*slaps table*

Listen!

There is something super sweet and healing and hopeful about Gale, "I was groomed and still don't realize it and had 'sex' with the Goddess of Magic via mental/spiritual/astral projection regularly. Also, I'm kind of addicted to magic." Deciding to approach you first to flirt with "You being all sweaty after battle is so fucking hot."

Because it's Real. It's physical. Yeah, it's horny, but it's the realization that the mortal realm can be equal to the godly one, if not superior, despite it being different. Like, he's not Losing something by not being with a God and he can heal.

TONIGHT!!!!!! 'LOCAL LEGENDS' CLOSING PARTY Tonight is the closing party for LOCAL LEGENDS. Displayed here is my latest wall installation alongside dozens of Bay Area artists. CLOSING TONIGHT!!!!! 7-10pm AT @mirusgallery Portraits and hands include: @brandiegrogan @alynnpaint @zerogravitycake (hands) @mqplanet Jarrod Ingram @dyoungv (hands) @wildspirit_queen All pieces are: Micron 08 Pen on Bristol Paper 19x24in. 2019-2022 $500 (glass optional) This exhibition will features a survey of local Bay Area artists, including a special feature of "Local Legends" Local Legends is curated by @irenehfeiks of @wonderlandsf Every year, Mirus Gallery invites Bay Area based artists to apply for the open submission to be featured in the Locals Only exhibition. Opening Reception: Friday March 4, 7-10pm Closing Reception: Friday April 8, 2022 7-10pm Featuring: Adam Caldwell, AJIN No, Alec Huxley, Amandalynn, Amber Allen, Angela Efe, APEXER, Art Poesia, Blane Asrat, Brandon Hurley, Brian Barneclo, Calvin Lai, Casey Cripe, Celine Vasquez, Chanoh Heo, Chor Boogie, Daniel Segrove, Daryll Peirce, David Chong Lee, D Young V, Dilcia Giron, Doug Rhodes, Dylan Blackstone, Dylan Mertz, Eddie Colla, Emily Fromm, Eric Joyner, Felicia Ann, Gale Hart, Helice Wen, Ian Ross, Jaxon Northon, J.L. King, Jeremiah Allen Welch, Jessica Caputo, Joel Villegas, Jose D' Gregorio, Josh Thurman, Joshua Lawyer, Julie Engelmann, King Nissen, Lady Henze, Laura Gonzalez, Leon Loucheur, luciano Roque, Luis Tinoco, Marion Navasero, Max Ehrmann, Micah Lebrun, Michael Walsh, Mike Davis, Mike Texada, Misha Vladimirski, MJ Lindo, Nate Geare, Nate VanDyke, Nick Flatt, Nome Edonna, Optimist, Patrick Hofmeister, Paul Kalcic, PEMEX, Phillip Hua, Ransom and Mitchell, Raul D'Mauries, RED-X TEX, Ricky Watts, Robert Bowen, Romanowski, Russel Deleon, Ryan stubbs, Sam Flores, Sarupa Sidaarth, SILENT (Nicolas Tamura), Sofia Venegas, Ted Vasin, Ted Wong, Terry Hoff, Tex Buss, Todd Kurnat, Yijun Ge. #locallegends #mirusgallery #irenehfeiks #wonderlandsf #sanfrancisco #DYOUNGV (at Mirus Gallery) https://www.instagram.com/p/CcGaMTsJC6Z/?igshid=NGJjMDIxMWI=

S05E17: I Will Follow You Into the Dark

yesterday nanood ulit ako ng grey's anatomy. wala naisipan ko lang ulit kasi tapos ko na yung attack on titan na manga eh. yun na lang kasi pinapanood ko na anime. eh sa sobrang daming spoilers, ayun i decided to read the manga hanggang dun sa latest chapter.

