#Roslin Institute
Text
On February 14th 2003 “Dolly”, the sheep, the first cloned mammal, was euthanized.
When scientists working at the Roslin Institute in Scotland produced Dolly, she was only lamb born from 277 attempts, from those rom 277 cell fusions, 29 early embryos developed and were implanted into 13 surrogate mothers. But only one pregnancy went to full term, and the 6.6 kg Finn Dorset lamb 6LLS, that’s Dolly to you and I, was born after 148 days. She was born on 5 thJuly 1996 but they never announced her birth for six months.
Dolly lived a pampered existence at the Roslin Institute, not far where I grew up. She mated and produced normal offspring in the normal way, showing that such cloned animals can reproduce.
Dolly the sheep was produced at Roslin as part of research into producing medicines in the milk of farm animals. Researchers have managed to transfer human genes that produce useful proteins into sheep and cows, so that they can produce, for instance, the blood clotting agent factor IX to treat haemophilia or alpha-1-antitrypsin to treat cystic fibrosis and other lung conditions.
This was a major news story around the world, Dolly even appeared on the cover of Time magazine, although I think they missed a trick and the headline should have been “Will There Ever Be Another Ewe”
Dolly was given a lethal dose of an anaesthetic she lives on though conserved by taxidermists her remains were conserved and she is on display in The National Museum of Scotland on Chambers Street, Edinburgh.
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main series aus i kick around-
mya stone & jon snow engagement. it’s funny to me, we know i love bobby b and i think it fits his “unthinking and selfish love” type moves, it’ll probably give ned a heart attack before joffrey can ever get to him.
genderswap robb/roslin and jon/jocelyn au. been trying to follow this one into the weeds. this is where the sansa manderly stark trans fancast comes from (it’s nicole maines) because i decided for maximum drama, absolute primogeniture is fairly new to the north, only instituted by sansa after her uncle and husband jonnel dies.
jocelyn/joy (undecided on the name) baratheon au aka “cersei has all girls” au. shunnedmorlock mentioned cersei might just assume her own daughter is the ymbq and i have decided that’s so much fun lmao.
[no one bully me for this one omg] freya hightower au, where i put an oc of mine into canon and made her a dreamer aksjsjsj.
Literally Anyone reaches out to doran in book one or two before tyrion does. Shireen/Trystane is fun for me!! Robb/Arianne is kinda fun too tbh!!!!
Elia Stoneheart AU (Elia……Fireheart? Maybe they call her something like Mother Rhoyne instead?) but specifically the idea that Jaime is sent to deal with a weird cult that sprung up and runs into Elia’s zombiefied body.
#getting on my soap box#i’m talking about targ aus too much WE ARE BARATHEON AND STARK AND MARTELL STANS HERE
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Alexander Roslin (Swedish, 1718-1793)
The Comtesse d'Egmont Pignatelli in Spanish Costume
Minneapolis Institute of Art
#Alexander Roslin#Swedish#spanish#classical art#female portrait#female#portrait#women in art#pomaded hair#powdered hair#woman#black eyes#black hair#comtesse#art#fine art#fine arts#nobility#royal#royalty#noble#aristocracy#aristocrat#sweden#swedish art#brunette#dogs in art#1700s#18th century#hispanic
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Now 1763 -
Top: 1763 Comtesse d'Egmont Pignatelli in Spanish Costume by Alexander Roslin (Minneapolis Institute of Art - Minneapolis, Minnesota, USA) From liveinternet.ru/users/marylai/post292168318 3437X4625 @72 5.5Mj.
Second row left: 1763 Louise-Marie or Marie Adelaide de Bourbon by Francois-Hubert Drouais (Châteaux de Versailles et de Trianon - Versailles, Île-de- France, France). From Wikimedia 636X638 @96 113kj.
Second row right: 1763 Louise-Marie Bourbon attributed to Francois-Hubert Drouais (Châteaux de Versailles et de Trianon - Versailles, Île-de- France, France). From Wikimedia 1157X1415 @96 3.2Mp.
