I think what's really compelling about House's absolute unwillingness to bow down to anything or anyone (the ethical board, the law, extra rich CEO, vindictive police officer, and even the patients themselves) regardless of how absolutely batshit and downright illegal his actions are, is because it's coming from a chronically disabled person, in more ways than one.

He cannot walk without agony or his cane. His chronic and severe pain led him down the path of deep Vicodin addiction until he also becomes psychologically dependent on it too (once, Dr Cuddy gives him saline placebo and it "works", in that he is not feeling his leg pain anymore for a few hours).

He understands it deeply just how desperate people can be when they're in pain and nobody can (or are willing to) help them—at least, so far, until they land on his doorstep. Which is canonically the most extreme step patients take when everything else fails—you don't just go straight to Plainsborough Teaching Hospital and to Dr Gregory House MD's office; you have to go through dozens of other doctors in various specialties and failed treatments too.

(Although that's a separate discussion about how doctors, particularly resident ones, are overworked and underpaid and redtaped by shithead insurance companies even if they do know how to treat a patient and want to).

He knows, from the bottom of his heart, that having such a painful and life-limitting debilitating condition is comparable to hell on earth, because he has one. He knows, that despite his disability being visible to everyone, yet no one wants to put an effort to help him deal with it—is also hell on earth.

Cuddy simply throws money at him and turns the other way to his Vicodin abuse, like she is saying, "I don't care if he takes 10 Vicodin pills a day or more, and I have to pay at least $1M every year for lawsuits, as long as he gets the job done," (and when they decide to go into relationship, she immediately drops him when he relapses, even if the reason for his relapse is her—although, yes, there is another discussion to be had about keeping yourself and your child(ren) safe being a priority compared to helping an addict, recovering or not). Wilson, as loyal as he is to House, simply either enables him or lectures him without going into the root of the issue and thoroughly help House that way. His subordinates, especially after the original trio, are simply too scared, too ignorant, or too ambitious to even approach the issue and choose to keep their job than help House (also another discussion to be had about how you can't help people who don't want to help themselves and so on).

So when he sees a patient who has gone through hell trying to get a correct diagnosis and treatment, he becomes laser-focused on doing everything under the sun to get to the bottom of it and cure the patient. He doesn't care if he has to break into countless of houses (haha pun) and collect insane and probably biohazard samples to do it—he absolutely will, no question.

Yes, hate-criming and being a bigot is his favorite hobby (still livid at the asexual ep and the production's choice for the resolution, let's just say I still have beef with Hugh Laurie and the entire production team for it), and so is insulting patients in so many ways that Shakespeare would personally fly to New Jersey and shake his hands if someone manage to successfully perform necromancy on ol' Billy boy. But House is no one if not dedicated. "Yes, my patient is an idiot, everyone is an idiot too, but I WILL cure their condition like my life depends on it," is basically his middle name.

Besides, you can make the argument that he is more compassionate than all the other doctors around him, because despite his absolute disdain towards some of his patients' beliefs and stupidity, he still works his ass off to treat them. He will call your god an idiot in 7 different languages while putting you in a diagnostic machine he manipulated the whole hospital into letting him use so that you could get a test which weren't available to you before. He will tell you that your currently-happy marriage will end in a bloody divorce and your ex will leave you penniless so love is not real while injecting you with a medication he had to hack the CDC's database for.

There are even episodes that show him being truly earnest, like the clinic duty scene where he is snarky as usual to a girl who seemingly stupidly had unprotected sex until she lashes out, and House is like, "Oh shit, this is above my paygrade", and immediately goes to Cuddy with a very serious expression and no sarcastic dilly-daliying, demanding her to transfer the patient to someone else because he is not good with "curing" rape case (interesting choice on the writers' part to make the patient insist to have therapy with House, though).

