#afm logistics
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International Logistics Companies In India
Look no further in your quest for exceptional cargo companies in New Delhi, as AFM Logistics stands head and shoulders above the rest. The company provides high-quality logistics and transport services at cost-effective prices 24/7 – 365 days. AFM Logistics is an international logistics companies in India which is fully-licensed IATA, WCA cargo agent, and CHA-approved company that is known for its tailored solutions for all logistics needs.
The Company has a consolidated presence all across the supply chain verticals and provides one-stop solution to the customers to manage their own supply chain needs. we handle all kinds of specialized cargo such as priority cargo, perishables, oversized and fragile items. With the capability of offering single window end-to-end logistics solutions for dry bulk, containerised, break bulk and project cargo, TMILL offers a diverse portfolio of logistics services including Port Operations, Shipping, Freight Forwarding, International Freight Forwarders , Contract Logistics ,Custom House Agency, Project Logistics, Transportation and Distribution, Inland Logistics, Warehousing, Ship Agency, Rail Logistics & Supply Chain Management and many more to the list. We cater to major airports, seaports, and borders nationwide, offering an exceptional array of multilayered services encompassing air, sea, and road freight for both domestic and international consignments. We have served numerous domestic as well as international clients by transporting their shipments through air, road, and ocean freight. We build unique solutions according to your needs, with the services and modes that benefit you the most.
URL: https://afm.net.in/international-logistics-companies-in-india/
#IMPORT#EXPORT#shipping freight#freight forwarders#air freight#afm logistics#logistics#cargo#ocean freighy
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AFM Logistics stands out as one of the best air freight agents in India, offering unparalleled service and efficiency. With a robust network and expertise in handling various types of cargo, AFM ensures timely and secure delivery across international borders. Their commitment to customer satisfaction and comprehensive solutions makes them a preferred choice for businesses seeking reliable air freight services. es
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How and When to Choose a Transport Management System
Transport Management Systems (TMS) have become an integral part of the logistics and supply chain industry. They streamline operations, improve efficiency, and reduce costs. But how and when should you choose a TMS for your business? Let’s delve into this.
Understanding Transport Management Systems
A Transport Management System is a software solution designed to manage and optimize the daily operations of your transportation fleet. It encompasses everything from route planning and optimization, freight audit, payment, order visibility, carrier management, and reporting & analytics.
When to Consider a TMS?
The decision to implement a TMS often comes when a business identifies certain challenges or opportunities for improvement. Here are some signs that it might be time to consider a TMS:
Growing Operations: As your business expands, managing transportation manually can become increasingly complex and time-consuming. A TMS can automate many of these tasks, freeing up valuable time and resources.
High Transportation Costs: If your transportation costs are eating into your profits, a TMS can help. It can optimize routes and loads, negotiate better rates with carriers, and provide visibility into your operations to identify areas for cost savings.
Lack of Visibility: If you’re struggling to track shipments and provide updates to customers, a TMS can provide real-time visibility into your supply chain, improving customer service and satisfaction.
Complex Compliance Requirements: Navigating the regulatory landscape can be challenging. A TMS can help ensure compliance with regulations, reducing the risk of costly fines and penalties.
How to Choose a TMS?
Choosing the right TMS involves careful consideration of your business needs, budget, and future growth plans. Here are some factors to consider:
Functionality: Ensure the TMS has the features you need. This might include route optimization, freight audit and payment, carrier management, and reporting capabilities.
Integration: The TMS should easily integrate with your existing systems such as ERP, WMS, and order management systems.
Scalability: As your business grows, your TMS should be able to scale with you. Look for a system that can handle increased volume and complexity without performance issues.
User-Friendly: The system should be easy to use. A user-friendly interface and good customer support can significantly reduce the learning curve and ensure a smooth transition.
Cost: Consider both the upfront and ongoing costs. While a TMS can provide significant cost savings over time, it’s important to ensure the investment fits within your budget.
Manage user business from anywhere anytime with our Mobile apps and multi device web application- Avaal Technology
Technology is critical to the success of transportation companies these days. Having comprehensive and easy to use freight management software will help your business become more efficient and successful. AFM line of products includes AFM Suite, a cloud-based freight management suite, and AED Suite, a desktop-based software. Both come with multiple versions to accommodate your operations whether you are a freight carrier, auto hauler, intermodal, broker, or a 3PL company. AFM and AED come with four core modules: Dispatching, Accounting, Safety, and Reporting.
Quick create order.
Create Bulk Order
Quick Miles/Route
Edit Order List
Monthly and Yearly affordable plans.
5-100 trucks*
eManifest Integration
Unlimited Driver
Dispatching Module
Accounting Module
Safety and Compliance module
Reporting Module
Free training
24/7 Live Support
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Avaal Freight Management (Transport Management System).
#trucking#trucking company#truck load#truckingindustry#logistics#truckinglife#trucking factoring#avaal#ontario#canada#unitedstates
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In today’s accelerating transportation and logistics sector, operational efficiency and streamlined processes are paramount. Avaal Technology rises to the occasion by offering comprehensive truck dispatch software solutions and more, cementing its position as a valuable ally for the transport industry. With over 20 years of experience, Avaal provides an all-in-one platform encompassing trucking dispatch, fleet management, safety and compliance, and accounting aimed at enhancing operational efficiency and real-time tracking for carriers, freight brokers, and freight forwarders.
Avaal’s truck dispatcher software not only facilitates efficient route planning and live tracking but also integrates vital features such as driver settlements, invoicing, and freight tracking, making it a contender for the best trucking dispatch software solution in the market. Its commitment to innovation is further highlighted by its cloud based TMS software options and mobile app support, ensuring accessibility and seamless management for users on the go. With Avaal’s solutions, businesses are equipped to achieve peak performance, propelled by Avaal’s expertise in training, consulting, and cutting-edge software tailored to the modern demands of the transportation industry.
Key Features of Avaal’s Truck Management Software
Comprehensive Software Suites
Avaal offers a robust array of software solutions tailored for the transportation industry. The AFM Suite, designed to meet for automating critical business processes, includes features for ACE/ACI e-Manifest submissions essential for efficient cross-border transportation. Additionally, the AEM Suite enhances operational efficiency by streamlining order and customer management system. AFN Connect links freight carriers, brokers, and shippers for networking and collaboration to optimize load matches and reduce empty miles. One of the most time taking operational work is of manual data entry into their Tms which is automatically extracting the data from documents etc.
Mobile Application Integration
To ensure accessibility and convenience, Avaal provides mobile applications like AFM Driver and AEM Driver Apps. These apps extend the capabilities of Avaal’s software suites to mobile platforms, allowing users to manage transportation workflows effectively from anywhere.
Diverse Software Offerings
Avaal’s product lineup includes the AFM Suite, AED Suite, and Avaal Freight Network (AFN) Connect. These products offer seamless integration, user-friendly interfaces, and 24/7 support, making them highly effective for modern transportation.
Advanced Truck Management System (TMS)
Avaal Technology’s TMS integrates tools and features that facilitate the planning, execution, and optimization of trucking business operations. This system provides:
A unified interface for managing all aspects of the transportation workflow.
Enhancing visibility into the supply chain.
Improving delivery timelines.
Customization and Automation
The AVAAL Freight Management Suite offers features like automation, customization, and integration with major third-party providers. It supports multi-company management and provides a multi-version platform suitable for various transportation needs such as dispatch, brokerage, and auto hauler.
