Hail satan

She is a pick me girl

Rirr..

😴😒

Trick or treat!

You get the first (and only) paragraph of an original work that I rotate in my brain every now and then:

Rirr wasn’t a safe place for him to be, not now. The homeplace of the fae of old was the very center of the Galdanian-Kilernian conflict, a conflict that seemed to be rearing its head once again. The tiny village he’d situated himself among muttered to themselves, talked of border skirmishes and odd magical happenings, even looked askance at Tonro and blamed his appearance for the riling-up.

eries brand letters symbols from candace marie hughes rirre voiceings dfor skies datee voiced printer writtens given buttonedwrote gifts must return to candace marie hughes. on. paid. desin on paid. voiced on paid. mail kiy key card dh to candace marie hughes. on. paid. paid. paid.

Rirr😁😁😁👇👇what?

Class 1A really has no experience in saving regular people...being the main characters didn’t help in that area.

You know since everyone has been attacking them which is rirr I was not from search & rescue.

Hello Ollie! #dogsofinstagram #dogsofHasselt #crossbreed #dogs https://www.instagram.com/p/CbuVIV-rIRR/?utm_medium=tumblr

Jaaa, ma m vrit a me a mettr certe foto?? Daiii, io fidanzata m fa rirr

AOBASHI HOUR 20191102

静岡イベント告知回♪ M.Koi AONO KANAの三人がそれぞれ11月12月のInfoをオススメ曲と共に紹介。是非♪

Ken Ishii, Jeff Mills - Take No Prisoners

Will Easton - Technic

Dombresky, Noizu - Rave Alarm

ツダイーン - ドリフター

CO-FUSION - RES

■DJs

M.Koi https://twitter.com/MAlzKoi

AONO https://twitter.com/AONO_WTW

KANA https://twitter.com/dj_kana26

https://www.instagram.com/dj_kana26/

https://soundcloud.com/kanako-nozaki-625685071

■箱

〇dazzber 静岡県静岡市葵区常磐町3-2-12 タケジビル2F http://jakata.info/ https://twitter.com/dazzbar

〇PRIVATEROOM COA 静岡県静岡市葵区七間町11-5イマココ4F https://www.prcoa.com/ https://twitter.com/COA_SHIZUOKA

〇Etti 静岡県静岡市葵区紺屋町12-1ドン・キホーテ6F http://www.etti.jp/pc/index.html https://twitter.com/etti_shizuoka

〇EXE 静岡県浜松市中区田町327-27大蔵ビル1F

〇MAGO 愛知県名古屋市中区新栄2-1-9雲竜フレックスビル西館B２F http://club-mago.co.jp/ https://twitter.com/CLUBMAGO

■Party Info

Course of action @ PRIVATEROOM COA 11/23(Sat) 22:00- Door:¥3,500 ADV:¥3,000 ▷前売りチケット限定35枚(入場制限50名〜60名) 前売り問い合わせはDMもしくは メールアドレス[email protected]まで。

SPECTRA HOWAKO 10year anniversary tour @ dazzbar 11/02 (Sat) 21:00- Door:\2,000(with 1D) SPECIAL LIVE：HIROKI ARAKAWA Guest DJ：HOWAKO LIVE：MASTER MASTER DJ：SHIGe / Maatea / MEATGOODBYE / KANA LIVE PAINT：KOHARU

B×A+E @ Etti(静岡市) 11/08 (Fri) 21:00star-

ADVENT @ PRIVATEROOM COA 11/10 (Sun) 15:00- Doo:¥2,500(with 1D) with fryer:¥2,000(with 1D) GUEST DJ：SAKUMA (Modest) LIVE：S.O.N DJ：SHIGe / KUME / MEATGOODBYE / KANA / SHOKI LIVE PAINT：MASUMI

SIGNAL×VANQUISH @ EXE-hamamatsu-(浜松市) 11/23 (Sat) 21:00- Door:\3,000 Adv:\2,000 Special Guest：DJ Shimamura Guest：T-BRAVE with VANQUISH CREW DJ：ANCELLAX / AMANO / FOX / KANA / KOWSK / TAKUMI / TAKUYA / TOMOYA VJ：BRIGHT

