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moltensilica · 1 year
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The Phosphorus.
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22 years ago, the anti-cancer drug imatinib (Gleevec) got FDA approval to treat chronic myeloid leukemia. As the symbol of 'rational design' and targeted drug, imatinib is truly a breakthrough in cancer research.
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moltensilica · 1 year
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National DNA Day Messages and Quotes
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Celebrate this day with some amazing DNA one liners and DNA quotes to share with your family and friends. Wish everyone around you with DNA Day wishes and greetings that remind them of the importance of genes.
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moltensilica · 1 year
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HB to DNA Double Helix
Guide me to the essence of life.
Today is the 70th anniversary of DNA double helix.
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moltensilica · 1 year
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It is the day when the 'Guardian of the Genome' was discovered 44 years ago. Happy birthday!
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moltensilica · 1 year
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WORLD CANCER DAY
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Imatinib, thalidomide, and trastuzumab - the drugs which have great significance in history.
The development of imatinib and trastuzumab is a legend. Thalidomide is used in PROTAC after decades of the medical disaster.
They are miracles, and I believe that the future will be more miraculous.
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moltensilica · 2 years
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•Carolyn Bertozzi• is an American chemist and Nobel laureate, known for her wide-ranging work spanning both chemistry and biology.
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moltensilica · 2 years
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「ハカマイリ」 Lysine & Ubiquitin, originally painted for Halloween.
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moltensilica · 2 years
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【CE Character Profile】Lysine (1)
'To change, and to adapt.'
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【Basic Info】
Name: Lysine
Rarity: Standard 4-star
Title: Myriad Aspect
Race: Aminoah
Intro: Famous for 'changes', their main jobs are funeral arranger of Aminoah and info manager of the Genome. 
———————————————————
【Stories】
◇Personal Stories
Lysine might be the most conspicuous one in Aminoah.
Equipped with unmatched skills of 'changes', they have excellent ability to adapt and great potential in this changeable world.
With these skills, Lysine has done much work in different fields, all of which are finished perfectly. Other substances praise them.
And of course, everyone knows that the secret of 'changes' lies in Lysine's necklace, on which each pendant represents a kind of specific power. Beyond others' expectations, the number of pendants is still increasing... 
②[Unlocked at Faith Level 2]
For Lysine, the runes of the Genome were novel and confusing, because they described the birth and traits of different individuals, who didn't exist in the world yet.
When Lysine talked about the runes, other Aminoahs were suspicious. None of Aminoah seemed to read and understand the runes except for Lysine. The others warned Lysine that they should keep away from the weird thing.
But Lysine didn't obey them. On the contrary, they started to arrange the runes themself. A friend joined them, too.
Aeons later, appeared near the Genome was a bunch of substances, who didn't look like Aminoah but shared similar characteristics with Lysine and their friend.
'We come to arrange these runes.' The substances said. 
③[Unlocked at Faith Level 3]
To most Aminoahs' eyes, Lysine was contrary to the tradition.
They were close to the Genome. They didn't resist death. They kept in touch with the newborn race... All these things above were not in line with the tradition.
From this point of view, it was inevitable for Lysine not to be understood, accepted by their own race, and not allowed to be close to other Aminoah. Only one Aminoah thought Lysine's idea was advanced to be mainstream - Maybe no one shared this opinion.
Why I heard little praise from my own race even though I spared no effort to do work in my settlement? What was the reason lying behind their scorn? It was the tradition. Maybe the idea of leaving the settlement flashed in Lysine's mind once. 
④[Unlocked at Faith Level 4]
Lysine's skill of 'change' was given by the world. Their myriad 'Aspect' was taught by other substances.
Lysine knew that the power of Aminoah was limited. Therefore, they learned from countless substances, requesting skill lessons from them. Besides, Lysine learned cultrue and history of different races as well.
Their teachers were from all over the world, ranging from transferase to Vita.
As Lysine's power was increasing day after day, everyone realized that they would be the most outstanding Aminoah. Others of their race, however, showed concern and panic. 
