years.  He said that it was impossible to date, but the calcification put some parts of the tumor at about 5 years old.
Five years with this thing growing inside of your head, impeding on your ability to feel, to emote, to enjoy things or cry over things.  Impeding on your ability to live life and enjoy sex and taste the beauty in foods.
He didn’t even care if it was malignant or not, he just knew that with that thing on the outside instead of inside of you that your quality of life would soon change.
There were so many things he wanted to experience with you.
The bandaging around your head would take some explaining.  He wasn’t sure how you would take the massive patch of hair missing from your head.
He wasn’t sure how you would react to anything now.
But there was a nervous anticipation when you started to stir and groan.
“Y/N?” Spencer asks as he scoots closer to you, “Y/N...can you hear me?”
It took you a while before you had the strength to open your eyes.
“Spencer?” you breathe as you raise your free hand to the bandages on your head.
“What-...?”
You slowly began to feel around as your hands began to shake.  It had never occurred to you that, in order to get to there they needed to go, that they would have to remove the hair in that area in order to get there.
You loved your hair.
Wait...
You loved your hair.
You furrowed your brow as tears began to well in your eyes, and your chest began hiccuping as tears wafted down your face.
“Oh, sweetheart,” Spencer coos as he leans in and kisses your cheeks, “are you in pain?”
And soon, those tears of sadness turned to tears of relief.
“I love my hair, Spencer,” you breathe as you look over at him with wide eyes.
“Spencer...I’m sad that my hair is gone,” you urge as a smile breaks out across your face.
“Spencer...I feel sadness!’ you rejoice as tears of sadness and relief continue to waft down your face.
And Spencer got up off of his chair and embraced you close.
“I’m sad for my hair,” you sob into his neck as he holds you tight against him.
Even though the tumor came back as benign, your white blood cell count was still a bit higher than they wished, and after running a general antibiotic through your system for a couple of days, they decided to send you home with a chemo shot to take once a day for the next two weeks.
“You’ll experience spurts of exhaustion and nausea, but this will be the equivalent of one chemotherapy treatment that you would experience in a hospital.  The antibiotics didn’t bring your levels down, so this is precautionary, even though we removed all of the tumor.”
Spencer took off of work to be with you, and you were thankful.  While the nausea wasn’t too bad, the exhaustion was unbearable, and he had to help you get everywhere you needed to go.  You cried on his shoulder, embarrassment ripping through you whenever you couldn’t get down onto the toilet fast enough before urinating, and then you both would cry tears of joy at the fact that you felt embarrassment.
And after the the two weeks were up, you went back to see the doctor at the hospital clinic, who was all smiles when he reported that your white blood cell count was back to normal.
The two of you rejoiced in that room with tears of joy as you embraced one another, and then that night you two had celebrated as lovers who had missed each others bodies.
It had been so long since you had enjoyed sex with Spencer, and his body wracked yours with orgasm after orgasm as you laid there, spent and sweating, as your chest filled with a type of love you had not felt in months.
Had not felt in years.
And as you rolled over, with Spencer’s juices dripping down the inside of your thigh, you smiled lazily at him as he cupped your cheek and ran his thumb over your skin.
“I love you so much, Spencer,” you choke out as tears rush to your eyes.
“And I love you, Y/N,” he says before thrusting forward and encompassing your lips.
“And I love you,” he whispers against your skin.
135 notes · View notes
pbpress · 4 years
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Blood Candy: Chapters 7 and 8
by Ruqayyah Pickel
Lunch time arrived, and I found a note in the spot I usually sat at. 
“Change of plans,” it said. “Meet me in the back of the school. Forget your lunch; we’ll get food before we go. -A” 
Assuming that “A” was Akira, I headed out to the back of the school building. I honestly never liked coming back here; it’s where all the…shady things happened. It always smelled faintly of drugs, and cigarette remains were littered across the floor. It also didn’t help that there was a long, dark, recessed area where I suspected the shadiest of the shady things happened. I heard several people had been beaten up in this area. One person was even murdered, according to rumors—but Akira and Seb insisted that they weren’t dead…or at least not forever. (You’d think they’d use their skills to figure out who had murdered that poor kid and why instead of whether or not they were actually alive...but considering what Seb almost did to me last night, I really was in no position to make fun of him anymore.)
I felt a vibration in my pocket, and took out my phone to see a message from my mom. 
“Hey there,” it read, “I know you’re at school right now, and again, I don’t mean to alarm you, but I called the police station for updates on the investigation. They said that they’re gonna have to put it on hold for right now; they haven’t heard back from the officers that came by the house last night, so they’re trying to get in touch with them. That’s all. We’ll talk more when you come home. Love you, stay safe.” 
I let out a nervous sigh. In all honesty, I was rather nervous about going into this myself, so I was kind of counting on the police to find Seb and figure out just what had gotten into him. That being said, the police force was kind of unreliable, so confronting Seb myself could be a good thing...but the last time I saw him, he literally tried to kill me. 
I couldn’t even begin to imagine what Jasper would do once I saw him again. 
Suddenly, I heard an odd sound. It sounded like…something opening. A bag, probably. Had it not been for the faint, muffled giggling that accompanied that sound, then my heart would not have been racing as much. I turned the corner and found…nothing.
So what was that—
The tight feeling around my neck and the prickly feeling of a rope around it quickly answered my question. 
I found myself struggling to breathe, forcing in and out every breath, trying my hardest not to suffocate. The thick, prickly rope had already been tied quickly around my neck. I was on one knee as I tried to stop myself from getting dragged back by whoever had bound me. I struggled to turn around, but by the time I did, my heart sank.
It was Seb. 
A demented smile crossed his face as his peppermint pattern in his eyes continued to swirl. I could barely see the bloodstains on his baseball tee covered by his new black long coat. 
“S-Sebs…” I choked out, “wh-what’re y-you…” 
Once Seb realized he had me bound, he tied the other end of the rope to a nearby dumpster. I made one last feeble attempt to escape, but the world was already going dark. Though I was already blacking out, Seb made sure to finish the job by taking out the baseball bat I had used to knock him out the night before, and bringing it down hard on my head. The last thing I felt was my head hitting the hard concrete before everything went black. 
          ———————
[Chapter 8]
When I came to, I found myself in a sickeningly familiar office. 
I was bound to the same chair I was in yesterday using the same thick rope Seb used to choke me. 
“Hope the ride wasn’t too bumpy,” Jasper Kermit’s voice said. He entered the room and crouched down to my level with an arrogant smile. “Took you long enough. Though…” He frowned. “You’re not nearly as bloody as I expected you to be.” Jasper’s smile suddenly returned, only more cheerful this time. “Good! Means your little friend Sebs is actually marginally obedient and isn’t a greedy little leech.”
“Let me go!” I demanded as Jasper got up to go to his syringe cabinet. “I’ve done nothing to you!”
“I don’t exactly care,” he said, “but thanks for reminding me.” 
“I hope you realize I only took your stupid vampire candy just to be polite,” I snapped at him. “I should’ve just turned it down and saved myself the trouble.” 
Jasper laughed, a cruel and condescending sound. He crouched down to my level, syringe in hand. 
“You really think I would’ve given you that choice?” he taunted. “God, you are so naive. It’s embarrassing, really.” 
My heart was thundering. I was gonna die here, I thought. I’ve been kidnapped, I can’t call anyone for help, he’s gonna drain all of my blood and feed it to his army of vampires, he’s gonna—
Suddenly, Jasper started poking needles in the back of both hands, then in both wrists, and in both arms. Though the pain of blood works didn’t affect me as much anymore, having six needles stuck in my veins at once, plus the knowledge that these six needles were going to drain me of all my blood and kill me, made the entire process much more painful. 
Finally, he hooked all six needles up to one longer-than-normal syringe, with several others on the sidelines. 
“Oh…hold on,” Jasper said with a smirk. “Before we start, there’s one last thing I need to do.” 
He grabbed a nearby roll of duct tape, ripped off a piece, and taped it over my mouth. 