Desktop and Cloud-Based Solutions
Avaal provides both desktop-based and cloud-based TMS solutions. AVAAL Express Dispatch, a desktop-based TMS option, along with the cloud-based AFM Suite, offers robust automation and customization capabilities. These platforms are designed to cater to asset based carriers, freight brokers, and freight forwarders, enhancing freight accounting, auditing, and tracking.
Enhanced Security and Efficiency
Avaal’s truck dispatch software simplifies compliance with local regulations and offers real-time tracking of trucks and freight. It also streamlines accounting processes and improves order management, saves time and money while enhancing security and accuracy compared to traditional methods.
Integrated Accounting Features
The software includes a seamlessly integrated accounting system developed specifically for trucking & freight forwarding companies. This system facilitates time savings, improves customer relationship management and customer service, and addresses the specific financial management needs of the trucking industry. Additionally, it integrates with QuickBooks for efficient synchronization of financial transactions.
Paperless Operations and Real-Time Tracking
Avaal’s trucking software supports paperless operations and provides features for real-time tracking, simplified invoicing, and payroll management. This leads to streamlined order management and dispatch process & operations, ensuring compliance with regulations, and enhancing overall operational efficiency.
The Role of Avaal Technology in Enhancing Logistics and Transportation
Avaal Technology Solutions stands out as a pivotal force in revolutionizing logistics and transportation management. Known for its innovative logistics solutions, Avaal optimizes operations and significantly boosts profitability for businesses involved in freight management. The company’s approach not only enhances operational efficiency but also appeals to a broad spectrum of logistics stakeholders, from managers to truck drivers, by increasing profit margins and streamlining processes.
Sustainability and Innovation
A crucial aspect of Avaal’s innovation is its dedication to sustainability, mainly through initiatives to reduce empty miles, thereby contributing to environmental conservation. This commitment positions Avaal as a forward-thinking leader in the logistics sector, ready to meet future challenges and opportunities.
Enhancing User Experience
Avaal’s technology blends advanced technical sophistication with a user-centric design. This combination ensures that all users, regardless of their tech expertise, find the software intuitive and capable of meeting the rigorous demands of the logistics industry. Testimonials from industry users’ further evidence the positive user experience. Essi Torabi from Silver Start Transportation remarks on the efficiency improvements seen with Avaal Express software, noting significant operational enhancements. Similarly, Binny from Speed X Logistics highlights the exceptional support provided by Avaal’s dedicated team.
Operational Improvements and Professional Branding
Avaal not only assists in streamlining operations but also aids businesses in expanding through the acquisition of necessary permits and certifications. Additionally, it offers customized corporate branding solutions that enhance businesses’ professional image. Satwant Singh of Silver Start Transportation praises the software for its performance and its comfort to their accounting department.
By integrating these elements, Avaal Technology Solutions redefines the standards of efficiency and profitability in the logistics and transportation industry, ensuring businesses are well-equipped to thrive in a competitive market.
Integration Capabilities with Third-Party Providers
Avaal’s truck dispatch software stands out for its robust integration capabilities with various third-party providers, ensuring a seamless and efficient operational experience. Here are some key integration features:
Core System Integration: Avaal’s CORE system allows integration with API-enabled third-party providers, enhancing flexibility and connectivity across various platforms.
Electronic Logging Device Compatibility: The software supports integration with popular ELDs like Samsara, which are crucial for compliance and fleet performance and management.
Comprehensive Mobile App Integration: Avaal integrates with its own mobile applications and major third-party providers, offering a complete real time solution that caters to diverse transportation and logistics needs.
Creating API Tokens for Integration: Specific API tokens are required for integration with Samsara, and detailed instructions are available in the Samsara API documentation. This process involves creating a token with granular scopes and sending it to an Avaal representative to enable the integration.
Support and Configuration Assistance: Once the API token is created and submitted, Avaal’s support team assists with the configuration and guides users through the necessary steps to activate the integration, ensuring a smooth setup process.
Extended Integration with Avaal Express: Avaal Express supports third-party integrations with various applications, including PC Miler, Avaal eManifest, EDI, Loadboard, Customer Portal/App, and QuickBooks, enhancing the software’s utility and adaptability.
Customization for Various Business Sizes: Avaal’s eManifest software, which facilitates compliance for U.S.-Canada border crossings, is customizable to meet the needs of different trucking companies, from single operators to multinational corporations.
Through these integrations, Avaal not only simplifies the management of transportation and logistics operations but also ensures that businesses can leverage the best tools in the industry to enhance their operational efficiency and compliance.
User Experience and Support
Avaal’s dedication to providing a seamless user experience is evident through its comprehensive support system and user-friendly software design. Customers satisfaction & benefit from 24/7 access to support via phone and chat, ensuring that help is always just a call or click away. The software’s intuitive interface is complemented by various support options tailored to enhance user interaction and satisfaction.
Comprehensive Support Options
Avaal offers a robust support system that includes:
24/7 Phone and Chat Support: Users can contact the support team at any time for assistance with software integration, troubleshooting, or general queries.
Email and Help Desk: For less immediate concerns, users can email Avaal at [email protected] or utilize the help desk for detailed support.
Knowledge Base and FAQs: A well-organized knowledge base and frequently asked questions (FAQs) section provides users with quick answers to common issues and guidance on using the software effectively.
Training and Educational Resources
Avaal is committed to enhancing the industry knowledge of its users through:
Specialized Training Courses: Offering courses in Trucking Dispatch, Safety & Compliance, and Transportation of Dangerous Goods, available in multiple locations and online.
Customizable Learning Options: Courses are scheduled for weekdays and weekends, accommodating the diverse availability of participants.
Consulting and Additional Services
In addition to software solutions, Avaal provides valuable consulting services:
Trucking Authorities and Certification: Assistance with obtaining necessary certifications and authorities for trucking operations.
Corporate Branding and Customs Bonds: Services include help with corporate branding and securing customs bonds, which are essential for cross-border operations.
By integrating these elements, Avaal ensures that every user has access to top-tier software solutions and receives the support and resources needed to optimize their operational efficiency and compliance.
Pricing and Subscription Models
Avaal Truck Dispatch Software offers flexible subscription models tailored to meet the needs of businesses of various sizes, from freelancers to mid-size and small businesses. Here are the detailed pricing and subscription options:
Subscription Flexibility
Avaal provides options for both monthly and annual subscriptions, catering to different business requirements and budget constraints.
Pricing Details
Avaal Express Trucking Management Software:
Monthly Subscription: Starts at USD 99 (CAD 150).
Annual Subscription: Contact Avaal directly for yearly pricing options.
Free Trial: Available to help businesses evaluate the software before committing long-term.
Business Size Suitability
Freelancers: Avaal Express is designed to accommodate the operational needs of independent truckers and small operators.
Mid-Size Business: Offers features that help manage more complex logistics and dispatch operations.
Small Business: Tailored features that simplify small-scale businesses’ dispatch, expenses, and communication operations.
Contact for Custom Quotes
For businesses interested in custom solutions or those needing more specific information on pricing, Avaal encourages direct contact to discuss tailored subscription plans and pricing.
Desktop and Cloud-Based Options
Avaal Desktop Based Freight Management Software (AED): Available with options for both monthly and annual subscriptions, providing flexibility in software deployment based on business needs.
Conclusion
Throughout this exploration of Avaal’s truck dispatch software, we’ve witnessed an extensive showcase of how such technology can revolutionize efficiency, compliance, and overall operational effectiveness within the transportation and logistics sector. By integrating crucial features like efficient route planning, real-time tracking, mobile app integration, and comprehensive support for third-party integration, Avaal positions itself as an indispensable tool for businesses aiming to navigate the complexities of modern-day logistics. Its relentless focus on customization, automation, and user experience enhancement further underscores its commitment to meeting the diverse needs of its clientele, from independent operators to multinational enterprises.
