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pear-pies · 4 years

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Wom Journal - Oct 2000

(really, really awful google translate of the OCR scanned text below the cut)

The desires of Brian

More serious topics, healthier lifestyle more

Responsibility hopes to satisfy her third album

PLACEBO their greed for change

As a placebo in 1996 with their Seat but on the English Musitnar they offered the dazzling alternative ill de inogenic bands of Brit pop. Yours Guitar rock that was clearly ambiguous tare .. Frontman Brian Molko and the urge ZtegülnICKee they turned around self-shielding lings of the music press Provocative sayings dent 'former drama student Molka about the cast Lippert. Times he sold Sex monster, sometimes he flirted with his consumption. Placebos self-destruct trip - Frustration and emptiness that the band Asii at dee, attended their second AlburnWITHOUTIfretVM Accompanied NOTHING "We milked our music like Cow. "Molko leans on the Hoteldnigl his voice is deep his americans ground despite the many years in Londortjkrbeai We are months with the songs about the Globilige * tours. Then when we went to the studio then a bunch of new pieces about ddlniibentAtni .1 + interest in wincler's own music , .. " wake up. "It took nine months for Placebo'.fQr third baby BLACK MARKET MUSIC. Instead of that. A superstar producer's ego below the band produced together with Patti Coikeft for the first time itself. Never before has it unlike trio so easy Record songs. Fun and friend- determined the studio atmosphere sphere. The one they usually take care of Rock 'n' roll lifestyle was behind the Music back "Today we are focused more, our music enjoys the first Priority, "says Brian Molko." Body It will also be more strenuous shortly before the opening we celebrated like in 1997. After that I couldn't move for three days was the slogan for the studio: the party is over. Henceforth health food diet " This time placebo were on the “collaboration trip, "says Molko. On the electronic rock single" Taste In Men "Caroline Finch from the Brit band Ling- leum the BacIdngvocaLs. Rob Ellis, drummer from PJ Harvey, arranged the strings on the hidden. Track "Black Market Blood". And for that probably The most piercing piece of "Spite & Malice" filled the friend

Placebo singer 1341

itannitdti.dat word Oh

vet gold mine "we were like a hiba red, Film and am Hest * eiäältill dw But people are so. When we started, wielanges wore we Guth. Then we became the Glani.Bend But: mine is a movie, and placebo is that rea * lebeg,

US rapper Justin Warfield chanted the chorus. The approach to the US market is no coincidence. Was at the debut Sex d. I% Mai balm second Obilia11 which the Ban ' , to Aid SLACK MARKET MUSIC arctic american themes iep .. 'itch placebo 2000 with political: ii • MA (jipite & Malice "), the American pop 'Dissen of the parents ("Blackeyed") and init; , ! racism, ("hemoglobin"). "We lik '' always oppose any form of prejudice. ,, globin 'is our version of Billie Holidays b.,,, fruit of old jazz from the fifties .2 some strange fruit in the southern states sees dangling .. black people, .- ..; hangs whales. '" There is also on BLACK MARKET Placebo-typical love songs. But there are: telling and the characters that ie in the songs ebidergr Lind. "This is a natural Enrid. C3,21 3rd, BOnpritings. If you go to 30 jit you more on what's happening in the world : 'biletideitständig busy with yourself. Nap . make tin * nigh flitch angry. '., Ic

Minden, healed in the lyrics to zt4Inpatiev1isen degrees around myself '! • With BLACK MARKET MUSIC you have placeh various phases of self-experimentation Reliance level reached. Even if the complete • HUG of samples now live a backup key Molko leaves no need for it that their development is only successful well the badd of the synergy of the triangle, p, i, placebo works like a triangle. On. So it will never be even more than give. "KATJA 'SC

An offer, the role of Judas Priest in You refused to play "Metal God". I got the Hollywood script for a film with Jennifer Aniston and Marky Mark. At first I thought: Wow, this is Holly- wood! When I got to the second page of the script I said: No, • we are not rent-a-band for film bizz!

With the album title BLACK MARKET MUSIC associ is forbidden. Music on the black market is also a popular topic. The album title takes up what is currently on Napster and MP3 expires, the black market of the 21st century. It is attractive, something To have illegal things that are only available under the counter. But it is illegal if our album is in the Download the Internet from unauthorized sites. About it you no longer in control. It is not fair by an artist too expect him to work for nothing. Nobody works for free. Artists bear responsibility like everyone else. We want not living poor as Van Gogh. The artist life becomes novel represented by people. the hard work, the band brings with it, do not appreciate. It would be to these people no matter if we are hungry or unemployed.

As band members you all have a very different background. What welds you together?

We have the same ideas, the same goals, what we do with placebo want. We like the same drinks, vodka red bull in large Amounts. We all grew up with the feeling that to be more. That made us extremely independent individuals, and that's probably the bond that connects us.

