#organ transplant
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"For the first time, genetically modified pig kidneys provided “life-sustaining kidney function” during the course of a planned seven-day clinical study—a first step in addressing the critical crisis worldwide of kidney donor organ shortage.
The University of Alabama’s pre-clinical human study at Birmingham also advances the science and promise of xenotransplantation as a therapy to potentially cure end-stage kidney disease—just as a human-to-human transplants can.
“It has been truly extraordinary to see the first-ever preclinical demonstration that appropriately modified pig kidneys can provide normal, life-sustaining kidney function in a human safely and be achieved using a standard immunosuppression regimen,” said UAB transplant surgeon scientist Jayme Locke, M.D., director of UAB’s Comprehensive Transplant Institute and lead author of the paper...
The peer-reviewed findings published last month in JAMA Surgery describes the pioneering pre-clinical human research performed on a recipient experiencing brain death...
The pre-clinical human brain death model developed at UAB can evaluate the safety and feasibility of pig-to-human kidney xenografts, or transplants, without risk to a living human. It is named for transplant pioneer Jim Parsons, an organ donor whose family generously donated his body to advance xenotransplant kidney research, like the latest patient did.
A Critical Need
Kidney disease kills more people each year than breast or prostate cancer, while more than 90,000 people are on the transplant waiting list. More than 800,000 Americans are living with kidney failure and 240 Americans on dialysis die every day. The wait for a deceased donor kidney can be as long as five to 10 years, and almost 5,000 people per year die waiting for a kidney transplant.
Groundbreaking Study Details
The 52-year-old study subject for this research lived with hypertension and stage 2 chronic kidney disease, which affects more than one in seven U.S. adults, or an estimated 37 million Americans. As part of this study, the subject had both of his native kidneys removed and dialysis stopped, followed by a crossmatch-compatible xenotransplant with two 10 gene-edited pig kidneys, or UKidney.
The transplanted pig kidneys made urine within four minutes of re-perfusion and produced more than 37 liters of urine in the first 24 hours. The pig kidneys continued to function as they would in a living human for the entirety of the seven-day study. Also, the kidneys were still viable at the time the study was concluded.
“In the first 24 hours these kidneys made over 37 liters of urine,” said Dr. Locke. “It was really a remarkable thing to see.” ...
Gene editing in pigs to reduce immune rejection has made organ transplants from pigs to humans possible. The natural lifespan of a pig is 30 years, they are easily bred, and they have organs of similar size to humans. Genetically modified pig kidneys have been extensively tested in non-human primates, and the addition of UAB’s preclinical human research model—the Parsons Model—now provides important information about the safety and efficacy of kidneys in human transplant recipients."
-via Good News Network, September 17, 2023
#organ donation#organ donor#organ transplant#medical news#medical research#pigs#kidney transplant#kidney diseases#dialysis#good news#hope#hope posting#human biology
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#science#medicine#medical research#medical advances#pig kidney#kidney transplant#organ transplant#xenotransplantation
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The Peripheral (2022)
#horror aesthetic#eye horror#organ transplant#cw body horror#scifi horror#nightmare fuel#eye augmentation#horror#biomechanical#eye surgery#eerie#eerie aesthetic#cybernetics#gifs#gifset
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Albanian Jason Statham POV, after he decides to take a look inside the refrigerated container in the trunk of his Mercedes.
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When a donor organ becomes available to someone in need of a transplant, medical personnel need to act quickly. It only takes a few hours for expanding ice crystals to damage delicate tissue, leaving a window of less than 12 hours to assess, transport, and implant the new organ.
This not only creates a tremendous time crunch to perform a delicate procedure, but leaves many organs unviable for transplantation.
But a new breakthrough could vastly improve the landscape of liver transplantation: Scientists kept a liver preserved for three days, in non-frozen conditions, before transplanting it into a patient.
Moreover, that liver had been deemed unviable by transplant centers, since it had a tumor and came from a patient with sepsis (bacterial infection) that needed to be assessed and treated. The three-day window allowed the researchers to perform these actions, clearing the liver for transplant.
