Fat Checking

Protein called IGFBP2 secreted by healthy fat cells of the breast limit the progression of a non-invasive type of breast cancer to invasive

Read the published research paper here

Image from work by James R. W. Conway and colleagues

Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland

Image originally published with a Creative Commons Attribution 4.0 International (CC BY 4.0)

Published in Science Advances, July 2023

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Adipose tissue

More Endocrinology Stuff

Not the Oct 15th anon, but figured I'd add some stuff as I'm really interested in the medical aspects of obesity. In the study anon was talking about, they genetically modified mice to secrete loads of adiponectin and no leptin(typical in obesity studies as it makes the mice always feel hungry and lethargic). The chronic hyperadiponectinemia made the mice only gain subcutaneous fat and kept their visceral fat deposit lean and healthy. Consequently, the metabolic health of the mice remained phenomenal, even as they developed "morbid" obesity. There's not actually anything unhealthy about obesity itself, all the health issues are caused by visceral adipocytes becoming hypertrophic and metabolically diseased. If you were to periodically give a fatty acute hyperadiponectinemia, similar stuff would happen. All their excess visceral fat would be redistributed to their subcutaneous fat deposit, and their metabolic health would be perfect. If you looked at their bloodwork, their blood sugar, insulin levels, triglycerides, etc. would all be well within the healthy range. The only way you'd be able to tell they were fat would be their chronic hyperleptinemia, and potentially also chronic hyperadiponectinemia and sex hormone imbalance caused by the aromatase activity in their excess fat. Their body would basically be functioning as normal, just with a thick layer of healthy adipose tissue caking it.

Thank you Professor Thicc!

I was aware keeping subcutaneous fat and avoiding having visceral fat was the way to be healthy while gaining, but I didn't know there was hormones to dictate the way fat deposits (which in retrospect was pretty obvious).

Super interesting! I'm pretty floored about scientists testing that stuff on mice.

"Yes this is were we make the mice obese" sounds more like a fatfur artist desk than a lab.

hey uh if you post stuff like medical information or if you reference studies please cite the sources or like include links to what youre discussing because this is important stuff to be super careful aboug

Sure! This study is linked in the previous post, I'll link it here as well:

But more importantly, I don't want my Silly Little Posts to be interpreted as medical advice. I am not a doctor. I am not a health scientist. I can post research, but I am not a researcher. I think this information can be informative and interesting, but I don't want it to be a call to action. Don't go gain super quickly because some stranger on the internet says science proves it will go to your belly. And I'm sorry if that's how it was presented. I will annotate that in the OP.

And even more importantly, I get that medicine and the fat acceptance/feedism community are often at odds. And I know that a lot of folks here experience trauma and fatphobia from the medical community, as awful as that is. It's a major problem that needs addressing, and I certainly don't mean to add to the anxiety by discussing topics that can trigger that pain. I will try to stick purely to the abstract, and avoid actual health and medicine topics in my science posts.

Take care and stay safe y'all.

La bière n’est autre que de l’amidon fermenté liquide, c’est-à-dire une combinaison de sucre et de l’alcool. Elle contient en effet beaucoup de sucre de malt ou maltose qui fragilise les organes en induisant à la longue une inflammation discrète dans le corps. Elle possède en outre un index glycémique, indice qui mesure son impact sur le taux de sucre sanguin, extrêmement élevé : de 110 à 120… sur une échelle qui va de 0 à 100 ! C’est ainsi probablement l’aliment qui fait grimper le plus la glycémie, sodas et pain blanc compris. Les sucres et l’alcool apportés par la bière sont directement absorbés puis acheminés vers le foie. Celui-ci va alors rapidement saturer. Chez les gros buveurs de bière, il finit par s’infiltrer de graisse et dysfonctionner. Les sucres iront aussi remplir les adipocytes, cellules graisseuses, au niveau de l’abdomen, d’où une prise de poids importante, ainsi qu’un risque accru de diabète de type 2 et de maladie cardiovasculaire

Voilà une solution pour prendre conscience

Propaganda!

