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"Transformation" A Beauty and the Beast fanfic

Chapter 7, “Blastema,” rated T, now posted

Chapters: 7/17 now posted Fandom: Beauty and the Beast (Disney Animated Movies) Rating: Explicit

Romantic relationships: Belle/Beast, Gaston/Lumiere Platonic relationships: Gaston & Belle, Gaston & Beast

Key additional tags: Alternate Universe - Canon Divergence, Love, Happy Ending, Angst and Fluff and Smut, Monster Fucking, Pregnancy, Miscarriage, Redemption, Family, Friendship, see full list of tags on AO3

Excerpt from chapter 7:

“There. That’s perfect,” she purred. “You look so attractive right now, Beast.”

He made a pleased kind of rumbling hum and stepped close to her. “So do you.”

She gripped both his forearms and stood on her toes to kiss his lip. He let her for a few seconds, then reached an arm under her bottom and hoisted her up so her face was level with his. She made a surprised squeak and gripped his mane, then laughed, and saw her happiness reflected in his face before her.

“You’re very strong,” she said. “I like that almost as much as your rolled up sleeves.”

He chuffed out a soft laugh, then lifted her even higher so her neck was level with his mouth. He ran his tongue along her throat, and she sighed at the warm way it made her feel. He licked down to where her neck joined her shoulder, then pressed his face into the crook there. The tips of his tusks pressed into her skin, not hurting, but feeling exciting enough to make her breath hitch.

“I love how you smell,” he mumbled against her skin.

“How do I smell?”

“Delicious.” He swept his tongue over her pulse point.

“Oh? Is the big bad beast going to eat me up?” she teased.

She felt his muscles in his shoulders go tense and he let out a faint growling sort of groan. “Don’t say that.”

Anxiety stabbed at her chest. “I’m so sorry; I was just being silly. That was unkind of me.”

He lowered her back to her feet and shook his head. “It wasn’t unkind. It’s not that I didn’t like what you said. It’s that I liked it too much.”

Continue reading chapter 7 “Blastema” of “Transformation” on AO3

Summary:

Belle said she loved him. Everything transformed to how it used to be.

Except the Beast.

Forced into a new deal with the Enchantress, Beast will remain in this form forever. Belle doesn’t mind; she’s happy with him no matter what he looks like. Beast tries to just be happy, too, and for a while, everything is wonderful. Beast doesn’t know how he got so lucky, and Belle finally feels at home. But when the trauma of his past resurfaces, the future they’re trying to build together comes tumbling down.

Gaston’s ideal future isn’t going to plan either. Instead of getting married to Belle, it looks like he’s becoming friends with her, while developing feelings for someone else he’d never expected. This wouldn’t be so bad, except that the closer he gets to both of them, the more he learns to question his values and feel guilty for his past. And when that past finally comes to light, he stands to lose everything he’s gained.

This is a story about how sometimes the things we want to transform can’t be changed, and sometimes the things we think are hopeless can transform through love.

message from my boyfriend: One fascinating fact about Phylliidae, commonly known as leaf insects or walking leaves, is that they have a remarkable ability to regenerate lost limbs. If a leaf insect loses a leg due to injury or predation, it can regenerate and grow a new one. This regenerative ability is known as autotomy, and it allows leaf insects to recover from damage and continue their normal activities. The process of limb regeneration in leaf insects involves the growth of a specialized structure called a blastema, which gradually develops into a fully functional leg over time. This remarkable regenerative capability is still being studied by scientists and holds potential insights for regenerative medicine research.

it’s been 84 years since i managed to finish a writing piece but I DID. even tho it is VERY small it is a precious gem to me so have some Luchino/Rosario fluff :D

Universe: Identity V Summary: rainy evening cuddles Word Count: 501

     Rain murmured against the windowpane, lulling Rosario so thoroughly they found it difficult to focus on their book as their eyelids grew heavier by the minute. It didn’t help that Luchino, too, was yawning repeatedly as he rested his head on their thigh. After the fourth yawn Rosario gently tapped him on the tip of his nose. “Is your research material that dull?”

     “Hardly,” he replied. “The problem is that my pillow is far too warm and comfortable.”

     “Would reading aloud help keep you awake?” Rosario asked, setting their own book aside. 

    A wry smile crossed his features. “Wouldn’t that put you to sleep?” 

