Excerpt:

In a new study, Yale researchers show that a single dose of psilocybin given to mice prompted an immediate and long-lasting increase in connections between neurons. The findings are published July 5 in the journal Neuron.

“We not only saw a 10% increase in the number of neuronal connections, but also they were on average about 10% larger, so the connections were stronger as well,” said Yale’s Alex Kwan, associate professor of psychiatry and of neuroscience and senior author of the paper.

Previous laboratory experiments had shown promise that psilocybin, as well as the anesthetic ketamine, can decrease depression. The new Yale research found that these compounds increase the density of dendritic spines, small protrusions found on nerve cells which aid in the transmission of information between neurons. Chronic stress and depression are known to reduce the number of these neuronal connections.

Using a laser-scanning microscope, Kwan and first author Ling-Xiao Shao, a postdoctoral associate in the Yale School of Medicine, imaged dendritic spines in high resolution and tracked them for multiple days in living mice. They found increases in the number of dendritic spines and in their size within 24 hours of administration of psilocybin. These changes were still present a month later. Also, mice subjected to stress showed behavioral improvements and increased neurotransmitter activity after being given psilocybin.

For some people, psilocybin, an active compound in “magic mushrooms,” can produce a profound mystical experience. The psychedelic was a staple of religious ceremonies among indigenous populations of the New World and is also a popular recreational drug.

Static versions of the chibis I've been working on, featuring Kitti, Rose, Lilly, and Garish. :3 🎨 General art tag. 💫 Knights of Nodd 

Okok so you've smoked outta a pumpkin stem as the weirdest thing you've used to do your thing. But Psiloc, what's like, the funniest/strangest (not worst) thing you've ACTUALLY smoked?

"aaaaa fuckin' uhhhhh.... clown horn. y'know. them fuckin' honka honka things." -> The mimics the motion of honking a clown horn

Shu receives a message from "psychedelicSage". It was Psiloc of all trolls messaging him [PS] hey lil man... i uh... sent you a package. dunno when it's supposed to show up but like... found this lil jacket i thought u'd like or somethin'. it might be a lil big on ya since i'unno ur size or whateva. i made sure it was cleaned tho. hope ya like it, lil bud. lmk if u don't.

" ? "

Why is he of all people messaging you? You bit your lip, suddenly becoming lost in thought for a moment before you go to locate said package. Slowly opening it you give it one look over, letting out an irritated huff.

Of course it's far too big.

Why is this guy like this? From the moment you accidentally crossed paths with him nonsensical thoughts have plagued your mind. The strange abbreviations, the way he treats you like some sort of house cat. Worst of all though;

Nothing you do seems to bother him.

" Can you sTop hogging all The mail you sopor slime-brained moron? Don'T Tell me you've finally shorT ciruiTed? "

Holding the oversized jacket a little closer, you turn to your hivemate.

" just give me a mooment, looser. "

She goes quiet for a moment, not expecting the sudden clap-back.

" Eugh. Fine. "

As she walks off you think over the emotion known as hate. Unfamiliar signals firing off in your brain whenever you think about Psiloc, a man who infuriates you to no end. The only person able to infuriate you.

...You suppose there's something special to be had there.

Picked up my tablet for the first time in about five months.

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BUY MICRO MUSHROOMS ONLINE

https://asapexpress.center/product/micro-mushrooms/

Micro Mushrooms In the world of psychedelics, a “micro” dose is an amount of that is considered sub-perceptual for the user – not intended to get you “high” or drastically affect your perception in any way, but utilizing the drug in lower doses for a variety of alternative benefits. Users micro-dosing psychedelic mushrooms typically do so to combat depression or anxiety, enhance their creativity, energy levels, focus and senses overall – often with amazing results. Micro mushrooms Our microdoses contain a custom blend of our Cubensis and Mexicana strains, packaged in easy to swallow capsules in .2 gram doses (1/5th of a gram.) Buy Now Each order contains 30 individual capsules. (i.e. a quantity of 1 chosen below = 30 capsules, not just one.) Email: [email protected] WHATSAPP :  +371 25 298 304

Johns Hopkins Wants To Hear About Your Psychedelic Journeys For New ‘Real-World’ Study

Planning to trip on shrooms anytime soon? If you’re willing to fill out a few surveys, your experience could help chart the future of psychedelic science.

Researchers at Johns Hopkins University, who have been at the forefront of psychedelics studies in a lab setting, are partnering with a Denver-based nonprofit to gather thousands of real-world experiences with psilocybin, the main psychedelic component of so-called magic mushrooms. By diverging from a standard research setting, they’re hoping to gain a better understanding of the factors that influence a trip and its outcomes.