Moving forward, the role of Avaal Technology in simplifying logistics operations, reducing operational costs, and driving sustainability initiatives cannot be overstated. The broad implications of these advancements promise not only to elevate the standards of logistical operations but also to pave the way for more sustainable and efficient practices in the industry. As businesses seek solutions that provide a competitive edge, Avaal’s continuous innovation and dedication to user support offer a clear pathway to achieving operational excellence. For stakeholders in the transportation industry, Avaal’s logistics software is not just a tool but a strategic partner in the pursuit of optimization and growth.
FAQs
Q: What is the most recommended course for truck dispatch training?
A: Avaal Technology Solutions is recognized as the premier provider of Truck Dispatcher Training Courses in North America.
Q: Can you describe Avaal Express?
A: Avaal Express is an all-encompassing trucking management software that integrates features such as dispatching, fleet management (mid-size, small-size, large size) driver management, safety and compliance (Bill of lading, shipping documents), and accounting into a single, user-friendly platform. Avaal Express offers various versions to fit the diverse needs and requirements of its users precisely.
Checkout Our Courses:
Truck Dispatch Training In California
TMS
Consulting
Fuel Card
#truckdispatchercourse#truckdispatchingcourse#trucking company#truckingdispatchcourse#avaal#truckingindustry#trucking#california#tms
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Revolutionising Resource Management with Advanced Fuel Management Systems
In an era where sustainability and efficiency are paramount, the quest for innovative solutions to optimise resource management has become imperative. Among the critical resources under scrutiny, fuel stands out as a focal point due to its widespread usage across industries and its significant impact on both economic and environmental landscapes. In response to this challenge, the advent of Advanced Fuel Management Systems (AFMS) heralds a new chapter in resource management practices. These sophisticated systems integrate cutting-edge technologies and strategic methodologies to not only streamline fuel usage but also minimise waste, reduce costs, and mitigate environmental footprints. This article delves into the transformative potential of AFMS, examining how they are reshaping traditional paradigms and propelling industries towards a more sustainable future.
The Critical Importance of Effective Fuel Management
In today's rapidly evolving industrial landscape, managing resources efficiently is not just an option—it's a necessity for survival and growth. Fuel, being one of the most vital resources across various industries, requires sophisticated management techniques to ensure optimal utilisation and minimal wastage. Enter the advanced Fuel Management Systems (FMS), a transformative solution for businesses aiming to enhance accuracy, security, and productivity in managing their fluid assets. This article delves into the world of Fuel Management Systems, highlighting their significance, components, and the exceptional capabilities they offer to modern businesses, particularly through the pioneering technology brought forth by Banlaw.
Fuel management stands as a linchpin in the operational efficiency and sustainability of numerous industries, ranging from transportation and logistics to manufacturing and construction. With fuel costs often representing a significant portion of operational expenses, any inefficiency or wastage can swiftly erode profit margins and hinder competitiveness. Moreover, in an era increasingly defined by environmental consciousness and regulatory scrutiny, the environmental impact of fuel consumption has become a pressing concern for businesses worldwide. Effective fuel management not only entails optimising consumption to reduce costs but also entails minimising carbon emissions and other pollutants, aligning operations with sustainability goals and regulatory compliance.
Enter Advanced Fuel Management Systems (AFMS), equipped with cutting-edge technologies and intelligent algorithms designed to revolutionise the way businesses manage their fuel resources. Unlike traditional manual methods or basic fuel monitoring systems, AFMS offer a comprehensive suite of functionalities tailored to address the complexities of modern fuel management challenges. From real-time monitoring and precise inventory tracking to automated dispensing and consumption analytics, these systems provide invaluable insights and control over every aspect of fuel usage. Moreover, AFMS leverages connectivity and data integration capabilities to seamlessly integrate with existing infrastructure, enabling businesses to streamline operations, enhance decision-making, and unlock new levels of efficiency and cost savings. One such trailblazer in the field of AFMS is Banlaw, whose innovative solutions are setting new benchmarks for fuel management excellence and driving sustainable practices across industries.
Understanding Fuel Management Systems
Fuel Management Systems (FMS) play a pivotal role across various industries, serving as the cornerstone for efficient fuel utilisation and cost optimization. At its core, an FMS comprises a sophisticated amalgamation of hardware and software components meticulously engineered to safeguard, supervise, and regulate fuel-related activities. Whether in transportation, manufacturing, or agricultural sectors, where fuel consumption significantly impacts operational budgets and environmental footprints, these systems serve as indispensable assets. Through the seamless integration of control mechanisms and advanced analytics, FMS empowers organisations to maintain a comprehensive grasp over their fuel supply chain, from procurement to distribution, fostering enhanced transparency and accountability at every stage.
One of the primary functions of Fuel Management Systems is to ensure the secure and judicious allocation of fuel resources, mitigating the risks associated with unauthorised access or pilferage. By employing cutting-edge technologies such as RFID tags, biometric scanners, and GPS tracking, these systems establish robust layers of authentication and verification, thereby fortifying the integrity of fuel inventories against potential breaches or discrepancies. Moreover, by interfacing with fleet management software and telemetry systems, FMS enables real-time monitoring of fuel consumption patterns, allowing for timely interventions to optimise efficiency and minimise wastage. Such proactive measures not only bolster operational resilience but also contribute to substantial cost savings and environmental stewardship in the long run.
The analytical capabilities embedded within Fuel Management Systems furnish organisations with invaluable insights into their fuel utilisation dynamics, empowering data-driven decision-making and strategic planning. Through sophisticated algorithms and predictive modelling, FMS can forecast future fuel demands, identify areas of inefficiency, and recommend optimization strategies tailored to specific operational requirements. Whether by streamlining route planning to reduce fuel consumption or implementing maintenance schedules to enhance vehicle fuel efficiency, these actionable intelligence derived from FMS pave the way for continuous improvement and sustainable growth. In essence, Fuel Management Systems emerge as indispensable assets in the contemporary landscape, offering a multifaceted approach to enhancing fuel economy, operational efficiency, and environmental sustainability for organisations across diverse sectors.
Banlaw’s Innovative Fuel Management Solutions
Banlaw’s prominence in the fuel management sector stems from its unwavering dedication to providing cutting-edge solutions that address the intricate requirements of industries such as mining, rail transportation, and construction. Through meticulous attention to detail and a keen understanding of sector-specific challenges, Banlaw has established itself as a trusted partner for organisations seeking to optimise their fuel usage and mitigate operational risks. Leveraging advanced technologies like SecureFillTM and ResTrackTM, Banlaw ensures unparalleled precision in fuel monitoring and reconciliation, boasting an impressive track record of surpassing the 99.5% mark in fluid reconciliation rates. This commitment to accuracy not only enhances operational efficiency but also bolsters clients' confidence in their fuel management processes.
A cornerstone of Banlaw's success lies in its continuous pursuit of innovation, driven by a passion for excellence and a commitment to exceeding customer expectations. By staying at the forefront of technological advancements, Banlaw remains well-equipped to tackle emerging challenges and capitalise on new opportunities in the ever-evolving landscape of fuel management. Their specialised hardware and software solutions not only enhance fuel security and efficiency but also streamline regulatory compliance, providing clients with a comprehensive suite of tools to navigate complex industry requirements with ease. Through ongoing research and development initiatives, Banlaw remains poised to revolutionise the fuel management industry, driving progress and empowering clients to achieve their goals with confidence.
