A new research report titled "Global Guillain-Barre Syndrome Drugs market" successfully exhibits the complete scenario of the global and an individual analysis of the various regional segments.

Human Immunoglobulin (pH4) for Intravenous Injection is Estimated to Witness High Growth Owing to Rising Prevalence of Neurological and Immunodeficiency Diseases

Human immunoglobulin (pH4) is a blood plasma derived product administered intravenously for treatment of various neurological and immunodeficiency diseases. It contains antibodies which help strengthen the body's natural defenses against infectious agents. The rising incidences of immune deficiency disorders like agammaglobulinemia and common variable immunodeficiency have inflated the demand for immunoglobulin therapy. The global Human Immunoglobulin (pH4) for Intravenous Injection Market is estimated to be valued at US$ 17.5 billion in 2023 and is expected to exhibit a CAGR of 16% over the forecast period 2023-2031, as highlighted in a new report published by Coherent Market Insights. Market Opportunity: Rising prevalence of neurological and immunodeficiency diseases is estimated to witness high growth. Neurological disorders pose a significant healthcare burden globally and afflict millions worldwide each year. conditions like Guillain-Barre syndrome and chronic inflammatory demyelinating polyneuropathy require intravenous immunoglobulin as a mode of treatment. According to the World Health Organization, over 1 billion people suffer from some form of neurological disorder. The annual cost of neurological conditions in the U.S. alone is estimated to be over $800 billion. Thus, the growing cases of neurological diseases will spur demand for immunoglobulin therapy, acting as a high impact rendering driver for the market.

Porter’s Analysis Threat of new entrants: Low barrier to entry due to availability of raw material and manufacturing process knowledge. However, high capital requirements for production facilities and strong brand loyalty towards existing players limits threat. Bargaining power of buyers: Moderate bargaining power due to presence of substitutes. However, specialized production process results in inelastic demand. Bargaining power of suppliers: High dependence on plasma suppliers limits bargaining power. Suppliers can charge higher prices or refuse supply during shortages. Threat of new substitutes: Low threat as IgG products have no close substitute for treatment of certain immune disorders and deficiencies. Substitution requires regulatory approval and clinical trials. Competitive rivalry: Intense competition between major players. Companies compete based on product quality, reliability of supply, price and brand reputation. SWOT Analysis Strength: Established production facilities and regulatory approvals. Diversified product portfolio to treat range of conditions. Weakness: High capital intensity of production and vulnerability to plasma supply disruptions. Stringent regulatory norms increase compliance costs. Opportunity: Expanding patient population and increased diagnosis rate in developing regions. New clinical indications can boost revenue streams. Threats: Price controls and government reimbursement policies. Stringent import and export regulations across countries. Key Takeaways The global Human Immunoglobulin (pH4) for Intravenous Injection market is expected to witness high growth. The market is dominated by North America owing to high prevalence of immunodeficiency and autoimmune disorders. Rising healthcare spending and presence of major players in the US and Canada will drive the region's market share. Europe is the second largest regional market led by countries such as Germany, UK and France. Higher acceptance of IgG therapies and supportive national health strategies supplement the regional growth. Key players operating in the Human Immunoglobulin (pH4) for Intravenous Injection market are CSL Behring, Grifols, Baxter, Octapharma, Kedrion, CNBG, Hualan Bio and BPL. These players acquire plasma from approved donors and fractionate to produce standard and specialized IgG formulations.

Acute Flaccid Myelitis Market by Treatment Type (Pharmacological Treatment, Physical & Occupational Therapy, Plasmapheresis, and Others) - Global Outlook & Forecast 2023-2031

According to the deep-dive market assessment study by Growth Plus Reports, global acute flaccid myelitis market is expected to register a revenue CAGR of 3.2% during the forecast period.

