Genomic analyses of individuals living with HIV-1 revealed a region in chromosome 1 that is associated with reduced viral loads specifically in populations with African ancestry. This could point to much-needed therapeutic targets to address the global public-health crisis caused by HIV-1.

[h/t]

Author Correction: Africa-specific human genetic variation near CHD1L associates with HIV-1 load

http://dlvr.it/SvfqGT

New Drug Inhibits Oncogene That Causes Cancer Progression

New Drug Inhibits Oncogene That Causes Cancer Progression

CHD1L, also known as ALC1, was discovered in 2008 and within two years emerged as a novel oncogene. “Its over-expression or over-amplification in many cancers is associated with poor prognosis and with late-stage metastatic cancer,” explains LaBarbera, who also serves as co-director of the Drug Discovery and Development Shared Resource (D3SR). The D3SR is the main infrastructure of the CU…

View On WordPress

[h/t]

ALC1/CHD1L, a chromatin-remodeling enzyme, is required for efficient base excision repair.

Pubmed: http://dlvr.it/Q1c3Pp