Any genre of game can have a disabled protagonist if you aren't a coward / willing to put the work in, but I'm currently batting around the concept of specifically point-and-click puzzle adventure games with a highly disabled protagonist.

Often, the pace of such games tends sedate and contemplative. Your character is seldom in a hurry; they are mostly faced by trying to figure out how to accomplish a particular task, and if a deadline is imposed, it's an extra thing to juggle.

This could be an interesting presumption to incorporate from a watsonian lens, through the viewpoint of a protagonist who may have limited mobility, pain and/or fatigue that make hurrying punitively inaccessible. It'd let the player familiarize themselves with early puzzles if the first thing they have to figure out how to do is say, get their player character out of bed in an environment where they don't have their usual fallbacks.

(also if this is also a walking adventure, it'd let you dodge accusations of the insurmountable waist-high fence- your intrepid hero MIGHT be able to climb over those bricks if they didn't have two bad hips and a walker to worry about!)