You worked with David Bowie. Do you look at him like fans, or is it now? a friendship? It's definitely friendship. Placebo and Mr. Bowie have mutual respect for each other. Uncle Dave supported us before we even recorded the first album. With the Friendship has grown through time and tours, until it finally worked on "Without You I'm Nothing" came. It is indescribable when David Bowie calls you and asks: "Can I sing on your song?" And then it's natural incredible when this legend sings fin studio to your music. An absolute fulfillment for me.

It was probably a fulfillment. not meet for Calvin Klein lit placebo To take photos; which then biered in Prussia have never been published. ekuelleAmeri- Wasn't your butt 'Eärian Molko pretty enough? eg • qpitarrist, 27), My butt not pretty enough? You psexuals wanted me without makeup and in. ". ch de Stefan Olsclairriiirsist, 26) and oversized men's clothing images lietmovDirrnellsr nri H4witt I wanted to wear a skirt. Drummeh 21M out of the way. Molko and I didn't manipulate myself, A 5 first demos, leave as they would have liked. Her, Mtt acted as an alcikushilfsdrummer. The photos are then different from ChEm 1996 forth from their self-titled when she imagined it to be a Mairrer, D, LaPel, this time ben But at least I was able to use Robert Schultzlscrich * drums. Keep clothes. melee ii Jain luckid1 as she as - -stifle tour ein.Hewitt ,.> ,, A5A'A • came back to Drumm-lei Piacr? bo. About your buddy Marilyn ilf AnIriJrie VC'n Michgel Slkpe (REM.) You once corsored Manson, irk Dire Siind im says: "Marilyn makes the" Velrict Golf stefan". best blowjob. "Personal. cl: s yen steve orsbeirme: produ- • Experience with it? ricrte album l.'JlITHOkik 'irk!) I'M NO- Yes, but that's not exactly true. I flIflG 1999 it ii ilern theme song have never said that Marilyn makes the best DMett Florrvie again. With makes a blowjob. I already have the single hEvery 'feu, Every Me "on had better. em soundtrack "Ertl old angels" was INTERVIEW: KATJA SCHWEMM ERS Placulko still popular in Germany aier, Nettie CD: BLACK MARKET MUSIC.

#germans help me out here #placebo #brian molko #stefan olsdal #steve hewitt

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eastbayprintsale · 4 years

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7th ANNUAL EAST BAY PRINT SALE!

Featured Exhibitors:

Creative Growth -- Perfectly Acceptable -- Lucky Riso -- Bad Student -- Issue Press -- Colpa Press -- Bloom Press -- Ashley Lukashevsky -- Daria Tessler -- John Pham -- Jennifer Calandra -- Sophia-Yemisi Adeyemo-Ross -- Alex Bowman -- Malaya Tuyay -- Jeffrey Cheung Bijou Karman -- Deth P Sun -- Hellen Jo -- Rob Sato

Exhibitors:

Adrian Rotzscher - Alayna Tinney - Alex Martinez - Alfonso Aceves Alicia Cardell - Alondra Solis Guzman - Alyssa Aviles - Amanda Bernal Amy Burek - Amy Jo - Anastasia Itkina - Anjelica E Colliard Ann Altstatt - Anna Capurso - Ariana Sanchez - Arif Qazi - Boya Sun Brian Wilson - Calvin Crockett - Carmen McNall - Cenorina L Ramirez Chaitra Bangalore - Charisse Celestial - Chris Cuadrado - Christine Innes Christine Juon - Cianna Valley - Cindy Ostroff CTRL+SHFT COLLECTIVE - Daniel González - David Ryan Demian Bartholomew - Derek Pratt - Dongyi Wu - Ed Garnica - Eishin Yoshida Elinor Breidenthal - Em Corbo - Emily Gui - Emmanuel García - Enrique López Erica Newton - Erica Schapiro-Sakashita - Erica Wheeler-Dubin Ethan Snyderman - Evka Whaley-Mayda - Ezzie DeGiovanni - Floss Editions Giana Montero - Greg Borman - Haoyun Erin Zhao - Harry Diaz Heather Hardison - Ian Mackay - Jaime Valderrama - Jake Voinar-Fowler Jane Hargrave - Janina Arianna Larenas - Jeff Meadows Jesse Hawthorne Ficks - Jo Bee - Joan Zeta - Jonathan Jeweler - Jose Gonzalez - Julia Foote - Julianne Villegas - June Hong - Kasaia Luckel Katie Wheeler-Dubin - Kelly Autumn - Kevin VQ Dam - KIDTOFER Kristen Brown - Kristi McMahon - Krusty Wheatfield - Lili Arnold Linh-Yen Hoang - Lizzy Choi - Louis Bicycle - Louise Leong Lucas Elmer Gasperik - Lucy Stark - Mara N Gerson - Maren Preston Mariangela Le Thanh - Max Marcil - Maya Fuji - Melek Zertal - Melissa West Melody Overstreet - Meredith French - Micael Nuñez - Minnie Phan - Mira Liu Montana Manalo - Nichol Markowitz - Night Diver Press - Nina Aragon Ocean Escalanti - Orlie Kapitulnik - Pacolli - Paul Rangell Paulina Berczynski - Pável Acevedo - Peter Baczek Pulp Press - RABIA - Rajit Phiosuwan - Robert M Wilson - Robert Minervini Robin Milliken - Rosalie Z. Fanshel - Ross Sullivan - Ryan Harrison - Shirin Bina Sam Vaughan - Samantha Espinoza - Samantha Huang - Sami Graf Sarena Lesem - Sayuri Kimbell - Sean Vranizan - Shelby Rosabal Shirley Chong - Siavash Almeida - Stacy Javier - Stephanie Martin Sudi Wachspress - Suzie McMurtry - Tamar Beja - Tamiko Sidore Tanner Griepentrog - Toru Sugita -Valerie Perez Ordoñez - Veronica Graham Vincent Waring - Vivian Chen - Wesley Hrubes - Yerrie Choo - Yoko Kikuchi Zach Clark