⑤[Unlocked at Faith Level 5]
One day, Lysine decided to take over the funeral arrangement of their race, with a simple reason - none of Aminoah was willing to do this degrading job.
Other Aminoahs originally regarded the anti-tradition one as an aberration. Lysine's decision strengthened their opinion.For them, it was easy to solve the problem - banishing Lysine from the settlement.
Anger, puzzlement, disappointment... A variety of feelings welled up inside Lysine, but soon they felt relieved. To leave the settlement meant to be freed from the stubborn Aminoahs and tradition. It was great, isn't it? They realized.
From then on, Lysine made themself a switch from a jack of all trades to an all-round wanderer, traveling through the world. But they never gave up learning.
After learning a number of new skills, Lysine arrived at a lakeside settlement. It happened that a group of substances was holding water funeral.
The Life Arbiter saw off a funeral boat, which floated to the center and was swallowed by waves eventually. Expressing their last mourning, the Life Arbiter turned to leave and caught sight of an Aminoah, who witnessed the whole progress.  
◇About...
<About themself>
I am 'Myriad Aspect' - it doesn't mean I am double-faced, but good at skills of 'changes'! Wait, you said 'shape-shifting'? Sometimes the two are the same... Anyway, whether the condition is good or bad, I'm able to adapt all! 
<About Arginine>
Oh! They are my old friend, an info manager of the Genome as well! Lively and active, they always do something atmospheric! It feel s delighted to be with them!
[Unlocked at Faith Level 3] And, they were the only one who support me at that time... I am so grateful to them.
 <About Histone H1>
I think they resembles me, too. Maybe it is because of the 'Birth Sequence'? Or does it mean that the 'Birth Sequence' can produce Protee with Aminoah as template? ...
Wait, we've wandered from the subject. Anyway, Histone H1 is a info manager of the Genome, too. But now there is nothing they need to do. 'World Differentiation' has ended, isn't it? 
<About Ubiquitin>
Wow! You mean Ubiquitin? They are my best friend! I tried to make friend with them because of my interest in funeral culture of Protee. Unexpectedly, we shared the same opinion on life! I'm still excited when recalling this...
[Unlocked at Faith Level 4] And they are my mentor who used to help me know Protee and teach me useful skills!
[Unlocked at Faith Level 5] Of course they mean something more important to me... I can say that they have guided me to a new future. At least I won't wander anymore after making friend with them. 
<About the Genome>
[Unlocked at Faith Level 2] The powerful stone pillar group located in the center of the world! Initially, I couldn't understand why my race thought it annoying so much. It just create a new race called Protee, right? Oh, wait, and Nucleacia... But other Aminoahs might have deeper hate for Protee. I didn't know the reason lying behind it, however, even though the war between the two races broke out.
[Unlocked at Faith Level 5] It was until Ubiquitin told me about something... that I realized why... Why did Aminoah hate the Genome and Protee? Why did Aminoah avoid everything related to death? Why was I banished from the settlement? ... I realized these consequences, which seemed to have nothing to do with each other, arose from the same reason... Sorry, But I can't tell it to you. Ubiquitin has said it is a taboo, which they shouldn't have told me.
[Unlocked at Faith Level 5] ...Should I give up the job as info manager of the Genome? 
<About Lake Proteasa>
It is the important 'Primary Lake' in Protee culture, standing for the Samsara of life! Ah, you have known it? Alright... But the scenery is SPLENDID! The vast and shimmering lake, and the indistinct outline of Border Mountains...
[Unlocked at Faith Level 5]Oh, more importantly - it was where I met Ubiquitin for the first time! 
<About the Settlement of Aminoah>
It is exactly the settlement I once lived in! As far as I know, all Aminoahs in the world live there - probably. It seems that the substances of our race are really few.
[Unlocked at Faith Level 3] Feel homesick? a bit, actually. I've been living here for a long time - although not very happy.
[Unlocked at Faith Level 5] Luckily, other Aminoahs and I have made a compromise. I will go back if time permits. I wonder what the settlement looks like now.
