Biuret CAS#: 108-19-0

IdentificationPhysical DataSpectraRoute of Synthesis (ROS)Safety and HazardsOther Data

Identification

Product NameBiuretIUPAC NamecarbamoylureaMolecular Structure

CAS Registry Number 108-19-0EINECS Number203-559-0MDL NumberMFCD00007946Beilstein Registry Number1703510SynonymsBiuret 108-19-0 Allophanamide Allophanic acid amide IMIDODICARBONIC DIAMIDE Carbamylurea Molecular FormulaC2H5N3O2Molecular Weight103.081InChIInChI=1S/C2H5N3O2/c3-1(6)5-2(4)7/h(H5,3,4,5,6,7)InChI KeyOHJMTUPIZMNBFR-UHFFFAOYSA-NCanonical SMILESC(=O)(N)NC(=O)N Patent InformationPatent IDTitlePublication DateUS2015/18328THERAPEUTICALLY ACTIVE COMPOUNDS AND THEIR METHODS OF USE2015US2010/28280PROCESS FOR STRAIGHTENING KERATIN FIBRES WITH A HEATING MEANS AND DENATURING AGENTS2010US2006/127337Process for relaxing keratin fibres2006

Physical Data

AppearanceWhite crystalline powderWater SolubilitySlightly soluble(1.87e-02 g/L)Boiling Point100 °CRefractive index1.4264 (estimate)Water Solubility2 g/100 mL (25 ºC)SensitivityHygroscopic Melting Point, °C Solvent (Melting Point) 98 - 101dimethyl sulfoxide, toluene193 - 194ethanol109190185 - 190198.5 - 199.5201.5 - 202.5 Density, g·cm-3Measurement Temperature, °C1.45619.91.46919.91.46710 Description (Association (MCS))Solvent (Association (MCS))Partner (Association (MCS))IR spectrum of the complexdimethylsulfoxidemethyloxirane, methyldiazabicyclooctaneAssociation with compoundcobalt (3+)-ion Decomposition, °CSolvent for Crystallization (Decomposition) Amount (Decomposition), mol190111water0.7

Spectra

Description (NMR Spectroscopy)Nucleus (NMR Spectroscopy)Solvents (NMR Spectroscopy)Temperature (NMR Spectroscopy), °C Frequency (NMR Spectroscopy), MHzChemical shifts1Hdimethylsulfoxide-d6 400Chemical shifts 13Cdimethylsulfoxide-d6100Chemical shifts15Ndimethylsulfoxide-d630Chemical shifts 15Nnitromethane Description (IR Spectroscopy)Solvent (IR Spectroscopy)Comment (IR Spectroscopy) Bands, Spectrumpotassium bromide BandsacetonitrileSpectrumgas4000 - 500 cm**(-1)Bands3440 - 146 cm**(-1) Description (UV/VIS Spectroscopy)Solvent (UV/VIS Spectroscopy)Comment (UV/VIS Spectroscopy)Spectrumaq. NaOH210 - 250 nmSpectrumH2O210 - 250 nm, pH 8.

Route of Synthesis (ROS)

Route of Synthesis (ROS) of Biuret CAS 108-19-0 ConditionsYieldat 140℃ for 5h Experimental Procedure A four necked round bottomed flask was charged with 500 g(8.33 mole) of urea, stirred vigorously, and air was injected to the bottom side of the flask at the rate shown in following table 1.Simultaneously the reaction was carried out during 5 hours with the reaction temperature maintained at 140° C. by heating.After completion of reaction, the composition of the obtained solid was analyzed by using liquid chromatography and the result was disclosed by following Table 1.A 35 - 61 %Chromat. B 2 - 4 %Chromat. thionyl chloride at 140℃ for 5h Experimental Procedure biuret was prepared by the same method as Example 1 except that the reaction was carried out using 0.05 mole of various catalysts per 1 mole of urea, and the air injection rate is fixed at 2 L/min.After completion of reaction, the composition of the obtained solid is analyzed by using liquid chromatography and the result was disclosed by following Table 4.A 62 %Chromat. B 3 %Chromat.sodium phosphate at 140℃ for 1hA 61 %Chromat. B 3 %Chromat.sulfuric acidA 62 %Chromat. B 4 %Chromat. at 150 - 170℃ for 3hA 50 - 65 %Chromat. B 3 - 7 %Chromat.at 140℃ under 100 - 380 Torr for 5hA 50 - 57 %Chromat. B 3 - 4 %Chromat.