“Wouldn’t want a noise complaint, now, would we?” Jasper taunted. He wore a sadistic grin on his face...revealing fangs in his mouth and confirming any remaining suspicions. “Now we can get started…” 
Suddenly, a fire alarm went off in the building. 
“Wh-what the hell…?” he said, then turned to me, an annoyed look on his face. “I’m gonna go check out the alarm. Fortunately, you can’t really escape, so I guess enjoy the last minutes of your life.” He stood up and walked out the door. 
I tried to ignore the pain in my arms and wrists as I tried to figure out a way out of the situation. 
Chances are, I thought to myself, that I wouldn’t be able to escape before Jasper gets back. And if he sees that I tried to, then he’s probably gonna kill me even faster. I could sit here and die, and if/whenever Sebs snaps outta this, then he’ll have to live with the knowledge that he’s the reason his ‘best friend in the whole wide world since kindergarten’ is now six feet under with empty blood vessels and ghostly white skin. And you know what? I’m okay with that. I hope Seb feels like the scum of the earth for this—
Wait. No. Why am I blaming him? This is Jasper’s fault. He was the one who spiked the candy—with what?—he probably enlisted Seb to choke the consciousness outta me, and he is the person draining my blood. Not Seb. He didn’t want this. He wants me alive, and every remaining conscious part of him is probably screaming at himself mentally for putting me in harm’s way—
“Dakota!” a familiar voice called. I looked up to find Akira, Kaveri, and the kid from the other day, Oliver. He had a bandage wrapped around his shoulder with a bloody spot in the middle. 
“Hey! Finally!” I cheered. “GET THESE THINGS OUTTA ME NOW.”
“Alright, alright, geez,” Akira said. “You act like you’re dying.” She and Oliver began gently taking the needles out of my veins. The two of them raided the desk for bandages, and put them on my wrists and arms. 
“How did you guys find me?” I asked. 
“This hospital is one of the main headquarters of Clueham’s top vampire guild,” Kaveri explained as she was cutting me loose. “It’s also the only local hospital--because the Clueham officials all share a single brain cell--so I figured you’d be trapped here.”
“Oliver—or Oli, for short—is Jasper’s younger brother,” Akira said. “He was in the waiting room crying, and I asked him what was up. He told me about his brother who caused both the small bleeding hole in his shoulder and Seb’s newfound insanity. I triggered the fire alarm to cause a distraction, and boom!” She pulled out the last needle as Kaveri finished freeing me. “Here we are.”
“Akira, you genius,” I said. “Let’s go.”
“Let’s,” Oliver said, “before Jasper gets back. Exit’s just upstairs—“
“No,” I said. “I need to face Jasper.”
Oliver’s eyes widened with fear. 
“A-are you crazy?!” he cried. “He’ll kill you! And if he doesn’t, then Sebastian will!” 
“Seb wouldn’t kill me,” I said with a smile. “Hurt me, probably, but he could never bring himself to actually kill me.”
“I’m not so sure about that.” He pulled out his phone. “Can you set up some barricades?” he asked Akira and Kaveri.
He closed and locked the door, then opened up a video. Both girls nodded as they pushed the two chairs in the room in front of the door. Then, Oliver pressed play. 
The video showed Jasper in his office, experimenting with what I assumed to be blood and a variety of chemicals. The camera was positions a little higher up, but not high enough to be security footage.
“All the vampires in the facility—Jasper included—busted the security cameras,” Oli explained, “so I set one up behind the books in his office.
“What if he pulled out a book from that shelf?” Akira asked. 
“Well, he didn’t. He doesn’t read anymore; they’re just for show.”
Suddenly, Seb stormed into the office in the video. Jasper whirled his head around, a confused expression on his face. However, it quickly turned into a smile. 
“Oh, you must be Sebastian Briggs,” Jasper said. “Yeah, you definitely came here before. I recognize you from our database. How’s it going?” 
Silence. We could only see the back view of Seb, so if he was smiling, we couldn’t tell. 
Seb pointed to his neck with a shaky finger. “…m-make me…one of you…”
“Ohhhh…” Jasper said, nodding. “I see.” Suddenly, he gave Seb a slight glare. “Wait…no, no no no. I just…I can’t really do that, see. I don’t exactly know if I trust you to not be a filthy leech like some of the other greedy…subjects from before.” Jasper stood up. “See, you’re just the errand boy. You get Dakota for me, and once you do, then you get to start your real job. Got it?
Seb nodded.
“…b-but…I must…feed…like you…” 
Jasper sighed.
“You made a candy that gives people bloodlust,” Jasper murmured to himself. “Of course this was gonna happen.” He let out a sigh, and leaned back in his chair. 
“You know what?” Jasper said. “Sure. I’m gonna have to convert you anyways.” He stood up and grabbed something from his drawer. “But biting’s just…so informal, y’know? You’re my colleague now, I can’t just bite you on the neck like you’re some random on the street. Don’t worry. I got just the thing for that.” 
Jasper pulled out a small dagger-like device. The blade resembled that of the tooth of a wild beast, and the metal handle had dark red markings on it. 
“This little thingy allows me to give people the vampiric curse without biting them. Originally made for a vampire who got her teeth knocked out. Gimme your neck.”
Seb did, obeying Jasper with such blindness that it caused my blood to boil. I watched as Jasper held the other side of his errand boy’s neck as he made a decent-sized slit along his throat. As he did, the dagger’s markings lit up. When he was done, Seb was on his knees, holding the area where he was cut. Finally, he stood up, as Jasper gave a triumphant smile.
“Perfect,” he said. “Sebastian, you work for me from now on.” He took out a black long coat from his closet. “Put this on. There’s a small mirror over there if you wanna check yourself out.”
Seb put on the coat, and went over to a nearby mirror—which just happened to be on the bookshelf. That’s when Seb noticed the camera. 
The video cut off just after he looked at it. 
“I was controlling the camera from my phone,” Oliver explained. “So I turned it off right as I saw Sebastian looking at me.” 
“…so, he’s a vampire now?” I said. 
Kaveri nodded solemnly. I looked over at her.
“Can we cure him?” I asked. 
“We can probably cure his bloodlust,” she said, “but if you want him to, well, not be a vampire…you’re gonna have to kill him.”
I sighed. 
“Guess I’ll just have a vampire for a friend,” I said.
“Once this is over,” Akira said, “I want at least 90% of the credit for this conspiracy.”
“You’re still gonna make a post about this?!” Kaveri cried. “This isn’t a game, y’know. This is an actual threat.”
Akira just shrugged. 
“Gotta keep the hustle goin’,” she replied simply. “Besides...best to keep the people informed, right? They might take it a bit less seriously since it’s a ‘conspiracy,’ but they’ll believe us. They always do.” 
“Let’s actually get this done first,” I reminded her. “But yeah, I can respect that. Don’t want anyone else going through what we’ve been through.”
Suddenly, a loud BANG came from outside the door. 
“DAKOTA!” Jasper yelled from the other side of the door. “I better not find you untied in there, or I will MURDER YOU.” 
Akira rummaged through the drawers and shelves, then finally found and grabbed a reflex hammer. She motioned for Oliver and I to open the door. Reluctantly, we both stood on the other side of the door, out of sight, and pulled down the barricades. Jasper stormed into the room, just as Akira threw the reflex hammer at his head with a sickening thud. Jasper stumbled backward as Kaveri rammed into him, shoving him out of the threshold and trying to stick a dagger in his arm. However, Jasper kicked her out of the way.
“You three go on ahead!” Kaveri yelled. “I’ll deal with this vampire.” 
“Can you handle him?” I asked. “You just have a knife; is that gonna--” 
That’s when I noticed the other sheath on her belt. It was shorter than a full sword, but longer than her knife. The hilt appeared to be dark and wooden, and I could only pray that it was a stake.
“Yes,” Kaveri called, holding Jasper back. “Yes it will.”
I nodded, and took off down the hallway with my friends.
“Alright,” Akira said as we ran down the hallway. “Here’s the plan: Oli knows where the secret files are...don’t ask me how, he just does. I was confused too. Anyway, he’ll take us there and we’ll figure out what this whole candy situation is about.”