Acute Flaccid Myelitis Market Fundamentals 

Acute flaccid myelitis (AFM) is a life-threatening illness that appears like polio and was first identified in unusual clusters in California in 2012 and Colorado in 2014. With hundreds of cases recorded in Europe, Asia, Australia, Africa, North America, and South America, AFM is now recognized as a widespread condition. Recent AFM is thought to have been mostly caused by epidemic enteroviral infection, notably enterovirus D68 infection. Cases typically occur in geographic clusters in temperate climates and follow a clear seasonal-biennial pattern. Young children are most often affected by AFM, characterized by an abrupt onset of flaccid weakness in one or more limbs and abnormalities in the grey matter of the spinal cord. Additional muscles may be affected include the extraocular, respiratory, bulbar, and trunk muscles. Clinical signs of other acute weakness-causing conditions, such as Guillain-Barre syndrome, demyelinating myelitis, and other infectious myelitis, may resemble those of AFM.

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Less than 15% of incidents of AFM in adults (more frequently in the immunocompromised) occur, with AFM in adults perhaps needing to be more reported or recognized. AFM is mostly a pediatric condition. There may be a small preference for men. Most AFM patients experience a prodromal sickness that includes a fever and respiratory symptoms (such as a cough, rhinorrhea, pharyngitis, or a disease that resembles asthma). Vomiting and diarrhea are less common gastrointestinal complaints.

Headache, stiffness in the neck, or a return of fever can occur together with the development of neurological symptoms. Pain in the afflicted limb(s), neck, or lower back often precedes limb weakening in patients. Flaccid weakness usually affects one or more limbs and is asymmetrical, with a preference for the upper limbs and proximal muscle groups. In addition to limb weakness, over 30% of patients exhibit motor deficits localized to the brainstem's cranial nerve motor nuclei. These deficits are largely bulbar and facial weakness, with extraocular muscle weakness occurring less frequently.

The most effective diagnostic procedure for AFM is an MRI of the spinal cord. The distinctive feature of AFM is spinal cord grey matter T2 hyperintensity. When examined axially, early acute phase lesions impact the whole grey matter of the spinal cord. They are often confluent and poorly delineated, with varied degrees of surrounding white matter involvement and edema. Grey matter lesions in the spinal cord are often longitudinally widespread.

Acute Flaccid Myelitis Market Dynamics 

The acute flaccid myelitis market is growing due to rising awareness, increasing surveillance initiatives, identification and reporting of AFM cases. The number of reported cases of AFM has increased as medical professionals and public health organizations have become more cautious in finding and diagnosing the condition. For instance, Acute Flaccid Myelitis Association aims to increase public understanding and support for this disease.  They also offer assistance to parents, caregivers, and those who are experiencing AFM symptoms. Their funding is used to meet the requirements of the patients. They utilize donations to pay for therapies, treatments, and equipment not covered by insurance for families. More than 90% of donations are used immediately to meet the critical medical requirements of AFMA grant candidates. Additionally, the federal government has noticed the illness due to the advocacy efforts of AFM-affected families, the Acute Flaccid Myelitis Association (AFMA), and medical professionals who treat patients with the condition. Senator Kirsten Gillibrand, for example, proposed $1 billion in funding for AFM research in 2018.

Accurate and rapid diagnosis of AFM patients has been made possible by improved methods for diagnosis, including laboratory testing and enhanced imaging equipment. This is likely because more information is available on illness and its prevalence. For instance, according to the National Library of Medicine 2021, 96% of documented AFM cases in the USA 2018 were hospital admissions, with 58% going to an intensive care unit. Early management's cornerstone is supportive care and vigilant monitoring targeted toward possibly developing critical problems. Moreover, according to the Centers for Disease Control & Prevention, as of June 2, 2023, twenty reports of patients under investigation (PUIs) had been made, and three of those reports had been confirmed. Since August 2014, when CDC started monitoring AFM, there have been 727 confirmed cases. Since then, the CDC has conducted extensive investigations into cases. In 2014, 2016, and 2018, there was a rise in AFM incidence, particularly involving young children.