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hitchell-mope · 5 years

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Dark curse season two episode list

The mob. After the curse everyone wants Uma dead. Evie forms a mob to get her (think Doctor whale at the start of season two of ouat)

The old man and the tyrant. Wilhelmina (Victoria Justicr) makes herself known to yen sid (Hugh Laurie). Who’s stuck in a nursing home.

Queen Clarion. Gradie Doug and jay ask the queen of the Neverland fairies (Kiera knightly) for help in escaping Neverland

Alone. Evie (still reeling from her husbands disappearance) completely washes her hands of Mal because the dark fairy queen refuses to kill Uma. The episode ends with Evie meeting Wilhelmina at a bar

Sisters. Evie is brainwashed by Wilhelmina to be just like her.

Through the looking glass. Gradie Doug and jay finally make it out of Neverland. Only to land in the middle of a battle between the Hightopp clan and the remaining playing cards in Wonderland

The cat. Spotlight episode for Chester/Leon Taylor (Zac Efron). Mostly trying to get Evie free of her sisters conditioning

A most violent death. Chaudrey spotlight episode. It ends with their death at evil Evie’s hands.

Four witches. This is a turning point in Uma and Mal’s relationship. Mal saves her from Evie and Wilhelmina. Via a massive two vs two witch battle. That only ends because Uma causes a cave in that almost kills Wilhelmina

Reunion. Gradie Doug and jay make it back to Auradon. Grant and Doug reunite with their cousins and Evie. Hadie makes a beeline for Mal. Jay goes to Carlos. Only to find that Carlos is now with Jane.

Audrey. In the underworld Audrey seeks out the help of Charon the ferryman (Colin Salmon) in order to help Mal defeat Wilhelmina. Mid season finale

Father. Chaudrey gets an audience with hades (John Barrowman). At the end of the episode hades and chaudrey burst into Auradon in electric blue fire scaring the pants off of pain and panic (Chris and Liam Hemsworth)

The modern Prometheus. Hades (Eva Green) fully resurrects Harry and the twins. While Uma has a tearful reunion with the children Hadie pulls his (fully amnesiac) brother aside and threatens to murder him in front of Uma and the kids should he look at Mal the wrong way. (Hadie still hasn’t learned his lesson)

The Vorpal Sword. Dizzy decides that the only way to save her mother is to kill her aunt. Even if she dies in the process. Her life being put in danger is what finally breaks Evie free of Wilhelmina’s control

The first mate. This episodes flashbacks show Harry’s childhood. From birth (IE. when James Hook realised he conceived a child with the lord of the underworld) to his less the happy childhood as the overlooked and under cared for middle child (his father blatantly calls him “the bastard mistake”) to hades (Eva Green) reappearing in his life to meeting Uma to meeting Gil. All the way to his halfassed resurrection at Hadie’s hands. In the present day an amnesiac Harry is still trying to remember who he is. Hades (Sebastian Stan) lets Hadie have it for bringing Harry and the twins back in such w cruel traumatising way

The Godmother. Wilhelmina centred. Her (the titular godmother), Arthur (Tom Holland) and Guinevere Pendragon (Saoirse Ronan) and Silas (David Mazouz) summon the tweedle demons (Daniel Radcliffe and Matthew Lewis) to indoctrinate Taran Hightopp (Charlie Rowe) into their inner circle

The children of hades. The flashbacks consist of hades (Sebastian Stan, Eva Green and Jesse L Martin) meeting, falling in love with and subsequently siring children with Danae (Anne Hathaway) James Hook (Robert Carlyle) and Maleficent (Charlize Theron). In Auradon it’s Hadie who gets Harry to remember with a very mean spirited speech “you are nothing. You have always been nothing. You will always be nothing. Well. Nothing except what your father far too generously described you as. The bastard mistake”. Then Harry slaps him around the face. And they fight. Nearly causing a town wide blackout in the process