    “No!” They shook their head fervently. “I love listening to you. I’d be far too worried about missing something if I dozed off.”

    His expression softened into fondness. “Very well then.”

    Turning his attention back to his book, he began to read. “After exercising caudal autonomy, the initial blastema forms a cartilaginous tube encasing the regenerated spinal cord. This cartilaginous tube begins the process of ossification only proximally, with distal regions remaining unchanged. For this reason the regeneration process is considered imperfect. Also worth noting are the visible changes in the lizard’s dorsoventral patterning…”

    As they listened, Rosario subconsciously found their hands wandering to Luchino’s hair. At first they laid his braids out over their lap, then almost without thinking they began to loosen each one, carefully undoing the plaits and combing their fingers through the autumn-red waves. Their partner’s gusty sigh of contentment as he paused to turn the page told them their attention was more than welcome, so they began loosely re-braiding his hair to repeat the process again, then again. Luchino yawned again. “You’re trying to lull me to sleep.”

    Rosario paused. “Do you want me to stop?”

    “Not in the slightest.” He closed his book and rested it on his stomach. “Please continue.”

    They happily obliged, watching as he closed his eyes and the rising and falling of his chest slowed into deep, even breaths. Just when they thought he was asleep, he reached up to gently catch their hand and nuzzle into their palm. “Cuore mio,” he mumbled, “Let’s find a proper bed before I fall asleep on you.”

    “I don’t mind if you do,” Rosario assured him.

    He smiled. “A generous offer, but I would sleep even better if I held you in my arms instead.”

    A dreamy look came over them. “That sounds like heaven.”

    Standing, he stretched luxuriously before offering them his hand. When they accepted, he stooped to brush a quick kiss to their knuckles before escorting them back to the Hunters’ sleeping quarters. It took very little time for the pair to situate themselves comfortably in Luchino’s massive bed, Rosario cuddled against Luchino’s chest as he trailed the tips of his claws up and down their spine. Elsewhere in the Manor, the Violinist began to play a soft, sweet melody that blended harmoniously with the rhythm of the rain. Comfortable and content, the two soon drifted off to sleep together.

Nell'incompatibilità empatica, all'improvviso ciò che sembrava importante perde il suo fulgore, mistificando il blastema che sembrava averla creata, lasciandoMi solo flebile memoria dissoluta.

Smetto si attenzionare dove nulla ha importanza e protendo la sensibilità mentale verso nuove correnti ascetiche 👑

- M.Vèga

How jellyfish regenerate functional tentacles in days

At about the size of a pinkie nail, the jellyfish species Cladonema can regenerate an amputated tentacle in two to three days — but how? Regenerating functional tissue across species, including salamanders and insects, relies on the ability to form a blastema, a clump of undifferentiated cells that can repair damage and grow into the missing appendage. Jellyfish, along with other cnidarians such…

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Vanta - Blastema

How jellyfish regenerate functional tentacles in days - Technology Org

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How jellyfish regenerate functional tentacles in days - Technology Org

At about the size of a pinkie nail, the jellyfish species Cladonema can regenerate an amputated tentacle in two to three days — but how? Regenerating functional tissue across species, including salamanders and insects, relies on forming a blastema, a clump of undifferentiated cells that can repair damage and grow into the missing appendage. Jellyfish and other cnidarians, such as corals and sea anemones, exhibit high regeneration abilities, but how they form the critical blastema has remained a mystery until now.

The emergent model jellyfish Cladonema The jellyfish Cladonema pacificum exhibits branched tentacles that can robustly regenerate after amputation. Image credit: Sosuke Fujita, The University of To

A research team based in Japan has revealed that stem-like proliferative cells — which are actively growing and dividing but not yet differentiating into specific cell types — appear at the site of injury and help form the blastema.

The findings were published in the scientific journal PLOS Biology.

“Importantly, these stem-like proliferative cells in blastema are different from the resident stem cells localized in the tentacle,” said corresponding author Yuichiro Nakajima, lecturer at the Graduate School of Pharmaceutical Sciences at the University of Tokyo. “Repair-specific proliferative cells mainly contribute to the epithelium — the thin outer layer — of the newly formed tentacle.”

The resident stem cells that exist in and near the tentacle are responsible for generating all cellular lineages during homeostasis and regeneration, meaning they maintain and repair whatever cells are needed during the jellyfish’s lifetime, according to Nakajima. Repair-specific proliferative cells only appear at the time of injury.