However, AFM does not currently have a particular therapy other than symptomatic assistance. Research is still being done to understand the illness better and provide therapies. There are scientific possibilities and needs for further study in AFM, according to a 2020 article in Clinical Infectious Diseases. The long-term outcomes of AFM and juvenile transverse myelitis were compared in a 2020 study published in BMC Neurology.

Acute Flaccid Myelitis Market Ecosystem 

The global acute flaccid myelitis market is analyzed from the following perspectives by treatment type and region.

Acute Flaccid Myelitis by Treatment Type

Based on the treatment type, the global acute flaccid myelitis market is segmented into pharmacological treatment, physical & occupational therapy, plasmapheresis, and others.

There haven't been any regulated investigations of medical AFM therapies.  To increase the body's resistance to viruses, intravenous immunoglobulin (IVIG) can be administered. Steroids and plasma exchange are two common medications used to treat transverse myelitis (TM), and they have been tested in AFM with varying degrees of success. 

Early commencement of physical and occupational therapy (PT and OT) is essential for successfully treating AFM. Both occupational and physical therapy are crucial. Children frequently attend treatment sessions for weeks or months. For the greatest results, children with AFM need to be treated by a multidisciplinary team. Even if full muscle function cannot be recovered, early intervention may improve everyday functioning and restore function to the damaged limbs.

Acute Flaccid Myelitis by Region

Based on the treatment type, the global acute flaccid myelitis market is segmented into North America, Europe, Asia Pacific, Latin America, and the Middle East & Africa. 

The number of instances of poliomyelitis dropped to 209 worldwide in 2014 due to poliovirus vaccinations, with nonpolio enteroviruses being the main cause of new cases of acute flaccid myelitis. Acute flaccid myelitis cases have been observed most recently during enterovirus D68 outbreaks in North America and Europe, indicating the possibility of another non-polio enterovirus linked to acute flaccid myelitis. North America had an outbreak of enterovirus D68 infections in the autumn of 2014, the majority of which were accompanied by symptoms of the upper respiratory tract. The authors describe a cluster of three individuals who had acute flaccid myelitis in Alberta, Canada, during an enterovirus D68 epidemic, with enterovirus D68 found in two of these patients.

The number of reports of acute flaccid paralysis cases has increased in the United Kingdom (UK), with many cases being identified as AFM. Unexpected clusters of AFM were first recorded in the US in 2014. Clinically, various individuals often have poliomyelitis-like paralysis, affecting one or more limbs, with no discernible sensory loss and distinctive grey matter abnormalities on MRI. A prevalent EV virus known as EV-D68, which appeared to circulate biennially in late summer and fall and was connected to severe acute respiratory and neurological disease between 2014 and 2016 in Europe, Asia, and North America, was temporally associated with an increase in AFM cases.

Acute Flaccid Myelitis Market Competitive Landscape 

Some of the prominent market players in the global acute flaccid myelitis market include, 

Baxter International Inc.

Octapharma AG

Behring GmbH

BioScrip Inc.

Pfizer Inc.

Novartis AG

AstraZeneca

GSK Plc.

Cipla Inc.

Acute Flaccid Myelitis Strategic Development 

In August 2019, to comprehend the uncommon polio-like virus that affects children, the National Institute of Allergy and Infectious Diseases (NIAID) granted $10 million over five years for natural history research on acute flaccid myelitis (AFM).

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SYMPTOMS OF THESE FORMERLY MILD CHILDHOOD DISEASES (BEFORE THE MARKETING PROPAGANDA TO SELL VACCINES BEGAN TO RAMP UP)

Chicken Pox = itchy rash; 5-7 days; resolves itself

Diptheria = low fever, sore throat; many infections are asymptomatic or mild; treat with antitoxin and antibiotics

Haemophilus influenzae Type B (Hib) = flu symptoms, stiff neck; treat with antibiotics for 10 days

Hepatitis A = transmitted orally through feces; children usually have no symptoms; flu symptoms, jaundice; resolves itself

Hepatitis B = transmitted through blood, semen, vaginal fluids; flu symptoms, jaundice; most people do not show symptoms; acute Hep B resolves itself

