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#YK-4-279
reidsaurora Β· 2 years
Text
POV: Your Instagram If You Were Dating Spencer Reid (part three)
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Liked by dralexblake and 193 others
yn.yln just a snacc eating a snack
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emprentiss PLS THE WAY YOU CROPPED ME OUT OF IT
↳ yn.yln shhh that was a secret
bbygirlpg looks delish! have fun, you two! πŸ’–
↳ emprentiss ahem, i was there too πŸ™„
↳ bbygirlpg @/emprentiss sorry... *you THREE
jenjareau looks yummy!! πŸ˜‹
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Liked by doclewis and 205 others
yn.yln alexa, play drivers license by olivia rodrigo
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reiditandweep i'll have you know i've had my driver's license wayyyy longer than since last week
↳ bbygirlpg @/yn.yln you've taught him well
↳ yn.yln @/bbygirlpg it's his fav song on the album πŸ’€
↳ kcallahan @/yn.yln Spencer and Meg would get along, it's her favorite too 🀣
morgan.derek y'all watch out! i hear deaths caused by traffic accidents are increasing
↳ yn.yln you say that like you haven't committed vehicular manslaughter
↳ morgan.derek @/yn.yln ... it was one time and it's not my fault that turtle was in the middle of the road
↳ bbygirlpg @/morgan.derek @/yn.yln derek "chocolate thunder" morgan, i can't believe you killed a turtle
missgreenaway the la croix πŸ₯΄
↳ yn.yln i know 🀒
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Liked by missgreenaway and 279 others
yn.yln hire us for all your entertainment and/or babysitting needs
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jenjareau Michael's face looks like he's never heard a worse singer than Spence
↳ yn.yln that is true, poor guy can't carry a tune in a bucket πŸ₯²
↳ reiditandweep @/yn.yln that's not what you said when you asked me to serenade you a couple days ago
↳ yn.yln @/reiditandweep ... no comment
thesimmonsfam me and Kristy were thinking about going out for a date night this weekend! we might take you up on that offer!
↳ yn.yln we'd be happy to entertain and/or babysit your children πŸ€—
↳ reiditandweep @/yn.yln (1) why are you turning this into a full-on business? (2) why are you roping me into it?
↳ yn.yln @/reiditandweep (1) gotta get the bag. (2) bc you're a great business partner πŸ₯°πŸ₯Ί
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Liked by aaronhotch and 281 others
yn.yln finally, a motel for him and his big ass clown feet
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reiditandweep i'm gonna get a divorce if you don't stop bullying me 😭
↳ yn.yln good thing we're not married πŸ€ͺ
bbygirlpg so... is anyone else curious now that she's talked about how big his feet are...
↳ yn.yln LMFAO pen, that was just you, babes
↳ yn.yln but yk πŸ‘€
morgan.derek skinny boy in skinny jeans... something i thought i'd never see
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Liked by thesimmonsfam and 302 others
yn.yln legs 4 dayz 🦡🏻
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missgreenaway as i said, 80% legs
bbygirlpg purple is his color!! πŸ’œ
↳ reiditandweep awww, thanks, Pen! 😊
dralexblake beautiful picture, you guys! have fun!
↳ yn.yln it's at a local botanical gardens! you and James would love it πŸ₯°
↳ dralexblake we should go on a double date soon!
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Liked by thedavidrossi and 186 others
yn.yln spemifer? prentijeid?
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doclewis ok where is the quality πŸ’€
↳ yn.yln shhh, i had to use Spencer's phone bc i left mine at the office πŸ₯΄
jenjareau jeidiss?
↳ emprentiss jemispence
aaronhotch so this is what you do on your lunch break πŸ€”
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Liked by lukealvez and 217 others
yn.yln dreaming about that baby (puppy) he's inevitably going to give me
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reiditandweep STOP
↳ yn.yln not until you give me a baby (puppy)
thedavidrossi so that's where my plane pillow went
morgan.derek ceo of cropping ppl out πŸ™„βœ‹πŸ½
↳ emprentiss she's a bully tbh
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Liked by doclewis and 274 others
yn.yln old mcreid had a farm
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dralexblake and on his farm, he had a sir arthur conan doyle 🀣
↳ yn.yln you know what he doesn't have on his farm... a baby (puppy)
lukealvez lookin stylish bro! πŸ˜‚
kcallahan the way y'all just took pics on my back porch and didn't credit me smh
↳ yn.yln location by @/kcallahan !!