A year later, the recipient was perfectly healthy, with normal liver function and a normal quality of life. Although further investigation is necessary ahead of widespread clinical uptake, the results could mean, in the future, an increase in the number of livers deemed viable for transplantation.
Continue Reading.
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Was really feeling myself today.
#personal#myself#me#my face#selfie#liver transplant#organ donation#organ donor#organ transplant#words#girls with red hair#girls with tattoos#sober journey#soberliving#sober#sob
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For the horror, organ harvesting, I'm sure they'd go for a bit on the black market
Or Synergy crystal harvest, gotta get synergy for the battle ring from somewhere (I know it's probably natural stuff but like it's free crystal growth)
Why not both (gore under the cut)
I feel like Orpheus is the only one with the surgical precision necessary for such a feat as self-transplants. It seems he has found a way to make Syn's crystal cause his organs to heal and regrow. ... Somehow, he couldn't find the means to do this for his own self. So, he does the next best thing. As far as Gaia, he the same growth hormone yields an infinite supply if he rotates his crops correctly. All of this is made harder because he has trouble moving his head and neck.
#answered asks#m1#syn#gore#surgery#organ transplant#needle#organ harvesting#pokemon#mewtwo#shadow mewtwo#seaside aus
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Groundbreaking Pig Heart Transplant is Performed for the Second Time
For the second time ever, a pig heart has been transplanted into a living human recipient, the University of Maryland Medical Center announced on Friday.
The groundbreaking surgery was done on September 20 at UMMC by the same transplant team that preformed the first such experimental surgery in 2022.
In a news release, the hospital said the recipient, 58-year-old Lawrence Faucette, “is currently breathing on his own, and his heart is functioning well without any assistance from supportive devices.”
Faucette had end-stage heart disease. He had pre-existing peripheral vascular disease and complications with internal bleeding making him ineligible for a traditional heart transplant, the hospital said in the release. He was admitted to UMMC on September 14 after experiencing symptoms of heart failure.
“My only real hope left is to go with the pig heart, the xenotransplant,” Faucette told the hospital in an internal interview several days before the surgery.
The experimental xenotransplant surgery was green lit under the US Food and Drug Administration’s “compassionate use” program. According to the FDA, the program is “a potential pathway for a patient with a serious or immediately life-threatening disease or condition to gain access to an investigational medical product (drug, biologic, or medical device) for treatment outside of clinical trials when no comparable or satisfactory alternative therapy options are available.”
The pig heart used came from a genetically modified pig from Revivcor, a subsidiary the United Therapeutics Corporation. The pig had 10 genes edited, including three genes “knocked out” or inactivated to eliminate the alpha gal sugar in the pig’s blood cells, which can trigger a severe reaction in the human immune system, causing organ rejection. An additional pig gene was modified to control for the growth of the pig’s heart while 6 human genes were added into the pig’s genome to increase acceptance by the immune system. The FDA first approved the gene edited pigs in 2020 for potential therapeutic use and consumption.
Doctors are also treating Faucette with an experimental antibody treatment to further suppress the immune system and prevent rejection. He will be closely monitored for any signs of rejection or any development of pig related viruses. The donor pig was also closely screened for any signs of virus or pathogens.
“We are once again offering a dying patient a shot at a longer life, and we are incredibly grateful to Mr. Faucette for his bravery and willingness to help advance our knowledge of this field,” said Dr. Bartley Griffith, in the release. Griffith is the surgeon who performed the transplant and is a professor of surgery at the University of Maryland School of Medicine.
The hospital said Faucette fully consented to the experimental treatment and was informed of all the risks. In addition, he underwent a full psychiatric evaluation and discussed his case with a medical ethicist.
According to the hospital’s news release, Faucette is a married father of two from Frederick, Maryland and a 20-year Navy veteran who had most recently worked as a lab technician at the National Institutes of Health before retiring.
“We have no expectations other than hoping for more time together,” said his wife Ann Faucette, in the release. “That could be as simple as sitting on the front porch and having coffee together.” There are currently no clinical trials that utilize pig organs for transplants in living human beings. The University of Maryland performed the first such experimental surgery on 57-year-old David Bennett in January 2022. Bennett died two months following the surgery.