Influenza – a.k.a. “the flu”; high fever, cold symptoms, vomiting; lasts 7-10 days; resolves itself; vaccine contains mercury (thimerosal)

Measles = fever, cold symptoms, rash; 7-10 days; resolves itself

Meningitis = flu symptoms, stiff neck; usually caused by bacteria or virus; viral usually causes no symptoms and resolves itself; bacterial is spread through saliva (kissing, coughing); most people who ‘carry’ the bacteria never become sick; bacterial is treated with antibiotics

Mumps = fever, swelling of salivary glands; many people show no symptoms; resolves itself within a few weeks

Pertussis = a.k.a. “whooping cough”; treated with high doses of vitamin C

Pneumococcus = flu symptoms, stiff neck; treat with antibiotics

Poliomyelitis = 72% of infections cause no symptoms; 25% flu-like symptoms that last 2-5 days; 0.5% leads to more severe symptoms such as paralytic polio; only people with the paralytic infection are considered to have the disease

Rotavirus = vomiting, diarrhea; children, even those that are vaccinated, may develop rotavirus disease more than once.

Rubella = a.k.a. “three day measles”; flu symptoms; 1-3 days; 25 to 50% of people infected with rubella will not experience any symptoms; resolves itself

Tetanus = sudden, painful contractions of muscle groups; caused by Clostridium tetani transmitted through broken skin; prevention is to allow wound to bleed freely because the bacteria needs oxygen to germinate; treatment is tetanus immunoglobulin injection and hospitalization

VACCINE RISKS-ALL VACCINE INSERTS LIST NUMEROUS SIDE EFFECTS AND REACTIONS BECAUSE OF THE FREQUENCY AND SEVERITY OF THESE SIDE EFFECTS DURING TESTING AND THROUGH REPORTING BY THE VICTIMS AND T HEIR PARENTS--THEY INCLUDE GETTING THE ACTUAL DISEASE, IMPAIRED IMMUNE SYSTEM, CANCER, AUTOIMMUNE DISORDERS, PARALYSIS, PERMANENT BRAIN DAMAGE AND DEATH

Vaccine Risks = ALL product inserts list numerous potential reactions including impaired immune system; autoimmune disorders; and/or death.

Vaccines that shed (are contagious): Measles, Mumps, Varicella (Chicken Pox), Oral Polio, Rubella, Rotavirus, Influenza (Flumist).

And here are all the side affects to the vaccines these things (don't) prevent against.

Dtap (Infanrix)- Bronchitis, cellulitis, respiratory tract infection, Lymphadenopathy, thrombocytopenia, anaphylactic reaction, hypersensitivity, encephalopathy, headache, hypotonia, syncope, ear pain, cyanosis, apnea, cough, angioedema, erythema, pruritus, rash, urticaria, fatigue, injection site induration, injection site reaction, Sudden infant death syndrome (SIDS)

Dtap (Daptacel)- temp above 105 degrees within 48 hours, collapse or shock-like state, persistent/ inconsolable crying lasting more than 3 hours, seizures with or without fever, Guillain- Barre syndrome, anorexia, drowsiness, vomiting, lymphadenopathy, cyanosis, nausea, diarrhea, injection site pain/ swelling/ module/ mass/ cellulitis/ abscess, hypersensitivity, allergic reaction, anaphylactic reaction, convulsions, febrile convulsions, partial seizures, syncope, screaming

Dtap+IPV (Kinrix)- temp above 105 degrees, collapse or shock-like state, persistent/ inconsolable crying lasting more than 3 hours, seizures with or without fever, cellulitis, constipation, foreign body trauma, injection site vesicles, syncope, anaphylactoid reactions, anaphylaxis, angioedema, urticaria, apnea, lymphadenopathy, thrombocytopenia