The Merry Men. Evie’s in the prison along with Robin Hood. Both voluntarily. For the crimes they committed (Robin was a corrupt cop under the curse. Evie blames herself for the whole brainwashing thing) Silas visits them both. Commending Evie in her blandness. And saying that robin has 48 hours to locate his wife or she’s fed to the tweedles. This is where the Merry men come in

An oath on the Styx. Hadie, fed up with Harry being coddled and everyone seemingly forgetting that Uma cast the curse (She’s been hanging around Mal a lot recently trying to mend fences) forces pain and panic (now Abby Ryder fortson and Pearce Gagnon) to dispose of Harry in the most humiliating painful way possible. He doesn’t care what happens when hades finds out (probably renounce Hadie’s immortality) he just wants Harry gone and Uma to hurt. He makes the two swear on the river Styx. All three know that if it doesn’t happen. Terrible things will befall the pair

Taran Hightopp. Wilhelmina has been at it again. She’s successfully brainwashed her half brother Taran (Charlie Rowe) and has sent him to kill Uma. Taran dies at Harry’s hands. Meanwhile the subplot is about CJ Hook (Florence Pugh) and Sadie Meyer (Sabrina Carpenter) getting re-engaged. The flashbacks chronicle their relationship.

The death of Harry Hook. Hadie finally did it. He finally got his brother killed. The exact same way Wilhelmina killed Harriet. Sword to the gut and a heart rip. But this happened in front of the twins. So Uma tries to stab him with an in use fire poker. The episode ends with hades (John Barrowman) banishing Hadie to another realm. And Harry’s funeral. Which is only attended by Uma hades (Eva Green) and the twins

Rosemary. Wilhelmina sacrifices Arthur Pendragon to the Tweedles and brings her aunt (Rene’s mother) to Auradon from Wonderland Rosemary the former red queen (Jennifer Morrison) to help her kill Uma. In Arendelle Hadie seeks out the help of queen Eloise (Elizabeth Gillis) the daughter of Kristoff and Anna for help in getting back home and banishing his father back to the underworld.

#disney descendants #dark curse

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strangenoquestion · 3 years

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I pull out of the parking lot and drive down Bellaire, the main road that cuts through Chinatown. Four blocks down, I arrive at my destination. Situated at the junction of an L-shaped plaza, Boba Life is almost always packed on weekends. Like most teahouses, a row of flat-screen TVs above the counter displays the menu. The walls are painted black and covered with chalk murals by local artists. The exposed dark wood beams give the shop the illusion of having high ceilings. Tracks of pod lights illuminate the otherwise dim space, and a mix of K-pop and Billboard Hot 100 plays from the surround sound speakers. A long mahogany table sits in the middle of the front room, and smaller square or round tables line the wall.

Jennifer Yen, A Taste for Love

#setting #fictional bucket list #I'm feeling snacky #fact in fiction #that Asian American life

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aristocratslog · 4 years

Video

vimeo

Don't Ever Change from Don Swaynos on Vimeo.

The reunion between a woman and her estranged daughter is interrupted by a man with an unusual request.

World Premiere, Overlook Film Festival

International Premiere, Fantasia Film Festival

Official Selection, BendFilm, Cinepocalypse, Cucalorus, deadCENTER, Eerie Horror Film Festival, FearNYC, Frightening Ass Film Festival, Indie Memphis, Mayhem Film Festival, MonsterFest, Sidewalk Film Festival, Telluride Horror Show, BUT Film Festival, STUFF MX, Courts mais Trash, Final Girls Berlin, Landshuter Kurzfilmfestival, Cellu L'art, Norman Film Festival

Vimeo Staff Pick Short of the Week

donswaynos.com twitter.com/murderhubcz facebook.com/terminal75films/ facebook.com/partandparcelcreative/

Cyndi Williams, Karen Hickman Heather Kafka, Amy Frank Mosley, Jason

Writer/director: Don Swaynos

Producers: Jennifer Harlow & Matthew L Wallis

Director of Photography: Amy Bench

Art Direction: Caroline Karlen

Original Music: Curtis Heath

Gaffer: Austin Tolin

Sound mixer: Paul Toohey

HMU: April Swartz

Special Effect Make-up: Eric Zapata

DIT: Ted Powers

Still Photographer: Tate English

Sound Re-recording Mixer: Eric Friend, Optical Audio

Post-production Services Provided by TBD Post

Digital Intermediate Colorist: Brandon Thomas

VFX Artist/ Online Editor: Dennis Valk

Title Design: Yen Tan

Karen Hickman Has a Posse

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invenusable · 9 months

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#Vypra #Power Rangers #Time Force #Screenshots #Demons #Jennifer L. Yen #Villains #Generals

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aabany-group · 5 years

Link

AABANY congratulates the AABANY members who have been named Top Super Lawyers and Rising Stars in the New York Metro 2018 edition.

Both recognitions of Super Lawyer and Rising Star involve a very selective and intense process in which the selected attorney is nominated and approved by his or her peers in the same area of practice.