Third row: 1763 Infanta María Luisa by Lorenzo Baldissera Tiepolo (Museo del Prado - Madrid, Spain). From Wikimedia 861X1024 @300 216kj.
Fourth row left: 1763 Agnese Anhalt-Dessau, Baroness of Loen by Christian Friedrich Reinhold Lisiewski (location ?). I did not record the source of the image 2357X3000 @240 1.7Mj.
Fourth row right: 1763 Susanna Dacre, half-length, wearing a blue satin dress with blue ribbons by circle of Thomas Hudson (auctioned by Bonhams). From their Web site 4292X5262 @300 6Mp.
Fifth row: 1763 Marie-Fortunée d'Este, princesse de Conti by ? (location ?). From twitter.com/MuseeLouvre/status/638402789488619520/photo/1 2010X2360 @144 4.9Mp.
Sixth row: ca. 1763 Mary Little, Later Lady Carr by Thomas Gainsborough (Yale Center for British Art, Yale University - New Haven, Connecticut USA). From Wikimedia; spots, linear flaws from paint cracks, and veiling reflection suppressed with Photoshop with mixture of suppressing individual spots and flaws throughout image and blurring parts of the background with Photoshop 3384X4243 @9713.2Mp.
Seventh row: ca. 1763 Augusta von Hannover, Herzogin von Braunschweig-Lüneburg attributed to Thomas Frye (auctioned by Sotheby's). From Wikimedia 3101X3692 @96 4.7Mj.
#1763 fashion#Rococo fashion#Louis XV fashion#Georgian fashion#Comtesse d'Egmont Pignatelli#Alexander Roslin#Marie Adelaide de Bourbon#Francois-Hubert Drouais#Louise-Marie Bourbon#Infanta María Luisa#Lorenzo Baldissera Tiepolo#fur#Agnese Anhalt-Dessau#Christian Friedrich Reinhold Lisiewski#Susanna Dacre#Thomas Hudson#Marie-Fortunée d'Este#coiffure#Mary Little#roba à la française#sacque back#Princess Augusta#Thomas Frye#court dress
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attention, everyone, it is a very important day
[ID: An excerpt from the Wikipedia entry “Dolly (sheep)” that reads: Dolly (5 July 1996 - 14 February 2003) was a female Finnish Dorset sheep and the first mammal cloned from an adult somatic cell. She was cloned by associates of the Roslin Institute in Scotland, using the process of nuclear transfer from a cell taken from a mammary gland. Her cloning proved that a cloned organism could be produced from a mature cell from a specific body part. End ID]
HAPPY BIRTHDAY DOLLY THE SHEEP!!
Fun fact: she was not the first animal to be cloned, just the first animal cloned from an adult cell (which people hadn’t thought was possible at the time) but other fun fact: she’s the first in my heart
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Today in History: Today is Thursday, Feb. 22, the 53rd day of 2024.
On this date: In 1997, Dolly the Sheep, world's first cloned mammal (from an adult cell) is announced by the Roslin Institute in Scotland.
By The Associated Press
Today’s Highlight in History:
On Feb. 22, 1980, the “Miracle on Ice” took place in Lake Placid, New York, as the United States Olympic hockey team upset the Soviets, 4-3. (The U.S. team went on to win the gold medal.)
On this date:
In 1630, English colonists in the Massachusetts Bay Colony first sampled popcorn brought to them by a Native American named Quadequina for…
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Fwd: Graduate position: UEdinburgh.BovineGenetics
Begin forwarded message:
> From: [email protected]
> Subject: Graduate position: UEdinburgh.BovineGenetics
> Date: 26 November 2023 at 05:17:06 GMT
> To: [email protected]
>
>
>
> Hi,
>
> Join us at The Roslin Institute for a PhD and contribute to "Securing
> the genetic future of the cosmopolitan Holstein dairy breed".
>
> This is a Roslin Foundation Studentship with a nice salary and consumables
> package.