“Together, resident stem cells and repair-specific proliferative cells allow rapid regeneration of the functional tentacle within a few days,” Nakajima said, noting that jellyfish use their tentacles to hunt and feed.

According to first author Sosuke Fujita, a postdoctoral researcher in the same lab as Nakajima in the Graduate School of Pharmaceutical Sciences, this finding informs how researchers understand how blastema formation differs among different animal groups.

“In this study, our aim was to address the mechanism of blastema formation, using the tentacle of cnidarian jellyfish Cladonema as a regenerative model in non-bilaterians, or animals that do not form bilaterally — or left-right — during embryonic development,” Fujita said, explaining that the work may provide insight from an evolutionary perspective.

Two stem-like cell populations in the regenerating tentacle Resident stem cells (green) and repair-specific proliferative cells (red) contribute to tentacle regeneration in Cladonema. Image credit: Sosuke Fujita, The University of Tokyo

Salamanders, for example, are bilaterian animals capable of regenerating limbs. Their limbs contain stem cells restricted to specific cell-type needs, a process that appears to operate similarly to the repair-specific proliferative cells observed in the jellyfish.

“Given that repair-specific proliferative cells are analogues to the restricted stem cells in bilaterian salamander limbs, we can surmise that blastema formation by repair-specific proliferative cells is a common feature independently acquired for complex organ and appendage regeneration during animal evolution,” Fujita said.

The cellular origins of the repair-specific proliferative cells observed in the blastema remain unclear, though, and the researchers say the currently available tools to investigate the origins are too limited to elucidate the source of those cells or to identify other, different stem-like cells.

Regeneration of the jellyfish tentacle At 72 hours after amputation, the regenerating tentacle of Cladonema is fully functional. Image credit: Sosuke Fujita, The University of Tokyo

“It would be essential to introduce genetic tools that allow the tracing of specific cell lineages and the manipulation in Cladonema,” Nakajima said. “Ultimately, understanding blastema formation mechanisms in regenerative animals, including jellyfish, may help us identify cellular and molecular components that improve our own regenerative abilities.”

Source: University of Tokyo

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A recent study has uncovered evidence that cuckoos, a species of bird found throughout the world, play an unexpected role in the recovery of father-in-laws when their injuries are more serious. According to the research, the blastema formation in the injured father-in-laws is enhanced by the presence of a vocal cuckoo, whose soothing tones prove beneficial in the healing process.

The study, published in the journal Scientia, used 50 cases of father-in-laws who had suffered serious injuries. Half were exposed to the sound of a recorded cuckoo's call for 10 minutes each day, while the other half listened to a selection of relaxing instrumental music.

The results showed that those who had listened to the cuckoos had a much higher incidence of blastema formation at the injury site than those in the music group. Scientists believe this could be because the cuckoos' distinctive vocalization is able to modulate the levels of stress-associated hormones like cortisol, thereby aiding the body's natural healing process.

In addition, the researchers also noted that the cuckoo's verbal signals seem to almost lull the injured father-in-law into a calm state, potentially speeding up the blastema formation.

Given the success of this study, experts are now encouraging anyone with a seriously injured father-in-law to consider using a cuckoo as part of their recovery plan.

The mesonephros (Greek: middle kidney) is one of three excretory organs that develop in vertebrates. It serves as the main excretory organ of aquatic vertebrates and as a temporary kidney in reptiles, birds, and mammals. The mesonephros is included in the Wolffian body after Caspar Friedrich Wolff who described it in 1759. (The Wolffian body is composed of: mesonephros + paramesonephrotic blastema)

Mesonephros - Wikipedia

Humans are one step closer to regenerating hands legs limbs tstr

Deer regrows his broken horns. The lizard wags its tail. So can a person regrow their severed hands and feet? Not at the moment, but this work will not take many days. Man is only one step away from attaining this ability. Efforts must be made to get the cells from which hands and feet grow into the human body. The name of this cell is Blastema Cells. It is found in the body of deer. If the…

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Chinese scientists use stem cell technology to grow antlers on mice

Chinese scientists use stem cell technology to grow antlers on MICE in breakthrough that could one day allow humans to regrow lost LIMBS Deer can regrow their antlers every year thanks to stem cells at their base. These transform into ‘blastema’ cells, which grow into bone and antler cartilage. Scientists grew antler-like stumps on mice by transplanting the blastema cells.

