Promising discovery for Alzheimer's treatment

The findings were published on 8 Jan 2024 in Communications Biology and include discoveries of a druggable target and a drug candidate, made by Meenakshisundaram Balasubramaniam, Ph.D., the paper’s first author.

An estimated 50-65% of people with Alzheimer’s disease have inherited the Alzheimer’s gene, Apolipoprotein E4 (APOEε4), from one or both parents. About 25% of people have one copy of APOEε4 and are three times as likely to develop the disease. Those with two copies (one from each parent) make up 2-3% of the population and are 12-15 times as likely to develop Alzheimer’s.

Balasubramaniam, co-principal investigator on the NIH grant with Griffin, said UAMS built the first known full-length structure of APOEε4 protein in 2017, which he created using bioinformatics and computational modeling techniques. This foundational work led to the discovery of the druggable site on the APOEε4 protein, ApoE4. (APOEε4 refers to the gene, and ApoE4, without the epsilon symbol and no italics, is the protein.)

Balasubramaniam’s unique skills and curiosity, Griffin said, were the catalyst for the discoveries. “I don’t know of anyone else in the world but Dr. Balasubramaniam who can do the work that’s in this paper,” Griffin said of the assistant professor and Inglewood Scholar in the Department of Geriatrics.

Other research team members listed in the USMS article.

UAMS

Related story: The Despair of Persons Living With Alzheimer’s Disease by Jason Karlawish at The History Reader

Alwar Balasubramaniam

Ok but have you considered that nee peroka japamainadhi nee premoka thapamainadhi nee dhyaname varamainadhi ennallainaa

Undi lekaa unnadhi neeve unna kooda lenidhi neene naa repati adi aashala roopam nuvve

Dhoorana unnaa Naa thodu neeve nee dhaggarunna, nee neeeda naadhe naadhannnadhanthaa neeveee neeve...

Roop Suhana Lagta Hai Lyrics In Hindi | रूप सुहाना लगता है

Presenting the Roop Suhana Lagta Hai Lyrics in Hindi song from the bollywood movie The Gentleman. This song is sung by S. P Balasubramaniam & Chitra. Lyrics of the song is written by Indeewar and music composed by Anu Malik. Film The Gentleman directed by Mahesh Bhatt and produced by Allu Aravind. Starring Chiranjeevi, Juhi Chawla, Harish Kumar, Paresh Rawal, Deepak Tijori & others in lead…

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No one:

My mind whenever I hear SBP singing: Salman Khan ga rha hai🤓

where the heart is

a domestic syllabus [x]

"lecture on the history of the house" by claire schwartz

poem by american poet claire schwartz, published in poetry magazine and her 2022 collection civil service.

"the house. from cellar to garret. the significance of the hut" by gaston bachelard

the opening chapter to bachelard's seminal work the poetics of space. bachelard theorizes that the house's role as a site of reverie lends it a profound influence on the psyche. coining his own term, topoanalysis, to explore this influence; he surveys different poetic images of houses as representations of mind and soul.

the bedroom: an intimate history by michelle perrot, trans. by lauren elkin

french historian michelle perrot's history of the western bedroom as the site of birth, sex, illness, and death; from the ancient greek kamára to the postmodern bedrooms of today. perrot traces developments in the bedrooms of royalty, families, laborers, women, children, recluses, monks, and travelers. see also "black in bed" by art historian ella ray on the legacy of black bed art and "the bedroom of things" by caitlin blanchfield and farzin lotfi-jam for a discussion of private space through digital images.

rooms by rohan mcdonald

animated short film by illustrator rohan mcdonald featuring interviews with participants about their rooms and homes.

never home alone: from microbes to millipedes, camel crickets, and honeybees, the natural history of where we live by rob dunn

book by biologist rob dunn about the nearly 200,000 other species that live in our homes, from welcome pets to reviled pests. dunn's work researching the ecosystems of houses has illuminated the sheer scope of creatures that thrive there, often unbeknownst to both inhabitants and scientists, as well as the benefits of a biodiverse household.

"human stains" by heather havrilesky

author and "ask polly" columnist heather havrilesky on the endlessness of housework and "the strange gift that laundry brings to our lives."

the midcentury kitchen: america's favorite room from workspace to dreamscape, 1940s-1970s by sarah archer

a visual history of american kitchens, using examples of advertising and deisgn photography to show the evolution of their aesthetics, technology, and cultural ideals. see also sarah archer's episode of you're wrong about on martha stewart.

