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mangalamdrug · 8 months

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Mangalam Drugs: Pioneering the Fight Against Malaria as Anti-Malarial API Manufacturers

Introduction: Malaria continues to be a global health concern, affecting millions of people around the world. The battle against this deadly disease has been ongoing for centuries, with significant advancements in treatment and prevention. One key player in this fight is Mangalam Drugs, a renowned company dedicated to manufacturing Anti-Malarial Active Pharmaceutical Ingredients (APIs). In this blog post, we’ll delve into the critical role that Mangalam Drugs plays in combating malaria and explore their contributions to global healthcare.

Understanding Malaria and the Need for Anti-Malarial APIs: Malaria, caused by Plasmodium parasites, is transmitted through the bites of infected mosquitoes. It poses a substantial threat to public health, particularly in tropical and subtropical regions. The development of drug-resistant strains of the parasite has further complicated treatment efforts. This is where anti-malarial APIs come into play — they are the building blocks of effective medicines that combat malaria by targeting the parasites responsible for the disease.

Mangalam Drugs: A Beacon of Excellence in API Manufacturing: Mangalam Drugs has emerged as a prominent player in the pharmaceutical industry, specifically in the production of anti-malarial APIs. With a commitment to quality, innovation, and global health, the company has made significant strides in the battle against malaria. Here’s how:

Cutting-Edge Research and Development: Mangalam Drugs invests heavily in research and development to create advanced anti-malarial APIs. Their team of scientists and researchers continually work towards enhancing the effectiveness of medicines while minimizing side effects.

Stringent Quality Control: Quality control is paramount in pharmaceuticals, and Mangalam Drugs upholds the highest standards. Their manufacturing processes adhere to international quality norms, ensuring that the APIs they produce are safe, potent, and reliable.

Sustainability and Accessibility: The fight against malaria requires a comprehensive approach. Mangalam Drugs not only produces high-quality APIs but also focuses on making these life-saving medicines accessible to regions most affected by malaria, contributing to global efforts to eradicate the disease.

Collaborations and Partnerships: Mangalam Drugs collaborates with governmental organizations, NGOs, and international health agencies to maximize the impact of their products. These partnerships enable the efficient distribution of anti-malarial medicines to those in need.

Constant Innovation: The field of pharmaceuticals is dynamic, with new challenges and opportunities arising regularly. Mangalam Drugs remains at the forefront of innovation, adapting its strategies to address emerging trends in malaria treatment and prevention.

Conclusion: Mangalam Drugs’ dedication to producing high-quality anti-malarial APIs underscores their commitment to global health and the eradication of malaria. Through their rigorous research, manufacturing excellence, and strategic collaborations, they contribute significantly to the fight against this devastating disease. As we move forward, it’s crucial to recognize the pivotal role that companies like Mangalam Drugs play in shaping a healthier and malaria-free world.

#Anti-Malarial API Manufacturers

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annunews · 1 year

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#Anti-Malarial Drugs Market Scope

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poojascmi · 2 years

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The global anti-malarial drugs market was valued at US$ 839.1 million in 2019 and is expected to exhibit a CAGR of 4.4% during the forecast period (2019–2027).

Source link-https://www.coherentmarketinsights.com/market-insight/anti-malarial-drugs-market-3726

#anti-malarial drugs market #anti-malarial drugs market study #anti-malarial drugs market growth #anti-malarial drugs market analysis

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baddywronglegs · 4 months

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You hear quite often that humans liking spicy food is weird:

Spicy food evolved to discourage mammals from eating it, because we chew up the seeds so mammals are bad at spreading more plants so our shit isn't worth shit to them - birds, who are famously bad at chewing so can shit out a perfectly intact chilli seed, aren't affected, but to mammals it tricks heat receptors into thinking a Bad Heat is happening.

But then along came humans who go "You know what, put that pain in me, I want to be hurt on the way in and the way out" but this is also the species really reliant on cooking so I guess it makes sense that we'd have less aversion to something in our mouth appearing hot.

But bitterness? That's weird.

So how you taste the primary tastes is a reall loose categorisation done on what simple chemistry your tongue can manage:

Sweet is things your mouth thinks are sugars. Sugars mean quick energy, and body like quick energy so its reaction to them is "yum".