Lipid droplets, also referred to as lipid bodies, oil bodies or adiposomes, are lipid-rich cellular organelles that regulate the storage and hydrolysis of neutral lipids and are found largely in the adipose tissue. They also serve as a reservoir for cholesterol and acyl-glycerols for membrane formation and maintenance. Lipid droplets are found in all eukaryotic organisms and store a large portion of lipids in mammalian adipocytes.

Erythrocytes (red blood cells), also referred to as red cells, red blood corpuscles (in humans or other animals not having nucleus in red blood cells), haematids, or erythroid cells, are the most common type of blood cell and the vertebrate's principal means of delivering oxygen (O2) to the body tissues—via blood flow through the circulatory system. Erythrocytes take up oxygen in the lungs, or in fish the gills, and release it into tissues while squeezing through the body's capillaries.

Hope you aren't tired of seeing Praemium OCs, still got quite a few to draw! This time it's Jalapeño Popper, also known as Peño, a Jester who does entertainment alongside Breezy Adipocyte, providing smiles and laughs to those on the island and in the residency.

Naming the Fat Cell

Assistant: We've discovered that fat in the body is actually stored in specialized cells! And these cells are packed tightly together... they seem to form a cohesive tissue! What should we call these cells?

Researcher: Well, they store fat... so they'll be "fat cells." Maybe... "lipocyte" from the Greek or "adipocyte" from the Latin. Yes, that will do.

A: And the tissue?

R: Fatty... tissue.

A: Excuse me, sir?

R: It's tissue that's full of fat. Fatty tissue. Adipose tissue.

A: Yes but what of it's appearance... it's character?

R: No need. It's the place where fat is stored. That will suffice.

A: But Doctor, surely the tissue beneath the skin is a substantial mass that gives shape and heft to the body. It appears to sheath the entire body. What of this adipose tissue?

R: Fine, fine. That will be... the subcutaneous... adipose tissue.

A: That just means "under the skin," sir.

R: Yes. Yes it does.

A: So we're calling it "fat-filled tissue under the skin."

R: Precisely.

The Ozempic Face: A Comprehensive Analysis

Ozempic (semaglutide) is a well-known medication used in the treatment of type 2 diabetes. Apart from its efficacy in managing blood sugar levels, it has also been associated with a unique side effect known as the "Ozempic Face." This article sheds some light on the phenomenon of Ozempic Face, exploring its definition, potential causes, symptoms, and management, as well as its relevance in the context of diabetes treatment.

Understanding Ozempic

Ozempic is a glucagon-like peptide-1 (GLP-1) receptor agonist, a class of drugs that mimics the action of incretin hormones, leading to increased insulin secretion, decreased glucagon release, delayed gastric emptying, and reduced appetite. Semaglutide, the active ingredient in Ozempic, has been shown to be highly effective in improving glycemic control and promoting weight loss in patients with type 2 diabetes.

What is Ozempic Face?

The term "Ozempic Face" is not an official medical term but rather a colloquial expression used by patients and some healthcare professionals to describe a distinct change in facial appearance observed in individuals taking Ozempic. Reports suggest that patients undergoing Ozempic treatment may experience subtle alterations in facial appearance, such as fuller cheeks and a more youthful look. These effects are attributed to the medication's impact on subcutaneous fat and have garnered considerable attention in online diabetes communities and social media platforms.

Potential Causes

The exact mechanism behind Ozempic Face is not yet fully understood, and research in this area is limited. However, it is believed to be related to the medication's impact on adipose tissue, which is the body's fat-storing tissue located beneath the skin. Semaglutide's activation of GLP-1 receptors may affect adipocytes (fat cells) in a way that promotes fat storage and decreases fat breakdown, particularly in facial areas. Nevertheless, more research is needed to elucidate the underlying biological processes responsible for this phenomenon.

Symptoms of Ozempic Face

Patients who experience Ozempic Face typically report changes in facial features that include:

Fuller cheeks: One of the most commonly reported symptoms is a plumper appearance in the cheeks, giving a rounder and more youthful look.

Smoother skin: Some individuals notice a smoother texture to their facial skin, possibly due to increased subcutaneous fat.

Diminished wrinkles: There have been reports of reduced facial wrinkles or lines, contributing to a more rejuvenated appearance.

