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majesticnerdynerd · 2 years
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happy halloween! here is a ghost duet
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majesticnerdynerd · 2 years
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its suck my motherfucking dick sunday
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majesticnerdynerd · 2 years
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Halloween is trending! It’s our time 👻🍂🎃🎃🍁💀
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majesticnerdynerd · 2 years
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chapter 4 has been uploaded
also, yeah, hiatus. there's more info in the end note! @quicksilver-castiel friend, hello! just letting you know publically i'm not dead c: I saw your tag post and it's been haunting me, but hey! I didn't ignore you, I was just very busy with life, but I had time to read yo fic and damn, I love midam <3
the fifth installment of my destiel flower shop AU Chapters: 1/? (likely 5) Summary: It is September 28th - Cas’ birthday. The Sunday starts off slow as Cas goes to his flower shop to prep for the week ahead, and Dean and Kelly lose no time preparing a surprise birthday party for him. Jimmy, Cas’ twin brother, his wife Amelia and daughter Claire join the planning too - last but(d) not least, they meet! There’s cats, chocolate cake, decorating of said cake (Claire helps Dean), and so much fluff Cas could die seeing the people most important to him do such a gesture for him. 
“These look great, Kelly,” Dean said, petting Velma. Kelly smiled and started unpacking the balloons. But one vital thing was missing. “And where’s the cake?”
Kelly’s arms spasmed and yellow rose petals went flying everywhere. “WE FORGOT THE CAKE! Oh my God, what now?”
“Jesus, chill!” Dean tried to calm her down, but Kelly looked both terrified and disappointed in herself.
“I am a secretary to a city hall member,” she said, facepalming, “and I forgot a birthday cake! I keep track of dates and what not to forget and this happens? I am a terrible friend!”
What in the… Dean snapped out of his confusion and tried to console her. “Kelly, listen. Shit like that happens. You know what’s a good thing?”
“That we have balloons?”
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majesticnerdynerd · 2 years
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TUMBLR????
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majesticnerdynerd · 2 years
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OH MY GOD!!! this casting plus Russell T Davies returning, i keep winning for real
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majesticnerdynerd · 2 years
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Lemon pansy sugar cookies for Beltane! Love and Light ✨
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majesticnerdynerd · 2 years
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majesticnerdynerd · 2 years
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this whole situation is very funny
credit to @cryptvokeeper for the idea!
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majesticnerdynerd · 2 years
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*cackling*
If OTW weren’t around, this wouldn’t be “scaremongering”: It would be the inescapable status quo.
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majesticnerdynerd · 2 years
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Hey if u wanna weaponise my superlong superwholock fic too, make them DIE
listen people are starting to realize tumblr isn’t dead we all need to be as cringe as possible for the next few months, it’s vital to our survival
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majesticnerdynerd · 2 years
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majesticnerdynerd · 2 years
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How Long Covid Exhausts the Body
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Millions of people continue to suffer from exhaustion, cognitive problems and other long-lasting symptoms after a coronavirus infection. The exact causes of the illness, known as long Covid, are not known. But new research offers clues, describing the toll the illness takes on the body and why it can be so debilitating.
Diagnosing Long Covid
Patients with severe Covid may wind up in hospitals or on ventilators until their symptoms resolve. Damage to the body from severe Covid — pneumonia, low oxygen, inflammation — typically shows up on traditional diagnostic tests.
Long Covid is different: A chronic illness with a wide variety of symptoms, many of which are not explainable using conventional lab tests. Difficulties in detecting the illness have led some doctors to dismiss patients, or to misdiagnose their symptoms as psychosomatic. But researchers looking more deeply at long Covid patients have found visible dysfunction throughout the body.
Studies estimate that perhaps 10 to 30 percent of people infected with the coronavirus may develop long-term symptoms. It’s unclear why some people develop long Covid and others don’t, but four factors appear to increase the risk: high levels of viral RNA early during an infection, the presence of certain autoantibodies, the reactivation of Epstein-Barr virus and having Type 2 diabetes.