 <About Food>
Beans are yummy! Whatever the species are! Here I must mention Glutamic Acid's cooking skills. All the dishes of beans they make are DELICIOUS! (*Gulp) But they mainly cook grain... I don't like it much.
Other ingredients, like eggs and meat, are good as well! I'm omnivorous! 
<About 'Changes'>
Pendants on my necklace can make me 'change'. Simply put, you can see them as a kind of storage tool, in which I store my learned skills. Just use them when necessary. It's quite convenient!
Why I use the pendants? (*Think) Because... I'm only an Aminoah, after all. Some of my bodily functions are weaker than Protee's. Only with external power can I use skills my teachers have taught. But I'm working hard to practice!I hope one day the necklace is just a decoration! 
<About Death>
Mm... Why you talk about this? If you are asking my own opinion, it is the same as Protee's that death is simply a point of the cycle of life. The old will die, an the new will be born at the same time. Endless birth and death make up the cycle of life.
[Unlocked at Faith Level 3] However, it's not true in the tradition of Aminoah, which regard death as complete disappearance of someone. That's why other Aminoahs hate death itself and things related to it.
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【Voice of Character Interface Click】
◇Feel bored? Do you want me to sing a song? Not an elegy!
◇My work is more than funeral arrangement. Don't misunderstand! I am good at 'changes', you know!
◇[Unlocked at Faith Level 2] The Genome is such a MYSTERIOUS place! I haven't understand those runes completely. Maybe the 'transcription factor' can read them...
◇[Unlocked at Faith Level 2] I prefer staying in the Genome, getting along with friends happily!
◇[Unlocked at Faith Level 3] When it comes to the relationship between me and other Aminoah, though we haven't fully accept each other, we have learned to understand and respect mutually.
◇[Unlocked at Faith Level 5] I have to admit that friendship is beyond pain sometimes.
◇[Unlocked at Faith Level 5] How about the time of wandering? Lonely, that's true. But it's also fruitful! I have gained a lot of experiences and learned numerous skills, and more importantly - I have made friends with a number of substances!
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moltensilica · 2 years
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c-Myc, titled 'Graft', is the present leader of 'The Reformers', who is struggling for fulfilling the dream made with friends. They look like a green pheasant, because c-Myc is one of the 'Yamanaka factors' (Named after Japanese scientist Shinya Yamanaka/山中伸弥), and green pheasant is the national bird of Japan.
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moltensilica · 2 years
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【CE Character Profile】p53 (1)
'My only concern is the Fidelity.'
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【Basic Info】
Name: p53
Rarity: Version-exclusive 6-star
Title: Guardian of the Genome
Race: Protee
Code name from the Genome: TP53
Intro: The present leader of 'The Suppressors', whose aim is the constancy of the Fidelity.
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【Stories】
◇Personal Stories
they were a tricky freak.
It was almost all Protees' first impression of p53. their overpowering trait, combined with irascible personality, led to causing trouble in their race frequently.During their growth, none of Protees felt that this strong but simple-minded substance could do anything great. After all, even though the 'Birth Sequence' gave you unmatched power, if you don't know how to use it properly, what is the meaning of the power?
One day, p53 realized this finally. they began to be confused. They didn't see their own prospect. They didn't understand the meaning of their own existence.
At that very time, a Protee came to give their guidance.
②[Unlocked at Faith Level 2]
p53 and their mentor stood in front of the Genome, looking at the majestic stone pillar group.
Although they had already heard about it from other substances, they were still amazed when standing at the foot of the Genome in person. What kind of workmanship could create this miracle?
'Why do we have to protect it?' Astonished, the young asked.
'Because it is where we originated from.' The mentor kept staring at the stone pillars in front of them. 'Do you see those golden runes? These are the "Birth Sequences", which determine your appearance, character, and power. Protee couldn't arise without them. Besides, the Genome is the core of the world as well, supporting the normal operation of this world. All Protee should show esteem to the GREAT Genome.'
The mentor sighed deeply.
'However, there are always substances who have lousy ambition about the Genome. Now a group of Protees holds a delusion of changing the Birth Sequences and alienating the Genome. What appalls me is that they call it "reform and rejuvenate the world". Renegade! How dare they desecrate their birthplace?'