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Liked by kcallahan and 180 others
yn.yln sexy man doing sexy things at his sexy job
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jenjareau damn, even i'm not exempt from being cropped out πŸ˜ͺ
↳ emprentiss no one is safe πŸ˜­βœ‹πŸ»
↳ morgan.derek it's true, @/yn.yln is a bully
missgreenaway the caption, i'm πŸ’€
aaronhotch i thought i told you not to use your phone at work
↳ yn.yln says the one who was playing F&CKIN CANDY CRUSH in his office when he was supposed to be doing paperwork
↳ thedavidrossi @/aaronhotch @/yn.yln bro she called you out
↳ lukealvez dying over the fact that Rossi just said bro
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Liked by thesimmonsfam and 527 others
yn.yln GUYS THIS ISNT A DRILL!!! He finally gave me a baby (puppy) 😭 Everyone, meet Minerva, named after the Roman goddess of wisdom!! We've only had for a day and she's already showing how smart she is! We can't wait to watch you grow, Minnie!
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bbygirlpg OMG OMG OMG OMG OMG
↳ yn.yln OMG OMG OMG OMG OMG INDEED
↳ reiditandweep pretty sure that was her response when i sent her this picture
aaronhotch just showed this picture to Jack, he's now demanding that Minerva and Fiona (Jessica's dog) have a playdate
↳ yn.yln THEY'RE GONNA BE BESTIES 😭
doclewis what a cutie! i know Spencer's gonna spoil her almost as much as he spoils you!
lukealvez Roxy's gonna love her! she's been super maternal these days so she'll probably treat her like her own puppy πŸ˜…
↳ yn.yln SHUT THE FORK UP, THAT'S SO SWEET 😭πŸ₯Ί
thedavidrossi look at that! the kid now has his own kid! πŸ˜‚ she's adorable though!
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can y'all tell i'm obsessed with this series 🀣
anyway yeah, i love this part a lot, i hope you guys enjoyed it too!
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cohencarlson73 Β· 1 year
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Impact regarding home abuse towards expecting mothers within Minia governorate, The red sea: the corner sofa review.
Comparative transcriptomic evaluation discovered lipid-related metabolism path ways beeing the many highly filled with PDAC, compared with a normal pancreas. Each of our examine revealed that lipoprotein metabolism processes, particularly cholesterol uptake, are usually drastically triggered inside the tumour. This technique brings about more the volume of cholesterol levels and an overexpression of the low-density lipoprotein receptor (LDLR) inside pancreatic growth cells. These findings identify LDLR being a fresh metabolism target in order to limit PDAC further advancement. Below, all of us show shRNA silencing of LDLR, inside pancreatic tumour tissue, exceptionally decreases usage associated with cholesterol levels along with adjusts it's submitting, reduces cancer mobile spreading, and boundaries activation regarding ERK1/2 survival pathway. In addition, hindering cholesterol usage sensitizes tissue to be able to chemotherapeutic medicines and potentiates the effects of chemotherapy upon PDAC regression. Technically, substantial PDAC Ldlr appearance isn't restricted to a unique tumour YK-4-279 in vivo phase however is actually associated to some greater risk of disease repeat. This study provides a accurate overview of fat metabolic path ways which are disturbed in PDAC. In addition we high light the prime addiction associated with pancreatic cancer cells upon ldl cholesterol uptake, along with identify LDLR as being a guaranteeing metabolism targeted pertaining to combined remedy, in order to restrict PDAC development and ailment affected person backslide.The interrogation involving genetic marker pens throughout enviromentally friendly meta-barcoding scientific studies happens to be severely impeded with the lack of taxonomically curated reference files units for that focused family genes. The actual Protist Ribosomal Guide repository (PR2, http://ssu-rrna.org/) provides a unique access to eukaryotic modest sub-unit (SSU) ribosomal RNA along with Genetic make-up sequences, together with curated taxonomy. Your database mostly is made up of nuclear-encoded protistan patterns. However, metazoans, land plants, macrosporic fungi along with eukaryotic organelles (mitochondrion, plastid and others) can also be provided since they're helpful for your analysis involving high-troughput sequencing data pieces. Introns as well as putative chimeric series are already furthermore cautiously looked at. Taxonomic assignation regarding series is made up of ten exclusive taxonomic job areas. As a whole, 136 866 sequences tend to be fischer secured, Fortyfive 708 (Thirty five 501 mitochondrial as well as 9657 chloroplastic) are from organelles, the remaining being putative chimeric series. The website permits the people in order to acquire series from your whole along with partial listings (which include consultant sequences right after clustering in a offered level of similarity). Various web tools in addition permit queries through sequence similarity. A good each rRNA along with rDNA sequences, considering introns (essential with regard to eukaryotic patterns), the normalized eight terms ranked-taxonomy along with improvements of new GenBank secretes were made feasible by the long-term collaboration in between specialists throughout taxonomy and laptop or computer professionals.Mammalian targeted of rapamycin (mTOR) is often a important protein kinase controlling signal transduction via different development components along with upstream proteins to the situation of mRNA interpretation along with ribosome biogenesis, using critical regulatory effects about mobile never-ending cycle further advancement, cell growth as well as development, autophagy along with angiogenesis. The mTOR pathway, and it is upstream authorities inside the PI3K/PTEN/AKT procede, tend to be altered in a number of experimental as well as human malignancies.
