Multiple sclerosis (MS) is a chronic autoimmune disease affecting the central nervous system, characterized by inflammation, demyelination, and neurodegeneration.
Fatigue is prevalent and debilitating, impacting daily functioning. Vision problems often manifest as optic neuritis. Numbness and tingling result from nerve damage, while muscle weakness and spasticity impair mobility. Cognitive impairment affects memory and problem-solving, influencing work and relationships. Bowel and bladder dysfunction cause discomfort and embarrassment.
It's been a while since I've drawn these goofballs, I missed them :).
There are quite a bit of things that I have yet to explore with the world building. I'm still currently at the beginning in my playthrough of the new TTYD which will probably fill in some gaps in my knowledge.
With the remake coming out recently I'm going to hold back a little for the time being with talking about Shadow Mario because while quite a bit of people are familiar with the Queen, not everyone knows about him.
Genetics also appears to play a role in MS susceptibility. While not directly inherited in a Mendelian fashion, having a family history of MS increases one's risk of developing the condition. Specific genetic variations have been associated with heightened susceptibility to MS, suggesting a genetic predisposition that interacts with environmental factors.
Environmental influences further contribute to the intricate tapestry of MS causation. Viral infections, particularly Epstein-Barr virus (EBV), have been implicated as potential triggers for the autoimmune cascade leading to MS. Moreover, geographical disparities in MS prevalence, with higher rates observed at northern latitudes, suggest a role for environmental factors such as sunlight exposure and its impact on vitamin D levels.
I just had this idea, but what if for Chapter 7 in SPM, the main gang was redesigned to resemble what they would look like if they actually passed away. Mario and Luigi would look like Shaydes, Peach would be a Nimbi, and Bowser would be a Skelebit