MAGNA™: A Revolutionary New Technology for Studying Protein-Protein Interactions

Automotive Chassis Market Size, Share, Trends, Growth

The "Automotive Chassis Market Size" 2019 Research report presents an in-depth analysis of the Automotive Chassis Market size, growth, share, segments, manufacturers, and forecast, competition landscape and growth opportunity. This report also focuses on key trends, market drivers, challenges, standardization, deployment models, future road-map, revenue and 2025 forecast. Moreover, this research report categorizes the global Automotive Chassis Market by companies, region, type and end-user industry.

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Market Growth Drivers:

Harmful gases emission from the exhaust and amount of fuel combusted by a vehicle is directly proportional to emission control, which in return, results in increasing demand for low emission and fuel-efficient vehicles. Hence, the production of a vehicle with low weight chassis will significantly lower the weight of the vehicle, thus achieving the lower emission of harmful gases and better fuel efficiency. Considering this, various automotive design and engineering companies are designing lighter and robust chassis. Motorsport legend Gordon Murray’s automotive manufacturing system designed chassis frame ‘IStream Superlight’ that cuts vehicle weight in half and is claimed to apply to every segment from small city car to commercial vehicles. This new chassis delivers a vehicle only a half of the weight of a standard metal chassis of the same class and size. The complex new designs also helps achieve new levels of durability and rigidity and also maximizing the flexibility of the production platform for manufactures. Moreover, this method will also reduce the cost of automotive manufacturing. So these advancements in chassis frame helps lower the overall weight of the vehicle, eventually lowering the emission from the vehicle. Therefore, the automotive chassis system market is growing amid to the rising demand for low emission and fuel-efficient vehicle.

Points Covered in The Report:

The points that are discussed within the report are the major market players that are involved in the market such as manufacturers, raw material suppliers, equipment suppliers, end users, traders, distributors and etc.

The complete profile of the companies is mentioned. And the market size, capacity, production, price, revenue, cost, gross, gross margin, sales volume, sales revenue, consumption, growth rate, import, export, supply, future strategies, and the technological developments that they are making are also included within the report.

The market growth factors of the market are discussed in detail wherein the different end users of the market are explained in detail.

Who are the Major Automotive Chassis Market Vendors?

Schaeffler

Continental Ag

ZF

Aisin Seiki

Magna

CIE Automotive

F-Tech

KLT-Auto

AL-Ko

Bente

Key Points from Table of Contents:

1. Introduction 1.1. Research Scope 1.2. Market Segmentation 1.3. Research Methodology 1.4. Definitions and Assumptions

2. Executive Summary

3. Market Dynamics 3.1. Market Drivers 3.2. Market Restraints 3.3. Market Opportunities

4. Key Insights 4.1 Global Statistics — Key Countries 4.2 New Product Launches 4.3 Pipeline Analysis 4.4 Regulatory Scenario — Key Countries 4.5 Recent Industry Developments — Partnerships, Mergers and Acquisitions

5. Global Automotive Chassis Market Analysis, Insights and Forecast 5.1. Key Findings/ Summary 5.2. Market Analysis — By Product Type 5.3. Market Analysis — By Distribution Channel 5.4. Market Analysis — By Countries/Sub-regions

TOC Continued…!

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Automotive Camera Market 2020 Size, Regional Share, Overview, Supply and Forecast 2027

The rising government regulations regarding road safety is predicted to bolster healthy growth of the market in the foreseeable future, sates Fortune Business Insights in a report, titled “Automotive Camera Market Size, Share & Industry Analysis, By Technology Type (Digital, Thermal, Infrared), By Position Type (Front, Rear, Side), By Application Type (Park Assist System, Lane Departure Warning System, Drive Monitoring System, Adaptive Cruise Control System, Blind Spot Detection, Others), By Vehicle Type (Passenger Cars, Commercial Vehicles) and Regional Forecast, 2019-2026” the growing demand for automotive camera owing to growing awareness regarding accident prevention is likely to boost the automotive camera market revenue.

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Some of the Major Companies in the Automotive Camera Market Include:

Robert Bosch GmbH

Continental AG, Aptiv PLC

Stonkam Co., Ltd.

Mobileye N.V.

Autoliv Inc.

Magna International Inc.