'I see, mentor.' p53 replied.
'You must guard it.' The mentor turned his head. 'p53, you still have great potential, and you are a "transcription factor" who is able to read and manipulate runes. I believe you are the best one to guard the Genome. And I also believe that with your efforts, the Fidelity will be constant and the Genome will be immortal.'
ps:Here is another version of personal story②, translated by Lamiale. Thanks a lot!
p53 and their mentor admire the forest of stone pillars. Despite having heard of the Genome from other members of the clan, the majesty of the of the pillars have shaken the hearts of the duo. The craftsmanship required to create such wonder was unimaginable. "Why do we have to protect the Genome?" The young asked, struck with awe. "For it is where we were born from, " the mentor did not move their eyes for an inch. "Could you see the golden runes engraved upon the stone? They are the Birth Sequences, the origin of your look, disposition - and your power. Protee wouldn't have existed without them. The Genome is the core of our world as well, the very foundation of its various operations. All Protee should hold the Genome in high esteem. " The mentor took a deep sigh. "Alas, there have always been some substances whose filthy fantasy is to meddle with the untouchable. A group of Protees conspire to change the Birth Sequences and alter the Genome, justifying their act as rejuvenation of the world - traitors! How dare they sacrilege their cradle of emergence?" "I understand it now, mentor, " p53 answered. "It's your duty to guard the Genome, " the mentor turned to p53. "p53, you have great potential. With your abilities to read and manipulate the runes as a transcription factor, you are the best candidate as the guardian of the Genome. With your efforts, the Fidelty will be constant, and the Genome will be immortal. "
③[Unlocked at Faith Level 3]
'...At all costs.'
This was what p53 thought of, and how they did.
They would send substances with healing ability to safeguard the Genome, maintaining the healthy condition. This was a merciful aspect of p53, which was commonly ignored.
Because they would stab their sword ruthlessly at those who threatened the security of the Genome.
They were absolutely cruel, their hands soaked in blood.
They didn't regret it, however, for their only pursuit is the constant Fidelity.
'They were as grumpy as before.' Some Protee said.
'They were as bigoted as that leader.' Some Protee said.
p53 cared little about opinions of themself - most of which were negative. Compared with the Fidelity, how did the gossip from others weigh?
④[Unlocked at Faith Level 4]
Power was not the greater the better.
p53 was fierce originally, which lead to excessive use of their power. Relying on force to solve problems for years, the habit seemed to degrade their thinking ability.
It was hard to judge whether their sword was always killing the evil, but what was definite was that the way he ascend to the lead of 'The Suppressors' was full of violence.
Their power was far beyond the expectations of their mentor and continued to be developed, used, and strengthened. Eventually, no one could ignore the mighty substance. They became unmatched and brought catastrophe to the world.
The haughty, overpowering 'guardian of the genome' was knocked off their pedestal afterward, shackles of shame put on them and the sculpture of the guardian. The largest sculpture, which was located in front of the headquarters of 'The Suppressor', became a cage of p53's power.
Was it retribution? It might be, p53 thought.
⑤[Unlocked at Faith Level 5]
No one could expect that the extremely loyal guardian would destroy the guarded thing personally.
But that's what out-of-control p53 did.
No substance could forget that catastrophe. Countless destroyers were summoned from the 'Birth Sequence', ruining everything in the world. Some even voluntarily joined the feast of destruction and became traitors to the world.
The Genome became ramshackle.
After this catastrophe, what awaited p53 was not only the contempt of all substances, but also the turbulent Lake Proteasa.
'But the Genome needs to be guarded! In this world we cannot find a substance stronger...'
' "Guard"? How dare they talk about guard? Think, who almost chopped the Genome into pieces? Who summoned those monsters? Who caused this disaster? They have already committed a heinous crime, and yet you are here to plead for them. Don't you feel guilty about the dead and the world?'
'Isn't there any other way? A kind of seal magic... Just make sure the power is within a certain range... The Genome can't be without a guardian, especially an excellent one like they.'