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Wilms' tumor

Wilms’ tumor

Wilms’ tumor (nephroblastoma) is an embryonal renal cancer. Also known as nephroblastoma (as cancer arises from metanephric blastema cells of kidney) History: Timeline of key clinical advances that established the modern clinical management of children with Wilms tumour: 1) The National Wilms Tumour Study group (NWTS), which was supplanted by the Children’s Oncology Group (COG) in 2002, and…

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Induced Auto-Regeneration with Adipose Tissue in Humans – Beyond Frontiers of Healing

Opinion

The search for regeneration of the face and other structures of the human body has undergone several attempts, based on complex surgical techniques with the use of transplantation of fragments or limbs removed from donors, followed by the administration of immunosuppressive drugs for the rest of the patient’s life. The results of these face transplants are far from ideal and the degree of dissatisfaction in these patients is very high, leading to cases of severe depression, treatment abandonment and even suicide. In addition to technical problems such as recovery of facial mobility, transplantation of an external anatomical unit differs greatly from transplantation of an internal organ, as its immune behavior is very different. The skin represents the interface between the internal environment of our body and the external environment, therefore it has a rich defense system specialized in responding to all sorts of invaders, which makes it extremely antigenic. For this reason, the doses of immunosuppressive drugs need to be higher and constantly adjusted. We know that immunosuppressants have several side effects such as the possibility of bacterial, viral or fungal infections, with the risk of sepsis, kidney failure and even an increased incidence of malignant tumors, which adds an additional risk to a previously healthy patient [1-5].

The expectation of the patient with severe facial deformity is resocialization, the recovery of self-esteem, in short, psychosocial well-being. In practice, none of these factors materialize. The transplant has little facial mimicry, chronic edema, and the patient still needs to take several medications daily, living with the perennial prospect of rejection or the possibility of manifesting some side effect to the use of immunosuppressants For all these reasons, I believe that this search has not yet ended and that the path of transplantation should be replaced by that of biomimetic regeneration, through three-dimensional self-regeneration triggered or induced by some biomolecular mediator. If we take into account that there are other vertebrate organisms that have this capacity, such as some fish or amphibians, in particular the Salamander, that manage to perform the complete and perfect self-regeneration of a lost limb and remember that in the fertilization of the human egg, only one cell will give rise to the entire complex structure of our body, we can conclude that there is a way to activate this function in human tissues, we just haven’t mastered this knowledge yet. In my way of thinking, as long as we continue on the path of transplants + immunosuppressants, the more we will move away from the chance of achieving this cellular unlocking that will start the self-regenerating process [5-10].

Human cells have 3 differentiation blocking moments. In the formation of the zygote, cells are totipotent, that is, they can differentiate into any human cell. After that, the first block occurs, when the cells become pluripotent and differentiate by leaflets: ectoderm, mesoderm and endoderm, then the second block will occur, when the cells become multipotent, differing only in cells of a specific leaflet, and the third block occurs when the cell becomes differentiated, that is to say unipotent, just reproducing itself. But human cells have the capacity to transdifferentiate and reprogram themselves, as occurs in the female breast, where adipose tissue is transdifferentiated in the mammary gland at puberty and pregnancy, and vice versa after breastfeeding. In the Salamander, the regenerative process begins with the formation of a conglomerate of pluripotent cells called blastema that, controlled by the sympathetic nervous system, are differentiating and walking towards the member that will be newly formed [10- 19].

It is important to note that the current concepts of adipose derived stem cells (ADSCs) are rudimentary and in many publications do not consider the intercellular crosstalk and the importance of the cellular niche as a micro anatomical metabolic unit, where several cells of the same tissue (including stem cells) complement their cellular and molecular capabilities to achieve a single goal, whether revascularization, regeneration or other. Another consideration to be made is how to control the regenerative mechanism: what form to take and when to stop. These messages are certainly memorized in the nuclear DNA of all our cells, like a map or three-dimensional (holographic?) architectural project. Still far from being a regeneration like that of Salamander, we have been able to obtain very surprising results using the adipose tissue as an inducer of cell trans differentiation in complex wounds, obtaining a regeneration of the lesion with revascularization, epithelial growth, absence of fibrosis and mimicking the aspect prior to injury, which I called “Salamander effect”, as you will see in the following examples (Figures 1-3).

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