They’re asking people who plan to use psilocybin to share their experiences in order to build a better understanding of the drug’s effects outside a laboratory setting—at festivals and in nature, for example.

“Because our research is ‘real world,’ allowing participants to enroll for any reason and participate in any setting, we will learn unprecedented new details about how individuals are choosing to use this substance,” said Del Jolly, co-founder and director of Unlimited Sciences, the nonprofit funding the study. “We hope to grow our understanding with a large survey set.”

Any English-speaking adult planning to use psilocybin within the next six months can sign up to join the study. “Your input,” the website says, “could materially evolve our collective scientific understanding of psilocybin’s effects on the human mind.”

If that sounds like a worthy goal, be forewarned that there’s homework. Participants will be asked to take up to five surveys about themselves and their psilocybin experiences—one survey two weeks before taking psilocybin, the next in the hours before use, another in the days following the experience and then two follow-up surveys in the weeks and months afterward. Each survey is expected to take between 10 and 30 minutes to complete.

“Participants will be asked to describe details of both their ‘set’ (state of mind) and ‘setting’ (physical situation) at up to six time periods surrounding a planned psilocybin dose,” according to an Unlimited Sciences press release, “to isolate variables of experiences and how they relate to health and other outcomes.”

Researchers at Johns Hopkins have been studying psychedelics for decades, and last year the university launched a first-of-its-kind psychedelics research center. The Center for Psychedelic and Consciousness Research has focused primarily on potential therapeutic uses for psychedelics, such as smoking cessation and treatment for depression, Alzheimer’s disease, anorexia and opioid withdrawal. Assembling a repository of real-world data, Unlimited Sciences says, could help identify areas for future investigation.

“By expanding the study to include far more examples of real-life usage and outcomes, we can continue to learn more and refine our research,” said Heather Jackson, the nonprofit’s board president. “A study of this type can direct future controlled clinical trials.”

As with cannabis, the recent resurgence of interest in psilocybin and other psychedelics has propelled an effort to better understand the science behind the drugs’ effects. Unlimited Sciences was inspired by Realm of Caring, a nonprofit started in 2013 to gather data on how cannabis was being used medically.

“In late 2018, the founders of Unlimited Sciences saw a similar need,” Unlimited’s website says: “To collect scientific data and testimonials about how people use psychedelics in their lives.”

In the current study, Unlimited and Johns Hopkins want to learn more about the positive and negative outcomes of psilocybin use as well as factors that could influence those outcomes. “We aim to investigate variables such as demographics, lifestyle, mindset, and personality traits,” the study website says, “as well as characteristics of the experience itself such as dosage, ingestion method, intention, and setting, that could influence psilocybin’s long-term effects.”

As academics continue to investigate the effects of psilocybin and other psychedelics, advocates for safe access are making headway in both the U.S. and Canada.

Voters in Oregon this year will consider a ballot measure that would legalize psilocybin for therapeutic use as well as  separate proposal that would decriminalize all drugs and invest in treatment. In Washington, D.C., meanwhile, activists have qualified a measure for November’s ballot that would decriminalize plant- and fungi-based psychedelics, including psilocybin, ayahuasca and ibogaine.

Earlier this month in Canada, four cancer patients in end-of-life care successfully petitioned the country’s health minister to exempt them from the country’s laws against psilocybin, allowing them to legally use the drug as part of psychotherapy treatment. “This is the positive result that is possible when good people show genuine compassion,” said Thomas Hartle, one of the first Canadians in decades who will be able to use psilocybin legally. “I’m so grateful I can move forward with the next step of healing.”

Canada Will Let Terminally Ill Patients Use Psychedelic Mushrooms For End-Of-Life Care

Photo courtesy of Wikimedia/Workman

The post Johns Hopkins Wants To Hear About Your Psychedelic Journeys For New ‘Real-World’ Study appeared first on Marijuana Moment.

from Updates By Jane https://www.marijuanamoment.net/johns-hopkins-wants-to-hear-about-your-psychedelic-journeys-for-new-real-world-study/

💫 Garish💫 Knights of Nodd 🎨 General art tag.

Psiloc Judgements

Come see what this blazed af clown thinks of you.

Hey Shu. Have you ever tried to figure out why nothing seems to bother Psiloc? Like normally something bothers someone.

" ooh i've tried. several times. althoough i haven't really tried toooo hard too push his buttoons. i'm just trying too get a reactioon noot get him too punch me. "

" dooesn't help he seems toooo see my attempts as "cute". idioot. "

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