It is crucial to emphasize that these effects may vary between individuals, and not everyone taking Ozempic will experience Ozempic Face. Additionally, the intensity of these changes may differ from person to person.

Management and Relevance

There are no specific guidelines or recommendations regarding the management of Ozempic Face. Since it is considered a cosmetic change rather than a medical concern, many individuals do not seek treatment for this side effect. If the changes in facial appearance become bothersome to the patient, they may consider discussing alternative treatment options with their healthcare provider. However, it is essential to weigh the potential benefits of Ozempic's efficacy in managing diabetes and promoting weight loss against any cosmetic side effects.

It's important to note that Ozempic Face is not a reason to discontinue Ozempic treatment, especially if the medication is effectively controlling blood sugar levels and promoting weight loss, which are critical factors in managing type 2 diabetes.

As with any medication, it is essential for patients to be aware of potential side effects and to have open discussions with their healthcare providers about their experiences. If patients are concerned about Ozempic Face or any other side effects, they should seek guidance from their healthcare professionals to make informed decisions about their diabetes treatment plan. Overall, Ozempic remains a valuable option in managing type 2 diabetes, and its potential side effects should be weighed against the benefits it offers in improving patients' quality of life and overall health.

5 Best peptides for Weight Loss

1 Best Peptide for Weight Loss: Semaglutide

Semaglutide belongs to a class of medications known as glucagon-like peptide-1 receptor agonists, or GLP-1 RAs. It mimics the GLP-1 hormone, released in the gut in response to eating. The Semaglutide injection works by slowing down how quickly food leaves your stomach and allows you to feel full for a longer period of time. By reducing hunger, lowering your appetite and increasing feelings of fullness, it will reduce your calorie intake and allow you to lose weight, 1-2 pounds a week.

2 Peptide for Weight Loss: Tirzepatide

Tirzepatide is a novel medication that is FDA approved for the treatment of type 2 diabetes mellitus. Given its potent weight loss properties, tirzepatide be used off-label for obesity treatment. It works as a dual GLP-1 agonist and GIP agonist to maximize similar benefits that are seen with GLP-1 medications such as semaglutide. It is currently implemented as a second-line diabetes medication, similar to GLP-1 medications, and given as a once-a-week subcutaneous injectable.

3 Peptide for Weight Loss: Liraglutide

Liraglutide, is an anti-diabetic medication used to treat type 2 diabetes, and chronic obesity. It is a second line therapy for diabetes following first-line therapy with metformin. Its effects on long-term health outcomes like heart disease and life expectancy are unclear. It is given by injection under the skin.

5 Peptide for Weight Loss: Retatrutide

Retatrutide is an agonist of the glucose-dependent insulin otropic polypeptide, glucagon-like peptide 1, and glucagon receptors. As can be expected, such a significant reduction in body weight in overweight and obese people also resulted in an improvement in blood pressure, cholesterol, and glucose parameters. 

How do Peptides for Weight loss Work?  

Most of the peptides, if not all, work via a common mechanism of action. They increase the release of Growth Hormone from the anterior pituitary gland, which leads to systemic effects. This is primarily seen in peptides used explicitly for muscle growth and endurance.  

As far as weight loss peptides are concerned, it gets pretty interesting!  

Some of these peptides work by increasing growth hormone levels. The growth hormone, in turn, targets specific sites like adipocytes and hepatocytes, causing raised cellular metabolism and fat burning.  

Besides this, most peptides also work by rapidly increasing the process of lipolysis and simultaneously inhibiting excess lipogenesis from occurring. This leads to a net loss of fat.  

A few peptides also work by regulating hormones responsible for glycemic control, like insulin and glucagon. With more insulin, glucose is transported inside the cells for energy expenditure. This subsequently aids in further weight loss.  

热推

I apologize if this is a difficult one or one that has already been done, but could you please do a mix of Foresight and Fat Absorption?

For those of you who are ’s a play on adipocytes, the cells in your body that store fat.

