#i have my suspicions about 2C9 | Explore Tumblr Posts and Blogs

somecunttookmyurl · 9 months

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fwiw my physiotherapist told me that people with eds apparently metabolise things faster than other people, so your fast metabolisation of medications/caffeine/etc could be in part linked to that?

yes people with EDS (and other forms of chronic pain) are highly likely to have the abnormal liver enzyme thing

we don't really know *why* but it's just. a thing.

#it's why loads of us are resistant to local anaesthetic also #something like 80% of chronic pain sufferers have at least one abnormality on the P450 cytochrome #around 30% have more than one #the most common (for us) is CYP2D6 which is the one responsible for - among other things - anaesthetic and most psychiatric medication #caffeine is CYP3A4 #my 2D6 and 3A4 are for sure extremely overachieving #i have my suspicions about 2C9 #incidentally CBD is a potent inhibitor of 2D6 - meaning it will slow the metabolism and 'make things work better'#which may go some way to explaining the popularity of CBD among chronic pain folks #bupropion (wellbutrin) does the same thing which is why i'm prescribed it lmao #taking wellbutrin to make my liver talk to amphetamine

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