The Immune System
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“Dang, why am I always so sick?”— Messiah Rodriguez, 17
Long Covid patients appear to have disrupted immune systems compared to post-Covid patients who fully recover. Many researchers believe chronic immune dysfunction after a coronavirus infection may set off a chain of symptoms throughout the body.
One possibility is that the body is still fighting remnants of the coronavirus. Researchers found that the virus spreads widely during an initial infection, and that viral genetic material can remain embedded in tissues — in the intestines, lymph nodes and elsewhere — for many months.
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Figure: Coronavirus RNA is visible in different body tissues at 500x magnification. Daniel Chertow et al., preprint via Research Square
Ongoing studies are trying to determine if these viral reservoirs cause inflammation in surrounding tissues, which could lead to brain fog, gastrointestinal problems and other symptoms.
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Figure: Coronavirus components persist in one patient’s small intestine, 92 days after the start of their Covid symptoms. Christian Gaebler et al., Nature
Researchers have also found evidence that Covid may trigger a lasting and damaging autoimmune response. Studies have found surprisingly high levels of autoantibodies, which mistakenly attack a patient’s own tissues, many months after an initial infection.
A third possibility is that the initial viral infection triggers chronic inflammation, possibly by reactivating other viruses in the patient’s body that are normally dormant. The reactivation of Epstein-Barr virus, which infects most people when they are young, might help predict whether a person will develop long Covid, one study found.
Inside the intricate world of the immune system, these explanations may coexist. And just as different long Covid patients may have different symptoms, they may also have different immune problems, too. Identifying the problems that are central to each patient’s illness will be critical for guiding treatment, said Dr. Akiko Iwasaki, an immunologist at Yale.
For instance, a patient with autoantibodies might benefit from immunosuppressive medication, while a patient with remnants of the Covid virus should receive antivirals, Dr. Iwasaki said. “Depending on what each person has, the treatment would be quite different.”
The Circulatory System
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“Something as simple as climbing on a ladder all of a sudden became a mountain.”— Eddie Palacios, 50
Many long Covid patients struggle with physical activity long after their initial infection, and experience a relapse of symptoms if they exercise. Initial studies suggest that dysfunction in the circulatory system might impair the flow of oxygen to muscles and other tissues, limiting aerobic capacity and causing severe fatigue.
In one study, patients with long-lasting Covid symptoms had unexpected responses to riding a bike. Despite having apparently normal hearts and lungs, their muscles were only able to extract a portion of the normal amount of oxygen from small blood vessels as they pedaled, markedly reducing their exercise capacity.
One possible culprit: Chronic inflammation may damage nerve fibers that help control circulation, a condition called small fiber neuropathy. The damaged fibers, seen in skin biopsies, are associated with dysautonomia, a malfunction of automatic functions like heart rate, breathing and digestion that is very common in long Covid patients.
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Figure: Chronic inflammation in long Covid patients may damage small nerve fibers. Peter Novak et al., Annals of Neurology
These findings demonstrate that people with long Covid are suffering systemic physical problems, rather than just being anxious or out of shape, said Dr. David M. Systrom, an exercise physiologist at Brigham and Women’s Hospital who helped conduct the bike study.
“You can’t make up small fiber neuropathy by skin biopsy. That isn’t in somebody’s head,” Dr. Systrom said. “You can’t make up poor oxygen extraction to this degree. All of these are objective measures of disease.”
South African researchers found another circulation problem: Microscopic blood clots. Tiny clots that form during an initial Covid infection will typically break down naturally, but might persist in long Covid patients. These clots could block the tiny capillaries that carry oxygen to tissues throughout the body.
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Figure: Platelets in the blood can become hyperactivated in Covid and long Covid patients, contributing to microclots. Etheresia Pretorius et al., Cardiovascular Diabetology
Inflammatory substances called cytokines, which are often elevated in long Covid patients, may injure the mitochondria that power the body’s cells, making them less able to use oxygen. Walls of blood vessels may also become inflamed, limiting the uptake of oxygen.
Whatever the cause, low oxygen levels may contribute to long Covid’s most common symptom, severe fatigue. Some long Covid patients meet the criteria for ME/CFS (also known as chronic fatigue syndrome), which often starts after a viral infection. Researchers have found that ME/CFS patients also suffer from a lack of oxygen triggered by circulatory problems. That puts enormous strain on the body’s metabolism and makes simple activities feel like strenuous exercise.