DOTS  club MAGO(愛知県名古屋市) 12/08 (Sun) 14:00- Adv:\3,500 Special Guest DJ：Noizu (LA) ～NOIZU JAPAN TOUR～ 12/07 (Sat) DAY  @OSAKA JOULE 12/07 (Sat) NIGHT   @TOKYO  WOMB 12/08 (Sun) DAY   @NAGOYA  MAGO

GROOVE SATURDAY @ PRIVATEROOM COA 12/21 (Sun) Guest DJ：BUDDHAHOUSE Joint DJ：MEATGOODBYE / Maatea / FunkCarGo! / KANA / SHOKI / RIRR GROOVE SUNDAY DJ / Grifith / Soar / FOGGY FOOD：ビリヤニ zelenshchik

WALLS×SIN-ON @ dazzbar 11/9 (Sat) 21:00- Door:\2,000円 GUEST DJ：LOE / Arisa Shirota DJ：YSK / NAITO / AONO / CHANG SOUND：YMO system

■ネットラジオ

番組名：FnoobTecnoRadio『SIN-ON #19』 次回：11/28(木)21:00～23:00(4週毎木曜21:00～) HOST：AONO GUEST DJ：APEPA(from TOYAMA)

FnoobTecnoRadio⇒ https://fnoobtechno.com/ 視聴⇒ http://play.fnoobtechno.com:2199/tunein/fnoobtechno.mp3 SIN-ON ARCHIVE (AONO)⇒ https://www.mixcloud.com/yusukeaono12/ SIN-ON ARCHIVE (CHANG)⇒ https://www.mixcloud.com/kentaroueda39/

Mit jeden traum will ich dich mehr jedes mal schlafen bringt mich näher an den punkt an den gedanken ich begreife  ich rirre nur sinnlos umher

Kontra k -traumfrau

DA to ensure graft-free fertilizer bidding

#PHnews: DA to ensure graft-free fertilizer bidding

MANILA -- The Department of Agriculture (DA) has completed the procurement of the first batch of fertilizers under the Rice Resiliency Project, strictly following the procurement modality of negotiated procurement (emergency purchase), under Sec. 53.2 of RA 9184 and Government Procurement Policy Board (GPPB).

“We have initially procured a total of 1,811,090 bags of urea fertilizer at a price lower than the national average retail prices of PHP1,035.60 for April 27 to May 1; PHP1,037.53 for May 4 to 8; and PHP1,040.68 for May 11 to 15. The volume procured comprises four of the 16 lots for wet season 2020 cropping,” DA Secretary William Dar said in a virtual presser on Thursday.

"Such prices were a lot cheaper compared to previous purchases at the regions, ranging from PHP1,300 to PHP1,500 per 50-kilo bag of urea fertilizer," he said.

Dar said, at less than PHP1,000 per 50kg, the government is already saving a lot.

"And there is a downward trend of prices, as we are conducting a more transparent centralized bidding through the DA Bids and Awards Committee (BAC)" he said. The DA-BAC is chaired by Undersecretary Waldo Carpio.

The PHP1,000/bag (50kgs./bag) Approved Budget for Contract (ABC) was pegged after consultation with various players in the fertilizer industry, and recommendation of the DA's Fertilizer and Pesticide Authority (FPA) based on a four-month price monitoring trend.

“The DA-BAC considered the ABC submitted by the end-user of PHP1,000 per bag. As per end-user, the DA Operations Group, headed by Undersecretary Ariel Cayanan, the PHP1,000 was based on the FPA and PSA retail price of urea,” Dar said.

The DA conducted a series of negotiated procurement (emergency purchase) under the State of Calamity that attracted fertilizer distributors in the country, starting on Apr. 29, 2020, for the procurement of 5,691,477 bags with the ABC PHP5,691,477,000.

"As part of this process and in strict adherence to R.A. 9184 and its 2016 RIRR, we had to disqualify those whose technical capabilities were found to be questionable," he said.

The DA has issued Notices to Award and Purchase Orders to the two winning fertilizer companies:La Filipina Uy Gongco Corporation for the delivery of 97,615 bags at PHP990/bag to Region 4A; 694,904 bags at PHP995/bag to Region 6, and 911,073 bags at PHP995/bag to Region 3, on May 8, 2020 and May 14, 2020, respectively; and Atlas Fertilizer for the delivery of 107,498 bags at PHP900/bag to Region 7 on May 14, 2020.