There is an episode about a very workaholic woman executive in a fashion company who has tremor and partial paralysis, and later on it's shown that she seems to tie her worth as a person to her corporate success while band-aiding her deep psychological issue like her suicidal ideation, and House genuinely asks her, "Do you want to live? I cannot help you unless you want me to," or something along the line.

There is also the cursed 9-year-old terminal brain cancer episode where Chase kissed the patient (ew), where at first it shows House being a usual misanthophe to Wilson and saying, "She is not brave, it's the brain tumor clot talking because it must be near the amygdala." Later in the episode, House sits near the patient alone, and compassionately asks her if she even wants to live, going through the rest of her short-lived but horrible agony, even if they catch the clot. The surgery to find and get rid of the clot is risky and can debilitate her even more, and this is why House is laying the decision to her hands. That she gets to choose. This is what truly reveals to him that she is genuinely brave (aside from the scan showing the clot to be so far away from her amygdala), but for the wrong reason. She is brave for her mom, willing to go through horrible surgery and drag out her already painful cancer-ridden life because, "My mom needs me". When everyone is congratulating her in the end, you can tell House has a bittersweet expression of both awe towards her bravery, and sadness that this 9-year-old sick girl has to bear the brunt of her horrible pain just so that her mother is not sad. That he couldn't convince her to be a child until the nearing end of her life.

The most interesting evidence of his compassion to me is the gunman hostage episode. It might sound weird because in the whole episode, he is depicted to first want to outsmart the gunman patient, then becomes laser-focused but only because he sees it as a puzzle, then absolutely selfish and dangerous because he volunteers himself as the last hostage and gives the gun back to the guy after the MRI. I do think it's true that his dedication to solving patients-are-just-puzzle-to-me conditions shines through in the episode, especially the scene of him returning his gun, but there is something else I catch when I rewatched it before.

When the gunman patient is put in the MRI because Cameron tells him a theory through the hostage call, the remaining doctors in the room including House are wary at the gunman but also hopeful. Yet, when the result shows up on the screen, he realizes that the theory is wrong and the guy let go his only bargaining chip for nothing. If you watch this part carefully, you'll notice that House actually looks pitying and sad at the gunman's disappointed demeanor and expression. He realizes he is going to be another notch in the guy's failed doctors list, and at this point (with the gun given away and even the best, most talented doctor also not finding out what's wrong with him), the guy has given up hope that he will ever see the day he will be cured, certainly not behind the bars.

Yes, his thirst for puzzle is House's big driving force in giving back the gun, but you'll be lying to yourself if you don't notice House's compassion for the guy because he doesn't want the guy to go out empty-handed, with absolutely no more hope because House knows once they step out of the door, this guy will never, ever be allowed to be in the vicinity of any hospital or doctor ever again in his life, aside from jail's bare-minimum exams and medications. House can't handle the thought of putting someone else through his own disappointment—that nothing works to help his leg pain. He especially doesn't want to be the cause for this gunman guy's case either. Even in the end when House realizes the guy is a fucking moron because he doesn't know that Florida is, in fact, in earthwide-horizontal tropical zone and this is what stumps most of the guy's previous doctors—House still gives him a subtle salute to the guy while being handcuffed and led away, almost to say, "Enjoy your healing and the defeat of your arch nemesis The Sickness™, glad to be part of it."

Majority of his drive to stop at nothing until his patient is cured is definitely thanks to his own fucked-up leg, even if there are some dialogues with Cuddy and Stacy Warner (House's ex wife) that seem to imply he has always been a misanthrophe whose hobby is getting into malpractice (or general) lawsuits. I wholeheartedly believe that after his leg clot rendered him disabled and with chronic pain, he became much more dedicated and obsessed with getting to the bottom of a patient's medical information, even for info that seems innocuous or irrelevant that always turn out to be important (probably more like a plot armor than established characterization, to be honest), almost like this is his method of relating to the patients in his own weirdly human way, and maybe a little bit (actually, a lot) of projecting.

Thank you for coming to my TED Talk.