In a world where efficient resource utilisation is paramount, Banlaw stands as a beacon of innovation and reliability, offering tailor-made solutions that empower businesses to thrive in competitive environments. By fostering a culture of collaboration and continuous improvement, Banlaw remains dedicated to pushing the boundaries of what's possible in fuel management, driving positive change and delivering tangible value to clients worldwide. As industries continue to evolve and adapt to new challenges, Banlaw remains steadfast in its commitment to providing forward-thinking solutions that pave the way for a more sustainable and efficient future.
Key Features and Functionalities of Banlaw FMS
Banlaw's Fuel Management Systems (FMS) are distinguished by a rich set of features and functionalities designed to streamline the management of fuel resources across various industries. One of the standout features is the comprehensive handling of fuel delivery and storage processes. By accurately matching delivery dockets with physical consignments, Banlaw's systems provide an essential layer of transparency and accountability, minimising discrepancies and ensuring that fuel inventory remains accurately documented. Additionally, the systems support authorised access controls, safeguarding fuel storage facilities against unauthorised usage or tampering. Automated monitoring of fuel storage levels further enhances operational efficiency by providing real-time insights into inventory status, allowing for timely replenishment and optimization of resource allocation.
Efficient fuel dispensing is another key aspect of Banlaw's FMS, aimed at reducing fuel theft and enhancing fueling procedures. Leveraging advanced technologies such as Auto ID, Banlaw's systems enforce strict authentication protocols to ensure that fuel is dispensed only when proper identification is provided. This not only mitigates the risk of unauthorised fuel usage but also promotes accountability among users, fostering a culture of responsible fuel management. By automating the dispensing process, Banlaw's systems minimise human error and optimise throughput, enabling organisations to maximise the utilisation of their fuel resources while minimising waste.
At the heart of Banlaw's FMS lies the ResTrackTM software, a powerful tool that empowers organisations with remote monitoring and management capabilities. Through real-time data analytics and reporting functionalities, ResTrackTM provides invaluable insights into fuel usage patterns, consumption trends, and operational performance metrics. This enables proactive decision-making and strategic planning, allowing organisations to optimise their fuel management strategies for maximum efficiency and cost-effectiveness. Moreover, ResTrackTM facilitates compliance with regulatory standards by providing audit trails, documentation, and reporting features, ensuring that organisations remain in full adherence to industry regulations and environmental mandates. Overall, Banlaw's FMS, with its robust features and advanced functionalities, offers a comprehensive solution for fuel management challenges, empowering organisations to achieve greater operational excellence and sustainability.
A Strategic Asset for Future-Ready Businesses
Implementing Banlaw’s FMS not only optimises fuel usage but also integrates safety and environmental compliance into the fuel management process. The Dry Break Auto ID and Splash Fill Auto ID technologies exemplify Banlaw's commitment to providing secure and environmentally conscious solutions. These features not only streamline operations but also significantly reduce the risk of fuel spillages and theft, translating into cost savings and enhanced operational integrity.
For business owners, investing in a robust Fuel Management System like that offered by Banlaw signifies a step toward sustainability and efficiency. With its comprehensive features and reliable performance, Banlaw’s FMS stands out as a strategic asset that propels businesses towards achieving superior control and optimization of their fuel resources. In an era where every drop counts, having a system that offers precise management and substantial productivity gains is invaluable.
Take a decisive step towards transforming your business operations by integrating Banlaw’s leading-edge Fuel Management Systems. Contact Banlaw today to discuss your specific needs and see how their customised solutions can significantly benefit your business. Unlock the potential of advanced fuel management—because when it comes to resource efficiency, every measure matters. This comprehensive exploration into Fuel Management Systems clarifies their importance and showcases how Banlaw’s cutting-edge solutions pave the way for enhanced security, efficiency, and compliance in industrial fuel management. As industries continue to evolve, so too does the technology that supports them, making Banlaw’s FMS an indispensable tool for modern businesses.
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TOP 10 DEFENCE JOBS TRAINING IN INDIA
Introduction
In the realm of defense careers in India, there are numerous opportunities awaiting young individuals who are passionate about serving their country. Let's explore the top 10 defense jobs in India that offer exciting career paths and a chance to make a meaningful impact.
1. Indian Army
The Indian Army is of the largest defense forces in the world, offering a wide range of job opportunities to individuals from all walks of life. From the infantry to logistics and engineering, there is something for everyone in the Indian Army.
2. Indian Navy
With a rich maritime history, the Indian Navy provides opportunities for candidates to serve both on the seas and on land. Whether you are interested in naval aviation, submarines, or surface warfare, the Indian Navy has a role for you.
3. Indian Air Force
The Indian Air Force is known for its cutting-edge technology and advanced aircraft. Joining the Air Force allows individuals to become pilots, engineers, air traffic controllers, and more, ensuring a diverse and challenging career path.
4. Border Security Force (BSF)
The BSF plays a crucial role in safeguarding India's borders, offering positions in border management, counter-terrorism, and disaster response. Serving in the BSF provides a unique opportunity to protect the nation's borders and ensure national security.
5. Central Reserve Police Force (CRPF)
As one of the largest paramilitary forces in the world, the CRPF offers a variety of roles in law enforcement, counter-insurgency, and disaster response. Serving in the CRPF allows individuals to contribute to maintaining internal security and peace in the country.
6. Indian Coast Guard
The Indian Coast Guard is responsible for protecting the country's maritime interests and enforcing maritime law. Joining the Coast Guard provides opportunities to serve at sea, engage in search and rescue operations, and prevent maritime pollution.
7. Sashastra Seema Bal (SSB)
The SSB is a specialized force that focuses on border security and counter-terrorism operations. Serving in the SSB offers individuals a chance to work in challenging environments and protect the nation's borders from external threats.
8. Defence Research and Development Organization (DRDO)
The DRDO is India's premier defense research organization, responsible for developing cutting-edge defense technology and systems. Working with DRDO allows individuals to contribute to the nation's defense capabilities through research and innovation.
9. Armed Forces Medical Services (AFMS)
The AFMS provides medical and healthcare services to the armed forces, ensuring the health and well-being of service members. Joining the AFMS allows medical professionals to serve the country's defense forces and make a meaningful impact on the health of our armed forces.
10. Military Nursing Service (MNS)
The MNS offers opportunities for nursing professionals to serve in the armed forces and provide healthcare to service members. Serving in the MNS allows nurses to contribute to the well-being of our armed forces and support their medical needs.
By exploring these top 10 defense jobs in India, individuals can pursue their passion for defense, serve their country with pride, and build a fulfilling career in the defense sector.
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Clinical Trial Application Team Manager - Remote working opportunity UK/Europe/AfMe
Clinical Trial Application Team Manager – Remote working opportunity UK/Europe/AfMe
Job title: Clinical Trial Application Team Manager – Remote working opportunity UK/Europe/AfMe
Company: Pfizer
Job description: within designated Business Units, offering project/ line leadership and operational expertise in the logistics involved with execution…, Vendors, Contractors) in support of team strategies and operational efforts. Analyze reports and metrics generated…
Expected…
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Business Controller - Lagos
Business Controller – Lagos
Job title: Business Controller – Lagos
Company: eRecruiter Nigeria
Job description: Job Description:
Our client is a multinational logistics company. They currently have an opening for an experienced Business Controller – Lagos for their business in the Eastern region of Nigeria, who will be working from their office in Lagos state.