anyway ang galing lang talaga kasi grey's anatomy always know what to say eh. lalo 'pag gantong nagdadoubt ako sa sarili ko. timing pa kamo 'tong episode na 'to kasi eto yung episode na nalaman na ni izzie yung sakit niya. eto yung nagpapacase study siya kila lexie eh, yung si patient x. tapos eto rin yung episode na bago niya malaman yung sakit niya, sabi niya alex na alam daw niya na magiging future ng hospital si alex kasi naniniwala siya sa capabilities niya. tapos sa dulo ng episode na 'to, napuri si alex sa capabilities niya. may isang patient kasi na pinasok tapos nagkaka seizure siya. eh okay naman daw yung heart nung px sabi nila arizona, eh bakit daw kailangan pa i-check. nagka arrythmia kasi yung px nakita ni alex 'tas ayun dahil sa sinabi niya na need i-check yung puso, natuwa sila arizona kasi na-save ni alex yung patient. tapos ayun sa sobrang tuwa ni alex, sinabi niya yung news na yun kay iz. na first time lang daw niya mag-rise dahil lagi daw siyang nagsisink sa bottom. tapos si izzie natuwa pa rin pero syempre alam mo yung malungkot siya kasi nga nadiagnose na sakit niya.

pinaka nalungkot kasi ako dun sa sinabi ni alex kay iz. na ayaw daw niya maging future ng hospital kung wala sa tabi niya si iz. wala lang kasi parang sa context na 'yan, ako si alex tas si celine naman si iz. alam niyo naman na from the start, si celine lang lagi nakakakit ang capabilities ko eh. siya lang talaga naniniwala sakin kahit na palagi kong dinadoubt sarili ko. she always know what to say kapag wala akong tiwala sa sarili ko. and just like what alex said, ayoko rin maging future ng hospital kung wala siya sa tabi ko :(

kaya celine sana hindi ka mapagod magpatuloy sa laban mo. kasi kaming mga tao na nagmamahal sayo, hindi kami mapapagod na suportahan ka :( sabi nga ni iz sa episode na 'yan, "screw the odds and fight" :(

A new ultrafast insulin

Researchers at Stanford University are developing a new insulin formulation that begins to take effect almost immediately upon injection, potentially working four times as fast as current commercial fast-acting insulin formulations.

The researchers focused on so-called monomeric insulin, which has a molecular structure that, according to theory, should allow it to act faster than other forms of insulin. The catch is that monomeric insulin is too unstable for practical use. So, in order to realize the ultrafast potential of this insulin, the researchers relied on some materials science magic.

“The insulin molecules themselves are fine, so we wanted to develop a ‘magic fairy dust’ that you add into a vial that would help to fix the stability problem,” said Eric Appel, assistant professor of materials science and engineering at Stanford. “People often focus on the therapeutic agents in a drug formulation but, by focusing only on the performance additives – parts that were once referred to as ‘inactive ingredients’ – we can achieve really big advancements in the overall efficacy of the drug.”

After screening and testing a large library of additive polymers, the researchers found one that could stabilize monomeric insulin for more than 24 hours in stressed conditions. (By comparison, commercial fast-acting insulin stays stable for six to ten hours under the same conditions.) The researchers then confirmed the ultrafast action of their formulation in diabetic pigs. Their results were published July 1 in Science Translational Medicine. Now, the researchers are conducting additional tests in hopes of qualifying for clinical trials in humans.

One step back, two steps forward

Current commercial formulations of insulin contain a mix of three forms: monomers, dimers and hexamers. Scientists have assumed monomers would be the most readily useful in the body but, within vials, the insulin molecules are drawn to the surface of the liquid where they aggregate and become inactive. (Hexamers are more stable in the vial but take longer to work in the body because they first have to break down into monomers to become active.) This is where the “magic fairy dust” – a custom polymer that is attracted to the air/water interface – comes in.

Illustration depicting how fast different forms of insulin absorb in the bloodstream, and how the polymer developed by these researchers helps stabilize ultrafast-absorbing insulin in the vial. (Image credit: Joseph Mann and Caitlin Maikawa)

“We focused on polymers that would preferentially go to that interface and act as a barrier between any of the insulin molecules trying to gather there,” said Joseph Mann, a graduate student in the Appel lab and co-lead author of the paper. Crucially, the polymer can do this without interacting with the insulin molecules themselves, allowing the drug to take effect unimpeded.