>
> The student will be supervised by a multi-institutional team
> (Gorjanc@Roslin, Tsairidou@GAAFS, Banos&Mrode@SRUC) and will have the
> opportunity to engage with key dairy breeding organisations in the UK
> (Coffey@EGENES, Winters@AHDB) and internationally (InterBull, CTLGH/ILRI).
>
> More information at
> https://ift.tt/7EtbqJH
> or e-mail [email protected].
>
>
> With regards!
>
> University of Edinburgh Gregor Gorjanc, PhD
> The Roslin Institute Professor & Royal Society Industry Fellow
> Easter Bush @[email protected]
> EH25 9RG @[email protected]
> Scotland, UK www.ed.ac.uk/roslin/highlanderlab
>
>
> The University of Edinburgh is a charitable body, registered in Scotland,
> with registration number SC005336. Is e buidheann carthannais a th' ann
> an Oilthigh Dh?n ?ideann, cl?raichte an Alba, ?ireamh cl?raidh SC005336.
>
>
> [email protected]
>
> (to subscribe/unsubscribe the EvolDir send mail to
> [email protected]
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Five steps of Wikipedia for Wednesday, 1st November 2023
Welcome, Velkommen, 안녕하세요, Benvenuta 🤗
Five steps of Wikipedia from "Jean-Barthélemy Le Couteulx de Canteleu" to "A Royal Scandal (1945 film)". 🪜👣
Start page 👣🏁: Jean-Barthélemy Le Couteulx de Canteleu
"Jean-Barthélemy Le Couteulx, comte de Canteleu et de Fresnelles, seigneur de Yonville (4 March 1749 – 18 September 1818) was a French politician and banker, notable as one of the founders of the Banque de France...."
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Step 1️⃣ 👣: Bourbon Restoration in France
"The Bourbon Restoration was the period of French history during which the House of Bourbon returned to power after the first fall of Napoleon on 3 May 1814. Briefly interrupted by the Hundred Days in 1815, the Restoration lasted until the July Revolution of 26 July 1830. Louis XVIII and Charles X,..."
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Step 2️⃣ 👣: Absolute monarchy
"Absolute monarchy is a form of monarchy in which the monarch rules in his or her own right or power. In an absolute monarchy, the king or queen is by no means limited and has absolute power. Often such monarchies are hereditary. Absolute monarchy originally emerged in Europe after the social..."
Step 3️⃣ 👣: Absolutism (European history)
"Absolutism or the Age of Absolutism (c. 1610 – c. 1789) is a historiographical term used to describe a form of monarchical power that is unrestrained by all other institutions, such as churches, legislatures, or social elites. The term 'absolutism' is typically used in conjunction with some..."
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Step 4️⃣ 👣: Catherine the Great
"Catherine II (born Princess Sophie of Anhalt-Zerbst; 2 May 1729 – 17 November 1796), most commonly known as Catherine the Great, was the reigning empress of Russia from 1762 to 1796. She came to power after overthrowing her husband, Peter III. Under her long reign, inspired by the ideas of the..."
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Step 5️⃣ 👣: A Royal Scandal (1945 film)
"A Royal Scandal, also known as Czarina, is a 1945 American comedy-drama film directed by Otto Preminger, produced by Ernst Lubitsch. about the lovelife of Russian empress Catherine the Great. It stars Tallulah Bankhead, Charles Coburn, Anne Baxter and William Eythe. The film was based on the play..."
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On July 5th 1996 Dolly the sheep was born, the first mammal cloned from an adult cell.
When scientists working at the Roslin Institute in Scotland produced Dolly, she was only lamb born from 277 attempts,from those rom 277 cell fusions, 29 early embryos developed and were implanted into 13 surrogate mothers. But only one pregnancy went to full term, and the 6.6 kg Finn Dorset lamb 6LLS, that’s Dolly to you and I, was born after 148 days, they never announced her birth for six months until February 22nd 1997. She lived a pampered existence at the Roslin Institute. She mated and produced normal offspring in the normal way, showing that such cloned animals can reproduce.