“You guys do that,” I replied. “I’m gonna try and subdue Seb, then you guys come back up when you have a cure.” 
“You’ll be okay, right?” she asked. “Can you take Seb by yourself?”
“He and I used to play fight when we were younger,” I explained. “If I could take him then, I certainly can now.” 
Akira sighed. 
“Fine,” she said. “If there’s any trouble, find a hiding spot and text me ASAP. Worst comes to worst, we can abandon ship and find Seb another day. He’ll likely come to us, anyhow.”
“No. I’m ending this now.” We stopped at a stairwell.
“This is it,” Oli said, holding my hand. “Be safe, Dakota.”
“I will,” I said. “I have to be.” With that, we went our separate ways.
0 notes
jesseneufeld · 5 years
Text
Collagen vs. Whey: Which Protein is Best For Your Needs?
Collagen or whey. Which should you choose?
For years, collagen/gelatin was maligned by bodybuilding enthusiasts as an “incomplete protein” because it doesn’t contain all the essential amino acids, nor does it contribute directly to muscle protein synthesis.  There’s definitely truth to this. If you ate nothing but gelatin for your protein, you’d get sick real quick. That’s exactly what happened to dozens of people who tried the infamous “liquid protein diet” fad of the 70s and 80s, which relied heavily on a gelatin-based protein drink. Man—or woman—shall not live by collagen alone.
As for whey, it’s an extremely complete protein. It’s one of the most bioavailable protein sources around, a potent stimulator of anabolic processes and muscle protein synthesis. I consider it essential for people, especially older ones in whom protein metabolism has degraded, and for anyone who wants to boost their protein intake and get the most bang for their buck.
This said, which is best for your needs today? Let’s take a look….
Collagen and whey are two completely different foods. Whether you take one or the other depends on a number of factors.
The first thing to do is explore the different benefits and applications of whey and collagen.
Whey Protein: Uses and Benefits
Whey is one of two primary dairy proteins, the other one being casein. It gained its reputation in the fitness world as a proven muscle-builder, but it actually has some interesting health effects that have little to do with hypertrophy.
In fact, whey is more than just protein. It also includes bioactive components such as lactoferrin (which improves bone health), beta-lactoglobulin (which can promote glutathione synthesis and protect against allergy), alpha-lactoalbumin (which can improve resistance to the cognition-depleting effects of stress), and immunoglobulins (which have antimicrobial effects). Whey also turns into some interesting peptide metabolites upon digestion which, according to a review, can improve blood lipids and lower blood pressure.
What Are Some Good Applications Of Whey?
Obesity: Whey tends to reduce fasting insulin levels in the obese and overweight (but not healthy prepubertal boys, who could use the growth promotion), increase satiety, reduce food intake, and improve resting energy expenditure. If you’re trying to lose weight or prevent obesity, you can’t ask for a better trifecta than increased energy burning, increased satiety, and reduced intake.
Diabetes: Eaten before a meal, whey reduces the glucose spike from the subsequent meal in non-diabetics and type 2 diabetics alike. It achieves this by “spiking” insulin, but transiently; the insulin area under the curve improves even as the immediate insulin response increases. Plus, as seen above, fasting insulin tends to lower in people consuming whey protein. Spikes are not persistent elevations.
Fatty liver: In obese women, a whey supplement reduces liver fat (and as a nice side effect increases lean mass a bit). Fatty liver patients also benefit from whey, enjoying improvements in glutathione status, liver steatosis, and antioxidant capacity. Rats who supplement with whey see reduced fat synthesis in the liver and increased fatty acid oxidation in the skeletal muscle.
Stress: In “high-stress” subjects, a whey protein shake improved cognitive function and performance by increasing serotonin levels. The same shake had no effect on “low-stress” subjects. And dietary whey also lowers oxidative brain stress, at least in mice.
Cancer: Both the lactoferrin found in whey and the glutathione synthesis whey promotes may have anti-cancer effects. Lactoferrin shows potential to prevent cancer that has yet to occur and induce cell death in existing cancer cells. In a recent human study, oral lactoferrin suppressed the formation of colonic polyps. And in animal cancer studies and human cancer case studies, whey protein has been shown to increase glutathione (“foremost among the cellular protective mechanisms”) and have anti-tumor effects.
HIV: People with HIV experience a drastic reduction in glutathione levels. As the master antioxidant, getting glutathione higher is pretty important. Whey won’t cure anything, but it does improve CD4 (a type of white blood cell) count, lower the number of co-infections, and persistently increase glutathione status.
Cardiovascular disease: Last year, a review of the effect of whey on major cardiometabolic risk factors found that whey protein improves the lipid profile, reduces hypertension, improves vascular function, and increases insulin sensitivity and glucose tolerance. Whey peptides that form during digestion actually act as ACE-inhibitors, reducing blood pressure similarly to pharmaceuticals without the side effects.
Sarcopenia: Muscle wasting, whether cancer-related or a product of age and inactivity, is a huge threat to one’s health and happiness. Studies show that whey protein is the most effective protein supplement for countering sarcopenia, especially compared to soy. An anti-sarcopenia smoothie I always have people drink on bed rest is 20-30 grams of whey isolate, a couple egg yolks, milk, cream, and ice. Tastes like ice cream and works like a charm. One time a friend even gave this to his grandmother who was on bedrest in the hospital with diarrhea, mental confusion, and a total lack of appetite. She was in a bad state. After a day or two of the smoothie, she recovered quite rapidly, regaining her appetite and alertness.
Gastrointestinal disorders: Dairy gets a bad rap in some corners for its supposed effects on the gut, but a component of dairy can actually improve gut health, even in patients with gastrointestinal disorders. In Crohn’s disease patients, a whey protein supplement reduces leaky gut. In rodent models of inflammatory bowel disease, whey protein reduce gut inflammation and restore mucin (the stuff used to build up the gut barrier) synthesis.
Oh, and whey is great for hypertrophy.
When To Choose Whey
So…
If you lift and want some extra protein, whey’s a great choice.
If you’re older and worry about your ability to metabolize and utilize protein, some extra protein via whey can help.
If you have any of the conditions listed above, whey’s a great choice. Do note that some of the benefits may stem from simply eating more protein than before. Whey itself may not be the whole cause; an extra slab of steak or a few more eggs could possibly have the same effect.
Along with foods like organ meats, egg yolks, and shellfish, I consider whey to be an important “supplemental food”—a food that acts like a high-density nutrition supplement, powerful in small doses and worth including in almost every diet.
Collagen Protein: Uses and Benefits
I advocate collagen protein as a fourth macronutrient. It’s different enough from whey and other “regular” proteins, serving a totally different function in the body.
If whey has been the gold standard for the muscle building amino acid profile for 30 years, collagen is the gold standard for supporting collagen-based structures in the body (fascia, ligaments, tendons, cartilage, skin, hair, nails). We don’t get much collagenous material in a normal diet these days, and meat proteins and/or plant proteins and/or milk, eggs, etc. don’t have the collagen peptides nor the ideal ratio of glycine, hydroxyproline, and other amino acids found abundantly in collagen. Furthermore, metabolism of the amino acids present in muscle meat deplete our reserves of glycine, thereby increasing the requirement even further. The more meat you eat, the more collagen you need.
Why We Need Collagen So Much These Days
This (non)relationship with collagen is extremely novel for our species. For millions of years up until very recently we ate nose to tail. We ate the entire animal. To give you an idea of how much collagen we’d have eaten, the average cow is about half muscle meat and half “other stuff,” which includes bones, skin, tendons, ligaments, fascia, and other bits extremely rich in collagen. That’s a ton of glycine and a far cry from eating nothing but ground beef and ribeyes. And more recently, even when we moved toward shrink-wrapped select cuts of meat and away from bones and skin, we still had jello. Then, when jello got maligned, we had nothing. So for the past 20-30 years or so, most Americans have had no appreciable source of collagen peptides in their diet.