Job Overview
The Business Controller supports the AFM and ACX…
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Smart Polymers Market Driving Factors, Industry Analysis, Investment Feasibility and Trends, Outlook -2023
BASF SE (Germany), The Lubrizol Corporation (the U.S.), Spintech LLC (the U.S.), Akina, Inc. (the U.S.), SMP Technologies Inc. (Japan), Evonik Industries AG (Germany), Reactive Surfaces Ltd (the U.S.), Merck Group (Germany), NEI Corporation (the U.S.) among others are some of the prominent players at the forefront of competition in the Global Smart Polymers Market and are profiled in MRFR Analysis.
Smart Polymers Market – Overview:
Smart Polymers are those able to modify their physical and chemical properties in response to the variation of environmental factors. Smart Polymer systems can be designed to respond to a wide range of parameters, such as changes in pH, ionic strength, temperature, magnetic and electric field. These Smart Polymers can behave in several ways by altering solubility, shape, color, light transmitting abilities, wettability, conductivity, and surface characteristics. The extend of response of such polymers can be controlled by the intensity of the applied stimuli.
Now a days, the demand for Smart Polymers is increasing in biotechnology and medicine, electrical & electronics and automotive. Smart Polymers have also been useful as drug delivery systems and in the biotechnological field for enzyme immobilization. Despite, coating medical devices with smart polymers may significantly widen their range of applications. Devices able to attract certain cells of the body or devices that should perform as membranes or artificial muscles take advantage of these smart materials. A surface grafted with Smart Polymers has been highlighted for its interfacial and wetting applications. For example, a smart surface with switchable wettability could be potentially used in tissue engineering and antimicrobial coatings. In addition to this, a Smart Polymer material responsive to light or temperature could also be effectively used as a sensor which may drive the Global Smart Polymer Market. Presently, Smart Polymers have been mainly emphasized for their potential applications in nanotechnology, nanoscience, and nanomedicine.
Industry/ Innovation/ Related News:
February 2017 – A variety of stimuli-responsive polymers have been developed by researchers and used as actuators and/or artificial muscles, with the movement being driven by an external stimulus, such as electrical potential. Researchers highlighted actuators constructed from liquid-crystal elastomers, dielectric elastomers, ionic polymers, and conducting polymers. Researchers also discussed recent examples of a variety of actuators generated from these materials and their utility. The mechanism of actuation is detailed for most examples in order to stimulate possible future research, and lead to new applications and advanced applications.
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2017– Multi-functional nanoshuttles for remotely targeted and on-demand delivery of therapeutic molecules and imaging to defined tissues and organs hold great potentials in personalized medicine, including precise early diagnosis, efficient prevention and therapy without toxicity. Yet, in spite of 25 years of research, there are still no such shuttles available. To this end, researchers have designed magnetic and gold nanoparticles (NP)-embedded silica nanoshuttles (MGNSs) with nanopores on their surface. Fluorescently labeled Doxorubicin (DOX), a cancer drug, was loaded in the MGNSs as a payload. DOX loaded MGNSs were encapsulated in heat and pH sensitive polymer P(NIPAM-coMAA) to enable controlled release of the payload. Magnetically-guided transport of MGNSs was examined in: (a) a glass capillary tube to simulate their delivery via blood vessels; and (b) porous hydrogels to simulate their transport in composite human tissues, including bone, cartilage, tendon, muscles and blood–brain barrier (BBB). The viscoelastic properties of hydrogels were examined by atomic force microscopy (AFM). Cellular uptake of DOXloaded MGNSs and the subsequent pH and temperature-mediated release were demonstrated in differentiated human neurons derived from induced pluripotent stem cells (iPSCs) as well as epithelial HeLa cells. The presence of embedded iron and gold NPs in silica shells and polymer-coating are supported by SEM and TEM. Fluorescence spectroscopy and microscopy documented DOX loading in the MGNSs. Time-dependent transport of MGNSs guided by an external magnetic field was observed in both glass capillary tubes and in the porous hydrogel. AFM results affirmed that the stiffness of the hydrogels model the rigidity range from soft tissues to bone. pH and temperature-dependent drug release analysis showed stimuli responsive and gradual drug release. Cells’ viability MTT assays showed that MGNSs are non-toxic. The cell death from on-demand DOX release was observed in both neurons and epithelial cells even though the drug release efficiency was higher in neurons. Therefore, scientists have development of smart nanoshuttles have significant translational potential for controlled delivery of theranostics’ payloads and precisely guided transport in specified tissues and organs (for example, bone, cartilage, tendon, bone marrow, heart, lung, liver, kidney, and brain) for highly efficient personalized medicine applications.
Smart Polymers Market – Regional Analysis
North America region accounted largest market share in the Global Smart Polymer Market and expected to dominate during the forecast period due to advancement in drug delivery, nanotechnology, nanoscience, and nanomedicine and penetration of end user industry in the region. The unique properties of Smart Polymer to respond to a wide range of parameters, such as changes in pH, ionic strength, temperature, magnetic and electric field which makes it ideal in biotechnology and medicine, electrical & electronics that drive Smart Polymer Market in North America region. North America market is mainly occupied by the U. S. being largest consumer and manufacturer and exporter of smart polymer. Europe is the second largest market for Smart Polymer followed by North America.
Competitive Landscape:
The MRFR studies the key developments adopted by the companies between 2011 and 2016. Players in this market adopted various strategies to expand their footprint and augment their market share. The key strategies followed by most companies in the Global Smart Polymer Market were agreements and collaborations, mergers and acquisitions, joint ventures and expansion. Due to high demand of smart polymer in North America region, the manufacturers in North America region are using acquisition strategy of local producers in the other regions to increase their global market share.
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AORN Global Surgical Conference & Expo 2019 at U.S.A.(Nashville) 2019-April
food&beverages ingredients companies list, flavours&aroma's contact list, oils&extracts B2C ideas, colours&additives contact list, food processing technology B2B ideas, dairy processing technology Meetings, packaging machinery contact links, printing&labeling network, conveyors Meetings, material identification systems B2B ideas, and more. Exhibitors Directory, agriculture contact info, forestry B2B ideas, fishery and food?food & beverages Exhibitors, food processing Trade Shows, machinery directory, industrial technology ?other industrial machinery & equipment network, transportation Trade Fairs, logistics B2B ideas, packaging ?packaging (materials business ideas, machinery & equipment) contacts list, industrial technology ?manufacturing technology & engineering contact links
2019, April, Egypt, Cairo
AFM 2019 - Africa Food Manufacturing at Egypt(Cairo) 2019-April
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related products/services/industry/business. This trade show opens top business opportunities to exhibit products and services from food&beverages ingredients contact links, flavours&aroma's events, oils&extracts Fairs, colours&additives Trade Shows, food processing technology Expos, dairy processing technology B2B Opportunities, packaging machinery business contacts, printing&labeling companies list, conveyors business opportunities, material identification systems contacts list, and more. companies contacts, agriculture Meetings, forestry Exhibitions, fishery and food?food & beverages Trade Shows, food processing Trade Shows, machinery B2B ideas, industrial technology ?other industrial machinery & equipment Business events, transportation events, logistics contact info, packaging ?packaging (materials companies, machinery & equipment) events, industrial technology ?manufacturing technology & engineering contact info industry.