Safety and Hazards

Pictogram(s)

SignalWarningGHS Hazard StatementsH315: Causes skin irritation H319: Causes serious eye irritation H335: May cause respiratory irritation Information may vary between notifications depending on impurities, additives, and other factors. Precautionary Statement CodesP261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501 (The corresponding statement to each P-code can be found at the GHS Classification page.)

Other Data

TransportationNot dangerous goodsUnder the room temperature and away from lightHS Code294200StorageUnder the room temperature and away from lightShelf Life2 yearsMarket PriceUSD 10/kg Use PatternBiuret CAS#: 108-19-0 was used as a source of dietary nitrogen in purified diets for steers.bacterial infectionsBiuret CAS#: 108-19-0 is used as a preservative agent for compositions for udder hygienePreservative agent for compositions for teat hygienePreservative agent for compositions for treatment of mastitisSurface coating systemsFertiliser for agricultural compositions Read the full article

Biuret CAS#: 108-19-0

IdentificationPhysical DataSpectraRoute of Synthesis (ROS)Safety and HazardsOther Data

Identification

Product NameBiuretIUPAC NamecarbamoylureaMolecular Structure

CAS Registry Number 108-19-0EINECS Number203-559-0MDL NumberMFCD00007946Beilstein Registry Number1703510SynonymsBiuret 108-19-0 Allophanamide Allophanic acid amide IMIDODICARBONIC DIAMIDE Carbamylurea Molecular FormulaC2H5N3O2Molecular Weight103.081InChIInChI=1S/C2H5N3O2/c3-1(6)5-2(4)7/h(H5,3,4,5,6,7)InChI KeyOHJMTUPIZMNBFR-UHFFFAOYSA-NCanonical SMILESC(=O)(N)NC(=O)N Patent InformationPatent IDTitlePublication DateUS2015/18328THERAPEUTICALLY ACTIVE COMPOUNDS AND THEIR METHODS OF USE2015US2010/28280PROCESS FOR STRAIGHTENING KERATIN FIBRES WITH A HEATING MEANS AND DENATURING AGENTS2010US2006/127337Process for relaxing keratin fibres2006

Physical Data

AppearanceWhite crystalline powderWater SolubilitySlightly soluble(1.87e-02 g/L)Boiling Point100 °CRefractive index1.4264 (estimate)Water Solubility2 g/100 mL (25 ºC)SensitivityHygroscopic Melting Point, °C Solvent (Melting Point) 98 - 101dimethyl sulfoxide, toluene193 - 194ethanol109190185 - 190198.5 - 199.5201.5 - 202.5 Density, g·cm-3Measurement Temperature, °C1.45619.91.46919.91.46710 Description (Association (MCS))Solvent (Association (MCS))Partner (Association (MCS))IR spectrum of the complexdimethylsulfoxidemethyloxirane, methyldiazabicyclooctaneAssociation with compoundcobalt (3+)-ion Decomposition, °CSolvent for Crystallization (Decomposition) Amount (Decomposition), mol190111water0.7

Spectra

Description (NMR Spectroscopy)Nucleus (NMR Spectroscopy)Solvents (NMR Spectroscopy)Temperature (NMR Spectroscopy), °C Frequency (NMR Spectroscopy), MHzChemical shifts1Hdimethylsulfoxide-d6 400Chemical shifts 13Cdimethylsulfoxide-d6100Chemical shifts15Ndimethylsulfoxide-d630Chemical shifts 15Nnitromethane Description (IR Spectroscopy)Solvent (IR Spectroscopy)Comment (IR Spectroscopy) Bands, Spectrumpotassium bromide BandsacetonitrileSpectrumgas4000 - 500 cm**(-1)Bands3440 - 146 cm**(-1) Description (UV/VIS Spectroscopy)Solvent (UV/VIS Spectroscopy)Comment (UV/VIS Spectroscopy)Spectrumaq. NaOH210 - 250 nmSpectrumH2O210 - 250 nm, pH 8.