Dtap+Hep B+IPV (Pediarix)- pyrexia, gastroenteritis, bronchiolitis, Sudden infant death syndrome (SIDS), convulsive disorder, congenital immunodeficiency with sepsis, neuroblastoma, By chance alone some cases of SIDS can be expected to follow receipt of pertussis- containing vaccines. Chronic illness, asthma, febrile and afebrile seizures, infantile spasms, jaundice, meningitis, lichen planus

Dtap+IPV+Hib (Pentacel)- dehydration, gastroenteritis, asthma, pneumonia, death due to suffocation, head trauma, sudden infant death syndrome (SIDS), neuroblastoma, cyanosis, vomiting, nausea, meningitis, rhinitis, viral infection, decreased appetite, depressed level of consciousness, screaming, apnea, cough, erythema, skin discoloration, pallor

Intravenous Immunoglobulin Market Size Hit $18.67Bn, Globally, by 2028 Growing at 7.6% CAGR | Exclusive Report by The Insight Partners

The Insight Partners published latest research study on Intravenous Immunoglobulin Market Forecast to 2028 – COVID-19 Impact and Global Analysis – by Type (IgG, IgA, IgM, IgE, and IgD), Application (Hypogammaglobulinemia, Chronic Inflammatory Demyelinating Polyneuropathy, Immunodeficiency Diseases, Myasthenia Gravis, Multifocal Motor Neuropathy, Idiopathic Thrombocytopenic Purpura, Inflammatory Myopathies, Specific Antibody Deficiency, Guillain-Barre syndrome, and Others).

Global Immunoglobulin Market Expected to Advance at 6.77% CAGR by 2028

Triton Market Research presents the Global Immunoglobulin Market report sectioned by Type (IgM, IgD, IgG, IgE, IgA), Delivery Mode (Intravenous, Intramuscular, Subcutaneous), Application (Hypogamma Globulienemia, Inflammatory Myopathies, Specific Antibody Deficiency, Guillain-Barre Syndrome, Idiopathic Thrombocytopenic Purpura, Myasthenia Gravis, Chronic Inflammatory Demyelinating Polyneuropathy, Multifocal Motor Neuropathy, Primary Immunodeficiency Diseases, Other Applications), End-user (Homecare, Hospital and Clinics), Sales Channel (Specialty Pharmacy, Hospital Pharmacy, Other Sales Channels), and Geography ( Europe, North America, Latin America, Middle East and Africa, Asia-Pacific).

The report further discusses the Market Summary, Industry Outlook, Impact of COVID-19, Key Insights, Porter’s Five Forces Analysis, Market Attractiveness Index, Vendor Scorecard, Key Market Strategies, Drivers, Challenges, Opportunities, Competitive Landscape, Research Methodology and Scope, Global Market Size, Forecasts & Analysis (2022-2028).

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 The market report by Triton shows that the global immunoglobulin market is expected to grow at a CAGR of 6.77% during the forecast period 2022-2028.

Immunoglobulins refer to antibodies naturally produced by the body to fight infections and diseases. Generated by plasma cells, they are glycoprotein molecules acting as the critical component of the immune system. They recognize and bind to antigens like viruses and bacteria while aiding in their destruction.

The immunoglobulin market saw growth during as well as the post-COVID-19 pandemic. The market is further expected to grow during the forecasted year due to the driving factors like the increase in the geriatric population, the prevalence of immunodeficiency diseases, autoimmune disorders and increasing research and development activities. However, one of the major factors that restrict the market growth is the high cost of immunoglobulin therapy, which is directly associated with the type of delivery method used and the site of care. Another factor is the high risk of side effects due to immunoglobulin use.

Globally, the Asia-Pacific is expected to become the fastest-growing region in the immunoglobulin market. The rapid rise in the prevalence of different diseases, the rise in the aging population, and the research and development across the region are key factors expected to boost the market’s growth during the forecast period. Further, several market players are launching or are expected to launch innovative products, thereby supporting the immunoglobulin market’s growth.