Dolly the sheep was produced at the Roslin Institute as part of research into producing medicines in the milk of farm animals. Researchers have managed to transfer human genes that produce useful proteins into sheep and cows, so that they can produce, for instance, the blood clotting agent factor IX to treat haemophilia or alpha-1-antitrypsin to treat cystic fibrosis and other lung conditions.
This was a major news story around the world, Dolly even appeared on the cover of Time magazine!
Sadly Dolly died in February 2003 at the ripe old age of six she had large cancerous tumours and was given a lethal dose of an anaesthetic. She lives on though conserved by taxidermists her remains were conserved by The National Museum of Scotland where she is now on display.
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Living in the pastel
Marie-Suzanne Giroust, Augustine Suzanne Roslin, the Artist's Daughter, 1771, Nationalmuseum, Stockholm
The artist Marie-Suzanne Giroust was admitted to the Académie royale de peinture et de sculpture in Paris in 1770, one of only fifteen women to be accepted as full academicians in the 145-year history of the institution. Giroust died of breast cancer in 1772, aged 38.
#art history#art history memes#dad jokes#punny#puns#punsarelikeonions#art meme#women in art#women artists#museum nerd#breast cancer awareness#get a damn mammogram
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Just to Know!
Ian Wilmut, the renowned cloning pioneer responsible for the groundbreaking creation of Dolly the Sheep in 1996, has recently passed away at the age of 79.
In 1996, the birth of Dolly, a cloned sheep at the Roslin Institute in Scotland, rocked the world, sparking both excitement and fear about the possibilities of cloning technology.
This achievement marked the first time mature adult cells were induced to mimic newly fertilized embryo cells, resulting in the birth of a genetically identical animal, later named Dolly.
Wilmut's legacy extends beyond Dolly, as his work paved the way for advancements in regenerative medicine.
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[ad_1] Ian Wilmut, the British scientist who led the project that cloned a mammal for the first time, Dolly the sheep, shocking scientists who had thought that such a procedure was impossible, died on Sunday. He was 79.The Roslin Institute, a research center near Edinburgh where Dr. Wilmut had worked for decades, said in a statement that the cause was complications of Parkinson’s disease. It did not say where he died.Dr. Wilmut and his team were catapulted into headlines worldwide in February 1997, when they announced their ovine subject’s remarkable birth in the journal Nature.Cloning from embryonic cells was already known to work; in 1995, Dr. Wilmut and his research partner, Keith Campbell, had swapped out the nuclei of two sheep embryos with those of two others, producing two identical ewes, Megan and Morag. (Dr. Campbell died in 2012.) But most scientists had thought it would be impossible to clone an animal using adult cells.The problem, they said, was that an embryonic cell would accept only a nucleus from another embryo. It was Dr. Campbell who devised a solution: By taking a differentiated cell and starving it, he could essentially put it into hibernation, a state that would trick a receiving embryo into accepting it.The work was rough going. Out of some 300 attempts, only one embryo proved viable. Dolly, named for the singer Dolly Parton, was born in July 1996. Dr. Wilmut decided to keep the news secret until he and Dr. Campbell were sure that she would survive infancy.The announcement of Dolly’s birth was among the biggest news events of 1997, alongside the handover of Hong Kong from the British to China and the death of Diana, Princess of Wales. It was met with a mixture of awe and anxiety, with politicians and medical ethicists calling for an immediate ban on human cloning.Dr. Wilmut agreed. In the spring of 1997, he toured the United States, meeting with scientists, speaking to standing-room-only crowds and testifying before Congress.His message was consistent: Human cloning should never, ever be permitted. He called the very prospect of it “offensive,” because of both the risk of birth defects and the fact that a clone would never be accepted as a full human being.