Selections are made on an annual basis. Only 5% of attorneys are recognized as Super Lawyers, and only 2.5% of attorneys under 40 years of age are selected as Rising Stars. The attorney must prove to be ethical, have excellent client records and proven results. The 2018 digital edition of Super Lawyer and Rising Star can be found by following the link in the title.

Congratulations to you all on your efforts and achievements!

New York Metro Super Lawyers

Eugene L. Chang, Willkie Farr & Gallagher LLP

Kenneth Chin, Kramer Levin Naftalis & Frankel LLP

Sylvia Chin, White & Case LLP

Jane Chuang, Lee Anav Chung White Kim Ruger & Richter LLP

Huhnsik Chung, Stroock & Stroock & Lavan LLP

Eve C. Guillergan, Eve Guillergan PLLC

Andrew T. Hahn, Hawkins Delafield & Wood LLP

Lan Hoang, Baker & Hostetler LLP

Benjamin C. Hsing, Baker & Hostetler LLP

Annie Huang, Robins Kaplan LLP

Richard Kim, Wachtell, Lipton, Rosen & Katz

David K. Lam, Wachtell, Lipton, Rosen & Katz

Glenn Lau-Kee, Lau-Kee Law Group, PLLC

Kenneth E. Lee, Levine Lee LLP

Lawrence G. Lee, Lynch Daskal Emery LLP

Lisa S. Lim, Akerman LLP

Raymond Y. Lin, Latham & Watkins LLP

Marie Ng, Sullivan Papain Block McGrath & Cannavo P.C.

Tai H. Park, Park Jensen Bennett LLP

Eric Su, FordHarrison LLP

Vinoo Varghese, Varghese & Associates, P.C.

Ona Wang, Baker & Hostetler LLP

Allen Wong, Raimond & Wong LLC

Arjay G. Yao, Morris, Duffy, Alonso & Faley

Tsui H. Yee, Law Offices of Tsui H. Yee, P.C.

Pauline Yeung-Ha, Grimaldi & Yeung LLP

Andrew J. Yoon, Weil, Gotshal & Manges LLP

New York Metro Rising Stars

Keala Fumiko, Chan Hubbard

Joanna K. Chan, Cohen & Gresser LLP

Emily S. Chow, Ginsburg & Misk

Anthony K.C. Fong, Anthony K.C. Fong, Esq.

Zheng Gao, Kevin Kerveng Tung, P.C.

Ligee Gu, Halperin Battaglia Benzija, LLP

Yin Huang, Zuber Lawler & Del Duca LLP

Hanh Huynh, Rubin LLC

Jing Jin, Frank, Harris, Shriver & Jacobson LLP

Joyce E. Kung, Sive, Paget & Riesel P.C.

Tiffany Ma, Young & Ma LLP

Claudia Pak, Kramer Levin Naftalis & Frankel LLP

Anna J. Wang, Robinson & Cole LLP

Jennifer H. Wu, Paul, Weiss, Rifkind, Wharton & Garrison LLP

Shengyang Wu, Caesar and Napoli, P.C.

Ruofei Xiang, Mazzola Lindstrom LLP

Stephenie Yeh, Grimaldi & Yeung LLP

Vanessa Y. Yen, King & Spalding LLP

William Yeung, Law Office of Yeung & Wang PLLC

Michael D. Yim, Putney, Twombly, Hall & Hirson LLP

Ji-Young (Rachel) Yoo, Law offices of Rachel J. Yoo, LLC

Sojin Yoon, Kelley Drye & Warren LLP

#super lawyers #rising stars #new york metro #2018 #congratulations

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redcarpetview · 1 year

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95TH OSCARS® ROUNDS OUT SHOW PRESENTERS

Halle Berry, Paul Dano, Cara Delevingne, Harrison Ford, Kate Hudson, Mindy Kaling, Eva Longoria, Julia Louis-Dreyfus, Andie MacDowell, Elizabeth Olsen, Pedro Pascal and John Travolta round out the slate of presenters at the 95th Oscars®, executive producers and showrunners Glenn Weiss and Ricky Kirshner and executive producer Molly McNearney announced today. Hosted by Jimmy Kimmel, the Oscars will air live on ABC and broadcast outlets worldwide on Sunday, March 12, 2023, at 8 p.m. EDT/5 p.m. PDT.

Previously announced Oscars presenters include Riz Ahmed, Halle Bailey, Antonio Banderas, Elizabeth Banks, Emily Blunt, Jessica Chastain, John Cho, Glenn Close, Jennifer Connelly, Ariana DeBose, Andrew Garfield, Hugh Grant, Danai Gurira, Salma Hayek Pinault, Samuel L. Jackson, Dwayne Johnson, Michael B. Jordan, Nicole Kidman, Troy Kotsur, Jonathan Majors, Melissa McCarthy, Janelle Monáe, Deepika Padukone, Florence Pugh, Questlove, Zoe Saldaña, Sigourney Weaver and Donnie Yen.