The Brain
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“I approach a red light, my brain knows that it’s red, but it’s not reacting to the rest of my body to put my foot on the brake. Do you understand how terrifying that is?”— Samantha Lewis, 34
Even people with mild cases of Covid can experience sustained cognitive impairments, including reduced attention, memory and word-finding. Possible long-term neurological problems from Covid constitute “a major public health crisis,” according to Dr. Avindra Nath, the clinical director of the National Institute of Neurological Disorders and Stroke.
Researchers found a wide range of dysfunction in the brains of long Covid patients. Although it is unclear how often the virus directly penetrates the brain, even mild infections appear to cause significant brain inflammation, according to the researchers, who included Dr. Nath, Dr. Iwasaki and Dr. Michelle Monje, a neurologist at Stanford.
Infections may trigger the over-activation of immune cells called microglia in a way that appears similar to the process that can contribute to cognitive problems in aging and some neurodegenerative diseases.
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Figure: Microglia are activated in the brain of a Covid patient, contributing to brain inflammation. Anthony Fernández-Castañeda et al., preprint via bioRxiv. Photos: Myoung-Hwa Lee
Another research group found that long Covid may significantly reduce the amount of blood that reaches the brain, a finding that has was also seen in patients with a related chronic condition, ME/CFS, before the pandemic.
The Lungs
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“I couldn’t breathe. It literally felt like someone was sitting on my chest.”— Angelica Baez, 23
Shortness of breath is a frequent symptom of long Covid. But common lung tests — including chest X-rays, CT scans and functional tests — often come back normal.
Using specialized M.R.I. scans, a team of British researchers found preliminary evidence of lung damage in a small group of long Covid patients who had never been hospitalized. Detailed scans of their lung function indicated that most of the patients took up oxygen less efficiently than healthy people did, even if the structure of their lungs appeared to be normal.
The researchers cautioned that a larger group of patients will be needed to confirm the findings. If the results hold up, possible explanations for the observed shortness of breath include microclots in lung tissues or a thickening of the blood-air barrier that regulates the uptake of oxygen in the lungs.
Living With Long Covid
“It’s really not something you can push through.”— Dr. Abigail Bosk
Many hospitals now offer post-Covid clinics or recovery programs, which bring together doctors with experience treating long Covid patients. Given the number of patients, some doctors and programs have long waits for appointments. It can help to plan ahead and try multiple options.
— Survivor Corps keeps a directory of post-Covid clinics.
— Dysautonomia International offers a list of doctors with experience treating autonomic disorders commonly seen in long Covid.
— Body Politic hosts a Covid support group where thousands of long haulers share information and advice on Slack.
— The Long Covid Support Group hosts a community on Facebook.
— The Royal College of Occupational Therapists offers advice for managing post-Covid fatigue.
— An essay from Maria Farrell offers advice on how to get well, and the importance of making time to rest.
— ME Action, a group supporting people with ME/CFS, offers advice to long Covid patients on how to manage symptoms.
— Americans with long Covid may qualify for disability benefits, although without conclusive medical results, many people face roadblocks.
— Three leading researchers into long Covid often share information about the latest findings on Twitter: Dr. Amy Proal, a microbiologist at PolyBio Research Institute; Dr. David Putrino, the director of rehabilitation innovation for the Mount Sinai Health System; and Dr. Iwasaki, the Yale immunologist.
— Health Rising covers the latest research into long Covid, ME/CFS and other chronic illnesses in detail.
— Gez Medinger, a video producer, interviews some prominent researchers into long Covid on YouTube.
— A video interview with Dr. Svetlana Blitshteyn, a neurologist and the director of the Dysautonomia Clinic, offers advice for treatment and an overview of current research into autonomic disorders.
— A detailed guide to understanding, treating and living with orthostatic intolerance is available from the Johns Hopkins Children’s Center.
Source: by Josh Keller (The New York Times). Illustration by Violet Frances for Bryan Christie Design. Produced by Jonathan Corum. Additional reporting by Pam Belluck and Amanda Morris. 
