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Olha a alegria da pessoa na festinha do amiguinho Caio. Parabéns Caio! É obrigada pela festa tão linda @mamaededoisreal Clarice aproveitou! #Caio#fez1#Clarice#adorou#foi#pura#diversao 👶🎂🎉😍

Tudo mais q perfeito arrasou ❤ nega tudo lindo #Ranielly #fez1 (em Jardim Monte Verde)

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Asymmetric distribution of pallial-expressed genes in zebrafish (Danio rerio).

Related Articles

Asymmetric distribution of pallial-expressed genes in zebrafish (Danio rerio).

Eur J Neurosci. 2020 Jul 21;:

Authors: Messina A, Boiti A, Vallortigara G

Abstract The left and right distribution of a set of twenty-six genes in the zebrafish pallium was examined by RT-qPCR experiments. The analysis comprised four general pallial markers (eomesa, emx2, emx3 and prox1); eight genes, dapper1, htr3a, htr3b, htr4, id2, ndr2 and pkcβ and lmo4, that have been described as asymmetric distributed in the brain of mammals (human and mouse); six genes, arrb2, auts2, baiap2, fez1, gap43 and robo1, asymmetrically distributed in the mammalian cortex, that have been associated with autism in humans; and, eight genes, baz1b, fzd9, limk1, tubgcp5, cyfip1, grik1a, nipa1 and nipa2, which have been associated with developmental dyscalculia, a brain disability linked to brain laterality in human. We found a leftward bias in the expression of 10 genes (dapper1, htr3a, htr3b, htr4, id2, ndr2, pkcß,auts2, baiap2 and grik1a), and a rightward bias for 8 genes (lmo4, arrb2, fez1, gap43, robo1) in agreement with the data reported in mammals. We also found a rightward lateralization for nipa1 and nipa2, whereas the remaining genes (eomesa, emx2, emx3, prox1, baz1b, cyfip1, fzd9, limk1 and tubgpc5) were bilaterally distributed. These findings suggest a basic homology in the asymmetric expression of several pallial vertebrate genes.

PMID: 32692463 [PubMed - as supplied by publisher]

via pubmed: autism https://ift.tt/2CSq1yq

#UpNext: 10am - 12pm #AOTBLive - Top 40, Brand New, Dope & Classic Tracks all on 2 Hour Playlist AllDigitalRadio.com #LGBTUrbanCharts https://www.instagram.com/p/BrIUr6-Fez1/?utm_source=ig_tumblr_share&igshid=19skzzp3jyriv

KALP’ten KALBE Konuşanların Adresi... @gelinlikbursa #gelinlik#gelin#bride#white#wedding#weddingdresses#demetriosbride#cosmobella#cymbeline#chloesposa#bursaaksesuar#gelinçiçeği#aksesuar#evlilik#dugun#hazirgelinlik#ithalgelinlik#fashion#bridalstyle#love#gelinaksesuarı#gelinayakkabısı#düğünsalonu#kırdüğünü#gelinsaçı#savethedate#Weddings&Events (Beyaz Butik Bursa) https://www.instagram.com/p/BqpxG9-FEz1/?utm_source=ig_tumblr_share&igshid=pco4x3qk3eer

Um #aninho da minha bolotinha... #minnie #mouse #Mariá #Fez1 (em Campo Do Amem)

Sobre hoje a festinha de 1 ano do lindo do Caio! #Caio#fez1#teve#bom 😍🍻🎂👶🎉

Topper Mickey por @atelieenc . . #convitevideo #conviteaniversario #convitefesta #bolofake #baloes #centrodemesa #niverarthur #hapoybirthday #decoraçãofestainfantil #personalizados #aniversario #faz1 #faz6 #festainfantil #decoraçãofestainfantil #toppermickey #mickey #maedemenino #festainfantilgoiania #gyn #topperdebolo #personalizado #aniversario #baby #bday #artesanato #artesa #eva #feltro #fez1 #decoracao #dicas #atelie #mamaes #mamaesfesteiras #afestaqueeuquero #minhafesta #atelieencantado https://www.instagram.com/p/BoMlo_VgIoI/?utm_source=ig_tumblr_share&igshid=13k1f4jkqsi5v

Transcriptome reprogramming by cancer exosomes: identification of novel molecular targets in matrix and immune modulation

Abstract

Background

Exosomes are extracellular vesicles released by almost all cell types, including cancer cells, into bodily fluids such as saliva, plasma, breast milk, semen, urine, cerebrospinal fluid, amniotic fluid, synovial fluid and sputum. Their key function being intercellular communication with both neighbouring as well as distant cells. Cancer exosomes have been shown to regulate organ-specific metastasis. However, little is known about the functional differences and molecular consequences of normal cells responding to exosomes derived from normal cells compared to those derived from cancer cells.

Methods

Here, we characterised and compared the transcriptome profiles of primary human normal oral keratinocytes (HNOK) in response to exosomes isolated from either primary HNOK or head and neck squamous cell carcinoma (HNSCC) cell lines.

Results

In recipient HNOK cells, we found that regardless of normal or cancer derived, exosomes altered molecular programmes involved in matrix modulation (MMP9), cytoskeletal remodelling (TUBB6, FEZ1, CCT6A), viral/dsRNA-induced interferon (OAS1, IFI6), anti-inflammatory (TSC22D3), deubiquitin (OTUD1), lipid metabolism and membrane trafficking (BBOX1, LRP11, RAB6A). Interestingly, cancer exosomes, but not normal exosomes, modulated expression of matrix remodelling (EFEMP1, DDK3, SPARC), cell cycle (EEF2K), membrane remodelling (LAMP2, SRPX), differentiation (SPRR2E), apoptosis (CTSC), transcription/translation (KLF6, PUS7). We have also identified CEP55 as a potential cancer exosomal marker.

Conclusions

In conclusion, both normal and cancer exosomes modulated unique gene expression pathways in normal recipient cells. Cancer cells may exploit exosomes to confer transcriptome reprogramming that leads to cancer-associated pathologies such as angiogenesis, immune evasion/modulation, cell fate alteration and metastasis. Molecular pathways and biomarkers identified in this study may be clinically exploitable for developing novel liquid-biopsy based diagnostics and immunotherapies.

https://ift.tt/2L8Psyl

UNC-16/JIP3 and UNC-76/FEZ1 limit the density of mitochondria in C. elegans neurons by maintaining the balance of anterograde and retrograde mitochondrial transport.

http://dlvr.it/QXGZ26

Malú fez1 ❤

Maju fez1 ❤ (em Clube do Sargento)

Que honra pra nós da @doisoumfotofilme em parceria com @fotografa_thalitacastanha fazer parte de um momento tão único como esse... @dedesecco obrigado pela confiança em nosso trabalho. #mariaflor #fez1 (em Na Moitta)