Sour means it's acidic, that's literally just tasting hydrogen ions which are what make acids acids (mostly anyway but you don't want to taste any that are acidic any other way). Sour can mean "This fruit has gone from having sugar in it to having bad in it" so it's a not-great taste.

Umami is protein taste for the most part, and we need that to make more body, so yeah generally positive response.

Salty is salt. That's pretty much all I have for you there. It's your body looking out for sodium ions it needs *some of*. So it's pleasant in a modicum but your mouth has a way of telling you that's too much salt. Some people like their mouth telling them it's too much salt. It's not a perfect system.

And then there's bitterness. Bitterness is really vague, lots tastes bitter, because it's a really scattergun sense to detect poison.

That's literally all bitterness is to detect. Poison. It's your mouth telling you not to eat this.

Humans... Do not care. We name drinks after this taste, voluntarily buy and drink them. We cultivate plants for this taste. Hmm, this gin could do with tasting more like poison. What's your favourite kind of beer? Going-off fruit taste? Oh, mine's tastes-like-poison.

I'm not saying everything that tastes bitter is poison. But I am saying the most bitter thing known to man is strychnine. And the Victorians were so obsessed with the idea that if a sensation is unpleasant it must be good for you led to them trying strychnine as an anti-malarial.

It had some success, as it doesn't take much strychnine to guarantee you don't die of malaria.

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fatehbaz · 3 months

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hi! SUPER interesting excerpt on ants and empire; adding it to my reading list. have you ever read "mosquito empires," by john mcneill?

Yea, I've read it. (Mosquito Empires: Ecology and War in the Greater Caribbean, 1620-1914, basically about influence of environment and specifically insect-borne disease on colonial/imperial projects. Kinda brings to mind Centering Animals in Latin American History [Few and Tortorici, 2013] and the exploration of the centrality of ecology/plants to colonialism in Plants and Empire: Colonial Bioprospecting in the Atlantic World [Schiebinger, 2007].)

If you're interested: So, in the article we're discussing, Rohan Deb Roy shows how Victorian/Edwardian British scientists, naturalists, academics, administrators, etc., used language/rhetoric to reinforce colonialism while characterizing insects, especially termites in India and elsewhere in the tropics, as "Goths"; "arch scourge of humanity"; "blight of learning"; "destroying hordes"; and "the foe of civilization". [Rohan Deb Roy. “White ants, empire, and entomo-politics in South Asia.” The Historical Journal. October 2019.] He explores how academic and pop-sci literature in the US and Britain participated in racist dehumanization of non-European people by characterizing them as "uncivilized", as insects/animals. (This sort of stuff is summarized by Neel Ahuja, describing interplay of race, gender, class, imperialism, disease/health, anthropomorphism. See Ahuja's “Postcolonial Critique in a Multispecies World.”)

In a different 2018 article on "decolonizing science," Deb Roy also moves closer to the issue of mosquitoes, disease, hygiene, etc. explored in Mosquito Empires. Deb Roy writes: 'Sir Ronald Ross had just returned from an expedition to Sierra Leone. The British doctor had been leading efforts to tackle the malaria that so often killed English colonists in the country, and in December 1899 he gave a lecture to the Liverpool Chamber of Commerce [...]. [H]e argued that "in the coming century, the success of imperialism will depend largely upon success with the microscope."''

Deb Roy also writes elsewhere about "nonhuman empire" and how Empire/colonialism brutalizes, conscripts, employs, narrates other-than-human creatures. See his book Malarial Subjects: Empire, Medicine and Nonhumans in British India, 1820-1909 (published 2017).

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Like Rohan Deb Roy, Jonathan Saha is another scholar with a similar focus (relationship of other-than-human creatures with British Empire's projects in Asia). Among his articles: "Accumulations and Cascades: Burmese Elephants and the Ecological Impact of British Imperialism." Transactions of the Royal Historical Society. 2022. /// “Colonizing elephants: animal agency, undead capital and imperial science in British Burma.” BJHS Themes. British Society for the History of Science. 2017. /// "Among the Beasts of Burma: Animals and the Politics of Colonial Sensibilities, c. 1840-1940." Journal of Social History. 2015. /// And his book Colonizing Animals: Interspecies Empire in Myanmar (published 2021).