The leading companies excelling in the immunoglobulin market are Biotest AG, Grifols SA, CSL Behring, Octapharma AG, Bio Products Laboratory, Shanghai Raas Blood Products Co Ltd, Sanquin Plasma Products BV, Adma Biologics, Kamada Ltd, Sichuan Yuanda Shuyang Pharmaceutical Co Ltd, Sanquin Plasma Products BV, Shanghai Raas Blood Products Co Ltd, Takeda Pharmaceutical Company Limited, Kedrion Biopharma, LFB Group, and China Biologic Products Inc.

The products in the biotechnology industry are subject to multiple standards, regulations, and approvals from the regulatory authorities that can challenge the new market player. Thus, these factors lower the threat of new entrants to the existing players. Moreover, there is a high threat to the intensity of competitive rivalry due to industry fragmentation.   Additionally, prominent players have strengthened and expanded their customer base and geographical footings through strategic initiatives such as product launches, collaborations, joint ventures, and investments.

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Immunoglobulin Market Clinical Research Analysis 2022-2030

Increasing geriatric population along with improved immunoglobulin production are key factors driving the growth of the immunoglobulin market.

The Immunoglobulin Market is expected to grow at a CAGR of 5.4% from 2020-2030, according to a new research report by Next Move Strategy Consulting.

Immunoglobulins are produced by plasma cells and other lymphocyte to protect the body from diseases. They act as antibodies and support the immune system against viruses, bacteria and other disease causing agents. The growth of the immunoglobulin market is majorly driven by factors such as increasing geriatric population and rising number of hemophilic patients. Also, improved production of immunoglobulins due to the adoption of advanced technology for the extraction and introduction of enhanced purification processes in recent times, has been significantly contributing to the growth of the immunoglobulin market. However, strict government policies along with risk of side effects are anticipated to hinder the market growth during the forecast period to some extent.

On the basis of product, the market is segmented into IGG, IGA, IGM, IGE and IGD. On the basis of application, the market is segmented into Hypogammaglobulinemia, Chronic Inflammatory Demyelinating Polyneuropathy (CIDP), Immunodeficiency Disease, Myasthenia Gravis, Multifocal Motor Neuropathy, Idiopathic Thrombocytopenic Purpura (ITP), Inflammatory Myopathies, Specific Antibody Deficiency, Guillain Barre Syndrome, and Others. On the basis of mode of delivery, the market is segmented into intravenous and subcutaneous. Intravenous is sub segmented into 5% concentration, 10% concentration and others. Subcutaneous is sub segmented into 16.5% concentration, 20% concentration and others. Based on geography the market is segmented into North America, Europe, Asia Pacific and RoW.

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Geographically, North America holds the lion share of the global immunoglobulin market owing to factors such as presence of developed economies as well as increasing prevalence of haemophilia in this region. However, Asia Pacific is expected to show exponential growth within the forecast period. This is attributed to factors such as rising geriatric population, prevalence of inflammatory diseases, and increasing accessibility to healthcare facilities in this region.

According to the report, some the key players in the immunoglobulin market are CSL Ltd., Baxter international Inc., Octapharma AG, Grifols S.A, LFB group, Kedrion Biopharma Inc., China Biologics Products, Inc., Biotest AG, Shire (Baxalta), and Bayer AG among others.

Key Insights:

Current emerging trends and opportunities are extensively analysed in immunoglobulin market report.

The forecast of the immunoglobulin market comes along with additional information associated with opportunities, restrains and key drivers in the market.

The report Immunoglobulin Market – is segmented by product, application, mode of delivery and geography.

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It is thought that GB syndrome occurs due to an autoimmune response after exposure to acute infections like a chest infection or diarrhea. It attacks the peripheral nerves and damages the myelin, an insulating layer of the nerve which is important in nerve impulse conduction.

Guillain-Barre Syndrome  Market ”gives detailed outlook by Type, by Application, by Segmentation and Regional Forecasts.

“Guillain-Barre Syndrome Market” report provides a detailed analysis of global market size, regional and country-level market size, segmentation, market growth, market share, and competitive landscape.