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#morfin
morfinclass · 2 months
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2014e dönüyormuşuz
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You all have to deal with my idiot nonsense ship
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Raven au morfin
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Ekmek Mayası Bitkilerdeki Tıbbi Bileşiklerin Keşfini Hızlandırıyor
Ekmek Mayası Bitkilerdeki Tıbbi Bileşiklerin Keşfini Hızlandırıyor
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#Araştırmalar, #Aspirin, #BitkiEnzimleri, #BitkiTranskriptomik, #Bitkiler, #CornellÜniversitesi, #EkmekMayası, #EkonomikÜretim, #Fermantasyon, #FırıncıMayası, #Genler, #Ilaçlar, #Kemoterapi, #KratomEnzimleri, #MayaBazlıTarama, #Mitraginin, #Morfin, #ProteinProteinEtkileşimleri, #SaccharomycesCerevisiae, #TıbbiBileşikler https://is.gd/EPfBqU https://www.tibbivearomatikbitkiler.com/haberler/ekmek-mayasi-bitkilerdeki-tibbi-bilesiklerin-kesfini-hizlandiriyor/
Ekmek mayası bitkilerdeki Tıbbi Bileşiklerin keşfini hızlandırdığına dair araştırmaları sürüyor. Araştırmacılar, tıbbi bileşikleri nasıl ve hangi bitkilerin sentezleyebileceğini belirlemeyi çok daha verimli hale getiren yeni bir tarama yöntemi geliştirdiler. Tarama yöntemi, bitki enzimleri arasındaki protein-protein etkileşimlerinin yakalanmasına yardımcı olan fırıncı mayasına dayanmaktadır. Yeni yöntem, 20 adaydan altı kratom enziminin tanımlanmasına yol açtı.
Aspirin, morfin ve bazı kemoterapiler, bitkiler tarafından üretilen doğal bileşiklerden elde edilen ilaçlara örnektir. Ancak bitkilerin bu tür bileşikleri oluşturmasını sağlayan genlerin belirlenmesi sıkıcı ve pahalıdır.
Şimdi, Cornell Üniversitesi araştırmacıları fırıncı mayasını kullanarak uygun maliyetli ve oldukça verimli bir yaklaşım yarattılar. Hatta yeni yöntemi bir kratom ağacındaki anahtar enzimleri tanımlamak için bile kullandılar.
Maya nedir: Maya, mantar krallığının bir üyesi olan tek hücreli, yaşayan bir mikroorganizmadır. Bira mayası veya ekmek mayası olarak da bilinen Saccharomyces cerevisiae , binlerce yıldır fırıncılıkta, şarap yapımında ve bira yapımında önemli bir bileşen olmuştur. Fermantasyon işlemi sırasında şekerleri ve nişastaları alkol ve karbondioksite dönüştürdüğü için adını Latince Yunanca “şeker mantarı” anlamına gelen kelimeden almaktadır.
Angewandte Chemie’deki araştırmaya göre , yeni maya bazlı tarama yöntemi, bitki enzimleri arasındaki protein-protein etkileşimlerini yakalıyor ve bir bitkinin tıbbi bileşikleri nasıl biyosentezlediğinden nihai olarak hangi genlerin sorumlu olduğunu daha iyi belirlemek için diğer tarama yöntemleriyle birlikte çalışıyor.
Kimya ve biyomoleküler mühendislik yardımcı doçenti Sijin Li, “Geleneksel yöntemler, bitkide aynı anda bulunan protein gruplarını buluyor, ancak bizim yöntemimiz, bu gruplardan hangilerinin fiziksel olarak kümelenip birbirleriyle iyi oynadığına bakarak bunu tamamlıyor” dedi. ve çalışmanın baş yazarı. “İlaç için çıkarmak isteyebileceğimiz kimyasal türlerinden sorumlu olanlar bunlar.”
Gen adayları bitki transkriptomiği kullanılarak tahmin edildikten sonra, fırıncı mayası (bira yapmak ve ekmek pişirmek için kullanılanla aynı tür), hangilerinin birbiriyle etkileşime giren proteinler ürettiğini görmek için içindeki genlerle birlikte tasarlanır. Sonuç olarak biyokimyasal olarak taranması gereken genlerin sayısı önemli ölçüde azalır.
İyi araştırılmamış ancak farmasötik potansiyele sahip olduğu düşünülen kratom yapraklarıyla yapılan deneylerde, maya bazlı yöntem, mitragininin veya diğer hedeflenen kimyasalları ürettiği genetik taramayla tahmin edilen 20 adaydan altı kratom enziminin tanımlanmasına yol açtı. Daha sonraki biyokimyasal testler, atılan 14 adayın hiçbirinin işlevsel enzim olmadığını, maya bazlı yöntemle tanımlanan altı adaydan dördünün ise işlevsel olduğunu gösterdi.
Li, “Klinik deneyler için kimyasalın bitkiden saflaştırılması veya kimyasal bir yaklaşım kullanılarak sentezlenmesi gerekiyor ki bu çok pahalı” dedi. “Maya yöntemini kullanarak mitraginini ve bizi yeni ilaçlara yönlendirebilecek diğer kimyasalları daha ekonomik bir şekilde üretebiliriz.”
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forislynx · 1 year
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Mina tankar är rena och stolta. Jag kommer att vara lycklig ett par timmar. Framför mig har jag sömnen. Ovanför mig har jag månen, den har en gloria omkring sig. Efter en injektion är jag inte rädd för någonting.
