#i actually need help | Explore Tumblr Posts and Blogs

antholojade · 2 months

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vox is so fine

that's it, that's the post

#literally help me he's a fucking tv #hazbin hotel #hazbin hotel vox #i actually need help #i actually need him so bad

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fun-kyto-wn · 20 days

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I’m losing my mind like do y’all understand that we’re gonna get buck dating boys and kissing and holding hands and just being lovey dovey and it’s going to be casual and nobody is gonna die like it feels like a fever dream that we’re finally getting this representation

#911 abc #evan buckley #i’m losing my mind #i actually need help #tommy kinard #buddie #911 spoilers #911 fandom #911 season 7 #what is happening #i’m traumatized #supernatural #destiel #spn

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stonerrat420 · 9 months

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I don’t make the rules bro. I just work here.

Y’all…you’re gonna kill me. 86??!?!?!??

#art the clown #carrie white #brahms the boy #baby firefly #otis driftwood #michael myers #horror #slashers #i actually need help

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bluepluto03 · 4 months

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Me: what if instead of doing “trolls watch trolls” I grab the characters throw them in a weird meta box and make them watch everyone’s past. They can still watch trolls but i think it leaves more room for interesting development if we can watch the past of other members of brozone and like viva. Maybe I could even show some history of like Peppy and Bridget!

My several other WIPs: what if instead we beat the hell out of you with your own laptop

Me: that’d be fair

#trolls #trolls band together #I actually need help

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cardboardbox-fly · 5 months

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GUESS WHAT ELDRICH HORRORS I SAW WHILE CHRISTMAS SHOPPING TODAY

#the lords in black #i actually need help #the brainrot is too much #team starkid #christmas #nerdy prudes must die

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bookg1rl · 11 months

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my obsession with men who don’t know i exist is getting out of hand.. (im really delulu)

#delulu #jack champion #harry styles #zayn mailk #louis tomilson #tom kaulitz #bill kaulitz #jungkook #i actually need help #im so delulu #dm me lol #lana del rey #taylor swift #eminem #teenage dirtbag

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giulliadella · 1 year

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WE HAVE SOLVED THE MYSTERY OF WHY CELLS HATE NEUTROPHILS SO MUCH IN CAW

So, last night, my boyfriend and I got into some random discussion about programmed cell death and some new breakthroughs in medicine, you know, the usual things you talk about with your boyfriend at 1 AM. It is well known that leftover bodies of dead cells are phagocytosed (literally consumed) by macrophages. And that’s why I always wondered why aren’t cells scared of macrophages as much as they are of neutrophils, since neutrophils don’t consume the dead cells. With my limited understanding of immunity (which we technically don’t learn a lot about in biology) I thought that neutrophils only consumed invader bacteria and fungi.

And OH BOY was I wrong about that.

Because (and yes I have spent whole night researching this, I’ll provide the links to papers in the end lol) neutrophils are little freaks and not only do they phagocytose leftovers of cells they actually cause them to die in the first place. This happens during infections, especially with viruses that cause the excess release of cytokines (like Coronaviridae). Cytokines activate neutrophils who basically just follow the signal towards the infection site and there all hell breaks loose. Neutrophils phagocytose bacteria and virions (those are viruses that haven’t infected a cell yet) which is fine, but they also degranulate and NETose. I’ll explain this in simple terms to my best ability.

Degranulation is when granulocytes (neutrophils, eosinophils, basophils and mastocytes are all different granulocytes) release their granules which are kind of like little sacks inside their cytoplasm which contain various chemicals. Releasing these chemicals happens when the cell receives appropriate stimulus, the little granules expel their contents out of the cell’s interior. In the case of neutrophils, granules contain very toxic compounds that cause the formation of free radicals which damage DNA and proteins of the surrounding cells, as well as granules filled with digestive enzymes which, well, digest the surrounding tissues.

NETosis is a special type of cell death specific to neutrophils in which they literally degranulate pieces of their own, or their mitochondrial DNA together with more toxic compounds. This creates a net of DNA strands called chromatin which entangles invading bacteria and severely damages them and also marks them for phagocytosis by macrophages. But this process is not well controlled and some of that chromatin and toxic compounds can land onto neighboring cells which is, as you can conclude, very bad for them.

With these two abilities at hand, neutrophils are very well equipped to kill cells and destroy tissue. Which is good in cases when the cells are infected and the tissue is damaged, but their quite aggressive methods can damage healthy cells in the area as well, some of them will die and neutrophils will phagocytose their dead particles.

Basically, to neutrophils every infection is a huge kill and eat all you can buffet. They literally phagocytose until they physically cannot anymore and then go to the spleen or bone marrow to die. They also allow macrophages to consume them and thus pass on the antigens for antigen presentation which influences further immune response. But they can also cause a lot of damage, especially if cytokine storm happens and they completely lose control. This is what causes SARS and it can kill you if it’s severe enough.