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Location of the Event:Egypt(Cairo)
Year-Month:2019-April
Official Website:Event Website
source https://www.expomahal.com/2019/06/aorn-global-surgical-conference-expo.html
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Best Air Import Freight Forwarders In India
URL: https://afm.net.in/air-freight-forwarding-services/
KEYWORD DESCRIPTION:
AFM Logistics provide the ideal solution to ship time-sensitive goods in a cost-effective, secure, timely and efficient manner at affordable rates with flexible delivery speeds & service options to give you a hassle free experience. Our air cargo division being well equipped with the latest technology and a large network across the globe, assuring that the shipments are handled with the best care makes us the best air import freight forwarders in India.
We make sure that the shipments are delivered safely and on time to anywhere around the world with the help of our partner carriers operating in all major destinations worldwide. Whether door-to-door or port-to-port Airport to Airport, Airport to Door, Door to Airport delivery we tailor a service to match your deadlines. Thanks to our wide networking, we are able to reach a wide gamut of locations any where across the globe. We comply with all the aviation and safety regulations, having expert knowledge of customs regulations, and a maintaining worldwide expertise of import/export restrictions. Our air freight service handles consignment of any nature, size and shape. Also the government regulations across which the batch is forwarded is also assiduously complied with and we take care of the shipping documentation like Commercial Invoices, Certificates of Origin, Shipper Export Declaration filing etc. We assist our air forwarders in the post shipment documentation, documents transfer, order follow-up, temporary warehousing, marking, numbering insurance brokerage etc.
AFM Logistics also specialises in air freight consoles for both inbound and our bound shipments from Indian ports. Our team is available 24/7 to monitor and analyse every step of the air freight shipment.
We can assist you with:
Recognition and preferential rates from leading carriers.
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Consoles for Import and Export from and to major destination gateways.
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Door-to-Door Express Products.
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AFM Logistics is among the top freight forwarding companies in India, known for their robust service offerings and strategic logistics solutions. They handle all aspects of freight forwarding, including transportation planning, cargo handling, and regulatory compliance. Their commitment to innovation and customer service excellence sets them apart in the logistics industry. https://afm.net.in/air-freight-forwarding-services
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AED Suite is software solutions for Carriers, Freight Brokers, and Freight Forwarders. They offer the ultimate solution for freight accounting, freight auditing, freight tracking and many other freight management services. You can manage multiple freight, send and receive important documents, access status of shipments, manage profitability and analyze financial trends conveniently in one single place.
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Recruitment in Al Futtaim Group UAE National _Retail Marketing Manager| Al Futtain Lexus | Dubai (Dubai, AE)
Job Requisition ID: [[35389]]
No two days are the same at Al-Futtaim, no matter what role you have. Our work is driven by the desire to make a difference and to have a meaningful impact with the goal of enriching everyday lives. Take our engaging and supportive work environment and couple it with a company culture that recognises and rewards quality performance, and what do you get? The chance to push the limits every single day.
As a humble family business that started on the banks of the Dubai Creek in the 1930s, Al-Futtaim has expanded to a presence in 31 countries, a portfolio of over 200 companies, and 42,000 employees. You’ll find us in industries ranging from automotive and retail, to finance and real estate, and connecting people with international names like Lexus, Ikea, Robinsons, and Adidas. Our team is proudly multicultural and multinational because that kind of diverse representation gives us the global mindset to grow and impact the people, markets, and trends around us.
Come join us to live well, work better, and be the best.
JOB PURPOSE
Manage and handle all Tactical Campaigns for Sales, Aftersales, and Pre-Owned. Managing and planning events and execute all the key elements. Support showrooms/service centres with any POS or any Marketing Material required in improving the business.
KEY ACCOUNTABILITIES
Specify the output required from the job. Identify not more than 7 Key Accountabilities & their performance indicators. NB-Focus on outcomes not tasks
Description of the Accountabilit
To manage all Tactical Campaigns and coordinate preparations of all elements for Sales, Aftersales and Pre-Owned to support on achieving the target. Managing creative briefing process with Gmasco and ensuring all jobs are executing flawlessly and within budget.
Adequate planning and timely implementation of all activation elements of each event and exhibition to meet the KPI's as approved by management. Make sure to insure all units if applicable and arrange for logistics to transfer the units to the venue and back to its initial location.
Visits to showrooms and service centers and implementation of new/additional POS. Ensure all facilities have the approved Marketing materials/collaterals. Ensure that the e-brochures are updates on the websites along with the spec sheets.
Support internal branding and ensure a successful and smooth opening of any new or current facilities.
Prepare competitive advertising reports beginning/after each quarter campaign
To make sure that the appearance of our associates reflects our company’s image. Always seek for better uniforms quality to ensure our associate’s comfort
Support in proof reading Arabic content for tactical campaigns and e-brochures/showroom POS
JOB CONTEXT: Define organizational policy and other factors that have a critical impact on the job
The Retail Marketing Manager is responsible of handling and managing campaigns for sales, pre-owned and aftersales. Also, responsible of all Marketing materials POS/Collaterals across all AFM Lexus facilities as well as, enhancing the customer facing collaterals for a better customer experience. The candidate must be active to follow up with the concerned parties to deliver the material on time. The candidate must be creative and active to implement strategies and ideas that will have high impact on the business. Needs to be an advocate and support in achieving high number of enquiries (showroom walk ins/telephone) leads.
Additionally, the candidate must be passionate and driven to do the best at what they do. Also, be able to provide solutions and support for the company to improve the customer experience and the business as well to help in maximizing sales. The Retail Marketing Manager will work cohesively and collaboratively across the marketing, sales and aftersales functions as well as our in house ad agency Consumer & Customer Communications.
QUALIFICATIONS, EXPERIENCE, & SKILLS:
Minimum Qualifications and Knowledge
BS/BA degree required, preferably in Marketing, Communications or related field
Minimum 2 years marketing experience with specific focus in retail and brand communication
Able to work within a team
Goal oriented and highly motivated
Thrives in entrepreneurial environment while being creative and resourceful in addition to also building structure and process
Strong project management, creative development, and analytical skills
Strong attention to detail and follow through; outstanding oral/written communication skills
Demonstrated ability to work collaboratively with cross-functional team members to meet objectives
Ability to think creatively and critically as an individual while working effectively with a team
Comfort working in a fast-faced, constantly-changing environment
Highly motivated with a can-do attitude in a team-oriented culture, with a good sense of humor
Behavioural Competencies :
Integrity
Analytical
Customer Orientated
Follow-up
Oral Communication
Teamwork
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We’re here to provide excellent service but a little help from you can ensure a five-star candidate experience from start to finish.
Before you click “apply”: Please read the job description carefully to ensure you can confidently demonstrate why this opportunity is right for you and take the time to put together a well-crafted and personalised CV to further boost your visibility. Our global Talent Acquisition team members are all assigned to specific businesses to ensure that we make the best matches between talent and opportunities. We not only consider the requisite compatibility of skills and behaviours, but also how candidates align with our Values of Respect, Integrity, Collaboration, and Excellence.
As part of our candidate experience promise, we also want to make ourselves available to you throughout the application process. We make every effort to review and respond to every application.
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Thin Client Market to Expand with a CAGR of 1.16% due to Growing Adoption from Small and Mid-Sized Enterprises - TMR
Transparency Market Research (TMR) observes the global thin client markethas competitive vendor landscape. Some of the prominent players operating in the thin client market are Samsung Electronics, HP Development Company, NComputing Co. Ltd., Cisco Systems, Inc., and Dell. These companies are increasingly investing in research and development activities for product innovation and product differentiation. The players are actively taking part in activities such as partnerships, mergers, and collaboration in order to improve their product offerings and expansion of the business.