Route of Synthesis (ROS)

Route of Synthesis (ROS) of Biuret CAS 108-19-0 ConditionsYieldat 140℃ for 5h Experimental Procedure A four necked round bottomed flask was charged with 500 g(8.33 mole) of urea, stirred vigorously, and air was injected to the bottom side of the flask at the rate shown in following table 1.Simultaneously the reaction was carried out during 5 hours with the reaction temperature maintained at 140° C. by heating.After completion of reaction, the composition of the obtained solid was analyzed by using liquid chromatography and the result was disclosed by following Table 1.A 35 - 61 %Chromat. B 2 - 4 %Chromat. thionyl chloride at 140℃ for 5h Experimental Procedure biuret was prepared by the same method as Example 1 except that the reaction was carried out using 0.05 mole of various catalysts per 1 mole of urea, and the air injection rate is fixed at 2 L/min.After completion of reaction, the composition of the obtained solid is analyzed by using liquid chromatography and the result was disclosed by following Table 4.A 62 %Chromat. B 3 %Chromat.sodium phosphate at 140℃ for 1hA 61 %Chromat. B 3 %Chromat.sulfuric acidA 62 %Chromat. B 4 %Chromat. at 150 - 170℃ for 3hA 50 - 65 %Chromat. B 3 - 7 %Chromat.at 140℃ under 100 - 380 Torr for 5hA 50 - 57 %Chromat. B 3 - 4 %Chromat.

Safety and Hazards

Pictogram(s)

SignalWarningGHS Hazard StatementsH315: Causes skin irritation H319: Causes serious eye irritation H335: May cause respiratory irritation Information may vary between notifications depending on impurities, additives, and other factors. Precautionary Statement CodesP261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501 (The corresponding statement to each P-code can be found at the GHS Classification page.)

Other Data

TransportationNot dangerous goodsUnder the room temperature and away from lightHS Code294200StorageUnder the room temperature and away from lightShelf Life2 yearsMarket PriceUSD 10/kg Use PatternBiuret CAS#: 108-19-0 was used as a source of dietary nitrogen in purified diets for steers.bacterial infectionsBiuret CAS#: 108-19-0 is used as a preservative agent for compositions for udder hygienePreservative agent for compositions for teat hygienePreservative agent for compositions for treatment of mastitisSurface coating systemsFertiliser for agricultural compositions Read the full article

Biuret CAS#: 108-19-0

IdentificationPhysical DataSpectraRoute of Synthesis (ROS)Safety and HazardsOther Data

Identification

Product NameBiuretIUPAC NamecarbamoylureaMolecular Structure

CAS Registry Number 108-19-0EINECS Number203-559-0MDL NumberMFCD00007946Beilstein Registry Number1703510SynonymsBiuret 108-19-0 Allophanamide Allophanic acid amide IMIDODICARBONIC DIAMIDE Carbamylurea Molecular FormulaC2H5N3O2Molecular Weight103.081InChIInChI=1S/C2H5N3O2/c3-1(6)5-2(4)7/h(H5,3,4,5,6,7)InChI KeyOHJMTUPIZMNBFR-UHFFFAOYSA-NCanonical SMILESC(=O)(N)NC(=O)N Patent InformationPatent IDTitlePublication DateUS2015/18328THERAPEUTICALLY ACTIVE COMPOUNDS AND THEIR METHODS OF USE2015US2010/28280PROCESS FOR STRAIGHTENING KERATIN FIBRES WITH A HEATING MEANS AND DENATURING AGENTS2010US2006/127337Process for relaxing keratin fibres2006