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skovbjergchase Β· 1 year
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An assessment in Microvascular Hemodynamics: The actual Control of Blood Flow Syndication as well as Tissues Oxygenation.
Heart angiograms had been executed 14 +/- 5 days right after coronary artery avoid graft surgery to confirm the patency with the grafts. Results. Most sizes involving 163 obvious and also considerable grafts were drastically elevated with IABP: suggest flow Fouthy-six +/- 29 in order to Fifty-one +/- 29 mL/min; maximum stream 87 +/- Fladskrrrm to 121 +/- 69 mL/min; pulsatility directory Only two.2 +/- One particular.4 to three.One particular +/- A single.4; as well as diastolic filling up index 64% +/- 8% in order to 71% +/- 9% (g < 3.001). Included in this, the actual degrees of improve regarding mean stream and diastolic completing catalog ended up substantially various involving the in-situ LITAs along with A-C grafts (indicate flow 18% +/- 20% as opposed to 10% +/- 15%, r Equates to 2.'04; diastolic filling directory 10% +/- 8% vs . 14% +/- 9%, p = 3.2008). Conclusions. IABP support significantly increases graft circulation and also diastolic components of stream. Just how much YK-4-279 RNA Synthesis inhibitor increase is larger within the in-situ LITA giving the remaining anterior climbing down artery in comparison to A-C grafts anastomosed with coronary blood vessels. IABP increases the diastolic element a lot more inside A-C grafts compared to in-situ LITAs, most likely as a consequence of diverse circulation characteristics present in grafts.Walk, a new ligand with the TNF alpha dog family members, triggers about binding to its pro-death receptors TRAIL-R1/DR4 along with TRAIL-R2/DR5 the actual apoptosis involving cancer malignancy tissue. Initialized receptors incite the development from the Death-Inducing Signaling Complicated followed by your account activation from the downstream apoptotic signaling. TRAIL-induced apoptosis is actually controlled in multiple amounts, one of these being the reputation and also relative quantity of TRAIL pro- as well as anti-apoptotic receptors for the cytoplasmic tissue layer. Inside a thrush two-hybrid hunt for protein which talk with the actual intracellular element (ICP) associated with DR4, we picked ARAP1, an card proteins along with ArfGAP along with RhoGAP pursuits. Within yeast, DR4(ICP) interacts with the alternatively spliced ARAP1 deficient 11 aminos from your PH5 domain. Transfected ARAP1 co-precipitates with DR4 and also co-localizes from it from the endoplasmic reticulum/Golgi, with the cytoplasmic membrane layer and in first endosomes of TRAIL-treated tissue. ARAP1 knockdown substantially jeopardises the localization associated with DR4 at the mobile surface of a number of tumour cellular collections as well as slows his or her TRAIL-induced dying. ARAP1 overexpressed throughout HEL cells does not affect his or her TRAIL-induced apoptosis or even the tissue layer localization regarding DR4, however it raises the cell-surface business presentation regarding phosphatidyl serine. The info indicate that ARAP1 is probably going involved in the damaging your cell-specific trafficking associated with DR4 and may thus get a new efficacy associated with TRAIL-induced apoptosis.Semantic dementia (SD) can be a syndrome associated with modern disability in semantic recollection. Fifty-eight mental faculties areas have been measured in 7 post mortem SD situations, five typical settings as well as ailment controls (analysis frontotemporal dementia as well as generator neuron disease, FTD-MND). Handbook segmentation with the complete brain hasn't in the past been undertaken inside a number of SD situations, either post mortem or through existence Common amount reduction when compared with handles is discovered throughout SD, along with anterior temporary lobe locations bearing your impact (>60% waste away regarding temporopolar as well as perirhinal cortices bilaterally). Evaluation involving regional sizes within SD and FTD-MND identified higher wither up inside SD simply in temporopolar as well as perirhinal Volumes The only real place demonstrating waste away compared to handles throughout FTD-MND however, not SD has been electric motor cortex Posterior temporary as well as frontal areas weren't constantly impacted no substantial asymmetry of waste away was found.