Just based on what we know about human biochemistry, this is a disaster. The human body requires at least 16 grams of glycine per day for basic metabolic processes, yet we can only synthesize 3 grams, and the typical omnivorous diet provides just 2-3 grams per day, so we’re looking at an average daily deficit of 10 grams that we need to make up for through diet. Collagen is roughly 1/3 glycine, so that means we need to be eating about 30 grams of collagen per day to hit our 10 gram dosage. And in disease states that disrupt glycine synthesis, like rheumatoid arthritis, or on plant-based diets that provide little to no dietary glycine, we need even more.
I suspect a lot of pro athletes who have connective tissue issues could use even more collagen, especially since they’re exposing their tissues to such incredible stress. I know I did back during my competition days.
What Does Collagen Do For Our Bodies?
It supports our connective tissue and collagen-based structures: fascia, ligaments, tendons, cartilage, skin, hair, and nails.
It improves sleep quality. Human studies show that 3 grams of glycine taken before bed increases the quality of your sleep and reduces daytime sleepiness following sleep restriction. Now that’s isolated glycine rather than collagen, but collagen is the best source of glycine. I can say that a big mug of bone broth or a couple scoops of collagen peptides before bed knock me out and give me great sleep.
It balances your muscle meat intake. I mentioned this earlier, and we see both observational and interventional evidence for it.
Observational: In one recent observational study, the relationship between red meat and diabetes was abolished after controlling for low-glycine status. People with low glycine levels and high meat intakes were more likely to have diabetes; people with higher glycine levels could have higher meat intakes without any issues. In another study, low circulating levels of glycine predicted diabetes risk.
Interventional: In both worms and rodents, excessive intake of methionine (the amino acid most abundantly found in muscle meat) reduced longevity, while adding in glycine restored it.
It improves gut health. When I gave up grains and stopped endurance training at age 47 my gut health improved immensely. Like, world-changing for me. But I was still at 90-95%. When I started supplementing with collagen, my gut finally had that last 5% of repair/support/healing it needed to get to 100%.
It’s a great pre-workout. Though maybe not for the reasons most people take “pre-workouts.” I’ve also experienced rapid healing of tendinitis through using pre-workout collagen with vitamin C. I’m not just imagining it because I’ve dealt with a ton of tendon issues over the years, and they never healed that quickly until I introduced pre-workout collagen.
I’ve noticed that my hair and nails grow much faster than before.
Final Answer: Which One?
So, should you use whey or collagen? Let’s get to the bottom line, Sisson.
I made Primal Fuel because I wanted a high quality, low-sugar, moderate-fat meal replacement whey protein.
I made Collagen Fuel and Collagen Peptides because I wanted an easier way to get more collagen into my diet.
Personally, I had a need for both.
If I had to choose one, collagen is a better choice for the vast majority of you.
Essential amino acids aren’t a big problem on most ancestral diets, like paleo, Primal, or Primal-keto, and if you’re eating enough animal protein you don’t really need whey. Now, can you benefit from whey despite eating meat? Sure. Necessary does not mean optimal; whey has been shown to improve hypertrophy and muscle recovery from resistance training, plus all the other benefits I already detailed earlier. Almost anyone who does anything in the gym will see benefits from adding 20 grams of whey per day.
But almost no one is getting enough collagen, even the ancestrally-minded eaters who are aware of its importance. And that is a historical aberration on a massive scale. It hasn’t been done before. I wouldn’t recommend testing those waters.
And of course, powders aren’t the only way to get collagen and whey. They both appear in plenty of foods. The powders are just convenient to have on hand when you forget to make the bone broth (chicken, beef, turkey) or throw the oxtails in the crockpot. (Check out those linked recipes if you prefer broth or stew sources.)
Which do you prefer—whey or collagen? What benefits have you noticed from each?
Thanks for reading, everyone. Let me know your thoughts, and take care.
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window.onload=function(){ga('send', { hitType: 'event', eventCategory: 'Ad Impression', eventAction: '66572' });}
References:
Wodarski KH, Galus R, Brodzikowska A, Wodarski PK, Wojtowicz A. [The importance of lactoferrin in bone regeneration]. Pol Merkur Lekarski. 2014;37(217):65-7.
Markus CR, Olivier B, De haan EH. Whey protein rich in alpha-lactalbumin increases the ratio of plasma tryptophan to the sum of the other large neutral amino acids and improves cognitive performance in stress-vulnerable subjects. Am J Clin Nutr. 2002;75(6):1051-6.
Pal S, Ellis V, Dhaliwal S. Effects of whey protein isolate on body composition, lipids, insulin and glucose in overweight and obese individuals. Br J Nutr. 2010;104(5):716-23.
Hall WL, Millward DJ, Long SJ, Morgan LM. Casein and whey exert different effects on plasma amino acid profiles, gastrointestinal hormone secretion and appetite. Br J Nutr. 2003;89(2):239-48.
Shertzer HG, Krishan M, Genter MB. Dietary whey protein stimulates mitochondrial activity and decreases oxidative stress in mouse female brain. Neurosci Lett. 2013;548:159-64.
Bounous G. Whey protein concentrate (WPC) and glutathione modulation in cancer treatment. Anticancer Res. 2000;20(6C):4785-92.
Meléndez-hevia E, De paz-lugo P, Cornish-bowden A, Cárdenas ML. A weak link in metabolism: the metabolic capacity for glycine biosynthesis does not satisfy the need for collagen synthesis. J Biosci. 2009;34(6):853-72.
The post Collagen vs. Whey: Which Protein is Best For Your Needs? appeared first on Mark's Daily Apple.
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lauramalchowblog · 5 years
Text
Collagen vs. Whey: Which Protein is Best For Your Needs?
Collagen or whey. Which should you choose?
For years, collagen/gelatin was maligned by bodybuilding enthusiasts as an “incomplete protein” because it doesn’t contain all the essential amino acids, nor does it contribute directly to muscle protein synthesis.  There’s definitely truth to this. If you ate nothing but gelatin for your protein, you’d get sick real quick. That’s exactly what happened to dozens of people who tried the infamous “liquid protein diet” fad of the 70s and 80s, which relied heavily on a gelatin-based protein drink. Man—or woman—shall not live by collagen alone.
As for whey, it’s an extremely complete protein. It’s one of the most bioavailable protein sources around, a potent stimulator of anabolic processes and muscle protein synthesis. I consider it essential for people, especially older ones in whom protein metabolism has degraded, and for anyone who wants to boost their protein intake and get the most bang for their buck.
This said, which is best for your needs today? Let’s take a look….
Collagen and whey are two completely different foods. Whether you take one or the other depends on a number of factors.
The first thing to do is explore the different benefits and applications of whey and collagen.
Whey Protein: Uses and Benefits
Whey is one of two primary dairy proteins, the other one being casein. It gained its reputation in the fitness world as a proven muscle-builder, but it actually has some interesting health effects that have little to do with hypertrophy.
In fact, whey is more than just protein. It also includes bioactive components such as lactoferrin (which improves bone health), beta-lactoglobulin (which can promote glutathione synthesis and protect against allergy), alpha-lactoalbumin (which can improve resistance to the cognition-depleting effects of stress), and immunoglobulins (which have antimicrobial effects). Whey also turns into some interesting peptide metabolites upon digestion which, according to a review, can improve blood lipids and lower blood pressure.
What Are Some Good Applications Of Whey?
Obesity: Whey tends to reduce fasting insulin levels in the obese and overweight (but not healthy prepubertal boys, who could use the growth promotion), increase satiety, reduce food intake, and improve resting energy expenditure. If you’re trying to lose weight or prevent obesity, you can’t ask for a better trifecta than increased energy burning, increased satiety, and reduced intake.
Diabetes: Eaten before a meal, whey reduces the glucose spike from the subsequent meal in non-diabetics and type 2 diabetics alike. It achieves this by “spiking” insulin, but transiently; the insulin area under the curve improves even as the immediate insulin response increases. Plus, as seen above, fasting insulin tends to lower in people consuming whey protein. Spikes are not persistent elevations.
Fatty liver: In obese women, a whey supplement reduces liver fat (and as a nice side effect increases lean mass a bit). Fatty liver patients also benefit from whey, enjoying improvements in glutathione status, liver steatosis, and antioxidant capacity. Rats who supplement with whey see reduced fat synthesis in the liver and increased fatty acid oxidation in the skeletal muscle.