"full spectrum" and "if these walls could talk, listen, and record" by emily anthes

excerpts from the great indoors by science journalist emily anthes, which investigates the intersections of health and design in indoor spaces. "full spectrum" (republished by next city as "everyone has a basic right to good design") follows an apartment complex designed for autistic adults. "if these walls could talk, listen, and record" (republished by slate as "senior care homes are becoming high-tech medical devices") reports on the promise and limitations of smart home technology for the elderly.

"inside out, or interior space" by rebecca solnit

essay from rebecca solnit's collection of work on place, the encyclopedia of trouble and spaciousness. solnit discusses the pursuit of the "dream home" through decoration and renovation, examining our desire to craft the perfect nest.

windowswap by sonali ranjit and vaishnav balasubramaniam

a collaborative online database of user-submitted videos shot from windows around the world. conceived as a way to "travel" during early phases of the covid-19 pandemic, visitors can shuffle through videos to experience the views from homes in a plethora of different environments.

where is that fanart of miles morales as sp balasubramaniam

Lost Light | 2022 (Detail) Alwar Balasubramaniam                                            Mirror on the ground

 Nicolas Party,

 Frac Lorraine Collection: Alwar Balasubramaniam, Manon de Boer, Boris Ondreicka, Jiri Skala February 23 – June 17, 2018

Song of the week from the previous show:

Video Link: https://youtu.be/hIDQeuH3MWc

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Music Band: Madhan's Band & Team Location : SVV Mahal

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Original Song Credits:

Movie: Chinna Kounder (1992) (சின்னக் கவுண்டர்) Music: Ilaiyaraaja Year: 1992 Starring: Vijayakanth , Suganya Singers: P. Susheela, S. P. Balasubramaniam Lyrics: Gangai Amaran

பாடல் வரிகள்:

(இசை) ஆண்: முத்து மணி மாலை உன்னத் தொட்டுத் தொட்டுத் தாலாட்ட வெட்கத்துல சேலை கொஞ்சம் விட்டு விட்டுப் போராட

உள்ளத்துல நீதானே உத்தமி உன் பேர்தானே ஒரு நந்தவனப் பூதானே புது சந்தனமும் நீதானே

முத்து மணி மாலை உன்னத் தொட்டுத் தொட்டுத் தாலாட்ட

(இசை)

பெண்: கொலுசுதான் மெளனமாகுமா மனசு தான் பேசுமா

ஆண்: மேகந்தான் நிலவை மூடுமா மவுசு தான் குறையுமா

பெண்: நேசப்பட்டு வந்த பாசக் கொடிக்கு காசிப்பட்டு தந்த ராசாவே

ஆண்: வாக்கப்பட்டு வந்த வாசமலரே வண்ணம் கலையாத ரோசாவே

பெண்: தாழம்பூவுல வீசும் காத்துல வாசம் தேடி மாமா வா…

ஆண்: முத்து மணி மாலை பெண்: என்னத் தொட்டுத் தொட்டுத் தாலாட்ட ஆண்: வெட்கத்துல சேலை பெண்: கொஞ்சம் விட்டு விட்டுப் போராட

(இசை)

ஆண்: காலிலே போட்ட மிஞ்சி தான் காதுல பேசுதே

பெண்: கழுத்துல போட்ட தாலி தான் காவியம் பாடுதே

ஆண்: நெத்திச்சுட்டியாடும் உச்சந்தலையில் பொட்டுவச்சதாரு நான் தானே

பெண்: அத்திமரப் பூவும் அச்சப்படுமா பக்கத்துணை யாரு நீ தானே

ஆண்: ஆசை பேச்சுல பாதி மூச்சுல லேசா தேகம் சூடேற

பெண்: முத்து மணி மாலை என்னத் தொட்டுத் தொட்டுத் தாலாட்ட வெட்கத்துல சேலை கொஞ்சம் விட்டு விட்டுப் போராட

உள்ளத்துல நீ தானே உத்தமரும் நீதானே இது நந்தவனப் பூ தானே புது சந்தனமும் நீதானே

ஆண்: ஒரு நந்தவனப் பூ தானே புது சந்தனமும் நீதானே

Natural Lateral - Tapestry of Life - Latin-tinged jazz & jazz-funk led by keyboardist Aziz Mustafa, with guest spots by Chip Wickham and Tamar Osborn