A report from TMR estimates, the global thin client market is predicted to attain a value of US$ 2,124.7 mn by the end of 2026. The market is expected to expand with a CAGR of 1.16% over the forecast period between 2018 and 2026. Based on the component, the hardware segment is expected to account for the major share in 2018. Based on the enterprise size, the market for a thin client is dominated by the small and mid-sized enterprise segment and likely to be foremost over the forecast period. Based on the region, North America is dominating the global thin client market followed by Europe and the Asia Pacific.
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Growing Adoption due to Advancements to Propel Growth
The thin client market is gaining traction due to the growing adoption of quick delivery and installation of products coupled with the growing availability of the thin client market. In order to achieve this, the key players are focusing on the improvement of their distribution channel. This improvement has resulted in lowering the cost of the hardware and PCs, which is again fuelling the growth of the thin client market. Additionally, rising need for cost-saving among small and large enterprises by lowering the cost of devices and uptake of energy efficient devices is benefitting to the growth of the global thin client market.
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Growing transformation of old devices to newer devices, which are known generally known as the thin client, is offering the opportunity to cost-sensitive enterprises to lower the cost of devices. Thus, the enterprises are increasingly adopting the new thin client devices and are likely to propel the growth of the global thin client market. Additionally, growing technological advancements across numerous end-use industries are propelling growth of the global thin client market.
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Numerous Incapability of Thin Client Devices to Hamper Growth
However, the user resistance such as incapability to support to the CD drives, USB and other thumb devices are limiting adoption thin client and is likely to restrain growth of the global thin client market. Additionally, these devices are not able to support any local machines settings. This is another factor hampering growth of the global thin client market. Nonetheless, the positive impact on the productivity and efficiency of the performance is likely to offer lucrative opportunities during the forecast period.
This information is encompassed in the new report by TMR, titled “Thin Client Market ((Components-Hardware and Services); (Enterprise Size - Large Enterprises, and Small and Medium Enterprises); (End-Use Industry - BFSI, Healthcare, Retail, Manufacturing, Government, IT & Telecom, Education, Transportation & Logistics, and Others); and (Geography-North America, Europe, Asia Pacific, MEA, and South America)) - Global Industry Analysis, Size, Share, Growth, Trends, and Forecast 2018 - 2026.”
Browse Press Release - https://www.transparencymarketresearch.com/pressrelease/thin-client-market.htm
For the study, the thin client market has been segmented as follows:
By Components
Hardware
Services
By Enterprise Size
Large Enterprises
Small and Medium Enterprises
By End-Use Industry
BFSI
Healthcare
Retail
Manufacturing
Government
IT & Telecom
Education
Transportation & Logistics
Others
By Geography:
North America
Europe
Asia Pacific
South America
Middle East & Africa
U.S.
Canada
U.K.
Germany
France
Spain
Italy
Rest of Europe
China
Japan
Australia
India
Rest of Asia Pacific
Brazil
Mexico
Rest of Latin America
South Africa
Saudi Arabia
Rest of Middle East & Africa
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The Recurring Puzzle of an Illness That Paralyzes Children
As the summer of 2014 gave way to fall, Kevin Messacar, a pediatrician at Children’s Hospital Colorado, started seeing a wave of children with inexplicable paralysis. All of them shared the same story. One day, they had a cold. The next, they couldn’t move an arm or a leg. In some children, the paralysis was relatively mild, but others had to be supported with ventilators and feeding tubes after they stopped being able to breathe or swallow on their own.
The condition looked remarkably like polio—the viral disease that is on the verge of being eradicated worldwide. But none of the kids tested positive for poliovirus. Instead, their condition was given a new name: acute flaccid myelitis, or AFM. That year, 120 people, mostly young children, developed the condition across 34 states. The cases peaked in September and then rapidly tailed off.
“We didn’t know if it would go away,” Messacar says. “Unfortunately, it came back.”
After just a few dozen new cases the following year, AFM returned in force in 2016, afflicting 149 more people. The next year: another lull. And in 2018: another spike, with 62 confirmed cases so far and at least 93 more under investigation. Parents have described their children collapsing mid-run like “marionette dolls,” or going to bed with a fever and waking up paralyzed from the neck down.
This third wave confirms what many doctors had feared: AFM wasn’t a one-off, but likely a new biennial normal. It’s still rare, affecting just one in a million people, but that’s little comfort for the roughly 400 children who’ve been affected, many of whom are looking at lifelong disability or paralysis. “It’s exceptionally frustrating to see it again this year, when we know how much people’s lives are overturned,” says Priya Duggal from the Johns Hopkins Bloomberg School of Public Health. “We don’t really know much more than we knew in 2014—but we’re trying.”
AFM is a new term, but not a new syndrome. Its package of symptoms can be caused by a wide range of factors including, as the Centers for Disease Control and Prevention notes, poliovirus, West Nile virus, environmental toxins, and genetic disorders. The question isn’t what causes AFM per se, but what is specifically behind the biennial spikes that have appeared since 2014. (There was a small peak in 2012, too, before the condition came to national attention.)
That has proven to be a tough problem to crack. In this era, it seems that scientists could easily grab tissue samples, sequence the genes of everything in it, and pinpoint some consistent microbial culprit. But that hasn’t happened—so far, no single germ has shown up in every case. Despite all the tools of modern science, new diseases, especially rare ones, can be very hard to understand.
AFM is uncommon enough that a hospital might get just a handful of cases in a given year, if any. Many centers must join forces to pull off a rigorous study—and that’s logistically complicated. The condition is also geographically unpredictable. Some places had cases in 2014 but none this year, and vice versa.
More importantly, it’s too risky to take biopsies of the actual affected tissues—the nerves of the brain and spine. Instead, doctors have mostly drawn and analyzed samples of spinal fluid, and there’s no guarantee that whatever causes AFM is actually there.
So far, most of the signs point toward a virus as the cause, and specifically some kind of enterovirus. Unlike influenza, which circulates in the winter, enteroviruses are infections of the autumn, which is when AFM cases peak. They mostly infect young children, and the average AFM patient is 4 years old. Enteroviruses need a large enough population of susceptible hosts in which to circulate, so many lie low after waves of infection and crop up in cycles of two or three years—just as AFM does. And although many enteroviruses circulate widely but have little effect, they have a track record of occasionally infecting the spinal cord and causing paralytic illnesses.
“It’s not too far of a jump [to suspect them],” says Roberta DeBiasi, an infectious disease chief at Children’s National Health System.
One particular enterovirus, known as EV-D68, has emerged as the lead suspect. First discovered in 1962, it seemed rare and unexceptional. But in 2014, it caused a huge surge of respiratory illness throughout the U.S. That year, “our hospital was the busiest it’s ever been,” Messacar recalls. “The floors were packed, and we hit capacity.” And when paralyzed children started showing up at the same time, he put two and two together. He and others noted that in 2014 and 2016, EV-D68 was the most commonly identified virus in people with AFM.
[Read: How will Trump lead during the next global pandemic?]
But it’s not in every patient. So far, the CDC has only found the virus in the spinal fluid of a single child, and in fewer than half of the stool samples or nasal swabs they tested. “I am frustrated that, despite all of our efforts, we haven’t been able to identify the cause of this mystery illness,” said Nancy Messonnier, who directs the CDC’s National Center for Immunization and Respiratory Diseases, in a recent press briefing. The agency notes on its website that “the cause of most of the AFM cases remains unknown.”