Stress: In “high-stress” subjects, a whey protein shake improved cognitive function and performance by increasing serotonin levels. The same shake had no effect on “low-stress” subjects. And dietary whey also lowers oxidative brain stress, at least in mice.
Cancer: Both the lactoferrin found in whey and the glutathione synthesis whey promotes may have anti-cancer effects. Lactoferrin shows potential to prevent cancer that has yet to occur and induce cell death in existing cancer cells. In a recent human study, oral lactoferrin suppressed the formation of colonic polyps. And in animal cancer studies and human cancer case studies, whey protein has been shown to increase glutathione (“foremost among the cellular protective mechanisms”) and have anti-tumor effects.
HIV: People with HIV experience a drastic reduction in glutathione levels. As the master antioxidant, getting glutathione higher is pretty important. Whey won’t cure anything, but it does improve CD4 (a type of white blood cell) count, lower the number of co-infections, and persistently increase glutathione status.
Cardiovascular disease: Last year, a review of the effect of whey on major cardiometabolic risk factors found that whey protein improves the lipid profile, reduces hypertension, improves vascular function, and increases insulin sensitivity and glucose tolerance. Whey peptides that form during digestion actually act as ACE-inhibitors, reducing blood pressure similarly to pharmaceuticals without the side effects.
Sarcopenia: Muscle wasting, whether cancer-related or a product of age and inactivity, is a huge threat to one’s health and happiness. Studies show that whey protein is the most effective protein supplement for countering sarcopenia, especially compared to soy. An anti-sarcopenia smoothie I always have people drink on bed rest is 20-30 grams of whey isolate, a couple egg yolks, milk, cream, and ice. Tastes like ice cream and works like a charm. One time a friend even gave this to his grandmother who was on bedrest in the hospital with diarrhea, mental confusion, and a total lack of appetite. She was in a bad state. After a day or two of the smoothie, she recovered quite rapidly, regaining her appetite and alertness.
Gastrointestinal disorders: Dairy gets a bad rap in some corners for its supposed effects on the gut, but a component of dairy can actually improve gut health, even in patients with gastrointestinal disorders. In Crohn’s disease patients, a whey protein supplement reduces leaky gut. In rodent models of inflammatory bowel disease, whey protein reduce gut inflammation and restore mucin (the stuff used to build up the gut barrier) synthesis.
Oh, and whey is great for hypertrophy.
When To Choose Whey
So…
If you lift and want some extra protein, whey’s a great choice.
If you’re older and worry about your ability to metabolize and utilize protein, some extra protein via whey can help.
If you have any of the conditions listed above, whey’s a great choice. Do note that some of the benefits may stem from simply eating more protein than before. Whey itself may not be the whole cause; an extra slab of steak or a few more eggs could possibly have the same effect.
Along with foods like organ meats, egg yolks, and shellfish, I consider whey to be an important “supplemental food”—a food that acts like a high-density nutrition supplement, powerful in small doses and worth including in almost every diet.
Collagen Protein: Uses and Benefits
I advocate collagen protein as a fourth macronutrient. It’s different enough from whey and other “regular” proteins, serving a totally different function in the body.
If whey has been the gold standard for the muscle building amino acid profile for 30 years, collagen is the gold standard for supporting collagen-based structures in the body (fascia, ligaments, tendons, cartilage, skin, hair, nails). We don’t get much collagenous material in a normal diet these days, and meat proteins and/or plant proteins and/or milk, eggs, etc. don’t have the collagen peptides nor the ideal ratio of glycine, hydroxyproline, and other amino acids found abundantly in collagen. Furthermore, metabolism of the amino acids present in muscle meat deplete our reserves of glycine, thereby increasing the requirement even further. The more meat you eat, the more collagen you need.
Why We Need Collagen So Much These Days
This (non)relationship with collagen is extremely novel for our species. For millions of years up until very recently we ate nose to tail. We ate the entire animal. To give you an idea of how much collagen we’d have eaten, the average cow is about half muscle meat and half “other stuff,” which includes bones, skin, tendons, ligaments, fascia, and other bits extremely rich in collagen. That’s a ton of glycine and a far cry from eating nothing but ground beef and ribeyes. And more recently, even when we moved toward shrink-wrapped select cuts of meat and away from bones and skin, we still had jello. Then, when jello got maligned, we had nothing. So for the past 20-30 years or so, most Americans have had no appreciable source of collagen peptides in their diet.
Just based on what we know about human biochemistry, this is a disaster. The human body requires at least 16 grams of glycine per day for basic metabolic processes, yet we can only synthesize 3 grams, and the typical omnivorous diet provides just 2-3 grams per day, so we’re looking at an average daily deficit of 10 grams that we need to make up for through diet. Collagen is roughly 1/3 glycine, so that means we need to be eating about 30 grams of collagen per day to hit our 10 gram dosage. And in disease states that disrupt glycine synthesis, like rheumatoid arthritis, or on plant-based diets that provide little to no dietary glycine, we need even more.
I suspect a lot of pro athletes who have connective tissue issues could use even more collagen, especially since they’re exposing their tissues to such incredible stress. I know I did back during my competition days.
What Does Collagen Do For Our Bodies?
It supports our connective tissue and collagen-based structures: fascia, ligaments, tendons, cartilage, skin, hair, and nails.
It improves sleep quality. Human studies show that 3 grams of glycine taken before bed increases the quality of your sleep and reduces daytime sleepiness following sleep restriction. Now that’s isolated glycine rather than collagen, but collagen is the best source of glycine. I can say that a big mug of bone broth or a couple scoops of collagen peptides before bed knock me out and give me great sleep.
It balances your muscle meat intake. I mentioned this earlier, and we see both observational and interventional evidence for it.
Observational: In one recent observational study, the relationship between red meat and diabetes was abolished after controlling for low-glycine status. People with low glycine levels and high meat intakes were more likely to have diabetes; people with higher glycine levels could have higher meat intakes without any issues. In another study, low circulating levels of glycine predicted diabetes risk.
Interventional: In both worms and rodents, excessive intake of methionine (the amino acid most abundantly found in muscle meat) reduced longevity, while adding in glycine restored it.
It improves gut health. When I gave up grains and stopped endurance training at age 47 my gut health improved immensely. Like, world-changing for me. But I was still at 90-95%. When I started supplementing with collagen, my gut finally had that last 5% of repair/support/healing it needed to get to 100%.
It’s a great pre-workout. Though maybe not for the reasons most people take “pre-workouts.” I’ve also experienced rapid healing of tendinitis through using pre-workout collagen with vitamin C. I’m not just imagining it because I’ve dealt with a ton of tendon issues over the years, and they never healed that quickly until I introduced pre-workout collagen.
I’ve noticed that my hair and nails grow much faster than before.
Final Answer: Which One?
So, should you use whey or collagen? Let’s get to the bottom line, Sisson.
I made Primal Fuel because I wanted a high quality, low-sugar, moderate-fat meal replacement whey protein.
I made Collagen Fuel and Collagen Peptides because I wanted an easier way to get more collagen into my diet.
Personally, I had a need for both.
If I had to choose one, collagen is a better choice for the vast majority of you.
Essential amino acids aren’t a big problem on most ancestral diets, like paleo, Primal, or Primal-keto, and if you’re eating enough animal protein you don’t really need whey. Now, can you benefit from whey despite eating meat? Sure. Necessary does not mean optimal; whey has been shown to improve hypertrophy and muscle recovery from resistance training, plus all the other benefits I already detailed earlier. Almost anyone who does anything in the gym will see benefits from adding 20 grams of whey per day.
But almost no one is getting enough collagen, even the ancestrally-minded eaters who are aware of its importance. And that is a historical aberration on a massive scale. It hasn’t been done before. I wouldn’t recommend testing those waters.
And of course, powders aren’t the only way to get collagen and whey. They both appear in plenty of foods. The powders are just convenient to have on hand when you forget to make the bone broth (chicken, beef, turkey) or throw the oxtails in the crockpot. (Check out those linked recipes if you prefer broth or stew sources.)