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Related spirit/focus. If you liked the termite/India excerpt, you might enjoy checking out this similar exploration of political/imperial imagery of bugs a bit later in the twentieth century: Fahim Amir. “Cloudy Swords” e-flux Journal Issue #115. February 2021.

Amir explores not only insect imagery, specifically caricatures of termites in discourse about civilization (like the Deb Roy article about termites in India), but Amir also explores the mosquito/disease aspect invoked by your message (Mosquito Empires) by discussing racially segregated city planning and anti-mosquito architecture in British West Africa and Belgian Congo, as well as anti-mosquito campaigns of fascist Italy and the ascendant US empire. German cities began experiencing a non-native termite infestation problem shortly after German forces participated in violent suppression of resistance in colonial Africa. Meanwhile, during anti-mosquito campaigns in the Panama Canal zone, US authorities imposed forced medical testing of women suspected of carrying disease. Article features interesting statements like: 'The history of the struggle against the [...] mosquito reads like the history of capitalism in the twentieth century: after imperial, colonial, and nationalistic periods of combatting mosquitoes, we are now in the NGO phase, characterized by shrinking [...] health care budgets, privatization [...].' I've shared/posted excerpts before, which I introduce with my added summary of some of the insect-related imagery: “Thousands of tiny Bakunins”. Insects "colonize the colonizers". The German Empire fights bugs. Fascist ants, communist termites, and the “collectivism of shit-eating”. Insects speak, scream, and “go on rampage”.

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In that Deb Roy article, there is a section where we see that some Victorian writers pontificated on how "ants have colonies and they're quite hard workers, just like us!" or "bugs have their own imperium/domain, like us!" So that bugs can be both reviled and also admired. On a similar note, in the popular imagination, about anthropomorphism of Victorian bugs, and the "celebrated" "industriousness" and "cleverness" of spiders, there is: Claire Charlotte McKechnie. “Spiders, Horror, and Animal Others in Late Victorian Empire Fiction.” Journal of Victorian Culture. December 2012. She also addresses how Victorian literature uses natural science and science fiction to process anxiety about imperialism. This British/Victorian excitement at encountering "exotic" creatures of Empire, and popular discourse which engaged in anthropormorphism, is explored by Eileen Crist's Images of Animals: Anthropomorphism and Animal Mind and O'Connor's The Earth on Show: Fossils and the Poetics of Popular Science, 1802-1856.

Related anthologies include a look at other-than-humans in literature and popular discourse: Gothic Animals: Uncanny Otherness and the Animal With-Out (Heholt and Edmunson, 2020). There are a few studies/scholars which look specifically at "monstrous plants" in the Victorian imagination. Anxiety about gender and imperialism produced caricatures of woman as exotic anthropomorphic plants, as in: “Murderous plants: Victorian Gothic, Darwin and modern insights into vegetable carnivory" (Chase et al., Botanical Journal of the Linnean Society, 2009). Special mention for the work of Anna Boswell, which explores the British anxiety about imperialism reflected in their relationships with and perceptions of "strange" creatures and "alien" ecosystems, especially in Aotearoa. (Check out her “Anamorphic Ecology, or the Return of the Possum.” Transformations. 2018.)

And then bridging the Victorian anthropomorphism of bugs with twentieth-century hygiene campaigns, exploring "domestic sanitation" there is: David Hollingshead. “Women, insects, modernity: American domestic ecologies in the late nineteenth century.” Feminist Modernist Studies. August 2020. (About the cultural/social pressure to protect "the home" from bugs, disease, and "invasion".)