Physical Data

AppearanceWhite crystalline powderWater SolubilitySlightly soluble(1.87e-02 g/L)Boiling Point100 °CRefractive index1.4264 (estimate)Water Solubility2 g/100 mL (25 ºC)SensitivityHygroscopic Melting Point, °C Solvent (Melting Point) 98 - 101dimethyl sulfoxide, toluene193 - 194ethanol109190185 - 190198.5 - 199.5201.5 - 202.5 Density, g·cm-3Measurement Temperature, °C1.45619.91.46919.91.46710 Description (Association (MCS))Solvent (Association (MCS))Partner (Association (MCS))IR spectrum of the complexdimethylsulfoxidemethyloxirane, methyldiazabicyclooctaneAssociation with compoundcobalt (3+)-ion Decomposition, °CSolvent for Crystallization (Decomposition) Amount (Decomposition), mol190111water0.7

Spectra

Description (NMR Spectroscopy)Nucleus (NMR Spectroscopy)Solvents (NMR Spectroscopy)Temperature (NMR Spectroscopy), °C Frequency (NMR Spectroscopy), MHzChemical shifts1Hdimethylsulfoxide-d6 400Chemical shifts 13Cdimethylsulfoxide-d6100Chemical shifts15Ndimethylsulfoxide-d630Chemical shifts 15Nnitromethane Description (IR Spectroscopy)Solvent (IR Spectroscopy)Comment (IR Spectroscopy) Bands, Spectrumpotassium bromide BandsacetonitrileSpectrumgas4000 - 500 cm**(-1)Bands3440 - 146 cm**(-1) Description (UV/VIS Spectroscopy)Solvent (UV/VIS Spectroscopy)Comment (UV/VIS Spectroscopy)Spectrumaq. NaOH210 - 250 nmSpectrumH2O210 - 250 nm, pH 8.

Route of Synthesis (ROS)

Route of Synthesis (ROS) of Biuret CAS 108-19-0 ConditionsYieldat 140℃ for 5h Experimental Procedure A four necked round bottomed flask was charged with 500 g(8.33 mole) of urea, stirred vigorously, and air was injected to the bottom side of the flask at the rate shown in following table 1.Simultaneously the reaction was carried out during 5 hours with the reaction temperature maintained at 140° C. by heating.After completion of reaction, the composition of the obtained solid was analyzed by using liquid chromatography and the result was disclosed by following Table 1.A 35 - 61 %Chromat. B 2 - 4 %Chromat. thionyl chloride at 140℃ for 5h Experimental Procedure biuret was prepared by the same method as Example 1 except that the reaction was carried out using 0.05 mole of various catalysts per 1 mole of urea, and the air injection rate is fixed at 2 L/min.After completion of reaction, the composition of the obtained solid is analyzed by using liquid chromatography and the result was disclosed by following Table 4.A 62 %Chromat. B 3 %Chromat.sodium phosphate at 140℃ for 1hA 61 %Chromat. B 3 %Chromat.sulfuric acidA 62 %Chromat. B 4 %Chromat. at 150 - 170℃ for 3hA 50 - 65 %Chromat. B 3 - 7 %Chromat.at 140℃ under 100 - 380 Torr for 5hA 50 - 57 %Chromat. B 3 - 4 %Chromat. More: Inquiry all available synthetic routes with detailed experimental procedures

Safety and Hazards

Pictogram(s)

SignalWarningGHS Hazard StatementsH315: Causes skin irritation H319: Causes serious eye irritation H335: May cause respiratory irritation Information may vary between notifications depending on impurities, additives, and other factors. Precautionary Statement CodesP261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501 (The corresponding statement to each P-code can be found at the GHS Classification page.)