Currently, there is an on-going procurement for the remaining 12 lots. After a thorough review of the Terms of Reference, the End-user regrouped these 12 lots to 26 lots to ensure wider participation of fertilizer distributors. The respective bidding for the 26 lots are ongoing.

“I can personally vouch for the truthfulness and trustworthiness of the procurement process that the DA-BAC has exercised for these fertilizers. Guided by our legal office and in constant consultation with the GPPB, we made sure we followed to the number the prescribed procurement procedure as required by the law,” the DA chief said.

Dar earlier instructed the DA-BAC to look into the most feasible and fastest way to provide for the fertilizer in time for the main wet cropping season.

“We have been very transparent on the procurement of fertilizer as we know this might be used to stir false information against the government. The DA will not wrongfully hold any information that should be known to the public. I encourage everyone to help us look even closer to ensure that every peso we allot is going to where it should be spent,” he said.

Dar said the DA has further streamlined the procurement for the remaining bid lots to ensure that the suppliers comply to every requirement that is advantageous to the government and the people.

"This is one of our responses to the call of President Rodrigo Roa Duterte to provide transparency and integrity in all government transactions and interventions, as part of our recently created 'integrity circles,' dubbed as 'Agriculture Dialogue and Information Network Groups' or ADING," he said.

ADING is a systematic and institutional system that will enable us to monitor and evaluate our agri-fishery policies, programs, and projects on the ground, and if these are effectively and cost-efficiently implemented, without any shade of graft and corruption.

"We vowed from the beginning of a no-corruption policy at the Department of Agriculture," he said. (PR) 

   ***

References:

* Philippine News Agency. "DA to ensure graft-free fertilizer bidding." Philippine News Agency. https://www.pna.gov.ph/articles/1105684 (accessed June 12, 2020 at 03:13AM UTC+14).

* Philippine News Agency. "DA to ensure graft-free fertilizer bidding." Archive Today. https://archive.ph/?run=1&url=https://www.pna.gov.ph/articles/1105684 (archived).

الضرائب على المشروبات المحلاة خفضت حجم المبيعات في شيكاغو – صالة الأطباء

الفئة: الغدد الصماء | طب الأسرة | الطب الباطني | طب الاطفال | مجلة

العودة إلى مقالات المجلات

آخر تحديث: 25 فبراير 2020.

أدت ضريبة المشروبات المحلاة في مقاطعة كوك إلى انخفاض كبير في حجم بيع المشروبات التي يتم فرض ضرائب عليها ، وفقًا لدراسة نشرت على الإنترنت في 25 فبراير في حوليات الطب الباطني.

وكان الانخفاض أكثر من 20 في المئة حتى عند المحاسبة للتسوق عبر الحدود

التعليقات: (0)

اخبر صديق

الثلاثاء ، 25 شباط (فبراير) 2020 (HealthDay News) – أدت ضريبة المشروبات المحلاة في مقاطعة كوك (SBT) إلى انخفاض كبير في حجم بيع المشروبات التي يتم فرض ضرائب عليها ، وفقًا لدراسة نشرت على الإنترنت في 25 فبراير في حوليات الطب الباطني.

قامت ليزا باول ، الدكتوراه ، من جامعة إلينوي في شيكاغو ، وزملاؤها بتقييم تأثير "مقاطعة كوك" SBT 2017 على حجم المشروبات الخاضعة للضريبة وغير الخاضعة للضريبة التي تباع في مقاطعة كوك ، إلينوي ، ومنطقة الحدود التي تبلغ ميلين باستخدام بيانات الماسح الضوئي لمستوى تخزين المنتج العالمي. وأجريت مقارنات مع سانت لويس بولاية ميسوري ، والتي لم تمر على SBT.