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In fields like geography, history of science, etc., much has been said/written about how botany was the key imperial science/field, and there is the classic quintessential tale of the British pursuit of cinchona from Latin America, to treat mosquito-borne disease among its colonial administrators in Africa, India, and Southeast Asia. In other words: Colonialism, insects, plants in the West Indies shaped and influenced Empire and ecosystems in the East Indies, and vice versa. One overview of this issue from Early Modern era through the Edwardian era, focused on Britain and cinchona: Zaheer Baber. "The Plants of Empire: Botanic Gardens, Colonial Power and Botanical Knowledge." May 2016. Elizabeth DeLoughrey and other scholars of the Caribbean, "the postcolonial," revolutionary Black Atlantic, etc. have written about how plantation slavery in the Caribbean provided a sort of bounded laboratory space. (See Britt Rusert's "Plantation Ecologies: The Experiential Plantation [...].") The argument is that plantations were already of course a sort of botanical laboratory for naturalizing and cultivating valuable commodity plants, but they were also laboratories to observe disease spread and to practice containment/surveillance of slaves and laborers. See also Chakrabarti's Bacteriology in British India: laboratory medicine and the tropics (2012). Sharae Deckard looks at natural history in imperial/colonial imagination and discourse (especially involving the Caribbean, plantations, the sea, and the tropics) looking at "the ecogothic/eco-Gothic", Edenic "nature", monstrous creatures, exoticism, etc. Kinda like Grove's discussion of "tropical Edens" in the colonial imagination of Green Imperialism.

Dante Furioso's article "Sanitary Imperialism" (from e-flux's Sick Architecture series) provides a summary of US entomology and anti-mosquito campaigns in the Caribbean, and how "US imperial concepts about the tropics" and racist pathologization helped influence anti-mosquito campaigns that imposed racial segregation in the midst of hard labor, gendered violence, and surveillance in the Panama Canal zone. A similar look at manipulation of mosquito-borne disease in building empire: Gregg Mitman. “Forgotten Paths of Empire: Ecology, Disease, and Commerce in the Making of Liberia’s Plantation Economy.” Environmental History. 2017. (Basically, some prominent medical schools/departments evolved directly out of US military occupation and industrial plantations of fruit/rubber/sugar corporations; faculty were employed sometimes simultaneously by fruit companies, the military, and academic institutions.) This issue is also addressed by Pratik Chakrabarti in Medicine and Empire, 1600-1960 (2014).

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Meanwhile, there are some other studies that use non-human creatures (like a mosquito) to frame imperialism. Some other stuff that comes to mind about multispecies relationships to empire:

Lawrence H. Kessler. “Entomology and Empire: Settler Colonial Science and the Campaign for Hawaiian Annexation.” Arcadia (Spring 2017)

No Wood, No Kingdom: Political Ecology in the English Atlantic (Keith Pluymers)

Archie Davies. "The racial division of nature: Making land in Recife". Transactions of the Institute of British Geographers Volume 46, Issue 2, pp. 270-283. November 2020.

Yellow Fever, Race, and Ecology in Nineteenth-Century New Orleans (Urmi Engineer Willoughby, 2017)

Pasteur’s Empire: Bacteriology and Politics in France, Its Colonies, and the World (Aro Velmet, 2022)

Tom Brooking and Eric Pawson. “Silences of Grass: Retrieving the Role of Pasture Plants in the Development of New Zealand and the British Empire.” The Journal of Imperial and Commonwealth History. August 2007.

Under Osman's Tree: The Ottoman Empire, Egypt, and Environmental History (Alan Mikhail)

The Herds Shot Round the World: Native Breeds and the British Empire, 1800-1900 (Rebecca J.H. Woods, 2017)

Imperial Bodies in London: Empire, Mobility, and the Making of British Medicine, 1880-1914 (Kristen Hussey, 2021)

Red Coats and Wild Birds: How Military Ornithologists and Migrant Birds Shaped Empire (Kirsten Greer, 2020)

Animality and Colonial Subjecthood in Africa: The Human and Nonhuman Creatures of Nigeria (Saheed Aderinto, 2022)

Imperial Creatures: Humans and Other Animals in Colonial Singapore, 1819-1942 (Timothy P. Barnard, 2019)

Biotic Borders: Transpacific Plant and Insect Migration and the Rise of Anti-Asian Racism in America, 1890-1950 (Jeannie N. Shinozuka)

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love-islike-abomb · 2 months

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Mexico

Roman reigns x Mystic (OC)

"Yo-ho, Mexico! Far to the south where the cactus grow! Take me away from the ice and the snow! Let's go to Mexico!"

(a/n: you know the photo Paul posted of him saying "when the tribal chief summons you" it gave me an idea so here we are. I actually started this a while ago but I've been in a creative rut so it took me longer then I thought it would)

Warnings: fluff, smut, errors I may have missed, its also LONG!!