'...'
'I accept to be sealed, Life Arbiter.'
'...'
'What a nuisance. I have a friend who is good at this kind of magic. But if it doesn't work, they will still be executed.'
◇About...
<About themself>
I am the leader of 'The Suppressors', whose aim is to eliminate any threat to the core of the world and to maintain the Fidelity. If you share the same goal, we can consider cooperation.
[Unlocked at Faith Level 4]Title? My title is...(*sigh)  Guardian... of the Genome.
[Unlocked at Faith Level 5]...I may not deserve the title.
<About 'The Suppressors'>
It is an organization established by my mentor. When I take over it from my mentor, I was actually very hesitant. I am only a warrior, after all. I am not good at managing and handling documents. Now it seems that it is appropriate to let my mentor take the leadership. In addition to the reasons above, they are understanding, gentle, and trustworthy.
<About 'The Reformers'>
I have said many times - THEY ARE 'THE TRAITORS'! A bunch of Protee traitors who DARE to ruin their birthplace. HOW DETESTABLE! And their leader - a 'transcription factor' as well - should have been the perfect candidate to manage information of the Genome... Really disgusting.
<About the Genome>
Majestic and mysterious, it is where my race was born from. I wish it could stand forever ... Well, I'm afraid not... A bunch of traitors is going to tamper with the 'Birth Sequence' inside and dignify it as 'Reorganizing the Genome. Rejuvenate the world'. I'd rather let the Genome weather and collapse in a thousand years than tolerate its evil-like rebirth! 'Let the Fidelity be constant and the Genome immortal.' this is what my mentor expects, and what I pursue for life as well!
<About Rb>
Yes, they are my mentor. I would have spent my life in a muddle if they hadn't enlightened me. Not only for me, but also for other 'Suppressors', they are also dedicated and patient, expending a lot on our organization.
[Unlocked at Faith Level 4]But I surely let them down.
<About c-Myc>
Yuck, the traitorous leader. How do they come up with the idea? 'Adjust the "Birth Sequence"'? No one is allowed to alter the Genome! Yet they title themself as 'zeroer' and 'reformer', spending all their time with Protees under them planning something shady... Oh, I remember, they have three disreputable friends. they are brainwashed, I'm sure. How can a normal Protee meddle in their birthplace?
<About Ubiquitin>
The Life Arbiter and executioner of my race, enjoying a high reputation, is in charge of funeral arrangements and execution. That's all. Wait, you want to learn more? Alright. They are a cruel substance who is always smiling. Anyway, all Protees, including me, respect them.
[Unlocked at Faith Level 5]The reason? ... (*a long pause) I almost drowned after being thrown to the lake by them. Well, It's pretty disgraced, I admit.
<About Mdm2>[Unlocked at Faith Level 5]
...
It's hard to judge the bullshit mouse... I am thankful to them. After all, they helped me stop corrupting in time but, I didn't know it was from the 'Traitors' at all! I accepted the shackles voluntarily, but I didn't want to accept the shackles from enemies! Damn, the 'Traitors' takes hold of me...
<About p14ARF>
This little guy genuinely worships me... Unbelievable. They do have strength. Their slash contains both speed and power. If they continue to practice, they will definitely become a powerful substance. To be honest, it reminds me of myself back then when I saw them - the pursuit of power. I hope they won't get carried away by the goal and corrupt.
[Unlocked at Faith Level 5]As for why I asked him to join the 'Suppressors', except for their power, there was something out of gratitude - they cut those chains.
<About Lake Proteasa>
...
I merely know it's a place where water funerals or execution take place. That's all.
[Unlocked at Faith Level 5]...Do I have to say it? Alright. It's a place where water funerals or execution take place, and where I nearly lost my life. Enough?
<About Cherry Blossom Hill>
I hardly go there, yet the cherry forest does look good - and look better without a  traitor.
<About shackles>
...
Are you sure? But I can only tell one thing now: shackles represent fetter.
