UK 1987

Requested by anon

Eclipse.

In fifth grade I dreamt my best friend turned out to be Barack Obama in disguise and then he stole my shoe and claimed that I was living in a simulation.

Exercise #3. 2022. in North Hollywood. Oil, acrylic, inkjet, graphite, wax pencil, paper collage on canvas. via Jet Le Parti archive.

From Emergency Room: Disaster Strikes

The Matrix (1999) - Glitch in the Matrix

Not a bit of this real world is real

John Gerrard (Irish, b.1974)

Flare (Oceania) - 2022

シェンムー 一章 横須賀 (1999)

Requested by anon

Nursing Home Looks Normal On Outside – Inside Is Designed To Be A Familiar 1940s Neighborhood. The Lantern of Chagrin Valley, located in Chagrin Falls, Ohio is one and only of three astounding offices designed specifically for Alzheimer's and dementia patients.

In a major scientific breakthrough, researchers at the University of Chicago have succeeded in creating a comprehensive model of the nuclear pore complex with the HIV-1 virus capsid. This sheds new light on the complex processes viruses like HIV use to enter host cell nuclei and replicate.

HIV-1 transports genetic material into the nucleus through nuclear import and viral capsid uncoating, two essential stages in the life cycle. The process is facilitated by the nuclear pore complex (NPC), where complete capsid transit is frequently accommodated in the central channel. The specific mechanisms behind this process are still unknown. 

This study published in PNAS looks at the molecular mechanisms that control capsid translocation via the central channel by interacting with the HIV-1 capsid and the NPC. The transfer of the capsid to the central channel from the cytoplasmic side of a human NPC is the main subject of the investigation. The compatibility of capsid form and channel dimension, along with the correct orientation of the capsid, drive the translocation dynamics. Additionally, the study finds that docked intact capsids exhibit associated striated patterns of lattice disorder, which are probably connected to intrinsic capsid elasticity. According to the study, the capsid’s inherent “elasticity” may aid in stress adaptation and structural integrity during translocation.

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