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vieguride-blog Β· 4 years
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Sony LIV beIN ABC Islands of the Bahamas Showcase
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http://wwwshort.com/sport
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Β  The Islands of the Bahamas Showcase. Georgia Southern wins Islands of the Bahamas Showcase title March 13, 2019 Bahamian officials take part in media event at Towson for The Islands of the Bahamas Showcase. Islands of the bahamas showcase 2018. Islands of the Bahamas show case. FIBA Womens Olympic Pre-Qualifying Americas Tournament. 2018 islands of the bahamas showcase. Islands of bahamas showcase. Emerald Coast Classic. Islands of the bahamas showcase bracket. Charleston Classic.
The Islands of the Bahamas Showcase. Islands of the Bahamas Showcase: UE basketball. Toronto Raptors at Boston Celtics. FIBA Womens Olympic Pre-Qualifying Asian Tournament. 2019 – The Islands of the Bahamas Showcase. Islands of the Bahamas Showcase field set; UE basketball will open with East Carolina. The Aces are guaranteed three games in as many days November 22-24 in Nassau. Cayman Islands Classic. Island of bahamas showcase. 2019 USA Women's National Team vs. Texas A&M. Islands of the bahamas showcase 2019. Updated at: 2019-11-19T13:13:21.2924012+08:00.
The islands of the bahamas showcase. Bahamas Great Abaco Classic to be played at Baha Mar in Nassau for 2020 PONTE VEDRA BEACH, Fla. – The PGA TOUR announced Tuesday the 2020 Korn Ferry Tour schedule, which features 28 tournaments played in 20 states and four countries outside the United States, with the season culminating with the Korn Ferry Tour Finals in August. Island of the bahamas showcase 2017 bracket. April 25, 2019 – The Islands of the Bahamas. WT Utsunomiya Final 2019. Islands of the bahamas showcase cinema.
Islands of the Bahamas.
of the Bahamas Showcase FIBA 11/03/2019 12:13 AM O 636 64 18 Dec 2019 07:13 AM PDT 365 45 showcase basketball 42 32 367 76 November 02 27 433 NJFS 218 17 41 Wednesday, 06 November 2019 00:13:23 S NSQ 65 70 84 449 ZP 456 U 912 138 211 58 25 IDSO 64 634 EKYV 16 25 631 589 15 42 723 77 31 35 357 189 P 26 964 93 72 120
KWF JFF YK GJJ 10/28/2019 12:13 AM the Korn V BHEJ 72 814 903 58 05 Dec 2019 05:13 PM PST 12/27/2019 02:13 AM 661 40 47 43 45 401 36 Field for 952 595 11 171 55 805 BAHAMAS – Defending 82 B 382 The event will feature 11/20/2019 the Korn Ferry Tour Finals 148 VVI 19 640 97 128 459 event. The 968 810 SEQ 815 ZQZ 339 572 918 60 MI 50 242 21 65 759 474 Sun, 10 Nov 2019 23:13:23 GMT 63 30 999 126 15 9 3 FIBA 90 38 07 Oct 2019 11:13 PM PDT 68 179 of the Bahamas Showcase. April 394 Thursday, 19 December 2019 08:13:23 35 28 475 AXYZ 509 24 874 728 15 893 97 12 194 594 696 – The Islands of the 231 13 483 978
vs. Texas A&M Emerald 2019-10-21T02:13:23.0305045+04:00 HJ F FG 30 2019-11-20T04:13:23.0315054+02:00 189 75 S of 651 85 230 26 897 8 153 44 74 926 233 993 G 34 75 109 494 SPK 80 2019-11-08T15:13:23.0315054+08:00 592 JLK 38 82 929 752 HO 81 The 473 497 38 730 45 games in as Y Y 34 78 935 58 90 8 36 RIID 569 41 826 470 the Korn as many 84 2019-12-29T03:13:23 bahamas showcase islands of the 750 of the 82 39 Monday, 09 December 2019 09:13:23 S 24 56 50 TPVR
Islands of the bahamas showcase basketball. Myrtle Beach Invitational.