Word count: 1.4k

Tag list: @acknowledge-reigns @reignsangel444 @mzv11 @marchm-langdon @mandeelemons @pittieprincess22 @queengreenarrowmia89 @romanreignshairdresser @weirdgirl16355

_______

The winter months in Canada are so harsh! A 20° day is a heatwave here! It was so cold that when I threw boiling water in the air it turned to ice almost instantly. Some people had some fun with it and put food coloring in the water before throwing it while it did make for a bit of fun I wanted somewhere warm.

"you look deep in thought Mystic. What's on your mind" Paul asked.

"I'm just missing my husband that's all" I said with a half smile.

"well he's called me resently and he's bought you a plane ticket" Paul smiled.

"wait what? To where?" I asked.

"Mexico City" Paul smiled "your flight leaves in 3 hours so pack your bags and I'll take you to the airport"

I hadn't seen my husband in 3 months and I had a surprise for him. Paul was the only person I'd told because I had to tell someone "you haven't told him have you?" I asked.

"your secret is safe with me" Paul smiled "but i know he'll be over the moon"

"you think so?" I said, trying to hide the worry in my voice. We had talked about kids but never really got into detail about it. I was afraid Paul was just trying to soothe my nerves.

"mystic, he's always wanted kids. There's no need for you to worry" Paul smiled.

I took what he said at face value. I was worried but we've been married for 2 years now and I'm pretty sure he wasn't going anywhere "alright I'll go get packed" I said with a soft smile, walking away from paul to Roman and i's room. I grabbed my suitcase out of the closet and packed my bikini, several pairs of shorts, shirts, panties, bras, pajamas, and flip flops. I grabbed the pregnancy test I took and wrapped it in tissue paper and put it in the front of my suitcase. I zipped up my suitcase and walked out to Paul "come on mystic, I'll drive you to the airport" paul smiled, grabbing my suitcase.

"paul I'm pregnant not an invilet" I laughed "im perfectly capable of rolling my own bags"

"my tribal chief has told me that I take care of his wife while she's traveling to him. Im just doing what I'm told" he smiled.

I shook my head and smiled "I truly did marry an amazing man!"

At the airport

Sitting on his private jet I wondered how he was gonna react. I didn't have much time to think on it because my phone rang and he was on Skype. I answered and saw his gorgeous smile "hey babe!" I smiled.

"hi babygirl!" He smiled "I see Paul has taken you to the airport. I can't wait to see you! I was planning on taking you to the ruins of Tenochtitlan!" He smiled.

"I would love that! You know if it wasn't for the indigenous a lot of things people use every day wouldn't exist. Things like rubber wouldnt exist and we wouldn't have tires or those expensive shoes we wear wouldn't have their rubber souls. Mouthwash wouldn't exist, syringes, baby bottles and baby formula, the cultivation of corn, snow goggles, birth control, oral and topical pain killers, cable suspension bridges and many othes! None of those things would exist and we really should appreciate them more!"

"I agree! Also quinine!" He smiled.

"you've done your research! The first ever anti malarial drug!" I smiled.

"flight 21 now boarding for Mexico City!" The announcer said over the intercom.

"that's me babe! I'll see you soon!" I smiled "I love you"

"I love you to baby girl" he smiled back.

"you're a very lucky woman!" An older woman next to me said "he's a very handsome man!"

"he's my everything!" I smiled back, getting up to board the plane.

I handed my ticket to the stewardess "oh Mrs Anoa'i your on a private plane!" She smiled.

"he never disappoints" I smiled.

10 hours later in Mexico city

The flight here was uneventful and when I arrived I couldnt get off the plane fast enough. I knew he'd be at the airport waiting for me. I grabbed my carry on and headed off the plane. The the fight attendant opened the door he was standing at the bottom of the stairs with a smile on his face. I ran down the stairs and leapt into his arms, wrapping my legs around his waist "hey baby" he smiled giving me a kiss "I missed you"

"i missed you to!" I smiled back as he set my feet back on the ground.

"We'll go to Tenochtitlan tomorrow!" He smiled "i have something planned for tonight" he said with a smirk. I knew what that meant. I wasn't gonna know my own name. the mere thought of him taking me all over the hotel room- "mystic? Are you ok baby? You look kinda pale"

"yeah I'm fine. I'm just a little queasy. I have a surprise for you" I smiled

"oh what's that's?" He asked.

