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Promising discovery for Alzheimer's treatment
The findings were published on 8 Jan 2024 in Communications Biology and include discoveries of a druggable target and a drug candidate, made by Meenakshisundaram Balasubramaniam, Ph.D., the paper’s first author.
An estimated 50-65% of people with Alzheimer’s disease have inherited the Alzheimer’s gene, Apolipoprotein E4 (APOEε4), from one or both parents. About 25% of people have one copy of APOEε4 and are three times as likely to develop the disease. Those with two copies (one from each parent) make up 2-3% of the population and are 12-15 times as likely to develop Alzheimer’s.
Balasubramaniam, co-principal investigator on the NIH grant with Griffin, said UAMS built the first known full-length structure of APOEε4 protein in 2017, which he created using bioinformatics and computational modeling techniques. This foundational work led to the discovery of the druggable site on the APOEε4 protein, ApoE4. (APOEε4 refers to the gene, and ApoE4, without the epsilon symbol and no italics, is the protein.)
Balasubramaniam’s unique skills and curiosity, Griffin said, were the catalyst for the discoveries. “I don’t know of anyone else in the world but Dr. Balasubramaniam who can do the work that’s in this paper,” Griffin said of the assistant professor and Inglewood Scholar in the Department of Geriatrics.
Other research team members listed in the USMS article.
UAMS
Related story: The Despair of Persons Living With Alzheimer’s Disease by Jason Karlawish at The History Reader
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Servotech’s outcome of the board meeting on 25th May 2023
We are pleased to inform you that the Board of Directors of Servotech Power Systems Limited, following the recommendations of its sub-committees, convened a meeting on May 25th, 2023. During the meeting, several important matters were considered, approved, and duly noted. The details are as follows:
Sub-division (stock split) of Equity Shares: The Board approved the sub-division of the Company’s fully paid-up Equity Shares with a face value of Rs. 2/- (Rupees Two only) each, into two Equity Shares with a face value of Rs. 1/- (Rupees One only) each. Further information can be found in Annexure-I.
Alteration of Capital Clause in the Memorandum of Association: The Board approved the alteration of the Capital Clause in the Company’s Memorandum of Association. For detailed information, please refer to Annexure II.
Appointment of Non-Executive Independent Director: The Board nominated Mr. Meenakshisundaram Kolandaivel (DIN: 09854605) as a Non-Executive Independent Director, subject to the approval of the Company’s Shareholders. A brief description of Mr. Kolandaivel’s appointment is enclosed in Annexure-III.
Extra-Ordinary General Meeting: An Extra-Ordinary General Meeting of the Company’s members has been scheduled for Thursday, June 22nd, 2023. The purpose of this meeting is to seek the approval of the Members on the aforementioned points numbered 1 to 3.
Appointment of Scrutinizer: Mr. Debabrata Deb Nath, Practicing Company Secretary (ICSI Membership №7775 and C.P. №8612), has been appointed as the scrutinizer for conducting the remote e-voting process.
The meeting commenced at 03:00 P.M. (IST) and concluded at 05:40 P.M. (IST).
Furthermore, we provide the required details under Regulation 30 of the SEBI Listing Regulations, as per SEBI Circular No. CIR/CFD/CMD/4/2015 dated September 9th, 2015:
DETAILS OF SUB-DIVISION (STOCK SPLIT)
Split Ratio 2:1 — [Each existing Equity Share with a face value of Rs. 2/- (Rupees Two Only) each, fully paid-up, will be sub-divided/split into two equity shares with a face value of Rs. 1/- (Rupees One Only) each, fully paid-up.]
The rationale behind the split of equity shares — The split aims to enhance the liquidity of the Company’s equity shares and encourage broader participation in the stock market.
Pre and Post-Share Capital Structure — The pre and post-sub-division capital structure of the Company is as follows:
Particulars Pre sub-division Post sub-division — No. of equity shares Face Value (INR) Total Share Capital (INR) No. of equity shares Face Value (INR) Total Share Capital (INR)
Authorized Share Capital 110,000,000 2 2,200,000,000 220,000,000 1 2,200,000,000 Issued, Subscribed and Paid-up Share Capital 106,327,145 2 2,126,542,900 212,654,290 1 2,126,542,900
Expected time of Completion- The process is expected to be completed within approximately 2 months from the date of approval by the Board of Directors.