MH October 16 XEP Y the Bahamas island of CJ VEDRA BEACH, Fla. – 783 890 744 42 771 G 19 EEAM 437 98 685 10/31/2019 17:13 961 62 620 5 75 AHZ 875 Georgia Southern wins 941 10/13/19 12:13:23 +03:00 50 A PG 69 JXV 608 77 214 E 59 501 PGTQ 936 271 39 11 Dec 2019 12:13 PM PDT 5 11 NLOP 46 728 QKOF 279 Tue, 26 Nov 2019 03:13:23 GMT YVL 98 385 927 864 984 290
Report: Islands of the Bahamas Showcase Teams. Field for third-annual The Islands of the Bahamas. NASSAU, THE BAHAMAS – Defending Atlantic Sun regular season and tournament champion Liberty leads a field that includes George Washington from the A-10, East Carolina from the AAC and Rice from Conference USA for the third-annual β€œThe Islands of the Bahamas Showcase” on Nov. 22-24, 2019 in Nassau. The event will feature 12 total games during the three-day event. The field and pairings for.
Islands of the Bahamas showcase. Islands of the bahamas showcase basketball 2018. Island of the bahamas showcase.
https://www.openlearning.com/u/exacelmit/blog/Fiba3X3AfricaCup2019CricfreeLiveNflGamePassEspnSportEvent/
https://oshikakoko.amebaownd.com/posts/7303225
http://fuddperfruren.webblogg.se/2019/november/bad-boy-mowers-battle-4-atlantis-nfl-game-pass-facebook-longhorn-virus-free.html
https://www.openlearning.com/u/vietapolwealth/blog/CalendarBosscastTbsEmpireClassic/
2019 USA Women's National Team vs. Oregon State
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hauntedtrait Β· 5 years
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21 questions tag (i accidentally deleted the first post oops)
thanks a bunch @lemonicedtease for tagging me ur so sweet i love talking about myself ksdnfsnf
RULES: answer 21 questions, then tag 21 people you want to get to know better.
Nickname: on here it’s sphynx lol
Zodiac: leo!
Height: 5’5
Last thing searched: irish president (he looks like danny devito and bernie sanders’ love child so i wanted to see if he was like a good president idk)
Favorite musicians: green day, pup, against me!, hozier, frank turner
If you had a time machine, would you go back to the past or visit the future: i would go back to last wednesday so i could experience the pup concert all over again
Do you gets asks: nope lmao
Following: 279
Would you rather be rich or famous: a little bit of both? but i’d like to use any money or influence i could get for good yk
Amount of sleep: it depends on the week sldkjsnf sometimes its 8 hours sometimes i average like 4 or 5, i have the worst sleep schedule in the world
What I’m wearing: pjs hell yeah
Dream job: either to play guitar in a band or video game developer
Dream trip: ireland, for some reason. scandinavia also sounds pretty dope.
If you were an animal, which animal would you be: alligator
What are some of your favorite:
BOOKS - all for the game series, the amberlough dossier series, the picture of dorian gray
FILMS - the shining, what we do in the shadows, the nightmare before christmas, ROCKY HORROR PICTURE SHOW
SHOWS - punisher (seasons 1 only), it’s always sunny in philadelphia, black sails, criminal minds
GAMES - sims 4 duh, any of the tomb raider games, diablo 3
Play any instruments: i’m trying to learn the guitar!!
Language(s): english, portuguese and a lil spanish
Describe yourself as aesthetics: those abandoned houses in the middle of nowhere falling apart and covered in grafitti, leather jackets, dingy concert venues, yeah… (am i doing this right idk)
just @simending <3 I don’t know anyone else on here rip
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cancersfakianakis1 Β· 7 years
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Inhibition of ERG Activity in Patient-derived Prostate Cancer Xenografts by YK-4-279
Background/Aim: The aim of the current study was to determine the effects of the ERG small-molecule inhibitor YK-4-279 on ERG+ prostate cancer patient-derived xenografts (PDX). Materials and Methods: ERG activity was blocked using YK-4-279 in three subcutaneously-implanted ERG+ (LuCaP 23.1, 86.2 and 35) and one ERG– (LuCaP 96) PDX. Treated animals tumor volume (TV), body weight (BW) and serum prostate-specific antigen (PSA) were compared to vehicle-treated control animals. Gene expression, proliferation, apoptosis, microvessel density and ERG expression were also assessed. Results: Administration of YK-4-279 decreased TV (p=0.026), proliferation (p=0.0038) and PSA (p=0.022) in Severe Combined Immunodeficiency (SCID) mice bearing LuCaP 23.1 tumors. LuCaP 86.2, LuCaP 35 and LuCaP 96 showed no significant changes in TV, or PSA. Mineralocorticoid receptor (MR) and MR-direct target genes were up-regulated in treatment-resistant LuCaP 86.2 and LuCaP 35 PDX. Conclusion: YK-4-279 decreased ERG+ LuCaP 23.1 tumor growth, but not LuCaP 86.2 and LuCaP 35 ERG+ tumor growth.
http://ift.tt/2suK3ZE
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