I took a deep breath and reached into the front of my bag and took out the pregnancy test i'd taken before handing it to him.

"what's this?" He asked.

"what does it look like" I smiled nervously.

"are you pregnant?" He smiled.

"yes" I smiled back.

"baby why are you shaking?" He asked.

"I'm scared" I said "I'm scared that you'll leave now that you know"

He put his hand under my chin, gently moving my gaze to meet his "baby i don't know why you'd think I'd leave just because you're pregnant. I know we've vaguely talked about kids but you have nothing to worry about!" He smiled and I felt my body relax. I leaned into him, feeling his strong arms wrapping around me, realizing I was safe in his arms.

"come on let's get back to the hotel" he smiled. I'm sure you're tired"

"I am but I want my husband!" I said with a smirk.

"oh yeah?" He said licking his lips "I'll take you all over our hotel room!"

At the hotel

"fuck baby girl!" He growled "that mouth feels so good!"

I felt him twitch in my mouth and I knew he was close. I felt him pull me off him, my mouth making a popping noise "face down ass up baby!"

I happily obeyed, shaking my ass when I was on all 4s. I felt him tease me with the tip, sliding it through my wet folds "Roman please!" I whined.

"so impatient!" He said finally sliding himself inside me, both of us moaning out in pleasure. I don't know if it was the pregnancy hormones or not but feeling him inside me for the first time in 3 months activated a part of me I didn't know was there. I moved my hips against his, fucking myself on his hardened flesh "oh fuck baby girl! That's it! Fuck yourself on my cock!" The sound of his hand connecting to my ass rang out and he ran his hand up the curve of my back and into my hair before grabbing a handful and pulling me back, thrusting into me, His hips snapping against mine. He pulled me so I was on my knees and reached his hand around to grab my throat "i'm gonna take you all over This hotel room! You'd like that wouldn't you? You wanna be my little whore?" He growled in my ear.

I bit my lip "yes daddy!" I groaned.

"say it to me!" He growled.

"please use me!" I groaned.

"that's my good girl!" He growled.

"fuck baby! The way that pussy is gripping me I think you're close! Be a good girl and cum on my cock!" He growled. Fuck his dirty talk always got me. "Fuck! Yesss!" I groaned.

"that's it baby! Let it go!" He groaned into my ear "uhn fuck! That's it milk my cock! Milk it dry! Uhn I'm gonna fill that pussy!"

His thrusts became sloppy and eratic, his hot cum coating my walls. A few last sloppy thrusts and he stilled inside me, both of us trying to catch our breath. He slowly pulled out of me and collapsed on the bed and I followed him, snuggling into him "I love you" I smiled.

He smiled back "I love you to baby girl"

#Spotify #roman reigns #big daddy uce #the only daddy☝️😩🫦#wwe smackdown #roman reigns fanfiction #wwe fanfiction #wwe x oc #roman reigns x oc #wwe smut #roman reigns smut #wwe #wwe fic #roman reigns imagine

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macgyvermedical · 1 month

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Hey babe, wanna hear something hot? *whispers* history of metformin

Ok okay I'll talk

So metformin is commonly thought of as the most boring of diabetes drugs. Like, everyone who has ever thought about maybe having type 2 diabetes is taking it unless it gives them diarrhea, and even then their doctor still probably wants them to take it. But it's a first line because it's old, it's cheap, it doesn't often cause hypoglycemia, and it has relatively few side effects compared to other diabetes drugs. Also, like a lot of older drugs, it does way more than it says on the packaging. And a lot of stuff we're still learning about.

In order to talk about metformin, we have to talk about a plant called goat's rue. Goat's rue is a plant native to Europe, Africa, and Asia, and currently grows just about everywhere. In ancient times it was used as an anti-parasitic, a plague remedy, and to relieve the excessive urination caused by what might have been diabetes. In 1918 it was found to contain a chemical called galegine, which did lower blood sugar. Galegine as an anti-diabetes medication is probably too toxic to use long term. However, with a few chemical tweaks, it could become a drug that lowered blood sugar without the toxic effects. Metformin was born.

Metformin came out in 1923 and is a type of drug called a biguanide. it's actually the only type in it's class still available as an anti-diabetic agent, because the other drugs in it's class that came out in the 1920s and 30s caused lactic acidosis and liver problems (similar to the types of reactions seen with galegine), and were taken off the market.