Class of shares which are sub-divided — Equity shares (The Company has only one class of equity shares, with a face value of Rs. 2/- each).
The number of shares of each class pre and post-split — Please refer to our response in points 3 and 5 above.
The number of shareholders who did not receive any shares in consolidation and their pre-consolidation shareholding — Not Applicable.
DETAILS OF ALTERATION IN MEMORANDUM OF ASSOCIATION OF THE COMPANY, IN BRIEF
The Board of Directors, in the meeting held on May 25th, 2023, subject to the approval of the Company’s members, approved the alteration and substitution of the existing Clause V of the Memorandum of Association. The new Clause V is as follows:
“V. The Authorized Share Capital of the Company is Rs. 22,00,00,000/- (Rupees Twenty-Two Crores only), divided into 22,00,00,000 (Twenty-Two Crores only) equity shares of Rs. 1/- (Rupees One only) each.”
DETAILS REGARDING NOMINATION OF APPOINTMENT OF NON-EXECUTIVE INDEPENDENT DIRECTOR
Director’s Name: Mr. Meenakshisundaram Kolandaivel (Director Identification Number: 09854605)
Reason for Appointment: Mr. Meenakshisundaram Kolandaivel has been nominated for the position of Non-Executive Independent Director, subject to approval from the Company’s Shareholders. His extensive experience in the banking sector and his expertise will contribute to the Company’s overall development and provide a new direction for its growth.
Date of Appointment: The appointment will be effective from June 25th, 2023.
Terms of Appointment: Mr. Kolandaivel’s appointment will be for a term of three years, subject to approval from the Company’s Shareholders.
Brief Profile: Mr. Meenakshisundaram Kolandaivel is a highly experienced banking professional with over 35 years of corporate experience. He specializes in credit operations and risk management, having worked in both corporate and branch banking. He holds a Post Graduate Diploma in Management and Finance, as well as a Post Graduate Degree in Economics from Madras University.
Throughout his career, Mr. Kolandaivel has held significant positions in prestigious organizations, including the Indian Air Force, where he started as an Airman in the technical wing. He has served as Assistant General Manager in New Delhi Regional Office and Risk Management Department (Head Office), as well as in the Large Corporate Branch in Chennai. Additionally, he has held the position of General Manager, responsible for Credit, Forex, HR, and IT at the zonal level at PNB Zonal Office in Delhi. Furthermore, he has served as the Chief Risk Officer at Tamil Nadu Mercantile Bank. Mr. Kolandaivel is also a Member of the Investor Grievance Redressal Cell at MCX Chennai Chapter.
Disclosure of Relationships between Directors: There are no relationships between Mr. Meenakshisundaram Kolandaivel and other directors of the Company.
*Upon the successful approval of Mr. Kolandaivel’s appointment by the shareholders, the respective committees will be reconstituted in compliance with the requirements stated in the SEBI (Listing Obligations and Disclosure Requirements) Regulations, 2015.
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Commenting about INSC 2023 Dr U. Meenakshisundaram, said that stroke is ...
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Sree Meenakshisundaram Textiles
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Qualification: BCom/MCom/Equivalent knowledge in Accounts
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Classical Dance: Contribution of Rukmini Devi in Bharatanatyam
Bharatnatyam is one of the oldest and most popular forms of classical dance performed in the state of Tamil Nadu by Devadasis in the courts of Kings and the temples. Nowadays, it is common to see many individuals taking extra interest in this impressive dance form. Bharatnatyam is a worldwide phenomenon liked by kids and adults alike.
But, discussing this classical dance form would be incomplete if we forget to mention the great Rukmini Devi Arundale. She was both a reputed Bharatnatyam dancer and choreographer. Her contribution and charismatic personality to the Indian classical music renaissance helps her attain her niche in the Indian culture arena.
It is believed that Rukmini Devi even declined the President's chair when Morarji Desai (then President of India) offered her the same. She dedicated her life to protecting animal rights and their welfare.
The early life of Rukmini Devi
Rukmini Devi was born on 29th February 1904. Her father's involvement in the Theosophical Society helped her get influenced by Annie Besant at a very early age.