Which do you prefer—whey or collagen? What benefits have you noticed from each?
Thanks for reading, everyone. Let me know your thoughts, and take care.
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window.onload=function(){ga('send', { hitType: 'event', eventCategory: 'Ad Impression', eventAction: '66572' });}
References:
Wodarski KH, Galus R, Brodzikowska A, Wodarski PK, Wojtowicz A. [The importance of lactoferrin in bone regeneration]. Pol Merkur Lekarski. 2014;37(217):65-7.
Markus CR, Olivier B, De haan EH. Whey protein rich in alpha-lactalbumin increases the ratio of plasma tryptophan to the sum of the other large neutral amino acids and improves cognitive performance in stress-vulnerable subjects. Am J Clin Nutr. 2002;75(6):1051-6.
Pal S, Ellis V, Dhaliwal S. Effects of whey protein isolate on body composition, lipids, insulin and glucose in overweight and obese individuals. Br J Nutr. 2010;104(5):716-23.
Hall WL, Millward DJ, Long SJ, Morgan LM. Casein and whey exert different effects on plasma amino acid profiles, gastrointestinal hormone secretion and appetite. Br J Nutr. 2003;89(2):239-48.
Shertzer HG, Krishan M, Genter MB. Dietary whey protein stimulates mitochondrial activity and decreases oxidative stress in mouse female brain. Neurosci Lett. 2013;548:159-64.
Bounous G. Whey protein concentrate (WPC) and glutathione modulation in cancer treatment. Anticancer Res. 2000;20(6C):4785-92.
Meléndez-hevia E, De paz-lugo P, Cornish-bowden A, Cárdenas ML. A weak link in metabolism: the metabolic capacity for glycine biosynthesis does not satisfy the need for collagen synthesis. J Biosci. 2009;34(6):853-72.
The post Collagen vs. Whey: Which Protein is Best For Your Needs? appeared first on Mark's Daily Apple.
Collagen vs. Whey: Which Protein is Best For Your Needs? published first on https://venabeahan.tumblr.com
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ssteezyy · 7 years
Text
Ask the Vet: Dr. Kris Answers July’s Questions
Welcome to our regular “Ask the Vet With Dr. Kris” segment! Once a month, Dr. Kris answers as many of your questions as he can, and you can leave new questions for him in a comment.
Dr. Kristopher Chandroo is a veterinarian, scientist, photographer, animal welfare advocate, and creator of Stress to Success (STS): The Essential Guide to Medicating Your Feisty, Grumpy or Reluctant Cat.  Dr. Kris wants  your cats to be twenty years old. And counting! And he wants to provide medication and therapy to them in a way that respects the bond between cat and human.
Here are Dr. Kris’ answers to some of your questions asked in June. If your question didn’t get answered here, Dr. Kris will answer them on his own website in the future. Subscribe to his updates so you’ll be notified when the answers are published.
Cat pees on nearest wall or other object
Hi Dr Kris,
My 4 year old indoor/outdoor male cat (Hansel Von Whiskerheimer:) has developed a habit of backing up to the nearest wall or other object, looking me in the eye, and urinating with his tail up and a little butt wiggle. This behavior seems to always follow a request he has made that I have not attended to immediately. He will meow and if I don’t feed him or even just give him some attention, he walks over to me, stares right at me, and pees. There has only been one time when the urine has had the “cat marking smell”-otherwise it just smells like urine. Also, he only does this with me-not my husband, sister, or any of the cat sitters.
So far my theory is that he first developed this habit when he had a UTI in the winter and needed to go outside (he prefers to urinate outside) as soon as he felt the urge and it was his way of telling me to hurry up and let him out, but since then it has continued. He has had a urinalysis on multiple occasions and the vet can’t find anything medically wrong with him. This has been going on for over a year at this point. It’s not every day but usually just when I think he has stopped, he will do it again. I have added a couple more cats to my household, so I could see that being a trigger. I don’t want to be reinforcing the behavior by giving him food/treats/cat nip on demand, but I also don’t want my house to be covered in pee! before this particular behavior began, he would knock over as many things as he could if I did not meet his meow request immediately.
I thought that was annoying, but I would take a spilled cup of water or broken vase over a urine soaked yoga mat any day. Do you have any ideas for behavior modification? I just started giving him extra attention all the time since he now has other cats to compete with, but other than that, I really am at a loss. Thanks!
Hansel Von Whiskerheimer!
Ha! Love the name!
Take a video of the Von Whiskerheimer (with that name, you know he loves to be in front of the camera!).
Show it to your vet.
I can’t tell you how many times a video has revealed what words and urinalysis could not! Your first task is in fact to confirm if this is marking behaviour.
If so, they can provide you with some steps from there to resolve the soggy yoga mat.
Good luck
Dr. Kris
Treating hyperthyroidism with homeopathy
What are your thoughts about treating cats with homeopathy?
My rescue cat has most recently been diagnosed with hyperthyroidism. I am trying a remedy, but thinking I will do the traditional meds. Also, he has tested positive for exposure to the Corona virus, originally the vet thought he definitely had FIP, but now she doesn’t. Can you please comment on the Corona virus? It is my understanding that many are exposed, but in only a few does it mutate into FIP.
Hi!
Someone who is considering homeopathy is someone who is thinking about their cat.
Someone who is thinking about their cat is someone who will treat their cat.
Someone who will treat their cat will go through a process to see what works best for their cat.
So even though people debate homeopathy, I’m more interested in someone’s mindset. Where they are coming from, and what their cat means to them.
So, I won’t find fault in someone trying.
Putting in the effort.
That is pretty special, because many people don’t. I can guarantee you that, and their ain’t many guarantees in vet medicine.
If you want to use a non-conventional treatment for hyperthyroidism, it becomes simple. Find someone trained in homeopathy, try it, and re-test their blood in 4-6 weeks. If it’s working, you’ll know because their excessive thyroid level will start to normalize.
If you don’t see that happening in a convincing way, switch gears. Quickly. Because untreated hyperthyroidism damages many organs in the body, and some of us believe that in fact it’s a source of kidney damage.
Dr. Kris
Resident cat is upset at new kitten
We received a new 11 week old kitten. My 2 1/2 year old cat hissed at him and seems upset. What can I do to unite them?
Your 2.5 year old was living the life of a millennial. Finished school late, tonnes of debt, so he moved back home. Part-time job.
But…he’s more socially conscious, more likely to become an entrepreneur, makes purchases with his smartphone, and stays updated with brands through social networks. He would suffer more from losing a phone than losing a car.
Your kitten is a big ol’ baby boomer. He is dramatic social change on four paws. Counterculture.
He values individual identity over group think.
When you stick a baby boomer and a millennial together really quickly, and say make something great happen, what you hope for is Hathaway and Deniro in “The Intern”.
But sometimes instead, you get Hathaway and Streep in “The Devil Wears Prada”.
Watch those movies!
See, it can take weeks or months for relationships to form, and it’s complicated.
Separate them after the conflict.
Give them a chance to get to know each other on their terms.
Make sure they don’t compete over anything.
Take it slow. Their time. Not our time.
It’s an old formula Hollywood knows well!
Dr. Kris
Gabapentin for arthritis pain
Dr Kris, my 9 year old cat is already on prednisone twice a day for arthritis in the rear spine/hips/legs but was still limping so the vet gave me Gabapentin to give to her, in liquid form, 1.5ml twice a day. She had no side effects but I had trouble giving her the liquid form so I asked for it in pill form. She was prescribed 50mg twice a day but all anyone had was the capsule form that I could not cut in half. After speaking to the vet about it, She just increased the dose, in capsule form to 100mg every 12 hrs. Her first dose she got that drunken sailor syndrome, balance was off, she couldn’t walk straight. Is this normal until a few doses? I’m wondering if that dose is too high for her starting off. Several blogs I read only had cats on doses of no higher than 50mg a day! My vet had increased her prednisone to twice a day since she was still limping and added Gabapetin saying sometimes you have to initially hit them hard in the beginning with higher doses then wean them back. Need some advice, I think the dose is too high, but I’m not a Dr. Thanks
100mg is the sedation dose I use with specific cats in specific circumstances.