“Human cloning has grabbed people’s imagination, but that is merely a diversion and one we personally regret and find distasteful,” Dr. Wilmut wrote in “The Second Creation: Dolly and the Age of Biological Control,” which he published in 2000 with Dr. Campbell and Colin Tudge.Dolly’s life seemed to play out some of the risks. Though she was able to bear lambs, she developed early-onset arthritis and exhibited other traits more commonly associated with older animals. After she developed a viral lung infection in 2003, veterinarians euthanized her.Her stuffed body was put on display at the National Museum of Scotland later that year.“She’s been a friendly face of science,” Dr. Wilmut said in an interview with The New York Times after Dolly’s death. “She was a very friendly animal that was part of a big scientific breakthrough.”Ian Wilmut was born on July 7, 1944, in Hampton Lucy, a village near Stratford-upon-Avon, England. His parents, Leonard (also known as Jack) and Eileen (Dalgleish) Wilmut, were teachers.He entered the University of Nottingham intending to become a farmer, but gave up after he realized that he was, he later said, “helpless on tractors.” A summer internship in an animal-science lab at Cambridge University persuaded him to try academic research instead.After graduating with a degree in animal science in 1967, he went directly to Cambridge, where he received a doctorate in embryology in 1971; his dissertation was on freezing boar semen. He continued that work at the Animal Breeding Research Station, outside Edinburgh. (The facility became the Roslin Institute in 1993.)In 1973, Dr. Wilmut and a team of scientists became the first to breed a calf from a frozen embryo, an achievement that revolutionized animal husbandry.By the 1980s he had become more interested in the medical, rather than the commercial, applications of his work. His father had lived with diabetes, which left him blind for the last 30 years of his life, a family tragedy that drove Dr. Wilmut forward.He and Dr. Campbell chose to work on sheep, they said, because in Scotland the animals are everywhere, and they are cheap. Their original goal was to create milk containing proteins used to treat human diseases and to make stem cells that could be used in regenerative medicine.After the clamor around Dolly’s birth died down, Dr. Wilmut continued to research cloning. Despite his early opposition to working with human cells, in 2005 he received a license from the British government to clone human embryos in order to produce stem cells, with the understanding that the embryos would be destroyed before becoming viable.But he soon gave up that work after a team of scientists in Japan found a way to develop stem cells without the use of embryos, a much more efficient process — and one that relied directly on his own work.Dr. Wilmut received a knighthood in 2008, an honor that was met with some protest by medical ethicists, who contended that his achievement was morally fraught, and by former colleagues who believed that other people, including Dr. Campbell, deserved more of the credit. He moved to the University of Edinburgh in 2005 and retired in 2012.Dr. Wilmut married Vivienne Craven in 1967. She died in 2015. He is survived by his second wife, Sara; his son, Dean; his daughters, Naomi Wilmut and Helen Wilmut; and five grandchildren.Dr. Wilmut revealed that he had Parkinson’s disease in 2018. It was incidentally one of the conditions that he had envisioned his work addressing. He also said he would participate in a research program to test new types of treatments intended to slow the disease, which affects the part of the brain that controls movement.“It was from such a rich seedbed that Dolly developed,” he told The Times in 2018, “and we can hope for similar benefits in this project.” [ad_2]
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Scientist who led team that created Dolly the cloned sheep dies at 79
Peter Mathieson, the vice-chancellor of Edinburgh University, hailed Wilmut as "a titan of the scientific world" whose work cloning Dolly "transformed scientific thinking at the time".
Ian Wilmut, who revealed in 2018 he had been diagnosed with Parkinson’s disease, helmed the team at the Roslin Institute at the University of Edinburgh in Scotland, which cloned Dolly in 1996.
Dolly was the first mammal to be cloned from an adult cell, and the breakthrough garnered global headlines and led to new advances in animal and medical research.
Peter Mathieson, the vice-chancellor of Edinburgh University, hailed Wilmut as “a titan of the scientific world” whose work cloning Dolly “transformed scientific thinking at the time”.
“This breakthrough continues to fuel many of the advances that have been made in the field of regenerative medicine that we see today,” he said in a statement.