وجد الباحثون أن حجم بيع المشروبات الخاضعة للضريبة انخفض بنسبة 27 في المئة (نسبة نسب معدل الإصابة [RIRR]، 0.73) في المتوسط ​​في مقاطعة كوك مقابل سانت لويس خلال الأشهر الأربعة التي كان فيها SBT ساري المفعول (في نفس الفترة قبل الضريبة لمدة أربعة أشهر). وكان الانخفاض الصافي 21 في المئة بعد النظر في الزيادات في حجم بيعها في منطقة الحدود (التسوق عبر الحدود). تباين الانخفاض في الحجم المباع بين أنواع المشروبات الخاضعة للضريبة: −32 في المائة (RIRR ، 0.68) للصودا مقابل 11 في المائة (RIRR ، 0.89) لمشروبات الطاقة ، −37 في المائة (RIRR ، 0.63) للمشروبات المحلاة صناعياً مقابل 25 في المئة (RIRR ، 0.75) للمشروبات المحلاة بالسكر ، و 29 في المئة (RIRR ، 0.71) للحجم العائلي مقابل 19 في المئة (RIRR ، 0.81) للمشروبات الفردية.

وكتب المؤلفون "ستظل التقييمات الأطول أهمية في الولايات المتحدة المحلية ، خاصةً عندما يكون التسوق عبر الحدود تهديدًا ، وستحدد ما إذا كانت هناك إمكانية لتغيير السلوك بشكل دائم والتحسينات في الصحة".

كشف المؤلفون عن منح من بلومبرغ للأعمال الخيرية.

الملخص / النص الكامل (قد يلزم الاشتراك أو الدفع)

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Tetramethylpyrazine attenuates the endotheliotoxicity and the mitochondrial dysfunction by doxorubicin.

PMID:  Oxid Med Cell Longev. 2019 ;2019:5820415. Epub 2019 Dec 3. PMID: 31885804 Abstract Title:  Tetramethylpyrazine Attenuates the Endotheliotoxicity and the Mitochondrial Dysfunction by Doxorubicin14-3-3/Bcl-2. Abstract:  Doxorubicin (Dox) with cardiotoxicity and endotheliotoxicity limits its clinical application for cancer. The toxicitic mechanism involves excess ROS generation. 14-3-3s have the protective effects on various injured tissues and cells. Tetramethylpyrazine (TMP) is an alkaloid extracted from the rhizome of Ligusticum wallichii and has multiple bioactivities. We hypothesize that TMP has the protective effects on vascular endothelium by upregulating 14-3-3. To test the hypothesis, Dox-induced endotheliotoxicity was used to establish vascular endothelium injury models in mice and human umbilical vein endothelial cells. The effects of TMP were assessed by determining thoracic aortic strips' endothelium-dependent dilation (EDD), as well as LDH, CK, caspase-3, SOD, CAT, GSH-Px activities and MDA level in serum, apoptotic rate, and histopathological changes of vascular tissue (). Also, cell viability, LDH and caspase-3 activities, ROS generation, levels of NAD/NADH and GSH/GSSG, MMP, mPTP opening, and apoptotic rate were evaluated (). The expression of 14-3-3and Bcl-2, as well as phosphorylation of Bad (S112), were determined by Western blot. Our results showed that Dox-induced injury to vascular endothelium was decreased by TMPupregulating 14-3-3expression in total protein and Bcl-2 expression in mitochondria, activating Bad (S112) phosphorylation, maintaining EDD, reducing LDH, CK, and caspase-3 activities, thereby causing a reduction in apoptotic rate, and histopathological changes of vascular endothelium (). Furthermore, TMP increased cell viability and MMP levels, maintained NAD/NADH, GSH/GSSG balance, decreased LDH and caspase-3 activities, ROS generation, mPTP opening, and apoptotic rate (). However, the protective effects to vascular endothelium of TMP were significantly canceled by pAD/14-3-3-shRNA, an adenovirus that caused knockdown 14-3-3expression, or ABT-737, a specific Bcl-2 inhibitor. In conclusion, this study is the first to demonstrate that TMP protects the vascular endothelium against Dox-induced injury via upregulating 14-3-3expression, promoting translocation of Bcl-2 to the mitochondria, closing mPTP, maintaining MMP, inhibiting RIRR mechanism, suppressing oxidative stress, improving mitochondrial function, and alleviating Dox-induced endotheliotoxicity.

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Eres un diamante cariño, no te pueden romper.

RIRR

like how can you hate her ?