It will make some cats sleepy, wobbly, and less emotionally reactive (which is the goal in that situation).
I use it when life is really rough for a cat, whose fear, stress or anxiety needs to be managed before they come see me in a vet hospital setting.
If I’m using Gabapentin for arthritis, I’m going to start low, then increase it until the kitty feels better. If the patient gets drowsy, I might tolerate that temporarily, but I don’t want a drunken sailor 7 days a week. Since I’ve never seen your cat, I don’t know what low is relative to what your cat is dealing with. But 100mg is my sedation dose.
There are alternatives to prednisolone and gabapentin, but myself (and anyone else) would need to know a lot more about your cat (hands-on) and the specific rationale for the choices so far before recommending anything else. It really is that individualistic, and what works for some really doesn’t work at all for others.
I know I keep saying this but I will create an “arthritis masterclass” for cats. It’s just squeezing the time to make it happen. But it’s on the list. If people want this, fill the comments with what specifically you would like to see in it.
Dr. Kris
Feeling guilty about not being able to afford care for a sick cat
I have a male cat that I gave a home off the street for about 14-15 years. He has elevated liver and kidney enzymes as well as too many white blood cells. There is no money available to give him an ultrasound and whatever treatment he may need which probably won’t help. Now all I have to do is wait and he is still eating and functioning except that he no longer sleeps with and stays on my bed as he always did. I feel guilty even though I prevented him from having a life on the street where he wouldn’t have lived this long.
Don’t feel guilty.
It sounds like from your description that he is really ill.
There might not be anything you can do about that.
But let’s talk about this:
“And whatever treatment he may need which probably won’t help…”
Say no to that.
You don’t need that way of thinking.
Your cat doesn’t need that way of thinking.
Maybe it’s true, that treatment won’t help at all.
But so what.
You don’t know until you try.
It’s never the outcome, because none of us get out of this game alive.
It’s the journey. Your choices when life got rough.
And trying does not have to mean an ultrasound, expensive or complicated – you need a team of people that understands that.
That understands that when you take a cat off the street, give it a home for 15 years, they deserve something.
And you deserve the feeling that comes when you try.
We had a saying back in school. When you have a very sick cat, who is trying to survive, you can always try to give them X. You want to try and give them X before you euthanize them if people want to try. Because sometimes it works.
Your vet should know what X is.
Dr. Kris
Cat with diarrhea
I have a four year old that was sick with diarrhea a few months ago. Now still a little wet giving probiotics every day much better but not normal Like before .could this be stress?
It can be stress plus: http://ift.tt/2wvwTg4
Needy tortie is screaming all the time
Hi Dr. Kris,
I have a very sweet 8 year old Tortie. We rescued her from my Mom 4 years ago. I love her to death but she is so needy. I understand she wants to be fed a 1/2 hour to an hour beforehand but she will not drink from her water bowl unless we show her there is water in there and she is not getting it from the faucet. She does not like watching her drinking but I tell her I am not leaving till she drinks it. You would think after 6 years she knows the drill. She screams all the time and makes me feel like I am not a good pet parent. Her daddy screams at her back. I tell him she is female you cannot win an argument with her. I am afraid her screaming is going to get us kicked out of are apartment well it has not for 4 years. What to do?
“I tell him she is female you cannot win an argument with her.”
Best line of the day!
Seriously though, there is much to unpack in your question, and many questions that I would have to ask to figure it out. I would want to know the floor plan of your home, feeding times, feeding stations, number of scratching posts and other entertaining things that your cat might have.
It can get really detailed and specific, but also really solvable at the same time.
Best thing to do?
I’m serious.
Counseling.
Mikel Delago does it, check her out here: http://ift.tt/2vE85lA
Do you have a question for Dr. Kris? Leave it in a comment and he’ll answer it next month!
The post Ask the Vet: Dr. Kris Answers July’s Questions appeared first on The Conscious Cat.
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jesseneufeld · 5 years
Text
Collagen vs. Whey: Which Protein is Best For Your Needs?
Collagen or whey. Which should you choose?
For years, collagen/gelatin was maligned by bodybuilding enthusiasts as an “incomplete protein” because it doesn’t contain all the essential amino acids, nor does it contribute directly to muscle protein synthesis.  There’s definitely truth to this. If you ate nothing but gelatin for your protein, you’d get sick real quick. That’s exactly what happened to dozens of people who tried the infamous “liquid protein diet” fad of the 70s and 80s, which relied heavily on a gelatin-based protein drink. Man—or woman—shall not live by collagen alone.
As for whey, it’s an extremely complete protein. It’s one of the most bioavailable protein sources around, a potent stimulator of anabolic processes and muscle protein synthesis. I consider it essential for people, especially older ones in whom protein metabolism has degraded, and for anyone who wants to boost their protein intake and get the most bang for their buck.
This said, which is best for your needs today? Let’s take a look….
Collagen and whey are two completely different foods. Whether you take one or the other depends on a number of factors.
The first thing to do is explore the different benefits and applications of whey and collagen.
Whey Protein: Uses and Benefits
Whey is one of two primary dairy proteins, the other one being casein. It gained its reputation in the fitness world as a proven muscle-builder, but it actually has some interesting health effects that have little to do with hypertrophy.
In fact, whey is more than just protein. It also includes bioactive components such as lactoferrin (which improves bone health), beta-lactoglobulin (which can promote glutathione synthesis and protect against allergy), alpha-lactoalbumin (which can improve resistance to the cognition-depleting effects of stress), and immunoglobulins (which have antimicrobial effects). Whey also turns into some interesting peptide metabolites upon digestion which, according to a review, can improve blood lipids and lower blood pressure.
What Are Some Good Applications Of Whey?
Obesity: Whey tends to reduce fasting insulin levels in the obese and overweight (but not healthy prepubertal boys, who could use the growth promotion), increase satiety, reduce food intake, and improve resting energy expenditure. If you’re trying to lose weight or prevent obesity, you can’t ask for a better trifecta than increased energy burning, increased satiety, and reduced intake.
Diabetes: Eaten before a meal, whey reduces the glucose spike from the subsequent meal in non-diabetics and type 2 diabetics alike. It achieves this by “spiking” insulin, but transiently; the insulin area under the curve improves even as the immediate insulin response increases. Plus, as seen above, fasting insulin tends to lower in people consuming whey protein. Spikes are not persistent elevations.
Fatty liver: In obese women, a whey supplement reduces liver fat (and as a nice side effect increases lean mass a bit). Fatty liver patients also benefit from whey, enjoying improvements in glutathione status, liver steatosis, and antioxidant capacity. Rats who supplement with whey see reduced fat synthesis in the liver and increased fatty acid oxidation in the skeletal muscle.
Stress: In “high-stress” subjects, a whey protein shake improved cognitive function and performance by increasing serotonin levels. The same shake had no effect on “low-stress” subjects. And dietary whey also lowers oxidative brain stress, at least in mice.
Cancer: Both the lactoferrin found in whey and the glutathione synthesis whey promotes may have anti-cancer effects. Lactoferrin shows potential to prevent cancer that has yet to occur and induce cell death in existing cancer cells. In a recent human study, oral lactoferrin suppressed the formation of colonic polyps. And in animal cancer studies and human cancer case studies, whey protein has been shown to increase glutathione (“foremost among the cellular protective mechanisms”) and have anti-tumor effects.
HIV: People with HIV experience a drastic reduction in glutathione levels. As the master antioxidant, getting glutathione higher is pretty important. Whey won’t cure anything, but it does improve CD4 (a type of white blood cell) count, lower the number of co-infections, and persistently increase glutathione status.
Cardiovascular disease: Last year, a review of the effect of whey on major cardiometabolic risk factors found that whey protein improves the lipid profile, reduces hypertension, improves vascular function, and increases insulin sensitivity and glucose tolerance. Whey peptides that form during digestion actually act as ACE-inhibitors, reducing blood pressure similarly to pharmaceuticals without the side effects.