New Quirk Name: Adiposight

This Emitter type Quirk allows the user to rapidly burn their fat into a unique energy, augmenting their brain with it. This lets them rapidly predict things, similar to a super computer. The more fat the user burns, the further and clearer they can predict things. This can start out as a form of precognition, such as letting the user avoid attacks before they hit, to a broad future sight, having them see future events related to them. These visions can extend to others around the user, like seeing the potential actions of allies and enemies alike. This gives the user a good mix of defense and support, keeping them and their allies safe from whatever may happen. If nothing else, it can be a quick and easy way to burn off a few pounds. Though this does require the user to have fat reserves to work with and the Quirk will rapidly burn through them, especially if they take it too far, leaving them weak and exhausted. The user can only see a few minutes at most.

Research assistant examining long non-coding RNAs (lncRNAs) in fat cells Karolinska Institute Research Assistant examining how long non-coding RNAs shape the human adipocyte insulin response in health and disease. See the full job description on jobRxiv: https://jobrxiv.org/job/karolinska-institute-27778-research-assistant-examining-long-non-coding-rnas-lncrnas-in-fat-cells/?feed_id=76107 #crispria #Human_Adipose_Tissue #non_coding_RNAs #ScienceJobs #hiring #research

17th May 2024

CC: A&P - Types of Connective Tissues Terminology

Loose & Dense - The two subclasses of connective tissue proper.

Loose Connective Tissue - The subclass of connective tissue proper with relatively fewer protein fibers but more ground substance and cells.

Dense Elastic - The type of stretchy connective tissue proper found in the walls of many of our large arteries.

Fibrocartilage - The connective tissue with thick bundles of collagen fibers that is found in the menisci in our knees, and in our intervertebral discs.

Dense Regular - The type of connective tissue proper dominated by thick collections of collagen fibers all running in different directions.

Dense Regular - The type of connective tissue proper found in ligaments and tendons.

Dense Irregular - The type of connective tissue proper with thick bundles of collagen fibers running in lots of different directions; it is good at resisting forces in lots of different directions.

Elastic Cartilage - The connective tissue with extra elastic protein fibers, it provides the structure for our ear pinnae.

Hyaline Cartilage - The glassy connective tissue found in our nose, between the ribs and sternum, covering the ends of bones in joints.

Areolar - The most common type of loose connective tissue, found just under the epidermis and wrapped around every organ.

Areolar - The type of loose connective tissue defined by a random arrangement of fivers, few fibroblast cells, and lots of space of watery ground substance.

Reticular Tissue - The type of loose connective tissue proper that is dominated by reticular fibers instead of elastic or collagen.

Reticular Tissue - The type of loose connective tissue proper that provides the structure and space in the liver, spleen, lymph nodes and bone marrow.

Compact Bone - The type of connective tissue that uses calcium and other minerals to form very hard and durable structures.

Osseous Tissue - The type of connective tissue that uses calcium and other minerals to form very hard and durable structures.

Osseous Tissue - Very dense osseous tissue that acts as a shell over every bone, provides the strength of the shafts of long bones, and stores calcium for the body.

Spongy Bone - Porous but strong osseous tissue that provides space for bone marrow and is found inside the ends of long bones and throughout flat bones.

Fibrocartilage - The connective tissue with thick bundles of collagen fibers that is found in the menisci in our knees, and in our intervertebral discs.

Adipose - The type of loose connective tissue that functions as insulation and a storage for energy and in the form of fat.

Adipocytes - The name of the cells that take up most of the space in adipose tissue.

Blood - Type of connective tissue that transports materials to all parts of the body, in which the ground substances is called plasma, and the extracellular fibers are usually invisible.

Erythrocytes - The name of red blood cells, the dominant cell type in blood.

Genes, Vol. 15, Pages 640: Comparative Genome-Wide Alternative Splicing Analysis between Preadipocytes and Adipocytes

Alternative splicing is a ubiquitous regulatory mechanism in gene expression that allows a single gene to generate multiple messenger #RNAs (#mRNAs). Adipocyte development is regulated by many processes, and recent studies have found that splicing factors also play an important role in adipogenic development. In the present study, we further investigated the differences in selective shearing during different periods of adipocyte differentiation. We identified five alternative splicing types including skipped exon, mutually exclusive exon, Alternative 5’ splice site, Alternative 3’ splice site, and Retained intron, with skipped exons being the most abundant type of selective shearing. In total, 641 differentially expressed selective shearing genes were obtained, enriched in 279 pathways, from which we selected and verified the accuracy of the sequencing results. Overall, #RNA-seq revealed changes in the splicing and expression levels of these new candidate genes between precursor adipocytes and adipocytes, suggesting that they may be involved in adipocyte generation and differentiation. https://www.mdpi.com/2073-4425/15/5/640?utm_source=dlvr.it&utm_medium=tumblr