Biologically speaking, neutrophils are very important because they are the first ones to come to the sight of infection and their crazy methods usually finish the things before they get too severe. They themselves produce cytokines that mobilize macrophages and dendritic cells so that more immune cells can join and help them. They also have a role in repairing the tissues they damaged.

However, other immune cells, including macrophages and killer T cells, simply don’t cause as much damage. Neutrophils just go all out, which is why they live for such a short period of time compared to their colleagues (they live for only few days, compared to macrophages who can live up to a month and lymphocytes who can live for months, even years).

So, yeah, my boyfriend and I have concluded (at 4AM this morning) that neutrophils are so feared because they damage tissue, go crazy and violently kill healthy cells by accident, then consume them and that’s not by accident, it’s a mechanism to repair tissues.

I can’t believe I wasted whole night just for this. My boyfriend is also disappointed. But I hope that we finally have an explanation for this mystery. Tell me what you think lol.

References:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8589350/

https://www.nature.com/articles/nri.2017.105

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5820392/#:~:text=Neutrophils%20contribute%20to%20tissue%20injury,detail%20here%20(Kruger%20et%20al.

#cells at work #hataraku saibou #neutrophils #immunology #medicine #science #biology #i actually need help #it’s 4am

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rafeinterlude · 28 days

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i’m sorry i can’t hangout today i have a tumblr blog to run.

#i actually need help #girl interrupted #girlblogging #girl interupted syndrome #lana del rey #the virgin suicides #black swan #i talk ☆

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myrandommostlywkmthoughts · 2 years

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Our favorite glowy boy headcannon

New headcannon is that when dark cracks his bones his blue and red aura glows brighter like a goddamn glowstick

#wkm #wkm darkiplier #wkm the actor #wkm the colonel #wkm the mayor #markiplier #who killed markiplier #darkstache #markiplier fandom #markiplierfan #a heist with markipler spoilers #a heist with markiplier #i actually need help #wkm district attorney #a date with markiplier #mayor damien #darkiplier

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milkywaylane · 10 months

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We should bring back slut shaming, like I will be put down if he continues.

#dušan vlahović #dusan vlahovic #football #juventus #i actually need help #i hate his ass #hes so fine #giggling and twirling my hair #kicking my feet as we speak

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kip-has-fleas · 5 months

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i kinda hate being a therian/otherkin, can i just be really really connected to my fursona or something? or is there a way to get rid of phantoms? or can i just ignore it? maybe?

#i actually need help #otherkin #therian #alterhuman

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euphoricfilter · 3 months

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that epic relatable moment when you give your opinion in class about the film you watched and now you regret speaking because what if your opinion was bad even though that’s subjective and everyone probably hates you and thinks your dumb because you just have silly brain and will never be able to fully articulate your thoughts into words so they will never understand the whole point you were getting at

#can you tell i’m functioning okay #i actually need help #like why can’t i just be normal #and not have silly brain #and not think about stupid stuff that doesn’t even matter #like i barely talk in class #because it’s scary #but like what if im dumb #and i decided to be brave and share my little opinion for once #but it’s bad and stupid #ARG THATS IT #gonna go rot in bed 😔

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cheese-wizzy · 8 months

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#vast error #vesbb #sabine berare #ve #sbb #i actually need help #brainrot

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stonerrat420 · 8 months

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Stu Headcannons

Requested? Yes!

• Boob lover. We know this. Bro cannot keep his hands off of you and always finds a way to “casually” put his hands on your tits

•Hickey galore. Loves marking you up because why would you care if you had marks on you? You’re his and his only. There’s nobody to hide them from. Would pout if you covered them.

•Constantly leaving little soft kisses on your face or neck.

•LOVESSSS having you on his lap. “I’m not too heavy am I?” (Stu, literally smiling like a geek) “No, not at all!”

•if you don’t like being at home, he’ll happily have you over. Parents don’t let you sleep at boys’ houses? He’ll get a girl from school to be your cover up! He’s well known socially. Basically friends with everyone.

•super into physical touch but will try to respect your boundaries if you’re uncomfortable with it at first. Doesn’t mean he won’t cross them at times on accident.

• Nicknames include: Babe, baby, sweetheart, and mi amour when he’s being a real pain in the ass

•Will spoil you whether you like it or not. Love thrifting? He’ll buy whatever clothes or cool knick knack you find! Love Halloween shopping and going to spiritual shops? Crystals, sage, etc and awesome decorations are to be expected.

•This man is a pervert and very protective. Wanna wear something revealing? He’ll be your scary dog privilege while also feeling you up the whole night.

•Would be open to a poly relationship with you, him, and Billy but no promises that you’ll be able to walk the same ever again.