Sarcopenia: Muscle wasting, whether cancer-related or a product of age and inactivity, is a huge threat to one’s health and happiness. Studies show that whey protein is the most effective protein supplement for countering sarcopenia, especially compared to soy. An anti-sarcopenia smoothie I always have people drink on bed rest is 20-30 grams of whey isolate, a couple egg yolks, milk, cream, and ice. Tastes like ice cream and works like a charm. One time a friend even gave this to his grandmother who was on bedrest in the hospital with diarrhea, mental confusion, and a total lack of appetite. She was in a bad state. After a day or two of the smoothie, she recovered quite rapidly, regaining her appetite and alertness.
Gastrointestinal disorders: Dairy gets a bad rap in some corners for its supposed effects on the gut, but a component of dairy can actually improve gut health, even in patients with gastrointestinal disorders. In Crohn’s disease patients, a whey protein supplement reduces leaky gut. In rodent models of inflammatory bowel disease, whey protein reduce gut inflammation and restore mucin (the stuff used to build up the gut barrier) synthesis.
Oh, and whey is great for hypertrophy.
When To Choose Whey
So…
If you lift and want some extra protein, whey’s a great choice.
If you’re older and worry about your ability to metabolize and utilize protein, some extra protein via whey can help.
If you have any of the conditions listed above, whey’s a great choice. Do note that some of the benefits may stem from simply eating more protein than before. Whey itself may not be the whole cause; an extra slab of steak or a few more eggs could possibly have the same effect.
Along with foods like organ meats, egg yolks, and shellfish, I consider whey to be an important “supplemental food”—a food that acts like a high-density nutrition supplement, powerful in small doses and worth including in almost every diet.
Collagen Protein: Uses and Benefits
I advocate collagen protein as a fourth macronutrient. It’s different enough from whey and other “regular” proteins, serving a totally different function in the body.
If whey has been the gold standard for the muscle building amino acid profile for 30 years, collagen is the gold standard for supporting collagen-based structures in the body (fascia, ligaments, tendons, cartilage, skin, hair, nails). We don’t get much collagenous material in a normal diet these days, and meat proteins and/or plant proteins and/or milk, eggs, etc. don’t have the collagen peptides nor the ideal ratio of glycine, hydroxyproline, and other amino acids found abundantly in collagen. Furthermore, metabolism of the amino acids present in muscle meat deplete our reserves of glycine, thereby increasing the requirement even further. The more meat you eat, the more collagen you need.
Why We Need Collagen So Much These Days
This (non)relationship with collagen is extremely novel for our species. For millions of years up until very recently we ate nose to tail. We ate the entire animal. To give you an idea of how much collagen we’d have eaten, the average cow is about half muscle meat and half “other stuff,” which includes bones, skin, tendons, ligaments, fascia, and other bits extremely rich in collagen. That’s a ton of glycine and a far cry from eating nothing but ground beef and ribeyes. And more recently, even when we moved toward shrink-wrapped select cuts of meat and away from bones and skin, we still had jello. Then, when jello got maligned, we had nothing. So for the past 20-30 years or so, most Americans have had no appreciable source of collagen peptides in their diet.
Just based on what we know about human biochemistry, this is a disaster. The human body requires at least 16 grams of glycine per day for basic metabolic processes, yet we can only synthesize 3 grams, and the typical omnivorous diet provides just 2-3 grams per day, so we’re looking at an average daily deficit of 10 grams that we need to make up for through diet. Collagen is roughly 1/3 glycine, so that means we need to be eating about 30 grams of collagen per day to hit our 10 gram dosage. And in disease states that disrupt glycine synthesis, like rheumatoid arthritis, or on plant-based diets that provide little to no dietary glycine, we need even more.
I suspect a lot of pro athletes who have connective tissue issues could use even more collagen, especially since they’re exposing their tissues to such incredible stress. I know I did back during my competition days.
What Does Collagen Do For Our Bodies?
It supports our connective tissue and collagen-based structures: fascia, ligaments, tendons, cartilage, skin, hair, and nails.
It improves sleep quality. Human studies show that 3 grams of glycine taken before bed increases the quality of your sleep and reduces daytime sleepiness following sleep restriction. Now that’s isolated glycine rather than collagen, but collagen is the best source of glycine. I can say that a big mug of bone broth or a couple scoops of collagen peptides before bed knock me out and give me great sleep.
It balances your muscle meat intake. I mentioned this earlier, and we see both observational and interventional evidence for it.
Observational: In one recent observational study, the relationship between red meat and diabetes was abolished after controlling for low-glycine status. People with low glycine levels and high meat intakes were more likely to have diabetes; people with higher glycine levels could have higher meat intakes without any issues. In another study, low circulating levels of glycine predicted diabetes risk.
Interventional: In both worms and rodents, excessive intake of methionine (the amino acid most abundantly found in muscle meat) reduced longevity, while adding in glycine restored it.
It improves gut health. When I gave up grains and stopped endurance training at age 47 my gut health improved immensely. Like, world-changing for me. But I was still at 90-95%. When I started supplementing with collagen, my gut finally had that last 5% of repair/support/healing it needed to get to 100%.
It’s a great pre-workout. Though maybe not for the reasons most people take “pre-workouts.” I’ve also experienced rapid healing of tendinitis through using pre-workout collagen with vitamin C. I’m not just imagining it because I’ve dealt with a ton of tendon issues over the years, and they never healed that quickly until I introduced pre-workout collagen.
I’ve noticed that my hair and nails grow much faster than before.
Final Answer: Which One?
So, should you use whey or collagen? Let’s get to the bottom line, Sisson.
I made Primal Fuel because I wanted a high quality, low-sugar, moderate-fat meal replacement whey protein.
I made Collagen Fuel and Collagen Peptides because I wanted an easier way to get more collagen into my diet.
Personally, I had a need for both.
If I had to choose one, collagen is a better choice for the vast majority of you.
Essential amino acids aren’t a big problem on most ancestral diets, like paleo, Primal, or Primal-keto, and if you’re eating enough animal protein you don’t really need whey. Now, can you benefit from whey despite eating meat? Sure. Necessary does not mean optimal; whey has been shown to improve hypertrophy and muscle recovery from resistance training, plus all the other benefits I already detailed earlier. Almost anyone who does anything in the gym will see benefits from adding 20 grams of whey per day.
But almost no one is getting enough collagen, even the ancestrally-minded eaters who are aware of its importance. And that is a historical aberration on a massive scale. It hasn’t been done before. I wouldn’t recommend testing those waters.
And of course, powders aren’t the only way to get collagen and whey. They both appear in plenty of foods. The powders are just convenient to have on hand when you forget to make the bone broth (chicken, beef, turkey) or throw the oxtails in the crockpot. (Check out those linked recipes if you prefer broth or stew sources.)
Which do you prefer—whey or collagen? What benefits have you noticed from each?
Thanks for reading, everyone. Let me know your thoughts, and take care.
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Markus CR, Olivier B, De haan EH. Whey protein rich in alpha-lactalbumin increases the ratio of plasma tryptophan to the sum of the other large neutral amino acids and improves cognitive performance in stress-vulnerable subjects. Am J Clin Nutr. 2002;75(6):1051-6.
Pal S, Ellis V, Dhaliwal S. Effects of whey protein isolate on body composition, lipids, insulin and glucose in overweight and obese individuals. Br J Nutr. 2010;104(5):716-23.
Hall WL, Millward DJ, Long SJ, Morgan LM. Casein and whey exert different effects on plasma amino acid profiles, gastrointestinal hormone secretion and appetite. Br J Nutr. 2003;89(2):239-48.
Shertzer HG, Krishan M, Genter MB. Dietary whey protein stimulates mitochondrial activity and decreases oxidative stress in mouse female brain. Neurosci Lett. 2013;548:159-64.
Bounous G. Whey protein concentrate (WPC) and glutathione modulation in cancer treatment. Anticancer Res. 2000;20(6C):4785-92.
Meléndez-hevia E, De paz-lugo P, Cornish-bowden A, Cárdenas ML. A weak link in metabolism: the metabolic capacity for glycine biosynthesis does not satisfy the need for collagen synthesis. J Biosci. 2009;34(6):853-72.
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