OmniVision Technologies

and Valeoa

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Announcement for Advanced Camera Electronics (ACETM) Option by AEi to Foster Healthy Growth

Automation Engineering Inc. (AEi), the global technology leader in Active Alignment camera module assembly and test systems (CMAT) and active photonics alignment and test machines (PMAT), announced the release of Advanced Camera Electronics or “ACETM” for the CMAT-Modular camera assembly and test platform. The launch of the powerful camera is likely to aid the expansion of the market during the forecast period owing to the ACE camera electronics architecture that is the only single system available on the market that utilizes a standard interface connection and provides customers with the ability to communicate with all types of IMAGE sensors without the need to swap out hardware and software. ACE will be used to interface with cameras used in autonomous cars, ADAS systems, drones, virtual reality and mobile smartphone devices. ACE communicates and captures image sensor information and is available with any or all of the following standards: parallel, CSI-2 MIPI 4-lane, SPI, I2C, LIN, CAN, NTSC, Ethernet, GPIO, Power over Coax, Sony Proprietary sub-LVDS, up to 6 programmable, independent power supplies, programmable clock to 150MHz and VCM and OIS support. High-speed camera interface communication is an essential element of the active alignment camera assembly process. Furthermore, the Director of Product Strategy at AEi, George Rose, said in a statement, “the ACE architecture also supports stereoscopic camera alignment with RTATM (Real-Time Alignment) of two independent cameras, ACE’s stereo feature with RTATM is a huge advancement and is only available with ACE from AEi”

Increasing Vehicle Production to Encourage Market in North America

Geographically, the global automotive camera market is segmented into North America, Europe, Asia Pacific, and the Rest of the World. Asia Pacific is expected to dominate the automotive camera market and during the forecast period owing to the increasing vehicle production in the region. Manufactures in the region are focusing more on developing high-end cameras to attract more consumers and to have the edge over their competitors. Followed by Asia Pacific, North America is expected to show significant growth during the forecast period owing to government policies and initiatives to implement advanced safety features in entry-level vehicles as well. Europe is also expected to witness steady growth in this market owing to the existential and well-established automotive industry.

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‘All-digital’ CES 2021 kicks off

- By Nuadox Crew -

Due to the COVID-19 pandemic, CES 2021 is going 100% virtual. The annual trade show organized by the Consumer Technology Association officially kicks off today and will last until January 14 (yesterday was “media day”).

Here are a few highlights from key exhibitors:

+ Bosch: Showcased commitments to sustainability as the first global industrial enterprise to become carbon neutral and introduced an AI-enabled wearable fitness tracker that recognizes and records any type of fitness activity that is based on repetitive, cyclative patterns.

+ Canon: Provided a sneak peek of Canon's plans for the all-digital CES beyond cameras and printers, including redefining viewing the planet, skateboarding and tackling food waste.

+ Caterpillar: Shared the first application of command for Caterpillar's autonomous mining trucks and groundbreaking technology in the most challenging conditions.

+ Hisense: Announced the 2021 TriChroma Laser TV line.

+ Indy Autonomous Challenge: Unveiled the world's first autonomous racecar, to be used in the Indy Autonomous Challenge where 500+ university students are developing the technology to drive the racecar and win the competition for a $1.5 million prize.

+ Intel/Mobileye: Shared news around the future of mobility for Mobileye, including plans to open deployment centers in Shanghai, Tokyo, Paris and Detroit, and use house-built lidar sensors.

+ Kohler: Introduced a ceiling mount kitchen faucet with simple touch control; Kohler whole home water monitor that mounts underneath the cabinets, in partnership with Phyn; new Innate intelligent toilet; touchless bathroom faucets; freestanding soaking bath.

+ LG Electronics: Announced next generation of LG PuriCare™ line for high-quality air management solutions; reimagined side-by-side refrigerator, including a wider window, premium interior look and Craft Ice feature; WashTower™ with convenient controls, built in intelligence and advanced cleaning; 2021 OLED evo TV lineup and QNED MiniLED TVs; CLOi UV-C Robot for disinfection; ThinQ App will transform into an open platform for lifestyle innovation.

+ Magna International: Launched a joint venture with LG Electronics to manufacture e-motors, inverters and on board chargers and related e-drive systems for certain automakers, to support the growing global shift towards vehicle electrification.

+ Mercedes-Benz: Showcased the MBUX (Mercedes-Benz User Experience) Hyperscreen, which uses AI to offer a seamless driver and passenger experience.

+ OMRON Healthcare: Announced VitalSight – first remote patient monitoring service designed specifically for hypertension management.

+ Panasonic: Announced technology partnership with Illuminarium Experiences to bring the new 360-degree immersive entertainment centers to life; launched newest OLED TV JZ2000; new Technics wireless headphones will launch later this year.