The 95th Oscars will be held on Sunday, March 12, 2023, at the Dolby® Theatre at Ovation Hollywood and will be televised live on ABC and in more than 200 territories worldwide.

ABOUT THE ACADEMY

The Academy of Motion Picture Arts and Sciences is a global community of more than 10,000 of the most accomplished artists, filmmakers and executives working in film. In addition to celebrating and recognizing excellence in filmmaking through the Oscars, the Academy supports a wide range of initiatives to promote the arts and sciences of the movies, including public programming, screenings, publications, educational outreach, exhibitions, and more.

FOLLOW THE ACADEMY www.oscars.org www.facebook.com/TheAcademy www.youtube.com/Oscars www.twitter.com/TheAcademy www.instagram.com/TheAcademy www.tiktok.com/@oscars

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cancersfakianakis1 · 6 years

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Eradication of Triple-Negative Breast Cancer Cells by Targeting Glycosylated PD-L1

Publication date: 12 February 2018 Source:Cancer Cell, Volume 33, Issue 2 Author(s): Chia-Wei Li, Seung-Oe Lim, Ezra M. Chung, Yong-Soo Kim, Andrew H. Park, Jun Yao, Jong-Ho Cha, Weiya Xia, Li-Chuan Chan, Taewan Kim, Shih-Shin Chang, Heng-Huan Lee, Chao-Kai Chou, Yen-Liang Liu, Hsin-Chih Yeh, Evan P. Perillo, Andrew K. Dunn, Chu-Wei Kuo, Kay-Hooi Khoo, Jennifer L. Hsu, Yun Wu, Jung-Mao Hsu, Hirohito Yamaguchi, Tzu-Hsuan Huang, Aysegul A. Sahin, Gabriel N. Hortobagyi, Stephen S. Yoo, Mien-Chie Hung Protein glycosylation provides proteomic diversity in regulating protein localization, stability, and activity; it remains largely unknown whether the sugar moiety contributes to immunosuppression. In the study of immune receptor glycosylation, we showed that EGF induces programmed death ligand 1 (PD-L1) and receptor programmed cell death protein 1 (PD-1) interaction, requiring β-1,3-N-acetylglucosaminyl transferase (B3GNT3) expression in triple-negative breast cancer. Downregulation of B3GNT3 enhances cytotoxic T cell-mediated anti-tumor immunity. A monoclonal antibody targeting glycosylated PD-L1 (gPD-L1) blocks PD-L1/PD-1 interaction and promotes PD-L1 internalization and degradation. In addition to immune reactivation, drug-conjugated gPD-L1 antibody induces a potent cell-killing effect as well as a bystander-killing effect on adjacent cancer cells lacking PD-L1 expression without any detectable toxicity. Our work suggests targeting protein glycosylation as a potential strategy to enhance immune checkpoint therapy.

Teaser

Li et al. show that glycosylation of PD-L1 is essential for PD-L1/PD-1 interaction and immunosuppression in triple-negative breast cancer (TNBC). They generate a glycosylation-specific antibody that induces PD-L1 internalization and an antibody-drug conjugate with potent anti-tumor activities in TNBC models. http://ift.tt/2G7IeUY

#Oncology-Sfakianakis

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njawaidofficial · 7 years

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Casting Society to Honor Barry Levinson, Kevin Huvane at Artios Awards

http://styleveryday.com/2017/10/08/casting-society-to-honor-barry-levinson-kevin-huvane-at-artios-awards/

Casting Society to Honor Barry Levinson, Kevin Huvane at Artios Awards

Casting director Victoria Thomas will receive the Hoyt Bowers Award.

CAA’s Kevin Huvane, filmmaker Barry Levinson and casting director Victoria Thomas will be honored by the Casting Society of America at its 33rd annual Artios Awards, which will be held Jan. 18 simultaneously at the Beverly Hilton Hotel in Beverly Hills and Stage 48 in New York City.

Huvane, partner and managing director at CAA, will receive the Lynn Stalmaster Award for Career Achievement, recognizing his contributions to the industry. The honor is named after the first casting director in history to win an honorary Academy Award.

Levinson, the Oscar-winning director, screenwriter and producer whose credits range from Rain Man to HBO’s recent The Wizard of Lies, will be presented with the Marion Dougherty New York Apple Award, which is given to an individual who has made a special commitment to the New York entertainment industry through their collaboration with casting directors and which is named after pioneering casting director Marion Dougherty.

Artios Award-winner Thomas, whose credits include award-winning films such as Django Unchained, Hidden Figures, Edward Scissorhands, Sid and Nancy, Straight Outta Compton and Detroit, will be honored with the Hoyt Bowers Award for outstanding contribution to the casting profession. The award is named after casting director Hoyt Bowers. was a brilliant casting director and a supportive mentor.

CSA also announced its 2018 nominees for outstanding achievement in casting in the television, theatre, shortform series and short film categories. Nominees for feature film will be announced early next year.

