I think the funniest possible thing to do in a low stakes situation when someone subtly insults you is to ask them to elaborate.
In Seattle I was explaining environmental DNA and a woman said it “tickled” her to hear someone with my accent (rural Appalachia) “talk about science.”
So I said, “oh! 🙂 What an interesting perspective. Can you tell me more about what you mean?”
As you can imagine it went badly for her very quickly.