+ Philips: Discussed the Philips vision and experience in the consumer and professional health tech space and announced the Philips Sonicare 9900 Prestige that is backed by SenseIQ technology and artificial intelligence to intuitively adjust to the need of the user.

+ Samsung Electronics: Announced 4-Door Flex Bespoke refrigerator that can be customized for any kitchen; JetBot 90 AI+ uses object recognition technology and sensors to identify and classify objects and decide the best cleaning path; Eco-packaging will be used for all TV products; Galaxy Upcycling at Home program where users can decide how to repurpose the Galaxy as other convenient home devices.

+ Schneider Electric: Showcased Square D Energy Center, first-ever Square D connected light switches (X & XD range series) and Acti9 Active product, which together deliver a unique end-to-end energy management solution for homes in response to sustainability, resiliency, efficiency and personalization.

+ Skyworth: Presented 2021 TV line up for North America – five series of TVs comprised of 16 different models.

+ Sony: Introduced Airpeak, which integrates AI and robotics to enable creators to explore new heights for photo and video; shared preview of a new, immersive reality concert performance from Madison Beer to demonstrate the music showcase that will be available on Sony PlayStation VR, mobile devices, music video streaming platforms and more.

+ Taiwan Tech Arena: Previewed some of the 100 startup teams from Taiwan Tech Arena that will unveil innovation at CES 2021. Startups are divided into Smart Living, Tech for Good, Cybersecurity & Cloud Solutions, Healthcare & Wellness and Mobility Tech.

+ TCL: Announced OD Zero™ Mini-LED technology that provides viewers with a more realistic and sharper picture and allows for an ultra-thin TV profile; TCL's first-ever Google TV; NXTPAPER tablet, TAB10s, MOVEAUDIO S600 wireless headphones, MOVETRACK Pet tracker and TCL 20 Series phones, with the 5G and SE phones available this month.

Source: CES

Read Also

Top emerging technologies to watch in 2021 (report)

Explore Drugs Targeting RNA Riboswitches with Magna - Depixus

We’ve been working with Dr Jay Schneekloth, a leading expert in RNA-targeted drug discovery, to use our MAGNA™ technology to probe the interactions between the PreQ1 bacterial riboswitch and its natural ligand or a synthetic small molecule.

In a paper published as a preprint on bioRxiv and submitted for publication in a high impact journal, we showed how MAGNA provided novel insights into the distinct mechanisms of action of different ligands upon the target RNA at single molecule resolution.

What is the PreQ1 bacterial riboswitch?

Riboswitches are structured sequences of RNA that are commonly found in the 5′ untranslated regions of bacterial mRNAs and help to control metabolic pathways. They work through direct binding of a ligand such as a metabolite to the riboswitch, which induces a conformation change to their secondary structure and alters gene expression.

The PreQ1 riboswitch regulates downstream gene expression for the biosynthesis of queuosine in response to a metabolite called PreQ1 (7-aminomethyl-7-deazaguanine). Upon binding of PreQ1 the RNA changes into a shape known as a pseudoknot, which alters gene expression at either the transcriptional or translational level.

The ability of riboswitches to modulate bacterial gene expression in response to small molecules such as metabolites makes them an attractive group of novel antibacterial drug targets.

Using MAGNA to explore RNA-ligand interactions

Based on magnetic force spectroscopy, MAGNA is the first technology for exploring dynamic molecular interactions in real time from up to thousands of individual molecules. Here, we used it to probe the interactions between the PreQ1 riboswitch RNA from Bacillus subtilis (Bsu) and its natural ligand, PreQ1, or a synthetic ligand named Compound 4.

MAGNA allows us to precisely measure the effects of applying constant or gradually changing (ramped) forces to hundreds of immobilized riboswitch RNAs simultaneously (Figure 1A). This enabled us to capture the exact point at which each RNA molecule changes conformation.

We found that both PreQ1 and Compound 4 stabilized the riboswitch RNA structure, requiring more force to unfold it (Figure 1B). We were also able to explore the concentration dependency of their effects (Figure 1C, E, F).

Figure 1: (A) Overview of MAGNA as a single-molecule platform for exploring the interactions of bioactive small molecule ligands with their target RNA structures in real-time (B) Unfolding force distributions of the Bsu PreQ1 riboswitch aptamer in control (DMSO), Compound 4 and PreQ1 ligand conditions (C) Dose-response curve for the change in unfolding of the aptamer in the presence of 4 and PreQ1 (D) Raw traces of the constant-force experiments for control, 4 and PreQ1 of a single molecule with cumulative density histograms shown to the right. (E) The aptamer unfolding rate as a function of the concentration of 4 in constant force experiments. (F) The impact of PreQ1 ligand concentration on the occurrence probability of the stable folded state. n is the number of molecules analyzed. Taken from Parmar et al (bioRxiv, 2024).