Finding just the right polymer with the desired properties was a long process that involved a three-week trip to Australia, where a fast-moving robot created approximately 1500 preliminary candidates. This was followed by processing and testing individually by hand at Stanford to identify polymers that successfully exhibited the desired barrier behavior. The first 100 candidates didn’t stabilize commercial insulin in tests but the researchers pressed on. They found their magic polymer only weeks before they were scheduled to run experiments with diabetic pigs.

“It felt like there was nothing happening and then all of the sudden there was this bright moment … and a deadline a couple of months away,” said Mann. “The moment we got an encouraging result, we had to hit the ground running.”

In commercial insulin – which typically remains stable for about 10 hours in accelerated aging tests – the polymer drastically increased the duration of stability for upwards of a month. The next step was to see how the polymer affected monomeric insulin, which on its own aggregates in 1-2 hours. It was another welcome victory when the researchers confirmed that their formulation could remain stable for over 24 hours under stress.

“In terms of stability, we took a big step backward by making the insulin monomeric. Then, by adding our polymer, we met more than double the stability of the current commercial standard,” said Caitlin Maikawa, a graduate student in the Appel lab and co-lead author of the paper.

With a seed grant from the Stanford Diabetes Research Center and the Stanford Maternal and Child Health Research Institute, the researchers were able to evaluate their new monomeric insulin formulation in diabetic pigs – the most advanced non-human animal model – and found that their insulin reached 90 percent of its peak activity within five minutes after the insulin injection. For comparison, the commercial fast-acting insulin began showing significant activity only after 10 minutes. Furthermore, the monomeric insulin activity peaked at about 10 minutes while the commercial insulin required 25 minutes. In humans, this difference could translate to a four-fold decrease in the time insulin takes to reach peak activity.

“When I ran the blood tests and started plotting the data, I almost couldn’t believe how good it looked,” said Maikawa.

“It’s really unprecedented,” said Appel, who is senior author of the paper. “This has been a major target for many big pharmaceutical companies for decades.”

The monomeric insulin also finished its action sooner. Both beginning and ending activity sooner makes it easier for people to use insulin in coordination with mealtime glucose levels to appropriately manage their blood sugar levels.

A multifaceted success

The researchers plan to apply to the Food and Drug Administration for approval to test their insulin formulation in clinical trials with human participants (although no trials are planned yet and they are not seeking participants at this time). They are also considering other uses for their polymer, given how significantly it increased stability in commercial insulin.

Because their insulin formulation activates so quickly – and, therefore, more like insulin in a person without diabetes – the researchers are excited by the possibility that it could aid the development of an artificial pancreas device that functions without the need for patient intervention at mealtimes.

Additional Stanford co-authors include former visiting scholar Anton Smith (from Aarhus University in Denmark); graduate students Abigail Grosskopf, Gillie Roth, Catherine Meis, Emily Gale, Celine Liong, Doreen Chan, Lyndsay Stapleton and Anthony Yu; clinical veterinarian Sam Baker; and postdoctoral fellow Santiago Correa. Researchers from CSIRO Manufacturing in Australia are also co-authors. Appel is also a member of Stanford Bio-X, the Cardiovascular Institute, the Stanford Maternal and Child Research Institute and a faculty fellow at Stanford ChEM-H.

This research was funded by the National Institutes of Health, a Pilot and Feasibility seed grant from the Stanford Diabetes Research Center, the Stanford Maternal and Child Health Research Institute, the American Diabetes Association, the PhRMA Foundation, the U.S. Department of Defense, a Stanford Graduate Fellowship, the Natural Sciences and Engineering Research Council of Canada, the Stanford Bio-X Bowes Graduate Student Fellowship, the Novo Nordisk Foundation, Stanford Bio-X, and the Danish Council of Independent Research.