The full list of television, theatre, shortform series and short film nominees follows:

TELEVISION PILOT AND FIRST SEASON – COMEDY

Atlanta — Alexa L. Fogel, Tara Feldstein Bennett (Location Casting), Chase Paris (Location Casting), Kathryn Zamora-Benson (Associate) Better Things — Felicia Fasano, Tara Nostramo (Associate) Dear White People — Kim Coleman I Love Dick — Eyde Belasco Insecure — Victoria Thomas

TELEVISION PILOT AND FIRST SEASON – DRAMA

13 Reasons Why — Kerry Barden, Paul Schnee, Barbara Fiorentino, Nina Henninger (Location Casting), Joey Montenarello (Associate), Terese Classen (Associate) The Crown — Nina Gold, Robert Sterne The Handmaid’s Tale — Sharon Bialy, Sherry Thomas, Russell Scott, Robin D. Cook (Location Casting), Jonathan Oliveira (Associate) This Is Us — Bernard Telsey, Tiffany Little Canfield, Josh Einsohn, Ryan Bernard Tymensky (Associate) Stranger Things — Carmen Cuba, Tara Feldstein Bennett (Location Casting), Chase Paris (Location Casting), Wittney Horton (Associate) Westworld — John Papsidera, Deanna Brigidi (Associate)

TELEVISION SERIES COMEDY

Black-ish– Alexis Frank Koczara, Christine Smith Shevchenko Crazy Ex-Girlfriend — Felicia Fasano, Venus Kanani, Tara Nostramo (Associate) Girls — Jennife Eustons Transparent — Eyde Belasco Silicon Valley — Jeanne McCarthy, Nicole Abellera Hallman, Leslie Woo Veep — Dorian Frankel, Sibby Kirchgessner, Marlise Gunzenhauser (Associate)

TELEVISION SERIES DRAMA

Black Mirror — Jina Jay, Henry Russell Bergstein (Location Casting) Bloodline — Debra Zane, Shayna Markowitz, Lori Wyman (Location Casting), Marie-Thérèse Verbruggen (Associate), Erin Fragetta (Associate) Homeland — Judy Henderson, Kimberly Graham (Associate) The Affair — Ross Meyerson, Julie Tucker The Americans — Rori Bergman

LIMITED SERIES

Big Little Lies — David Rubin, Melissa Pryor (Associate) Fargo — Rachel Tenner, Jackie Lind (Location Casting), Stephanie Gorin (Location Casting), Charlene Lee (Associate) Feud: Bette and Joan — Robert J. Ulrich, Eric Dawson, Carol Kritzer, Jennifer K.M. Treadwell (Associate) The Night Of — Avy Kaufman, Sabrina Hyman, Susanne Scheel (Associate) When We Rise — Sheila Jaffe, Gail Goldberg, Sean Cossey (Location Casting), JJ Ogilvy (Location Casting), Nina Henninger (Location Casting)

FEATURE FILM – NON THEATRICAL RELEASE

Hairspray Live — Bernard Telsey, Abbie Brady-Dalton, Cesar A. Rocha (Associate) Killing Reagan — Junie Lowry Johnson, Libby Goldstein, Mark Fincannon (Location Casting), Craig Fincannon (Location Casting), Lisa Mae Fincannon (Location Casting), Monica Kelly (Associate) The Immortal Life of Henrietta Lacks — Cindy Tolan, Meagan Lewis (Location Casting), Daniel Cabeza (Associate) The Rocky Horror Picture Show, Let’s Do the Time Warp Again — Robert J. Ulrich, Eric Dawson, Carol Kritzer, Stephanie Gorin (Location Casting), Alex Newman (Associate) The Wizard of Lies– —Ellen Chenoweth, Susanne Scheel (Associate)

CHILDREN’S PILOT AND SERIES (LIVE ACTION)

Bunk’d — Howard Meltzer Girl Meets World — Sally Stiner, Barbie Block Julie’s Greenroom — Bernard Telsey, Conrad Woolfe (Associate) Nicky, Ricky, Dicky & Dawn — Danielle Aufiero, Amber Horn, Steven Tylor O’Connor (Associate) School of Rock — Suzanne Goddard-Smythe, Ty Harman (Associate)

TELEVISION ANIMATION

American Dad! — Linda Lamontagne Bob’s Burgers — Julie Ashton-Barson Bojack Horseman — Linda Lamontagne Family Guy — Linda Lamontagne Peanuts — Matthew Jon Beck

REALITY SERIES

Are You the One? — Damon Furberg, Heather Allyn Born This Way — Sasha Alpert Project Runway — Sasha Alpert Real World — Sasha Alpert True Life: We Are Transitioning — Tony Miros

SHORT FILMS

Crowbar Smile — Eyde Belasco Perfect Roast Potatoes — Rich Mento Plea — Marin Hope Public Speaking — Adrienne Stern The Sub — Amanda Lenker Doyle