While there were no signs of rejection in the initial weeks following the transplant, an autopsy concluded that Bennett ultimately died of heart failure from “a complex array of factors,” including Bennett’s condition prior to the surgery. Bennet had already been hospitalized and kept on a heart lung bypass machine for 6 weeks prior to the transplant. However, a case study by the doctors published in the Lancet also noted there was evidence of pig virus that had not been identified previously.
According to the federal government, there are more than 113,000 people on the organ transplant list, including 3,354 people in need of a heart. The group Donate Life America says that 17 people die each day waiting for a donor organ.
By Nadia Kounang,
#Groundbreaking Pig Heart Transplant is Performed for the Second Time#The University of Maryland Medical Center#Lawrence Faucette#heart#pig heart#heart transplant#organ transplant#xenotransplant#animals#strange#stranger things#science#science news
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A new one shot !!
Hey guys!! I am back again. This time,not with an update on the Valentine fic but with a new one shot
She Gave Me Two Hearts (read it on AO3)
Rating:Teen And Up Audiences
Archive Warning:No Archive Warnings Apply
Category:
M/M
Fandoms:Glee,Klaine-Fandom,Glee Klaine
Relationship:Blaine Anderson/Kurt Hummel
Words:3674
Characters:
Blaine Anderson,Kurt Hummel,Original Characters,Original Child(ren) of Kurt Hummel
Summary:
Kurt Anderson-Hummel found some reports pertaining to Blaine Anderson-Hummel about his past medical records which contained a very shocking secret. What would happen when Blaine finds it? How would they handle it together?
Older! Klaine
so the things that might trigger you: Organ transplant mention, incredibly heart breaking. You might cry (or you might not)
Things you dont have to worry: Blood, injury description.
#kurt hummel#blaine anderson#klaine#glee#blaine and kurt#klaine fanfiction#lgbtq#klaine fanfic#organ donor#organ transplant#emotional hurt/comfort#anna writes
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steddie ‘consumption as love’ blurb
tags: blood, guts, surgery, death, organ harvesting/transplant, graphic descriptions of violence, just generally grey’s anatomy type shit if they were really weird, very graphic
gang this one is real fucked up i BEG of you to proceed with caution. READ THE TAGS!!!
eddie would start out asking steve for a vial of his blood to wear around his neck. it’s certainly not the craziest thing he could ask, and by no means goes anywhere near the depths of his desires. these bone-deep, animalistic desires that threaten to overtake him every time he’s around him.
it’d start off with a vial of blood.
steve would reluctantly agree, if only because his boyfriend is weird as fuck and like, what’s the harm? they’ve all seen enough of each other’s insides, lord knows steve’s overdue for a blood test anyways. may as well, right?
it starts off that way.
in the end, steve’s decrepit body lay cold and pale in the bed they used to share.
he’s breathing, barely, his lungs rattling with the effort. messy stitches stretch across his abdomen like song lyrics scrawled in eddie’s journal. the handiwork is uneven, done by amateur fingers.
eddie’s tongue pokes out in concentration as he drags the knife across steve’s stomach. careful not to break the scars that have so tediously worked themselves into closure, his hand barely shakes this time around.
it takes a long time. harvesting organs is excruciatingly difficult, especially for someone with no formal training.
but he gets it.
after hours or days, steve’s raspy breathing only interrupted by weak moans, eddie’s hands wrap tenderly around one of the last viable organs in his body. he grips it carefully, fingers digging into the soft tissue.
eddie carries it over to a metal tin, laying on a bed of ice. he places it inside and makes his way back to his boyfriend.
he picks up the needle, a line of thread, and lovingly, painstakingly, stitches his lover back together.
the line is straighter this time, and he pats himself on the back. thinks steve will be quite proud of this one.
but steve’s long since stopped breathing. eddie doesn’t know when the rattling turned into gasping, when he started imagining it instead.
but he’s not worried about that right now.
right now, he’s laying down on the bed next to steve.
he’s bringing the tray over and placing it next to him.