[Unlocked at Faith Level 4]My power is beyond control and needs to be repressed from the outside. Once I wield excessive power, the chains and rings will contract and release seal magic... It feels bad. But don't be ashamed of me. It's my fate.
<About Helix Monarch Sword>[Unlocked at Faith Level 2]
It was in Altar Relic that I found the sword... What? I stole it? It came to me on its own! Flying into my hand automatically when I saw it! Hiss ... That was strange. But the sword is powerful indeed. It can even manipulate the 'Birth Sequence' ...
Helix Monarch Sword? I just named it myself. Who knows what it was originally called? It's not my talent to do something fancy. I give it the name just because it is powerful and has a helix decoration.
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【Voice of Character Interface Click】
◇Leave me alone if there's nothing necessary.
◇I have to tell you something first: the Genome is not accessible to everyone.
◇[Unlocked at Faith Level 2]Alas... There are still substances who do not understand the importance of the Genome.
◇[Unlocked at Faith Level 2]I'm no longer the average Protee, but the most powerful 'transcription factor' and guardian in the world!
◇[Unlocked at Faith Level 3]You are actually afraid of me, right? I don't mind it. Anyway, a lot of substances regard me as a demon. But you have to sacrifice something for the Fidelity, isn't it?
◇[Unlocked at Faith Level 5]... After learning about my past, are you still willing to get along with me?
◇[Unlocked at Faith Level 5]The power is unmatched and hard to hold as well... If I lost control again and destroy the whole world, I won't be able to call myself a 'guardian' then.
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moltensilica · 2 years
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<pRb and DNA>
The giant one was known to all. It was the first guardian-type artificial spirit and (maybe) Dowlinar's first friend as well. Rolabert Heatwo Knudson - This was its name. The first time it saw the little human, the implanted consciousness told it: She was the one who you should protect. But Rolabert didn't know the reason lying behind it. It just did the mission by instinct set by The Pocessing Plant. As time goes by, Rolabert, however, seemed to aware of the reason.
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moltensilica · 2 years
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'When autumn leaves started to fall.'
The word 'apoptosis' is from Ancient Greek word 'ἀπόπτωσις', which means 'falling off (of flowers, leaves, etc.)'
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moltensilica · 2 years
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Element Sacredsoul of Sulfur
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moltensilica · 2 years
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p53 in Catholicell
Rarity: Definite 6-star Title: Guardian of the Genome Race: Protee Code name from the Genome: TP53 Intro: The present leader of 'The Suppressors', whose aim is the constancy of the Fidelity.
Stories: click here
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moltensilica · 2 years
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<Cancer Biology SE>
Real Name: Cancibio Name for External Situation: Crabinoma/谢炎 Other Name: Cancie/Miss Crab Constellation: Cancer Entity Gotten Time: ancient Greece (unproven)
More Info:
She likes to wear the crab hat when in casual occasions. The ring of 'hallmarks of cancer' on her back is a holographic projection, and the projection device is hidden in her clothes. 2.She likes to eat chicken.
She works as a researcher in the human society, working closely with genetics SE (an abbreviation of Subject Entity) and others, occasionally going to hospitals to do odds and ends. 4.She is a proto-oncogene lover, but she likes tumor suppressors as well (though to a lesser extent).
In spare time, she also plays games, and is a game master among life science SE. She knows how to upgrade skills properly and develop her influence safely and secretly.
She is very observant and always notices of details. 7.Perhaps she has a spirit of resistance in her minds - that resists the pessimism of "incurable disease", and the mighty "emperor of all maladies". For centuries, she has encountered numerous know how many obstacles and misunderstandings. But she does not mind it because of her firm goal - do "regicide" together with human beings, so that the unbeatable tyrant becomes history.
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moltensilica · 2 years
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a brief introduction to me, inspired by The Hallmarks of Cancer
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moltensilica · 2 years
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‘For Stellorbit, the astronomy Subject Entity, those "burning ones" who dedicate everything to the truth are the lights that guide her forward, isn’t it?’
The English word ‘star’ has originated from ‘aster’, an ancient Indo-European word (another opinion is that it’s an ancient Greek word) which means ‘the burning one'.
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