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majesticnerdynerd · 2 years
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Start Unconditional Basic Incomes (UBI) throughout the EU
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https://eci.ec.europa.eu/014/public/#/screen/home
23/04/2022
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https://eci.ec.europa.eu/014/public/#/screen/home/allcountries
If you’re not an EU citizen or can’t sign please pass the info to EVERYONE you know, so they can help spread it!
(That means reblogging this, not just liking it … )
If the EU manages to get this implemented, it could really improve quality of life for everyone not just those living in the EU.
If this get’s of the ground no western governemnt has an excuse to not at least try the UBI!
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majesticnerdynerd · 2 years
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There are two timelines in my life:
Before Fanfic
B.F. was books, the library. Limited reading. No tags, no warnings. Lots of trial and error error error ... Nearly 1,000 books read. Always a struggle to find something good to read! Lots of disappointment and wishing iiiiiiihadbeenwarned.
&
After Discovery
A.D. ... I just wish every bookstore and library would learn from AO3 Tags. I want to KNOW what is in the book I'm about to read and invest time in. I WANT TO BE FOREWARNED of triggers and MCD tyvm!!! *but you'll spoil the twist!!* F U!!!!
Marvel, Agatha Christie, Star Wars, literally EVERY franchise and formulaic show proves, people want the option to know what they're getting! Buy a grab bag if you want a surprise. Shop a bookstore blindfolded!
I'm here to pick up my hyper-specific-trope-me-up dopamine hit!
Libraries are drug stores.
I want the warning labels!
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majesticnerdynerd · 2 years
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Working in retail stories:
first day in had a grumpy old lady come in complain about soap, she wanted the pure white block of soap, we had it, she complained she couldnt tear open the package to see if it was pure white despite the package stating (and me reading it) that it is *white* and she had a problem with "snowflakes" only ever wanting liquid soap now, despite the wide selection of bars of soap in front of us; she left grumpy saying tesco has it cheaper, so she had gone
a young woman came in, asked me for makeup advice, and despite not knowing a lot just basics i did my best. Well. she was looking for a foundation in her skin tone, darker than mine, and was germaphobic, so she didnt wanna try the tester on herself. So i was the test rabbit. Customer service right? Oh well, it doesnt end there. It became apparent she was drunk, and she had to put on good but simple makeup to get one over on her ex, which, okay, but when her vodka breath and despair hit my nostrils that predicted shenanigans already. To be specific, she asked if she could try the foundation on my hand. Thinking she'd put on a smol dollop i agreed, that's how you usually test a tester, right?? Right??! No!!!! She put a LOT on MY FOREARM and SPREAD it like WALL PAINT all over my arm!!!! ALL OVER IT I COULDNT EVEN REACT i just went welp i hope we got micellar water in the back. We didnt. But we had acetone! Stonks. So anyway that shade wasnt correct, so we tried a second foundation and guess what SAME THING HAPPENED DESPITE ME TELLING HER IT'S BEST DONE ON THE BACK OF YOUR HAND OH MY GOD BOTH MY ARMS ARE COVERED IN FOUNDATION THAT DOESNT MATCH ME (i am whiter than snow white) ah shit and then she asked about eyebrow pencils,,,,, thankfully she didnt need to test that nor would i allow her to clown-ize me, so she took those, thanked me (gotta give her credit she was very nice) and bought that.
I hope she's doing okay now
I had two highschoolers come in and one of them, much taller than me, sheepishly approached me and said "excuse me, do you have vaselline?" And my brain did error.exe cuz listen, I'm new, i dont know where half the shit is but i pointed him in its general direction while his friend said " you see? You ask such dumbass fuckery bullshit not even the poor girl knows which side of your ass it came from"
I laughed
Also, to be honest, never EVER fear that the cashier judges you for buying anything, i swear to you i am too focused on the bar codes being scanned and your store card and how to return money if you pay in cash than the mini condoms you apparently think matter or so
More to come
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majesticnerdynerd · 2 years
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Reblog if you write fic and people can inbox you random-ass questions about your stories, itemized number lists be damned.
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