Messacar thinks that the case for EV-D68 is stronger than the CDC is admitting. Certainly, caution is commendable; the wrong viruses have been blamed for perplexing illnesses before. But “I don’t think AFM is as much of an unknown as it’s portrayed,” he says. He is frustrated with its billing as a “mystery illness.”
Enteroviruses, he says, are not like typical nerve-infecting germs. They can move through nerves directly, so they don’t always show up in spinal fluid. And EV-D68 isn’t even like typical enteroviruses. Unlike other members of its family, it is quickly destroyed in the gut, and doesn’t show up in stool. It mostly thrives at the back of the nose—a place that few doctors thought to examine when AFM first showed up. Why look inside the respiratory tract of a child with a neurological disease?
Even when doctors did take nasal swabs, their odds of finding EV-D68 were low. In many neurological infections, the worst symptoms aren’t caused by the virus itself, but by the body’s disproportionate immune response. That response can continue even after the virus has been cleared, which means that patients often test negative for whatever first triggered their illness. All the researchers I spoke to think that AFM likely behaves in this way, especially since there can be a seven-day gap between the condition’s initial cold-like symptoms and the severe paralytic ones. By the time parents seek medical help, their children could be suffering from their bodies’ misplaced attempts to fight an enemy that’s no longer there. “The expectation that you’ll find a pathogen in every case is unrealistic because you’re already behind the clock,” says Messacar.
As a workaround, researchers could take the complicated steps of analyzing the bodily fluids of AFM patients for immune cells or antibodies that specifically recognize EV-D68. Their existence would at least suggest that the virus was once present. But even without such confirmation, there are other lines of incriminating evidence.
After the EV-D68 epidemic of 2014, a few hospitals, including Messacar’s, started actively searching for the virus in nasal swabs taken from patients with generic cold symptoms. Their surveillance showed that the virus disappeared in 2015 and returned a year later, coinciding with the second AFM wave. It vanished again in 2017 and returned this summer. When the latest AFM wave hit, Children’s Hospital Colorado actually saw it coming.
There’s also compelling evidence from laboratory studies. Last year, Alison Hixon at the Colorado School of Medicine showed that EV-D68 strains from the 2014 outbreak can paralyze mice by infecting and killing the movement-controlling neurons in their spines. When Hixon isolated the virus from those neurons and injected them into another group of mice, those rodents also became paralyzed. That fulfills all the traditional criteria for causality. It falls short of a slam-dunk case only because the experiments were done in mice.
Another enterovirus, EV-71, has also been implicated in AFM. It’s endemic to East Asia, where it infrequently causes a similar polio-like illness with the same two-to-three-year periodicity. Messacar’s team detected it in Colorado this spring, and they’ve found it in 11 patients with AFM. Several enteroviruses could be behind the AFM cases.
But even if that’s true, it doesn’t explain why the disease suddenly became a national problem in 2014. Conspiratorial corners of the internet were quick to suggest that immigrants had imported a mystery virus—a ludicrous hypothesis, since EV-D68 was first identified in California five decades ago.
It’s possible, though, that the virus has changed since then. In one experiment, strains from 1962 didn’t paralyze mice in the same way that those from 2014 did. This would hardly be the first time that long-known viruses suddenly became more dangerous. Zika virus, for example, was thought to be innocuous when it was discovered in the 1940s, but only recently acquired a mutation that seemingly allows it to cause severe neurological problems.
“For me, it’s not really about the viruses,” says Duggal. “I’m really trying to figure out what causes the paralysis.” Much like polio virus, which paralyzed just 1 percent of those it infected, it’s likely that AFM is caused by widely circulating viruses that only lead to problems for a small, susceptible minority. That’s why you don’t hear news reports of entire schools coming down with AFM. The disease doesn’t even sweep through entire families: Whenever an affected child has had a sibling, Duggal says, that other child has always been always healthy. In one dramatic case, scientists isolated genetically identical strains of EV-D68 from two Californian siblings, one of whom had AFM and the other of whom had the sniffles.
Duggal is now sequencing the genes of people from 60 affected families, to see if the ones with AFM have any unique mutations. Other factors might be relevant, too. Gut bacteria, for example, can affect an animal’s susceptibility to polio. And since humidity and temperature affect the global circulation of enteroviruses, Carlos Pardo-Villamizar from the Johns Hopkins School of Medicine wonders if the world’s changing climate is influencing the new trends in AFM.
To an extent, every disease behaves like this. No germ sickens every person it infects. Instead, the outcomes of encounters between pathogens and hosts almost always depend on their respective genes, and other factors like climate, diet, the microbiome, and more.
The point is: Diseases are complicated. If anything, scientists have been lucky to study many viruses—flu, Ebola, smallpox, to name a few—that are potent enough for their consequences to be clear, regardless of other variables. But there’ll be many instances in which the threads of cause and effect are harder to untangle. Epstein-Barr virus, for example, infects half of Americans before they get to middle-school, and 90 percent of them by adulthood. It usually does nothing, sometimes leads to mono, and very infrequently causes cancers.
AFM is similar, and its emergence provides a new opportunity for researchers to confront age-old questions. How do you prove what causes a disease? When does your evidence become strong enough? And while you’re collecting that evidence, what do you do for the people who are affected?
“In 2014 and 2016, there were only one or two cases of full recovery,” says Duggal. This year, for whatever reason, the children in Colorado infected with EV-71 are recovering more quickly. But at least one child has died, and some are facing long-term disabilities. Every patient immediately gets intensive physical therapy. If that fails, doctors have tried antibody infusions and plasmapheresis (a process that filters blood) to reduce inflammation, but it’s unclear if these do any good. “There’s no proven efficacy, but also little risk,” says DeBiasi. “Once you get to other therapies, you’re starting to go up the risk equation. It’s not a cookbook approach.”
There’s no clear line on prevention, either. With uncertainty lingering around viral causes, the CDC’s advice is generic: “It’s always important to practice disease prevention steps, such as staying up-to-date on vaccines, washing your hands, and protecting yourself from mosquito bites.” Basically: do the stuff that prevents other diseases.
Messacar would like them to be bolder. By all means, he says, be open to changing evidence and continue looking at other possible causes, but in the meantime, proceed as if EV-D68 is the actual culprit. That means two things. First, begin developing vaccines, a process that could take years. “It may seem early to start thinking about that, but if we don’t do the groundwork, and AFM comes back in a bigger way, we’re going to be years behind,” he says.
Second, Messacar says, public health workers should actively search for the virus in the same way that they do for flu. The CDC does have a surveillance program for enteroviruses, but it’s a passive system that relies on clinicians sending in samples. A more active program, of the kind that only a few hospitals do, would specifically test for EV-D68 in the noses of any child who gets admitted with respiratory problems.
A month ago, after the third wave of AFM had started, Pardo-Villamizar began convening a nationwide group of colleagues from hospitals that were seeing cases. Their goal is to share as much information as possible on how best to study, diagnose, and treat the illness. “We always depend on the CDC, but they’re designed to establish surveillance for diseases, not management and diagnosis,” he says. “We, as clinicians and scientists, should be doing that.”
For Messacar, the most important step is to take the disease seriously. “Right now, it’s very uncommon compared to polio in the 1950s, which caused tens of thousands of cases a year,” he says. “But I don’t want to downplay this as a rare disease, because of the long-term consequences. It’s jumping up the list of public health priorities, and it deserves increased funding and attention.” A fourth wave is likely to hit in 2020. He wants the country to be ready.
Article source here:The Atlantic
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