SHORTFORM SERIES

Confess — Fern Champion, Sharon Lieblein, Troy Daniel Smith (Associate) Now We’re Talking — Alexis Frank Koczara Party Girl — Nickole Doro, Shayna Sherwood Single By 30 — Sherrie Henderson, Romy Stutman, Vanessa Knight (Associate) Tales of Titans — Amanda Lenker Doyle, Chrissy Fiorilli-Ellington Tween Fest — Amanda Lenker Doyle

NEW YORK BROADWAY THEATRE – COMEDY OR DRAMA

A Doll’s House Part 2 — David Caparelliotis, Lauren Port Heisenberg — Nancy Piccione Indecent — Tara Rubin, Felicia Rudolph (Associate) Oslo — Daniel Swee Sweat — Heidi Griffiths, Jordan Thaler

NEW YORK BROADWAY THEATRE – MUSICAL

Charlie and the Chocolate Factory — Rachel Hoffman Come From Away — Rachel Hoffman Groundhog Day — Jim Carnahan, Jillian Cimini (Associate) Natasha, Pierre & the Great Comet of 1812 — Duncan Stewart, Benton Whitley, Andrea Zee (Associate) War Paint — Craig Burns, Bernard Telsey

NEW YORK BROADWAY THEATRE – REVIVAL, COMEDY OR DRAMA

Jitney — David Caparelliotis, Nancy Piccione Six Degrees of Separation — Daniel Swee The Front Page — David Caparelliotis, Lauren Port The Glass Menagerie — David Caparelliotis, Lauren Port The Little Foxes — David Caparelliotis, Kelly Gillespie

NEW YORK BROADWAY THEATRE – REVIVAL, MUSICAL

Falsettos — Tara Rubin, Eric Woodall, Kaitlin Shaw (Associate), Claire Burke (Associate) Hello Dolly — Craig Burns, Bernard Telsey Miss Saigon — Tara Rubin, Merri Sugarman, Claire Burke (Associate) Sunday in the Park With George — Carrie Gardner, Stephen Kopel Sunset Boulevard — Tara Rubin, Eric Woodall

NEW YORK THEATRE – COMEDY OR MUSICAL

A Funny Thing Happened on the Way to the Gynecologic Oncology Unit at Memorial Sloan-Kettering Cancer Center of New York City — William Cantler, Karyn Casl How to Transcend a Happy Marriage — Daniel Swee Sweeney Todd — Cesar A. Rocha Sweet Charity — Judy Henderson, Ally Beans The Band’s Visit — Tara Rubin

NEW YORK THEATRE – DRAMA

Dead Poet’s Society — William Cantler, Karyn Casl Small Mouth Sounds — Henry Russell Bergstein, Lauren Port The Hairy Ape — Tiffany Little Canfield, Cesar A. Rocha (Associate) The Wolves — William Cantler, Karyn Casl Yen — William Cantler, Bernard Telsey, Karyn Casl, Adam Caldwell

REGIONAL THEATRE EAST

A Sign of the Times — Tara Rubin, Felicia Rudolph (Associate) American Son – MA production — Pat McCorkle, Katja Zarolinski American Son – NJ production — Pat McCorkle, Katja Zarolinski An American Daughter — William Cantler, Karyn Casl Assassins — Tara Rubin The SpongeBob Musical — Patrick Goodwin, James Calleri, Paul Davis

REGIONAL THEATRE WEST

A View From the Bridge — Karyn Casl, Patrick Goodwin Actually — Phyllis Schuringa An Octoroon — James Calleri, Erica Jensen, Amy Potozkin Barbecue — Phyllis Schuringa Merrily We Roll Along — Beth Lipari Zoot Suit — Pauline O’con

LOS ANGELES THEATRE

The 24th Annual Young Playwrights Festival — Erica S. Bream, Cara Chute Rosenbaum The House in Scarsdale: A Memoir for the Stage— Nicole Arbusto The Tragedy of JFK (as Told by William Shakespeare) — Erica S. Bream, Cara Chute Rosenbaum Waiting for Godot — Amanda Lenker Doyle, Chrissy Fiorilli-Ellington When Jazz Had the Blues — Michael Donovan, Richie Ferris (Associate)

SPECIAL THEATRICAL PERFORMANCE

A Chorus Line — Margery Simkin, Michael Donovan, Richie Ferris (Associate) Aida — Rachel Hoffman Big River — Jay Binder Crazy for You — Tara Rubin, Kaitlin Shaw, Felicia Rudolph (Associate) Wonderful Town — Jim Carnahan

THEATRE TOURS

Fun Home — Jim Carnahan, Jillian Cimini Hamilton – West Coast National Tour — Bethany Knox, Rebecca Scholl (Associate) Hamilton – Chicago Company — Bethany Knox, Rebecca Scholl (Associate) Hedwig and the Angry Inch — James Calleri, Paul Davis The Curious Incident of the Dog in the Night-Time — Daniel Swee, Cindy Tolan

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