To read all stories about Stanford science, subscribe to the biweekly Stanford Science Digest.

Media Contacts

Taylor Kubota, Stanford News Service: (650) 724-7707; [email protected]

source https://scienceblog.com/517232/a-new-ultrafast-insulin/

Actual Act 1 interaction with Gale and my Tav Celine:

Celine: *winks Obviously at Gale*

Gale: *looks around confused, no one else is around him*

Gale: *points at self, mouths "me?"*

Celine: *nods while rolling her eyes*

Gale: *blushes and nods, pleased*

Celine: *talks Yurgir into offing his guards, his pet and himself*

Gale:

Not Tav knowing Mystra may essentially cast Gale out of the afterlife when he dies and going full Devil's Backbone by the Civil Wars and begging their god to claim him.

Karlach standing there like "Look at em go."

Celine: *Seldarine Drow College of Swords Bardadin*

Gale: Celine, my dear, why must you carry 4 blades with you?

Celine: Oh...well Phalar Aluve is the blade of Eilistaree's Chosen and she’s my goddess.

Gale: Hm

Celine: And Corellon Larthian is, as you know, her father.

Gale: I do know that yes.

Celine: So, I like to keep Larthian's Wrath with me as well. And the Adamantine longsword is very good at breaking shit when necessary.

Gale: Interesting...and the 4th?

Celine: Hm?

Gale: The 4th blade you carry. The one you've been making magnificent use of in battle recently. The one you used to Divinely Smite an avatar of the Lord of Bones himself.

Celine: I don't-

Gale: Was not the Infernal Blade a gift meant for Wyll, Celine?

Celine: *holding the hilt of the Infernal Blade in her scabbard*

Celine: I have no idea what you're talking about.

Wyll: *glaring at her from the tent next to theirs*

Respec-ed after getting the warped headband of intellect so Celine/Tav's base INT is 8 & 17 with the headband, but now I've got the hat that puts your Charisma to 22 and I haven't respec-ed again cuz...I had a headache.

(Swords bard/Pally using the infernal blade, her charisma is everything but AC.)

Anyway, I've been switching them out as I see fit, but I can imagine that anytime Gale wants to have a conversation, Celine/Tav is like, "Wait, wait a second, sweetheart." And switches the hat for the headband 😅.

Thinking about Gale x Tav and just Gale while listening to Lost by Dermot Kennedy?

Ooooh boy.

My Tav Celine is a Seldarine Drow Bard/Cleric of Eilistraee. She's romancing Gale, and you 100% know she is praying to her goddess like "Miss MA'AM?! DO YOU KNOW ABOUT YOUR BESTIE'S PREFERENCES?!"

Absolutely insane that the approval notifications stop if you have maxed out approval and I had to find this out after being very confused for a bit 😅

