I'm having some kind of feelings about it being pointed out to us in-story more than once in S3 that Isaac spends the majority of his time working in his lab alone (which Lamarr seems to believe is just perfectly relatable hyperfocus but Claire gets a little worried that it's about the crew not liking him).

Add to that the scene in Tale Of Two Topas in which he expressed worry about Kelly's reputation if the crew assumed that his visit to her rooms means they are romantically/sexually involved (Isaac is no old fuddy-duddy who cares about being a "man" alone with a woman in her chambers. It's the 25th century ffs, he doesn't care about being appropriate, he once made a sex-position survey. This is about Kelly possibly being involved with a Kaylon. Sidenote: whoever said something nasty about Claire in Isaac's hearing, I like to think their synthesizer developed a "mysterious" glitch where there's a little poop in everything).

Add to those the scene later that same episode where he said he didn't do the surgery for Topa's sake. He did it to improve his standing with the crew... to improve their efficiency. Please mind how we never SAW that alleged decrease in efficiency even implicitly, but we've seen people being nice to him in public and people being openly suspicious of him in public, and how do we think those two groups get on, especially if he's in the room? Or the kids of those groups of people (just imagine what the Mom from that teacher-parent meeting would have to say about it)? It's a small ship.