Marriage
Rukmini Devi came across Dr. George Arundale in 1917, who was an active Theosophical Society member. Rukmini Devi's love for humanity and humankind is what fascinated Dr. Arundale. And in the year 1920, with their family's approval and support, Rukmini Devi and Dr. Arundale got married.
However, society was not so keen on this marriage, especially the conservatives, given that Rukmini Devi was a Brahmin girl who married outside the caste.
Dance
In the olden days, Bharatnatyam was performed by Devadasis and was considered low and vulgar art during that period. Even after belonging to the upper caste, Rukmini Devi advocated the cause of Bharatnatyam and began to learn this classical dance from Mylapore Gauri Ammal. She even convinced the proficient Meenakshisundaram Pillai to come to Madras to teach her this mesmerizing dance form.
In 1935, Rukmini Devi gave her first performance during the diamond jubilee celebration of the Theosophical society.
Formation of Kalakshetra
Within a year of her first performance, Rukmini Devi and Dr. George Arundale decided to form Kalakshetra. Pandit S. Subramania Sastri, a Sanskrit scholar and Theosophical society member came up with the name.
Later, renowned dancers like Muthukumara Pillai, Karaikkal Saradambal Ammal, and Meenakshisundaram Pillai joined Kalakshetra as teachers.
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Are you intrigued by the role of Rukmini Devi Arundale in classical dance? Maybe it is time to enjoy what Rukmini Devi enjoyed in Bharatanatyam by joining the Bharatnatyam classes at Kafqa. We are sure you will end up feeling proud of your culture!
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New Post has been published on http://newsreaders.in/jayalalithaa-death-inquiry-arumughaswamy-commission/
Jayalalithaa death inquiry: Arumughaswamy commission sent summons to 6 doctors
Chennai : Fore steps on former Tamil Nadu Chief Minister Jayalalithaa death inquiry commission of Justice (retd) A Arumughaswamy probing the circumstances surrounding J Jayalalithaa’s death has now summoned six doctors from Apollo hospitals on February 5.
The commission, which had indicated that it would examine deputy CM O Panneerselvam on that day, has left him out of the summons list that was issued on Tuesday evening.
The commission has not yet indicated if OPS has been summoned on February 1 or February 5. Efforts to reach the officials from the commission proved futile.
The commission has issued summons to Dr Arulselvam, Dr Kamesh, Dr Ravichandran, Dr Ramagopal, Dr Sajan K and Dr Meenakshisundaram in response to an application filed by Raja Senthoor Pandian, counsel for VK Sasikala, in December.
Apollo had filed an application before the commission that doctors should be examined only if a 21-member medical board is formed. This application was rejected by the commission.
Pandian told, “The commission had initially summoned OPS on Tuesday, but adjourned the proceedings suo-motu without any of the parties asking for it. Now, the latest summons does not include his name,” he said.
The commission on Monday evening issued a letter stating that they would take up the hearing of application number 3 of 2018, which was filed by Apollo, to postpone the appearance of doctors.
However, the commission had already passed orders on this application last week. Sources on Tuesday said when it was brought to the commission’s notice, it acknowledged its error.
Read more : News Readers
#A Arumughaswamy#Dr Arulselvam#Dr Kamesh#Dr Meenakshisundaram#Dr Ramagopal#Dr Ravichandran#Dr Sajan K#J Jayalalithaa#Jayalalithaa death inquiry#Raja Senthoor Pandian#VK Sasikala
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R.MEENAKSHISUNDARAM A00647740 2/275 T.MELAKKADU POST THAMBIKKOTTAI PATTUKKOTTAI TK - 614704
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Bharatanatyam’s Pandanallur link - The Hindu
Bharatanatyam’s Pandanallur link – The Hindu
Meenakshisundaram Pillai is credited with having re-imaged the margam for the modern stage
As part of its celebrating 75 years of Independence, Kalakshetra Foundation has named an avenue in its campus after Pandanallur Meenakshisundaram Pillai, the revered guru who made the temple town of Pandanallur synonymous with Bharatanatyam. Meenakshisundaram Pillai (1869-1954) was a simple man who came to…
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Veteran Tamil director-actor Visu passes away
Written by Antara Chakraborthy
| Chennai |
Published: March 22, 2020 8:06:49 pm
Visu was a prominent figure in Kollywood in the 80s and 90s. (Photo: Manobala/Twitter)
Meenakshisundaram Ramasamy Viswanthan, popularly known as Visu in the Tamil film industry, passed away due to kidney failure on March 22. He was 74.