Michail Bulgakov, Morfin och andra noveller (ur novellen Morfin)
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ayilekonusankiz · 2 years
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gökyüzüne baktığın zaman
gördüğün ışıklar
belli ki sıcaklar
ama bize uzaklar
son feci bisiklet - morfin kafe
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corpsecomplex · 7 months
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guess who's become autistic about a bunch of diseased sailors
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rosietherivendell · 27 days
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The scene where Morfin is killed is so well done. There is so much happening all at once but it never feels busy and it packs such a punch. You've got Morfin, a man who is in so much pain that he is begging to be killed and when the others refuse he uses what little strength he has left and forces their hand. You've got Crozier, all calm and cool and keeping control over the crew. Fitzjames, once again watching Crozier hold the mantle of Captain in a way he would have thought impossible at the start of the expedition. Goodsir begging Morfin to let him help ease his pain. Silna watching Goodsir. And of course Tozer getting into position with his rifle. And all the while everyone is dead silent except for Neptune barking his head off in the background. But then there's Hickey. He turns away from Morfin and the crowd and walks away through the tents. And while you're absorbing everything else that's happening you think yeah of course he's walking away he did that with David Young too you think yeah that's his typical coldness...and then Morfin is shot and killed and you realize...Neptune has stopped barking.
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cinematicnomad · 8 months
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THE TERROR ▸ 1.07 horrible from supper
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badgart · 2 months
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had a lot of headaches lately.
Morflarp
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Let’s get this scurvy started!!1!
(/The scurvy song P!nk sang for a SpongeBob special, Terror!edition)
(For my @theterrorbingo prompt square “there will be poems.”)
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the-paper-monkey · 10 months
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When writing child Tom Riddle, what do you consider to be important notes/key elements/aspects to keep in mind? I really struggle with writing child Tom Riddle because there is only one scene we get from him as a young adult. I adore your characterisation of Tom
Even though we don't get to spend much time with child Tom, I do think that scene tells us a fair bit about his character. I would say it's even better character material than the memories we have of his teenage years, as this scene with Dumbledore shows us a Tom that isn't very good at masking yet.
One of the most important takeaways regarding little Tom, as outlined in this brilliant post, is his speech patterns. Tom at eleven is not sophisticated. He doesn’t speak like a precocious governess-tutored pureblood child. He’s blunt and direct, speaks without artifice and has little awareness or care for politeness or hierarchy. He interrupts Dumbledore repeatedly during their short conversation, even after being reprimanded for his manners and conduct.
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Since we know that the author doesn’t, um, shy away from writing out accents in dialogue, I think it’s fair to say he isn’t as ‘full Cockney’ as perhaps many of his peers, but Tom still has the manners of a street urchin and does not give a fuck. Tom is a child who is used to commanding respect from both his peers and the adult Muggles in his life. Dumbledore neither being intimidated nor capitulating to his demands makes Tom uneasy. He doesn’t feel safe around people who aren’t frightened of him.
Tom doesn't know how to handle a world where he isn't the top dog. He's learning, undoubtedly, and practising his future model student persona, but he isn't very good at it yet. It doesn't come naturally to him, and he's clumsy with it. To me, that's one of the things that makes eleven-year-old Tom so endearing.
Another thing that is clear with a child Tom but not a teenage Tom, is his high level of emotional volatility. He’s far from the creepy, distant child that we see in the HBP film. Book Tom oscillates from one emotion to the next fast enough to give any reader whiplash. He swings from distrust, to fury, to wild joy, to politeness, to fear, then finally withdraws to a shrewd, calculating distance—all within his brief conversation with Dumbledore. I do think it’s important to recognise that Tom has never been fearless; after all, he destroys himself precisely in response to an all-consuming obsession with those fears. We already see a preoccupation with death, his mother’s death in particular, and a belief that his magic will save him from a similar fate.  
But what Tom isn't is a coward. When faced with a person or problem that frightens him, he addresses this head-on at first and tries to brute force his way through it, either through aggression or violence. Only when that doesn't work does he draw back and begin to think strategically, attempting to charm and ingratiate himself. As a teenager we see that he learns that the second strategy is going to work best for him, but it isn't really in his nature. By adulthood, he has reverted to form. In many ways Tom at eleven is closer to Voldemort in behaviour than Tom at sixteen.
Also, side note: while I was rereading this scene for the post I noticed that Tom actually believes his father is dead. When he asks Dumbledore about him, he doesn’t ask if his father is a wizard, he asks if he was a wizard. At this age, it hasn’t yet occurred to Tom that his father might still be living, just with no interest in finding his son.
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capriddle · 3 months
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I find Merope Gaunt an extremely interesting character. First of all, she is one of the last living heirs of Salazar Slytherin, she lives as an abused person and in extreme poverty. She manages to understand love, but in an extremely distorted, sick and possessive form and this transforms her into an executioner. She even falls in love with a muggle and, in fact, she betrays her family and her origins, even going so far as to sell her family heirloom. She is, in my opinion, one of the most controversial characters in the entire saga and it's a real crime that they cut her out of the films. What can I say, I hope in this case too that the series can resolve it by showing her story.
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Yknow the picture of the guy with the moth
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rewatched the terror once again and this time i wanted to make some coldboys' 💅fashion💅 sketches. just for acrylic practice and self care
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forislynx · 2 years
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Jag bryr mig inte om någonting, behöver inte någonting, har ingenstans att ta vägen.
Michail Bulgakov, Morfin och andra noveller (ur novellen Morfin)
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d-lioncourt · 25 days
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In an alternate world, Tom was raised by his mom, along with the Gaunt side of his family in the shack they shared all together. The constant abuse from his grandfather and uncle towards Merope makes him have no lost love for them. Just about to face his last year at school, he prepares for his quest for power and aims to have you on his side.
Trigger warning: sensible material such as violence, abuse, toxic behavior, and incest.
Credits to: @mrsdarkandyandere7 who helped me out with the cousin idea for the viewer.
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