The best Side of Paroxysmal Adipose Hyperplasia (PAH)

CoolSculpting, or cryolipolysis, is usually a noninvasive treatment that takes advantage of controlled, localized cooling to lessen fat slightly below the skin. Through the method, a practitioner will spot a fold of system Body fat concerning two cooling plates. PAH treatment , also referred to as cryolipolysis, has emerged as the most popular of these alternatives, utilizing cold temperatures to stop working adipocytes.2 This process requires significantly less Restoration time and is taken into account safer than liposuction as it obviates the need for an invasive method and will not need general anesthesia.three A: Due to the fact Paradoxical Adipose Hyperplasia is relatively not known as there isn’t a substantial sample dimension, it hasn’t been the middle of obtainable treatments. I did the coolscupting And that i’ve have created paradoxical adipose hyperplasia and regret it large time. I had my chin/neck done and now I have a big lump of really hard Fats that bulges inside the front of my neck and agony. I preferred to remove the Body fat and now it’s a lot of worse. The enlarged Excess fat cells form obvious bulges that resemble the shape from the cryolipolysis applicator. PAH lumps are inclined to truly feel firmer compared to bordering tissue. Your Manual To CoolSculpting For Hips Unwanted fat deposits close to the hips are an generally-cited supply of insecurity For most. Weight loss as well as a demanding excess weight education program might help tone your thighs and hips and in some cases minimize Excess fat in Those people locations, but It's not necessarily unusual to strike a plateau – particularly when genetics are taking part in a job in Unwanted fat distribution. As much as sixty% of individuals with significant heart failure with lessened ejection portion (HFrEF) and approximately 70% of people with HFpEF could present with PH, that's found in almost all patients with severe symptomatic mitral valve ailment and in approximately 65% of These with symptomatic aortic stenosis. Moderate PH is typical in both of those severe Serious obstructive pulmonary ailment and interstitial lung ailment, but severe PH is uncommon Until the two conditions current together. Transthoracic echo is accustomed to picture the results of PH on the center and estimate correct ventricular (RV) systolic force or PAP from steady wave Doppler. Echo-Doppler should generally be done when PH is suspected. When treatment of PH is currently being viewed as, cardiac catheterization is needed. The V/Q scan continues to be the screening technique of choice for Persistent thrombolic PH as a consequence of its greater sensitivity compared with computed tomography pulmonary angiogram. Cardiac magnetic resonance imaging is precise and reproducible in the assessment of RV morphology and function, and makes it possible for noninvasive evaluation and RV mass. It is especially beneficial in detecting congestive coronary heart failure and supplies helpful prognostic facts at baseline and on treatment. High chance (>10% one-yr mortality) is described as scientific signs of correct heart failure, quick progression, recurring syncope, Globe Overall health Firm useful course (WHO FC) IV, 6-minute walk (6MW) fourteen mm Hg, cardiac index (CI) You will need to be logged in to save lots of on your library. . Paradoxical adipose hyperplasia following noninvasive radiofrequency treatment: a novel report and evaluate Wow. I’m so happy and sorry about all the amazing sculpting benefits. I to experienced the technique accomplished on my tummy and 2 months later my tummy was so swollen I couldn’t don normal slacks. All of my trousers experienced to own elastic waist, and the trousers I did wear no more suit me. My excess weight balooned and melancholy set in. Talking-for the clinic they started whispering and afterwards prompt I do the last treatment, I requested them if they have been nuts and to take a look at my tummy. Final results are usually not quickly apparent. Your immune method will start clearing Unwanted fat cells straight away, nevertheless it will take various months to check out entire final results. Nevertheless, most sufferers are happy with the final outcome, so Wait and see. Subsequent IRB approval via the University of Florida (Gainesville, FL), 4 individuals diagnosed with PAH away from 605 people who underwent cryolipolysis treatment from September 2016 by April 2022 at a quaternary educational health-related Centre were being determined utilizing an adverse function log maintained via the division scientific management. All people underwent cryolipolysis with a variety of CoolSculpting applicators. Demographic details ended up extracted from Each individual individual chart and provided age, race, ethnicity, BMI, background of diabetes mellitus, and history of tobacco utilization. Course of action-associated information have been also extracted and incorporated applicator variety, variety of cycles, photographic evidence of PAH progression and/or postoperative final results, and definitive treatment for PAH. These youngsters made lasting dimples within the cheeks. The coldness on the popsicles broken Fats cells inside the cheeks of these small children, creating depressions of their cheeks. The ultimate way to avoid difficulties is to work having a trustworthy service provider and follow all their instructions carefully. Those people exhibiting recognizable fat deposits or adipose hyperplasia That continues to be unresponsive to non-surgical treatment choices may be acceptable candidates. They must be in General fantastic overall health with no situations that impair therapeutic.