Bruce Whitelaw, the current head of the Roslin Institute, said it was “sad news”.
“Science has lost a household name,” he added.
Wilmut retired from Edinburgh University of 2012.
But in 2018, he announced support for new research into Parkinson’s, revealing he had diagnosed with the uncurable, progressive brain disorder, which can cause uncontrollable movements such as shaking.
“There was a sense of clarity, well at least now we know and we can start doing things about it,” Wilmut told the BBC at the time.
“As well as obviously the disappointment that it will possibly shorten my life slightly, and more particularly it will alter the quality of life.”
Parkinson’s is the second most common neurodegenerative disease after Alzheimer’s and affects more than 8.5 million people worldwide, according to the World Health Organization (WHO).
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Ships on the Water
read it on the AO3 at https://ift.tt/IAOMEPj
by Moondust_Yikisoul
In the early 1960s, The Xavier Institute was born.
41 years earlier in Brooklyn, New York Steve Rogers became Captain America and soon lost his best friend.
In 1995 A young mutant was born to Roslin Marttin and Geronom Marttin.
Bucky Jame Barns was found in an ex-Hydra compound By Erik Lehnsherr in 1953 on his search for Sebastian Shaw (the young Bucky had been transformed into a child(6 years old but with all his memories) by some sorcerer. It's a marvel it could have happened)
What do these three groups have in common?
Words: 4729, Chapters: 4/15, Language: English
Series: Part 1 of X-Men Avengers crossover that no one saw coming!
Fandoms: Marvel Cinematic Universe, Captain America (Movies), X-Men - All Media Types, X-Men (Alternate Timeline Movies), The Avengers (Marvel Movies), Iron Man (Movies), Metions of Guardians of the Galaxy (Movies)
Rating: Mature
Warnings: Graphic Depictions Of Violence, Major Character Death
Categories: F/M, Gen, M/M
Characters: Erik Lehnsherr, Charles Xavier, James "Bucky" Barnes, Steve Rogers, Hank McCoy, Raven | Mystique, Darwin, Angel Salvadore, Alex Summers, Scott Summers, Jean Grey, Peter Maximoff, Wanda Maximoff, Nina Lehnsherr, Ororo Munroe, Storm, Bobby Drake, Kitty Pryde, To be added - Character, Original Male Character(s), Magda (X-Men), Sean Cassidy, Tony Stark, Clint Barton, Natasha Romanov (Marvel), Bruce Banner, Thor (Marvel), Loki (Marvel), Jubilation Lee
Relationships: Erik Lehnsherr/Charles Xavier, James "Bucky" Barnes/Steve Rogers, James "Bucky" Barnes & Hank McCoy, Hank McCoy/Raven | Mystique, James "Bucky" Barnes & Logan (X-Men), James "Bucky" Barnes & X-Men first Class
Additional Tags: Avengers ReWrite, X-Men rewrite, Magical riturals done by HYDRA, Hydra (Marvel), mutant and proud, Mutant Bucky Barnes, It's a messed up mutatation caused in part by Hydra, Cross-Posted on Wattpad, Tags to be added, Nina Lives!, Many people know about Hydra, like the entirity of the X-Men suspect their still about, Witnter Solder litterly douse not happen at all, I mean not in the sense that it happens in the movie, Not Captain America: The Winter Soldier Compliant, like at all
read it on the AO3 at https://ift.tt/IAOMEPj
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Gene-edited chickens to beat bird flu
New Post has been published on https://petn.ws/2Ae8
Gene-edited chickens to beat bird flu
Scientists have moved a step closer to breeding flu-resistant chickens that can help see off future outbreaks of avian diseases. The study, a collaboration between researchers at the Roslin Institute, part of Edinburgh University, Imperial College London and the Pirbright Institute in Surrey has raised the possibility of producing gene-edited chickens that are resistant to […]
See full article at https://petn.ws/2Ae8
#BirdNews
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