Undeniably on the rise after the success of their first album, "Cogito Ergo Jam", which received support from the British Jazz scene and was featured on Gilles Peterson’s BB6 broadcast, the North London Based collective goes a step further this time by carefully crafting a new release of a tapestry of music stemming from rich jam sessions at the Lazy Robot Studio and representing the band's phenomenal musical canvas. Echoing jazz legends like Azymuth, Roy Ayers, Alice Coltrane and Miles Davis by paying tribute to those who paved the way but always searching for new musical territories, this six-track LP is moving, thought-provoking and engaging. It is a musical questing where each band member searches for meaning through sounds and rhythms - giving a new life to Jazz music and dropping the full spectrum of a vibrant tapestry of life into the listener's ears. The release moves through elements of vintage, yet also involves sophisticated sound production fusing Jazz with modern dance and world music sensibilities.  The band's work ethic is based on a sense of freedom in the studio filled with live jam sessions where it's all about "catching a moment" and letting the inspiration flow. "We just want to feel a sense of freedom and connection through playing. In the studio, it's the music which connects us all, and we just want to allow that process to unfold". PERSONNEL: Piano, synths, bass and programming by Aziz Mustafa Flute (A2) by Chip Wickham Saxophone and Flute (B3) by Tamar Osborn Horns (A2) by Eoin Grace Saxophone (A3) by Hoody Drums (A2) by David Mrakpor Production and Percussion (A1) by Prajñāghoṣa Monin Drums (A3) by Ozan Nidayi Drums (B1) by Malte Saabye From Drums (B2) by Tim Balasubramaniam Percussion by Ozan Nidayi Bass (B1) by Ozan Nidayi Written by Aziz Mustafa Artwork designed by Nick Collee

ALWAR BALASUBRAMANIAM (in)visible 2007

तेरा नाम लेकर छेड़े मुझे सखियां

tera naam le lekar chhede mujhe sakhiyaan

My friends tease me with your name

सखियों से अब मुझको पीछा छुड़ाना है

sakhiyon se ab mujhko pichhaa chhudaana hai

i want to run away from them now

पल भर की जुदाई फिर लौट आना है

pal bhar ki judaayi phir laut aanaa hai

Just a moment's separation, then you must return!

mujhse juda hokar,hum aapke hain koun (1994)

dev kohli | lata mangeshkar | s.p. balasubramaniam | raamlaxman

🕉️☯️⚡🧭🧬💫🎶🎵💝🦁👸🤴👑👩‍🎤💞HEY Check TODAY's SuperNatural GAYATRI MANTRA FROM YOURs Beloved King Kong VIKRAMAdityan JayaSri Raghavendraaya KALKI THE MR.LION KING MRIGASHIRARAAJA's KIKIKIKIK alias KING OF KINGS OF All Kingdoms OF Kiths and Kins alias THE MR.KARUNAVATARAN alias THE MEGA JESUS cum JESUS DADDY cum JESUS DADA alias PITAMAH to PATI Via PADRE = MAHAPATRI CHATRAPATI Shivaji Maharaj Gaikwad RAJINIKANTH alias Akhanda MAHA RAAJYONKA MADA GAJA MADHAGADHAMMA PRANEETA Subhash's CLONE SruthiVemulapalli'sShahjahaan Sri Sri Sri JAYASRI VIJAYASUDHA CHAMUNDESWARI SAHASRA SUVARNA SUMADHURA SUDARSHANA CHAKRAADHARA BALAJI Balasubramaniam alias MadhuSoodanaMohanaMagantiMuraliMohanaSnehPrajapatiKingVibheeshanan KVHR.JR alias AKHENATEN AMANHOTEP VI alias ALLAHU AKBAR AdiShaktiMaan AdiMahaVishnuvu AdiMahaAparaSahasraBrahma Allmighty Assembly Daddy AlltimeDaddy Dragonball z Series King Kong VIKRAMAdityan alias KING OMKARESHWAR RAO GARU ORIGINAL KALKI Krishna Kishore King Verily Kaveri Veera Bharat Bhushan KVBB 88 100% PAKKA since 1988 towards 2029 till Eternity ♾️

"https://youtu.be/-BH_rOz2XoE"

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"https://twitter.com/The_Junior_God/status/1585082951280517120?t=ePfGq8fA04_lyg_rEgmR5Q&s=19"

MJTYST: 06:55-"07:02-07:09"++ IST ON 10/10/2022-"26/10/2022"

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Shuffle Tag

@dirty-bosmer tagged me to shuffle my playlist for the first ten songs, so-

1. Let It Go - The Neighborhood, 2. Sneham Cherum - Rinu Razak, 3. Mun Paniya - S P Balasubramaniam, 4. Queen of Peace - Florence Plus The Machine, 5. Ghost of A Rose - Blackmore's Night, 6. Movement - Hozier, 7. Two - Sleeping At Last, 8. Bahara - Shreya Ghoshal, 9. Judas - Lady Gaga, 10. Teenage Witch - Suzy Wu

Tagging @aria-i-adagio and anyone who wants!

only want in life right now- garma garam mirchi bajji or cut mirchi as it rains outside and old S.P. Balasubramaniam songs playing on some cassette player.