he’s grabbing a scalpel, the same one he used on steve, and he’s gritting his teeth as he drags a red line across his own abdomen.
he’s looking past the dizziness, gasping against the pain, as he repeats the procedure on himself.
he’s careful not to drop his own organ as he takes it out and places it in the empty tin next to him, tinged red with steve’s blood.
he’s taking steve’s organ, he’s placing it into the cavity of his own abdomen.
he’s relishing in the feeling of his boyfriend’s blood beating beside his own. of the relentless ebb and flow of their shared vitality.
he doesn’t bother sewing himself back up. he simply holds steve’s hand, lets his, their blood bond their skin, and closes his eyes.
he joins steve in the afterlife with mismatched organs and hearts that beat in tandem.
#steddie#stranger things#eddie munson#steve harrington#steddie fanfic#steddie fic#steve x eddie#consumption as love#gore#its a LOT OF GORE#blood#guts#organ harvesting#organ transplant#this one is really fucked up please god proceed with caution#READ THE TAGS#eddie harvesting steves organs to put inside himself idk whAt to tell you
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Sending hugs always!
Time After Time: Send me a timestamp sometime in the future after the end of [that fic], or sometime in the past before the story started, and I’ll tell you what happened then
A few years later!
For living donation, please and thank you!
five years later
Jay glances at Hailey with tired eyes before turning back and knocking on the door.
It’s been a busy couple of days in the city and there just aren’t patrol officers available to canvas the street for them which means they get to do it themselves.
Which isn’t the worst thing in the world but it does take a lot of time away from the hundreds of other things they need to do today.
He pushes down those thoughts as the door opens, a teenage girl standing behind the screen door.
“Hi.” he says, plastering a smile across his face. “I’m -”
“Mr. Jay!” she says, eyes lighting up.
He stutters to a stop, studying her face and trying to figure out where he knows her from.
“J-Jennifer?” he asks, his own eyes going wide. “How are you doing?”
“It’s been amazing!” she says, swinging open the screen door and motioning them inside. “The liver has been incredible. I was able to start taking dance lessons after I recovered and now I do dance, cheer and tennis.”
“Yeah?” Jay asks, glancing around the room at the photos and trophies. “You look a lot more energetic and just healthy than I remember.”
She nods.
“Absolutely.” she agrees. “And it’s all thanks to you. I can’t thank you enough.”
“I was happy to help.” he tells her. “And even more happy to see how well you’ve been able to use it.”
“I knew that I was getting such an incredible gift and it was very important to me to make sure that I made good use of it.” she says, cheeks filling with color.
“Jennifer.” he says seriously. “This is all incredible but you know that all I wanted for you was that you lived past the age of nine. Everything else is you going above and beyond and living your best life and I am so happy for you.”
“Can I hug you?” she asks with a shy smile and he’s quick to nod, opening his arms for her to step into them.
When she steps back, he bites his lip.
“As much as I’d love to spend the rest of the day catching up,” he says reluctantly. “We are here for work. Is your mom here?”
“You guys are here about the home invasion down the street, right?” she asks.
“That’s right.” he confirms. “We’re talking to everyone on the street to see if anyone saw anything or maybe has outdoor cameras that might have picked something up.”
“I was away at cheer camp when it happened.” she says. “Just got home this morning but let me grab mom. Even if she didn’t see anything she can get you the tapes from the cameras.”
He nods and she hurries down the hall.
Hailey steps up, putting a hand on his arm.
“You okay?” she says quietly.
“I never even thought about how different her life would be after the transplant.” he whispers. “But she’s so… so happy and healthy.”
“You did something so special and beautiful.” she tells him. “And in case I haven’t told you lately, I am so proud of you. And not just for what you did for Jennifer.”
He offers her a slightly overwhelmed smile and she squeezes his arm before letting her hand fall as Jennifer and her mother come back into the room.
“Detective Halstead.” Eleanor says warmly, her face lighting up. “It’s so wonderful to see you.”
“Call me Jay.” he insists, smiling at her. “It’s amazing to see how well you guys are doing. And I so wish that I wasn’t here for work because I have a case to solve or I really would love to stay and catch up.”