Exploring the Benefits of Red Light Body Contouring: A Journey Towards Enhanced Well-being

In the dynamic realm of wellness and aesthetics, red light body contouring has emerged as a revolutionary and non-invasive method for achieving desired physical results and revitalizing skin health. Leveraging the potential of low-level red and near-infrared light, this state-of-the-art technology offers an array of advantages to individuals who aspire to sculpt their bodies and elevate their overall health. Unveiling Red Light Body Contouring Red Light Body Contouring, also referred to as low-level laser therapy, operates on the fundamental principle that particular wavelengths of light possess the capability to penetrate the skin’s surface and reach the deeper layers of tissue. These wavelengths engage with cells, especially adipocytes (fat cells), prompting various physiological responses that yield remarkable benefits for body sculpting and skin rejuvenation. Here are the key mechanisms through which red light body contouring functions:

Reduction in Fat Cells: Red Light Therapy Scottsdale possesses the distinctive ability to create temporary pores within the walls of fat cells, a phenomenon known as transitory pore formation. This process enables the release of stored fatty acids, leading to the contraction of fat cells. Consequently, treated areas experience a reduction in fat volume, resulting in improved body contours.

Stimulation of Collagen Production: Red light therapy effectively stimulates the production of collagen, an essential protein responsible for skin elasticity and firmness. Scottsdale Weight Loss Center will always help you. Elevated collagen levels lead to skin tightening and revitalization, effectively addressing concerns such as sagging skin and cellulite.

Enhancement of Blood Circulation: Red Light Therapy for Wrinkles plays a pivotal role in enhancing blood circulation and microcirculation within the targeted regions. This improved blood flow facilitates the efficient transport of oxygen and essential nutrients to cells, supporting overall cellular health and aiding in detoxification processes.

The Advantages:

Non-Invasive and Comfortable: Red Light Therapy for Anti Aging is entirely non-invasive and painless. It involves exposing the body to low-level light, eliminating the necessity for surgical procedures, anesthesia, or extended recovery periods.

Precise Fat Reduction: Red light therapy can be applied with precision to specific areas of the body where excess fat tends to accumulate. This targeted approach allows individuals to focus on their areas of concern, such as the abdomen, thighs, or arms.

Natural and Safe: Red light therapy represents a natural and safe approach to body contouring. It capitalizes on the body’s innate physiological processes, encouraging the release of stored fat and promoting collagen production without the utilization of chemicals or invasive interventions.

Complementary to a Healthy Lifestyle It is imperative to recognize that while red light body contouring offers substantial benefits, its efficacy is maximized when complemented by a balanced diet and regular exercise. Embracing a comprehensive approach to well-being, which encompasses healthy lifestyle choices, complements the effects of red light therapy, leading to enduring results. Red light body contouring emerges as an innovative and non-invasive technology that empowers individuals to pursue their aspirations of achieving their desired physical appearance and elevating their overall health. With its non-invasive nature, precise fat reduction, reliance on natural mechanisms, and visible outcomes, red light body contouring is an appealing option for those looking to enhance their physical well-being and aesthetic appeal.