TONIGHT!!!!!! 'LOCAL LEGENDS' I'll be displaying my latest wall installation alonside dozens of Bay Area artists. OPENING TONIGHT!!!!! (3/4 : 7-10pm) AT @mirusgallery Portraits and hands include: @brandiegrogan @alynnpaint @zerogravitycake (hands) @mqplanet Jarrod Ingram @dyoungv (hands) This exhibition will features a survey of local Bay Area artists, including a special feature of "Local Legends" Local Legends is curated by @irenehfeiks of @wonderlandsf Every year, Mirus Gallery invites Bay Area based artists to apply for the open submission to be featured in the Locals Only exhibition. Opening Reception: Friday March 4, 7-10pm On display through: Friday April 8, 2022 Featuring: Adam Caldwell, AJIN No, Alec Huxley, Amandalynn, Amber Allen, Angela Efe, APEXER, Art Poesia, Blane Asrat, Brandon Hurley, Brian Barneclo, Calvin Lai, Casey Cripe, Celine Vasquez, Chanoh Heo, Chor Boogie, Daniel Segrove, Daryll Peirce, David Chong Lee, D Young V, Dilcia Giron, Doug Rhodes, Dylan Blackstone, Dylan Mertz, Eddie Colla, Emily Fromm, Eric Joyner, Felicia Ann, Gale Hart, Helice Wen, Ian Ross, Jaxon Northon, J.L. King, Jeremiah Allen Welch, Jessica Caputo, Joel Villegas, Jose D' Gregorio, Josh Thurman, Joshua Lawyer, Julie Engelmann, King Nissen, Lady Henze, Laura Gonzalez, Leon Loucheur, luciano Roque, Luis Tinoco, Marion Navasero, Max Ehrmann, Micah Lebrun, Michael Walsh, Mike Davis, Mike Texada, Misha Vladimirski, MJ Lindo, Nate Geare, Nate VanDyke, Nick Flatt, Nome Edonna, Optimist, Patrick Hofmeister, Paul Kalcic, PEMEX, Phillip Hua, Ransom and Mitchell, Raul D'Mauries, RED-X TEX, Ricky Watts, Robert Bowen, Romanowski, Russel Deleon, Ryan stubbs, Sam Flores, Sarupa Sidaarth, SILENT (Nicolas Tamura), Sofia Venegas, Ted Vasin, Ted Wong, Terry Hoff, Tex Buss, Todd Kurnat, Yijun Ge. #locallegends #mirusgallery #irenehfeiks #wonderlandsf #sanfrancisco #DYOUNGV (at Mirus Gallery) https://www.instagram.com/p/Cas2MPYPloQ/?utm_medium=tumblr

'LOCAL LEGENDS' I'll be displaying my latest wall installation alonside dozens of Bay Area artists. OPENING THIS FRIDAY (3/4 : 7-10pm) AT @mirusgallery This exhibition will features a survey of local Bay Area artists, including a special feature of "Local Legends" Local Legends is curated by @irenehfeiks of @wonderlandsf Every year, Mirus Gallery invites Bay Area based artists to apply for the open submission to be featured in the Locals Only exhibition. Opening Reception: Friday March 4, 7-10pm On display through: Friday April 8, 2022 Featuring: Adam Caldwell, AJIN No, Alec Huxley, Amandalynn, Amber Allen, Angela Efe, APEXER, Art Poesia, Blane Asrat, Brandon Hurley, Brian Barneclo, Calvin Lai, Casey Cripe, Celine Vasquez, Chanoh Heo, Chor Boogie, Daniel Segrove, Daryll Peirce, David Chong Lee, D Young V, Dilcia Giron, Doug Rhodes, Dylan Blackstone, Dylan Mertz, Eddie Colla, Emily Fromm, Eric Joyner, Felicia Ann, Gale Hart, Helice Wen, Ian Ross, Jaxon Northon, J.L. King, Jeremiah Allen Welch, Jessica Caputo, Joel Villegas, Jose D' Gregorio, Josh Thurman, Joshua Lawyer, Julie Engelmann, King Nissen, Lady Henze, Laura Gonzalez, Leon Loucheur, luciano Roque, Luis Tinoco, Marion Navasero, Max Ehrmann, Micah Lebrun, Michael Walsh, Mike Davis, Mike Texada, Misha Vladimirski, MJ Lindo, Nate Geare, Nate VanDyke, Nick Flatt, Nome Edonna, Optimist, Patrick Hofmeister, Paul Kalcic, PEMEX, Phillip Hua, Ransom and Mitchell, Raul D'Mauries, RED-X TEX, Ricky Watts, Robert Bowen, Romanowski, Russel Deleon, Ryan stubbs, Sam Flores, Sarupa Sidaarth, SILENT (Nicolas Tamura), Sofia Venegas, Ted Vasin, Ted Wong, Terry Hoff, Tex Buss, Todd Kurnat, Yijun Ge. #locallegends #mirusgallery #irenehfeiks #wonderlandsf #sanfrancisco (at Mirus Gallery) https://www.instagram.com/p/CaqPvlJPeuZ/?utm_medium=tumblr