The…
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Awareness about stroke is awfully low, and this short film wants to change that
“Awareness on stroke is still very low,” says Dr U Meenakshisundaram, Senior Neurologist at Apollo Hospitals on Greams Road in Chennai.
from Google Alert - Neurologist https://ift.tt/2GGDzvF
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Science is solution to all problems, says Bharat Ratna awardee - education
Science is the solution to all problems and development of a nation depends on its scientific progress, Bharat Ratna professor C N R Rao said on Monday.Speaking after inaugurating a CNR RAO Research Centre at Avinashilingam Institute for Home Science and Higher Education for Women here through video conference, Rao, in his lecture on ‘Climbing the limitless ladder of excellence in science,’ said development of the nation depended on its scientific progress.Nations like China, Indonesia and Malaysia were growing vigorously because of their contribution to scientific development, he said.Problems in India can be easily solved if science and research progressed at a greater pace and youngsters should be dedicated to achieve laurels like ‘Missile Man’ A P J Abdul Kalam who was the President of the country, Rao further said.Rao, who also unveiled a statue of Kalam on the campus, told the students that “People from ordinary circumstances come out with extraordinary results” and asked the youngsters to develop their scientific skills which can solve a lot of problems. The Bharat Ratna awardee stressed on the importance of understanding basic science elements like atom weight and concept of the periodic table.He said science has no religion and the development of science would work miracles. Director of research at the National Assessment and Accreditation Council S C Sharma, managing trustee of Avinashilingam Institute Meenakshisundaram, its vic-chancellor Dr Premavathy Vijayan and registrar S Kowsalya also spoke on the occasion.
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Infected aorta of 55-year-old guy replaced MADURAIDoctors at Preethi Hospitals performed a complex surgery on a 55-year-old as her aortic root and ascending aorta were diseased. The acute aortic dissection surgery, which was performed for five hours recently, involved the preservation of the heart’s valve as its leaflets were in good shape. Speaking to The Hindu, R. Meenakshisundaram, senior consultant cardiothoracic… https://hosperity.com/infected-aorta-of-55-year-old-guy-replaced/
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IDG Ventures India Re-brands to Chiratae Ventures
IDG Ventures India Re-brands to Chiratae Ventures
Founded in 2006 by industry veterans Sudhir Sethi and TC Meenakshisundaram, Chiratae Ventures (formerly IDG Ventures India) has so far backed 76 companies across multiple funds
IDG Ventures India, one of the country’s leading venture capital firms with over $470 mn assets under advisory and a presence in 3 locations, has announced a re-branding to Chiratae Ventures.
Founded in 2006 by industry…
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How to have healthy habits
How to have healthy habits
What’s your healthy habit?
你有什么健康习惯？
获得187.1k好评的回答@Venkatasubramanian Meenakshisundaram：
•Drinking a liter of water empty stomach as soon as I get up.
•我一起床就空腹喝1公升水。
•No coffee or tea; teetotaler
•不喝咖啡或茶，滴酒不沾
•No water while taking food. Drink water about 20 to 30 minutes after food.
•吃饭时不喝水，饭后约20-30分钟再喝水。
•Avoid beverages, instead take fruit juices without sugar or just plain water.
•不喝饮料，用无糖果汁代替…
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Not just a headache: Five things about migraines you should know
Taking us through five important things to know about migraines is Dr U Meenakshisundaram, Senior Neurologist, Apollo Hospitals. Not always one- ...
from Google Alert - Neurologist https://ift.tt/2Pi2EUD
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Brain battles docs fight on ground
Neurologists tell us the myths they encounter on a daily basis. ... Dr U Meenakshisundaram, senior consultant neurologist, Apollo Hospitals, Chennai.
from Google Alert - Neurologist http://ift.tt/2mOK7B0
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