Other Data

TransportationNot dangerous goodsUnder the room temperature and away from lightHS Code294200StorageUnder the room temperature and away from lightShelf Life2 yearsMarket PriceUSD 10/kg Use PatternBiuret CAS#: 108-19-0 was used as a source of dietary nitrogen in purified diets for steers.bacterial infectionsBiuret CAS#: 108-19-0 is used as a preservative agent for compositions for udder hygienePreservative agent for compositions for teat hygienePreservative agent for compositions for treatment of mastitisSurface coating systemsFertiliser for agricultural compositions Read the full article

Biuret CAS#: 108-19-0

New Post has been published on http://www.chemwhat.com/biuret-cas-108-19-0/

Biuret CAS#: 108-19-0

Names & IdentifiersNew LiteratureSpectral PropertiesChemical & Physical PropertiesNew PatentsMarket InformationSafety & HazardsTransportation, Storage & UsageApproved Manufacturers

Names & Identifiers

Product NameBiuretMolecular Structure CAS Registry Number 108-19-0EINECS Number203-559-0 Synonymsallophanamide;Allophanic acid amide;Biuret [Wiki];carbamoylurea;Carbamylurea;Diamide dicarbonimidique [French] [ACD/IUPAC Name];Dicarbonimidic diamide [ACD/IUPAC Name];Dicarbonimidoic diamid;Dikohlenstoffimiddiamid [German] [ACD/IUPAC Name];Imidodicarbonic diamide [ACD/Index Name];MFCD00007946 [MDL number];ureidoformamide;(aminocarbonyl)urea;(carbamoylamino)formamide;1-(carbamoylamino)formamide;2-imidodicarbonic diamide;Allophanimidic acid (VAN);aminocarbonylurea;ARONIS002231;Biuret (Carbamylurea;DICARBAMYLAMINE;EINECS 203-559-0;Imidodicarbonic diamide);Imidodicarbonicdiamide;Isobiuret (VAN);ST040014;UNII-89LJ369D1H;Urea, (aminocarbonyl)- MDL NumberMFCD00007946 Beilstein Registry Number 1703510 Molecular FormulaC2H5N3O2 Molecular Weight103.08 SMILESC(=O)(N)NC(=O)N Std. InChiInChI=1S/C2H5N3O2/c3-1(6)5-2(4)7/h(H5,3,4,5,6,7) Std. InChIKeyOHJMTUPIZMNBFR-UHFFFAOYSA-N

Chemical & Physical Properties

AppearanceWhite crystalline powder Melting Point185-190℃ Boiling Point100 °C Refractive index1.4264 (estimate) Density1.01 g/mL at 20 °C Water Solubility2 g/100 mL (25 ºC) SensitivityHygroscopic

Safety & Hazards

SymbolIrritantSignalWarning GHS Hazard StatementsAggregated GHS information provided by 143 companies from 8 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. Reported as not meeting GHS hazard criteria by 27 of 143 companies. For more detailed information, please visit ECHA C&L website Of the 7 notification(s) provided by 116 of 143 companies with hazard statement code(s): H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation] H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] H335 (99.14%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation] Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. (The corresponding statement to each H-code can be found here.) Precautionary Statement CodesP261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501 (The corresponding statement to each P-code can be found here.) ToxicityCarcinogenicity IARC: No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.ACGIH: No component of this product present at levels greater than or equal to 0.1% is identified as a carcinogen or potential carcinogen by ACGIH. Transportation InformationADR/RID: Not dangerous goods IMDG:  Not dangerous goods IATA Not dangerous goodsPersonal Protective Equipment dust mask type N95 (US), Eyeshields, GlovesWGK Germany3

New Literature

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New Patents

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Transportation, Storage & Usage

TransportationUnder the room temperature and away from lightHS Code294200StorageUnder the room temperature and away from lightShelf Life2 yearsUsageBiuret (Carbamoylurea) was used as a source of dietary nitrogen in purified diets for steers.

Spectral Properties

IR of Biuret CAS 108-19-0HNMR of Biuret CAS 108-19-0Raman of Biuret CAS 108-19-0

Market Information

Reference Price(The average price based on Chemwhat’s market research)USD 9.8/kg