Metformin (and pretty much all oral antidiabetic agents in development at this time) didn't do well initially, probably because they came out the same decade as insulin, and insulin was a lot more effective at treating any kind of diabetes.

It fell out of use extremely quickly, and didn't get picked up again until the 1940s, when US access to antimalarial drugs was cut off, just as a war in the pacific was ramping up. Metformin was evaluated as an antimalarial during WWII, and while noted to have some anti-malarial properties (particularly as a malaria preventative) it also was noted to significantly lower blood sugar in diabetic patients- while not lowering blood sugar very much at all in non-diabetic patients.

This effect, rather than it's antimalarial properties, was what got scientists really interested. Unfortunately, it would not be until 1957 in France that metformin had its first major studies to determine that it did, indeed, work against diabetes. Metformin lost the race to the "first" (successful) oral antidiabetic agent by a year, to a different drug that was found while looking for a new antibiotic- Diabenese.

Metformin became a commercial success in France, while Diabenese became successful in the United States. Metformin would actually not be approved for use in the US until 1995.

But now we get to talk about what metformin does and why it's so freaking cool.

Type 2 Diabetes- lowers A1C (a measure of blood sugar control) by 1-2 full points

Prevents/reverses weight gain due to antipsychotics

Prevents and treats malaria

Makes the flu shot work better

Decreases severity of respiratory illness and complications related to the flu

Changes gut microbiome for the better

Regulates periods and reduces other symptoms in people with PCOS

Lowers risk of breast, colon, and prostate cancer

Lowers risk of dementia

Lowers risk of stroke

May increase lifespan

#whump reference #writing reference #diabetes #metformin #chronic illness

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doberbutts · 9 months

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Also can confirm anti-malarial drugs taste like ass and apparently the most effective doses are in liquid form so I have to draw it up in a syringe and squirt it to the back of my throat like a dog

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hero-israel · 8 months

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Re: the idea that Palestinian Liberation is important to environmentalism

Generally speaking, settler colonizers kick out natives, who tend to have various rules about treating the environment healthily, and then exploit the land for all its worth and more. Anti-Zionists’ proverbial money is riding on the narrative that Israel is a settler colonial state and Palestinians are its dispossessed natives, so they just have to insist there’s an environmentalist angle on these grounds. It’s also ofc apart of the Anti-Zionist tendency to hijack every other cause under the sun.

I’ll admit I know next to nothing about the environmental policies and actions of Israel/Zionists and Palestinian Arabs in any part of history or the present. I’ll admit industrialization is a more Western trend and it is brought by those who spent time in the West, like Ashkenazi Jews. And maybe pre-Israel Palestine was less industrious/polluting. And I’m not a fan of how capitalist Israel has gotten, and there’s probably some level of pollution coming from that. But again, I’m ignorant to the details. I have heard Israel has made a lot of environmentalist progress with reforestation and such (tho I swear I heard something from anti-Zionists about Israel planting non-indigenous trees like colonizers have historically done but this could be BS) and I’ve heard of organizations that focus on environmentalism and diplomacy together (Avodah I think it’s called).

But here’s a point I really want to make: The idea that Palestine taking all of Israel’s land is all about framing the Palestinian as the Noble Savage. It’s another fantasy made by activists with white guilt and without an understanding of Palestinians as a people who may or may not do good things for the environment in likely equal measure. They’re not nature shamans.

Good timing - I just got another ask also requesting "that post myth busting the idea that Israelis grew a pine tree or something that caused forest fires and desertification." So read this and this and this. Might as well read this and this too.

The entire Middle East has been heavily deforested by various colonial empires as well as being hard-hit by war. Israel has restored itself much better than its neighbors but it certainly doesn't have a perfect record; draining the malarial swamps in the 1940s devastated the indigenous painted frog so badly it was thought extinct for over 50 years. They are certainly industrialized / capitalist, but no worse than anybody else.

When "critics" try to call reforestation bad, they have totally lost the plot; just another example of what it means to be "Progressive Except Palestine."

See the tags for more on Israeli ecosystems :)

#israeli wildlife #wildlife of israel #forests #israel #palestine #antisemitism #middle east #reforestation #jumblr

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