In addition, Schneekloth and colleagues explored other structural aspects of the interaction between the riboswitch and various ligands, and their impact on gene expression in live bacterial cells. They were also able to show that Compound 4 could bind in a similar way to PreQ1 riboswitches from other species of bacteria, building up a fuller picture of the properties of this novel molecule.

Deeper insights for RNA-targeted drug development

Overall, the findings presented in the paper demonstrate that even though different ligands may appear to be the same in terms of RNA binding site and impact on gene expression, other factors including selectivity, mode of recognition, and impacts on both conformational kinetics and thermodynamics, can all play

 a role in the abili

ty of a compound to modulate biological function. These subtle yet important distinctions may not be apparent using analytical methods that rely on surrogate outputs or bulk measurements.

MAGNA’s unique single molecule approach enabled the Schneekloth team to visualize the binding of a novel ligand to its target in real time and gather insights into the distinct mechanisms of action, which would not have been possible using other methods.

With MAGNA we now have a technology that can not only identify compounds that bind to RNA, but also directly reveal how they impact its structure and function at the level of individual molecules. And we can use it to generate detailed information about the kinetics and concentration dependence of ligand binding.

These results demonstrate the capabilities of MAGNA to deliver valuable data about individual dynamic molecular interactions at scale, supporting lead selection in the development of novel RNA-targeted therapeutics.

Read More here: https://depixus.com/using-magna-to-explore-drugs-targeting-rna-riboswitches/  

MAGNA™: Revolutionizing Targeting RNA & Protein Interactions

Depixus® is a company that is pioneering a revolutionary new technology called MAGNA™. MAGNA™ is a single-molecule analysis platform that can be used to study the interactions of biomolecules, such as DNA, RNA, proteins, and peptides. This technology has the potential to revolutionize drug discovery by providing new insights into how drugs interact with their targets.

What is MAGNA™?

MAGNA™ is a magnetic force spectroscopy platform that can be used to measure the forces between single molecules. This allows researchers to study the interactions between biomolecules in real time and at the single-molecule level. This is a powerful tool that can be used to study a wide range of biological processes, including:

RNA-targeted drug discovery

Protein-protein interactions

Enzyme catalysis

Antibody-antigen interactions

How can MAGNA™ be used for drug discovery?

MAGNA™ can be used to study the interactions of small molecule drugs with RNA targets. This can help researchers to develop new RNA-targeted therapies. MAGNA™ can also be used to study protein-protein interactions. This can help researchers to develop new drugs that target protein-protein interactions.

The benefits of using MAGNA™

MAGNA™ offers a number of benefits over traditional methods for studying biomolecular interactions. These benefits include:

Single-molecule sensitivity: MAGNA™ can detect the interactions between single molecules. This is much more sensitive than traditional methods, which can only detect the interactions between large numbers of molecules.

Real-time measurements: MAGNA™ can measure the interactions between biomolecules in real time. This allows researchers to study the dynamics of these interactions

Label-free: MAGNA™ does not require the use of labels to study biomolecular interactions. This can make it easier to study complex biological systems.

Conclusion

MAGNA™ is a powerful new technology that has the potential to revolutionize drug discovery. This technology is still in its early stages of development, but it has already shown great promise. As MAGNA™ becomes more widely used, we can expect to see a new wave of drug discovery based on a deeper understanding of biomolecular interactions.

Depixus: Unveiling the Secrets of Life with MAGNA™ Technology

Imagine peering into the nanoscale realm, where delicate biomolecules like proteins and DNA orchestrate the symphony of life. MAGNA™ grants scientists this very ability, allowing them to observe and measure the forces at play in these crucial interactions. This unprecedented level of detail opens a treasure trove of possibilities for understanding the mechanisms of disease and designing targeted therapies.

But MAGNA™’s potential extends far beyond disease research. This versatile platform can also be used to study protein-protein interactions in healthy cells, furthering our understanding of fundamental biological processes. Additionally, it can be employed in drug discovery pipelines, accelerating the identification of promising drug candidates.

The implications of MAGNA™ are truly staggering. This revolutionary technology has the power to transform our understanding of life at its most fundamental level, paving the way for a future of personalized medicine and groundbreaking scientific discoveries. Depixus is at the forefront of this revolution, and with MAGNA™ in hand, they are poised to write a new chapter in the story of human health.