Support Reimena Yee’s Alexander, the Servant, and the Water of Life Comic!!

Reimena Yee has been part of Tumblr for many years. Some of her works include The World In Deeper Inspection

It features her gentleman Jersey Devil Detective Alcott Grimsley.

He solves mysteries for those who have passed beyond the mortal veil

Reimena Yee created the Carpet Merchant of Konstantiniyya.

The Eisner nominated story is a lush tapestry of romance and art set in 17th century Istanbul and 18th century England

She also created Séance Tea Party.

A heartfelt modern story about growing up and being true to yourself.

Reimena Yee’s latest work is Alexander, the Servant, and the Water of Life.

The comic is filled with historical beauty. It also shows a more intimate side of Alexander’s relationship with Hephaestion

If you’re a fan of Reimena Yee’s works, please consider supporting Alexander, the Servant, and the Water of Life. You’ll be in for an odyssey of history and art.

You can pre-order your physical copy of Book 1 here.

Toxics, Vol. 12, Pages 301: Oleanolic Acid Acetate Alleviates Cisplatin-Induced Nephrotoxicity via Inhibition of Apoptosis and Necroptosis In Vitro and In Vivo

Cisplatin is a widely used anti-#cancer drug for treating solid tumors, but it is associated with severe side effects, including nephrotoxicity. Various studies have suggested that the nephrotoxicity of cisplatin could be overcome; nonetheless, an effective adjuvant drug has not yet been established. Oleanolic acid acetate (OAA), a triterpenoid isolated from Vigna angularis, is commonly used to treat inflammatory and allergic diseases. This study aimed to investigate the protective effects of OAA against cisplatin-induced apoptosis and necroptosis using TCMK-1 cells and a mouse model. In cisplatin-treated TCMK-1 cells, OAA treatment significantly reduced Bax and cleaved-caspase3 expression, whereas it increased Bcl-2 expression. Moreover, in a cisplatin-induced kidney injury mouse model, OAA treatment alleviated weight loss in the body and major organs and also relieved cisplatin-induced nephrotoxicity symptoms. #RNA sequencing analysis of kidney tissues identified lipocalin-2 as the most upregulated gene by cisplatin. Additionally, necroptosis-related genes such as receptor-interacting protein kinase (RIPK) and mixed lineage kinase domain-like (MLKL) were identified. In an in vitro study, the phosphorylation of RIPKs and MLKL was reduced by OAA pretreatment in both cisplatin-treated cells and cells boosted via co-treatment with z-VAD-FMK. In conclusion, OAA could protect the kidney from cisplatin-induced nephrotoxicity and may serve as an anti-#cancer adjuvant. https://www.mdpi.com/2305-6304/12/4/301?utm_source=dlvr.it&utm_medium=tumblr

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さいきょうのふたり by TCMK

(Source)

By TCMK

SAP area menus beginning with T

SAP area menus beginning with T

# TBMN – Currency Hedges

# TCMK – Funds Management

# TCMN – Funds Management

# TDMN – Cash management

# TDMN_DIST – Distribution of TR Cash Mgt Data

# TFMN – Cash Flow

# TIMN – Derivative Financial Instruments

# TMMN – Money Market

# TP00 – Travel Management: Travel Planning

# TRANSFER – Transfer/Borrow-Loan-Payback Menu

# TRLM – Treasury Management Basic Functions

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Motorculardan "19 Mayıs Ata'ya Saygı Sürüşü"

Motorculardan “19 Mayıs Ata’ya Saygı Sürüşü”

Atatürk ve silah arkadaşlarının Samsun’a çıkışının 100. yılı dolayısıyla düzenlenecek etkinliklere katılmak üzere 12 ilden yola çıkan Türk Chopper Motor Kulübü (TCMK) üyeleri Çorum’a ulaştı.

Atatürk ve silah arkadaşlarının Samsun’a çıkışının 100. yılı dolayısıyla düzenlenecek etkinliklere katılmak üzere 12 ilden yola çıkan Türk Chopper Motor Kulübü (TCMK) üyeleri Çorum’a…

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Baba Mecnun 😎😎 #Mardin #TCMK #TürkChopper