“You’ll need my number for your report.” she says easily. “We can make plans to do dinner another time. Jennifer said you guys were asking about the home invasion.”
“We are.” Hailey confirms. “Did you see or hear anything out of the ordinary last night?”
“There was an unusual truck that spent a lot of time up and down the street.” she says. “Some early in the morning but it showed up again just after dinner. There wasn’t a logo and I didn’t get a plate but it was a blue pickup truck. And I can get you the outdoor cameras from the last couple of days and hopefully you can get more of what you need from that.”
“Thank you.” Jay says, taking the flash drive that she’s holding out. “I’ll reach out about dinner. It’ll be great to catch up properly.”
“Agreed.” she says, stepping forward to hug him quickly, stepping back before he has a chance to truly respond.
He and Hailey step toward the door, knowing that they have a lot more people to talk to before they can get back to the district and start piecing together what they might have found on the canvas but he feels a lot better about this canvas already.
“Bye Jay.” Jennifer calls and he glances back to wave at her, breaking into a wide smile when he sees her holding a familiar teddy bear, waving it’s little hand at him.
“Bye Jay.” he echoes, shaking his head at the bear that she’d named after him.
She’s laughing when he finally steps out of the door and the sound fills him with unbelievable warmth.
It had been a difficult recovery but he’d never once stopped believing that it had been one hundred percent worth it.
And seeing the happy, thriving life that Jennifer is living just makes it even more so.
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A surgeon who carried out the UK’s first womb transplant on a cisgender woman has said similar transplants for transgender women are probably about 10 to 20 years away.
In February, Imperial College London professor, James Smith, and his colleague, Isabel Quiroga, from the Oxford Transplant Centre, carried out the womb transplant on a married woman whose 40-year-old sister was willing to donate her own, having already given birth to two children.
The 34-year-old recipient, who lives in England and wishes not to be named, received the transplant during an operation lasting more than nine hours at the Churchill Hospital, in Oxford.
It is hoped that, in the future, womb transplants can be performed on trans women, giving them the chance to have a baby, but Smith said the reality of this is still decades away.
There is currently no “technical feasibility” to perform the operation on trans women due to a difference in the pelvic and vascular anatomy, the shape of the pelvis and issues with the microbiome – the network of micro-organisms that live in the human body, he explained...
Dr Narendra Kaushik, a surgeon in the Indian capital New Dehli, said in May 2022 that transplanting uteruses into trans women is “the future."
Uterine transplants are currently rare, costly and experimental surgeries that typically rely on donor organs. They are often done on people born without a uterus so they can become pregnant and give birth.
The first successful womb transplant took place at the University of Gothenburg in Sweden in 2014. Two years later, the operation was carried successfully once more in the US.
About 50 babies have now been born worldwide as a result of womb transplants.
Kaushik, who has 15 years of experience in gender-affirming surgeries, said: “We cannot predict exactly when this will happen but it will happen soon. We have our plans and we are very optimistic.”
-via PinkNews, August 23, 2023
#lgbtq#transgender#trans issues#trans women#trans healthcare#gender affirming care#trans rights are human rights#medical transition#organ transplant#organ donation#trans femme#united kingdom#uk#sweden#terfs are gonna have a fucking aneurysm and personally I can't wait#medical news#good news#hope
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Brb, just busy running ORs for organ transplants nowadays.
#organ transplant#OR#operating room#nurse#I’m still in the ICU no worries#I just decided I wasn’t busy enough and took a second job
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Anita
My Patreon page, featuring free access to my Eye Siren cartoons: https://www.patreon.com/AugustRenfelt
An overview of my erotic domination stories and where to buy them:
Arabic Femme Fatale Fantasy
Sci-Fi Futanari Domination and Impregnation
Sexy Agent of a Female Conspiracy
Furry and Scaly Fantasy
Sci-fi Mini-Giant Women novels
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“With a transplant, you exchange an illness for another one that we are more equipped to manage.”
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When you look into a viral tag "skin bank" in Israel but find out even more horrible things. Is this country trying to win a global terror award or something?
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